European Journal of Cancer Prevention最新文献_第7页

Compliance and satisfaction with BRCA surveillance in specialized clinics versus community follow-up. 专科门诊与社区随访对 BRCA 监测的依从性和满意度。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-03-01 Epub Date: 2024-06-14 DOI: 10.1097/CEJ.0000000000000904

Rita Vortman, Moran Echar, Amihood Singer, Lena Sagi-Dain

{"title":"Compliance and satisfaction with BRCA surveillance in specialized clinics versus community follow-up.","authors":"Rita Vortman, Moran Echar, Amihood Singer, Lena Sagi-Dain","doi":"10.1097/CEJ.0000000000000904","DOIUrl":"10.1097/CEJ.0000000000000904","url":null,"abstract":"Objective: To assess adherence to medical follow-up protocols among BRCA1/2 carriers and compare outcomes between dedicated carrier clinics and community healthcare settings.Methods: This cross-sectional study was conducted by distributing an anonymous questionnaire within the 'Good BRCA Genes - Support and Information Group for BRCA Carriers' association. The questionnaire assessed adherence to recommended surveillance and satisfaction with various aspects of the follow-up.Results: Of the 682 BRCA carriers surveyed, 68.5% reported fully adhering to recommended medical follow-up. Those not fully adhering cited bureaucracy challenges, scheduling difficulties, timing uncertainties, and difficulty remembering examination dates. Less than 50% were satisfied with appointment availability, scheduling, contact persons, and general practitioners' knowledge of BRCA carrier risks and follow-up. The 417 women monitored in dedicated breast clinics reported notably higher optimal adherence to recommended surveillance (78.3 vs. 53.6%, P < 0.0001). In addition, they noted greater satisfaction with appointment availability (63.7 vs. 25.0%, P < 0.0001), appointment scheduling process (58.1 vs. 24.7%, P < 0.0001), availability of breast surgeons/gynecology specialists (67.4 vs. 50.8%, P < 0.0001), and availability of a contact person for consultations between appointments (53.5 vs. 20.8%, P < 0.0001).Discussion: Our findings highlight the advantages of surveillance in dedicated BRCA1/2 clinics, including closer monitoring and increased satisfaction. Given the limited availability of such clinics and the growing number of BRCA1/2 carriers, the opening of additional dedicated clinics and the consideration of alternative surveillance-enhancing solutions, such as training healthcare professionals, using digital tools, and employing artificial intelligence, are essential.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"100-105"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends in the incidence of second primary cancers in Northern Portugal: a population-based study. 葡萄牙北部第二原发性癌症发病率的时间趋势：一项基于人群的研究。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-02-25 DOI: 10.1097/CEJ.0000000000000962

Elisabete Gonçalves, Filipa Fontes, Jéssica Rocha Rodrigues, Luis Antunes, Maria José Bento, Nuno Lunet, Samantha Morais

{"title":"Temporal trends in the incidence of second primary cancers in Northern Portugal: a population-based study.","authors":"Elisabete Gonçalves, Filipa Fontes, Jéssica Rocha Rodrigues, Luis Antunes, Maria José Bento, Nuno Lunet, Samantha Morais","doi":"10.1097/CEJ.0000000000000962","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000962","url":null,"abstract":"The growing number of cancer survivors has led to an increase in the frequency of multiple primary cancers. This study aimed to describe the temporal trends in the incidence rates and standardized incidence ratios (SIRs) of second primary cancers (SPCs) among patients diagnosed with a first primary cancer (FPC) in 2000-03, 2004-07 and 2008-11 in Northern Portugal. Population-based samples of patients diagnosed with an FPC (excluding skin non-melanoma) in 3 periods of 4 years, between 1 January 2000 and 31 December 2011, and registered in the Portuguese North Region Cancer Registry were followed for the diagnosis of an SPC or death until 31 December 2013. Incidence rates and SIRs were estimated for each period by sex, and considering the time between FPC and SPC diagnosis (synchronous and metachronous). During follow-up, 10 119 (7.4%) SPCs were identified among patients diagnosed with an FPC in 2000-11 (n = 136 382). The incidence rate of SPCs was over 10-fold higher in the first few months, remaining stable over the follow-up. Higher rates were observed in 2004-07 and 2008-11. Overall, a greater proportion of SPCs was diagnosed among males than females. The proportion of SPCs diagnosed increased with age. Increases in SIRs of SPCs were observed from 2000-03 to 2008-11, ranging from 1.16 to 1.77 and from 1.54 to 2.33, among males and females, respectively. This was particularly evident for FPCs and SPCs of the lip, oral cavity, pharynx, oesophagus and larynx among males, and colon and rectum, lung, ovary and cervix among females. Survivors of cancer in Northern Portugal had higher incidence rates of cancer than the general population, which have increased over time. Our findings highlight the need for enhanced surveillance and tailored strategies for survivors of cancer, emphasizing the challenges of their heightened cancer risk, patient expectations, and associated economic burden.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer mortality predictions for 2025 in Latin America with focus on prostate cancer. 2025年拉丁美洲癌症死亡率预测，重点是前列腺癌。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-02-25 DOI: 10.1097/CEJ.0000000000000959

Silvia Mignozzi, Claudia Santucci, Fabio Levi, Matteo Malvezzi, Paolo Boffetta, Giovanni Corso, Eva Negri, Carlo La Vecchia

{"title":"Cancer mortality predictions for 2025 in Latin America with focus on prostate cancer.","authors":"Silvia Mignozzi, Claudia Santucci, Fabio Levi, Matteo Malvezzi, Paolo Boffetta, Giovanni Corso, Eva Negri, Carlo La Vecchia","doi":"10.1097/CEJ.0000000000000959","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000959","url":null,"abstract":"We provided cancer mortality rate estimates for the year 2025 in six Latin American countries (Argentina, Brazil, Chile, Colombia, Cuba, and Mexico), focusing on prostate cancer. We extracted mortality data for all cancers combined and the most common sites from the WHO and population data since 1970 from the United Nations. Estimates for 2025 were computed applying a linear regression to the most recent segment identified through Poisson join-point regression. Avoided deaths number from 1991 to 2025 was estimated by applying the 1990 peak rate to population data. Mortality from all cancers is predicted to be favorable for both sexes in all countries. The lowest total cancer mortality rates are expected in Mexico (67.7/100 000 males; 61.4/100 000 females), while the highest ones in Cuba (136.6/100 000 males; 91.6/100 000 females). Prostate cancer mortality is declining in all countries, although rates remain high in Cuba (25.2/100 000 in 2025). Downward patterns are observed for all age groups in all countries, except the elderly in Cuba and Mexico. Declines in mortality are predicted for colorectal (except for males in Brazil and Cuba, and females in Chile), stomach (except Cuban males), pancreatic (except Argentinian and Cuban males), lung, bladder (except Argentinian females), breast, and ovarian (except Cuba) cancers. Uterine cancer mortality, particularly from cervical cancer, remains highin Argentina (10.2/100 000) and Cuba (10.4/100 000). Except for uterine, stomach, and prostate cancers, cancer mortality rates are still relatively low in Latin America, except Cuba. Controlling tobacco particularly in Cuba, implementing organized cervical cancer screening, and advancing cancer treatment also for prostate cancer remain crucial in all countries considered.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden and risk factors of colorectal cancer in Europe from 1990 to 2021. 1990年至2021年欧洲结直肠癌的负担和危险因素

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-02-18 DOI: 10.1097/CEJ.0000000000000963

Tao Zhang, Shuai Wang, Dongming Li, Yifei Wang, Xueyuan Cao

{"title":"Burden and risk factors of colorectal cancer in Europe from 1990 to 2021.","authors":"Tao Zhang, Shuai Wang, Dongming Li, Yifei Wang, Xueyuan Cao","doi":"10.1097/CEJ.0000000000000963","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000963","url":null,"abstract":"Background: Colorectal cancer (CRC) poses a significant health burden in Europe, but comprehensive studies on this region are limited.Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, we analyzed the regional distribution and temporal trends of the CRC and early-onset CRC burden in Europe from 1990 to 2021. Decomposition analysis was applied to quantify the contributions of population growth, aging, and epidemiological changes. The research also evaluated major risk factors associated with CRC and early-onset CRC.Results: The burden of CRC in Europe was found to be higher than the global average. While the age-standardized incidence rate (ASIR) increased, both the age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years rate (ASDR) decreased. Early-onset CRC exhibits similar distribution characteristics and patterns of change. Males had a significantly higher CRC burden than females. Population aging was the primary driver of increased burden in Europe. Risk factor analysis revealed that low whole grain intake and high red meat consumption were the primary contributors to the elevated ASMR and ASDR of CRC and early-onset CRC. Additionally, the CRC and early-onset CRC burden associated with high BMI and high fasting plasma glucose showed an increasing trend.Conclusion: The overall burden of CRC and early-onset CRC in Europe remains higher than the global level, with increasing ASIR and decreasing ASMR and ASDR. Targeted prevention and control strategies should be developed based on the major risk factors for CRC. Older adults and men should be prioritized for interventions.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global and regional burden of kidney cancer due to high body index in adults from 1990 to 2021 and predictions to 2036. 1990 年至 2021 年和预测至 2036 年全球和各地区成年人因高体质指数导致的肾癌负担。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-02-18 DOI: 10.1097/CEJ.0000000000000961

Meng Zhang, Yuefan Shen, Jianguo Gao, Sihai Shao

{"title":"Global and regional burden of kidney cancer due to high body index in adults from 1990 to 2021 and predictions to 2036.","authors":"Meng Zhang, Yuefan Shen, Jianguo Gao, Sihai Shao","doi":"10.1097/CEJ.0000000000000961","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000961","url":null,"abstract":"Monitoring the evolving global and regional burden of kidney cancer attributable to high BMI is vital for informing prevention and healthcare policies. This study aimed to evaluate historical trends in the global and regional burden of kidney cancer attributable to high BMI from 1990 to 2021 and to predict future trends through 2036 for individuals aged 20 years and older. We conducted a retrospective analysis using the Global Burden of Disease 2021 database. We analyzed data on mortality and disability-adjusted life years (DALYs) linked to kidney cancer from high BMI. Stratifications included sociodemographic index (SDI), region, sex, and age. Temporal trends were assessed using joinpoint regression models, while the relationship between SDI and regional burden was examined. Projections were generated using Bayesian age-period-cohort models. In 2021, high BMI contributed to 19.86% of global kidney cancer deaths (0.032 million) and 19.00% of DALYs (0.782 million), representing an increase since 1990. Globally, age-standardized mortality rate and age-standardized disability rate have declined in recent years. However, rates have risen in developing regions such as South Asia and East Asia. Projections indicate stable global rates with slight fluctuations through 2036. The global kidney cancer burden attributable to high BMI shows signs of decline but continues to rise in some developing regions. Addressing this disparity requires strengthening obesity prevention and control strategies tailored to regional needs.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global, regional, and national disease burden and risk factors of male breast cancer from 1990 to 2021: an analysis of the Global Burden of Disease Study. 1990年至2021年全球、区域和国家男性乳腺癌疾病负担和风险因素：对全球疾病负担研究的分析

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-02-14 DOI: 10.1097/CEJ.0000000000000952

Jia-Yan Qu, Jing-Bo Lu, Hui-Jun Sun, Cai-Ping Meng, Li-Yuan Rong

{"title":"The global, regional, and national disease burden and risk factors of male breast cancer from 1990 to 2021: an analysis of the Global Burden of Disease Study.","authors":"Jia-Yan Qu, Jing-Bo Lu, Hui-Jun Sun, Cai-Ping Meng, Li-Yuan Rong","doi":"10.1097/CEJ.0000000000000952","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000952","url":null,"abstract":"Male breast cancer (MBC) contributes to approximately 1% of total breast cancer diagnoses, with rapidly rising incidence and mortality rates worldwide. Since most breast cancer research has focused on women, this study intended to report the incidence, mortality, and disability-adjusted life years (DALYs) of MBC to aid in its control and prevention. The data on the incidence, DALYs, deaths, and age-standardized rates of MBC between 1990 and 2021 in different countries and territories were sourced from the Global Burden of Disease (GBD) 2021 study. In 1990 and 2021, Eastern Sub-Saharan Africa had the highest incidence, DALYs, and mortality rates. Countries in the middle socio-demographic index quintile showed the fastest growth in age-standardized incidence rate, ASDR, and ASMR. From 1990 to 2021, the incidence, mortality rate, and DALYs of MBC increased worldwide. Alcohol use, dietary risks, and tobacco use were risk factors for ASMR, with dietary risks ranking first in all GBD regions. The rise in the number of cases of breast cancer in men places substantial stress on humans. Hence, policymakers should establish effective interventions and strategies for patients with MBC in accordance with the local situation.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High utilization of colonoscopy and fecal occult blood testing for screening or diagnostic purposes in Germany: a longitudinal analysis. 在德国，结肠镜检查和粪便潜血检查用于筛查或诊断目的的高利用率：一项纵向分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-02-10 DOI: 10.1097/CEJ.0000000000000956

Michel Hornschuch, Sarina Schwarz, Ulrike Haug

{"title":"High utilization of colonoscopy and fecal occult blood testing for screening or diagnostic purposes in Germany: a longitudinal analysis.","authors":"Michel Hornschuch, Sarina Schwarz, Ulrike Haug","doi":"10.1097/CEJ.0000000000000956","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000956","url":null,"abstract":"It is often reported that participation in the German colorectal cancer (CRC) screening program is low. However, it must be considered that fecal occult blood testing (FOBT) and colonoscopy are offered in parallel and both are also used for diagnostic purposes. We aimed to quantify and characterize the uptake of these colorectal examinations in Germany. Using the claims database German Pharmacoepidemiological Research Database (~20% of the German population), we included persons aged 50 in 2011 in cohort 1 (cohort 2: age 55) and assessed whether they utilized FOBT or colonoscopy for screening or diagnostic purposes until age 59 (cohort 2: age 64). We have stratified the analyses, i.e. by gender and educational level. Among 185 949 50-year olds, 80% of women and 63% of men had ≥1 colorectal examination (i.e. FOBT or colonoscopy) until age 59; 25% of women and 31% of men had ≥1 colonoscopy (among those, 76 and 62% had a screening colonoscopy). In women with lower vs higher education, 79 vs 82% had any colorectal examination; in men, these proportions were 60 vs 67%. Among 156 258 55-year olds, 78% of women and 69% of men had ≥1 colorectal examination until age 64. Our study demonstrates a high utilization of colorectal examinations in Germany. It also illustrates the value of health claims data to monitor CRC screening in Germany due to their longitudinal character and because they include information on screening, on examinations done for diagnostic reasons as well as information suitable to characterize users and nonusers.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global, regional, and national burden of colorectal cancer attributable to smoking from 1990 to 2021: a population-based study. 1990年至2021年吸烟导致的全球、区域和国家结直肠癌负担：一项基于人群的研究

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-22 DOI: 10.1097/CEJ.0000000000000957

Shuai Wang, Tao Zhang, Dongming Li, Xueyuan Cao

{"title":"The global, regional, and national burden of colorectal cancer attributable to smoking from 1990 to 2021: a population-based study.","authors":"Shuai Wang, Tao Zhang, Dongming Li, Xueyuan Cao","doi":"10.1097/CEJ.0000000000000957","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000957","url":null,"abstract":"Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide, with smoking being a significant risk factor. Understanding the temporal and spatial patterns of the CRC burden attributable to smoking is crucial for global public health strategies. Data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 were used to calculate the number of deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR) per 100 000 population, and age-standardized disability-adjusted life year rate (ASDR). The average annual percentage change (AAPC) was calculated from 1990 to 2021 to analyze disease burden trends. Frontier analysis was conducted to assess efficiency, and predictions were made for the next decade. In 2021, the global death toll and DALYs attributable to smoking were 47 613 and 1 235 667, respectively. From 1990 to 2021, the absolute number of deaths and DALYs increased, while ASMR (AAPC: -1.20) and ASDR (AAPC: -1.22) showed a significant decline. The disease burden was notably higher in males than females. Analysis by the Social Development Index revealed that more developed regions had a higher burden than less developed areas. China ranked first in the number of deaths and DALYs, while Greenland had the highest ASMR and ASDR. From 1990 to 2021, the age-standardized burden of CRC attributable to smoking decreased globally. However, the absolute burden remains a significant public health challenge, requiring sustained and targeted interventions.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a prediction model based on Hemoglobin, Albumin, Lymphocyte count, and Platelet-score for lymph node metastasis in rectal cancer. 建立基于血红蛋白、白蛋白、淋巴细胞计数和血小板评分的直肠癌淋巴结转移预测模型。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-22 DOI: 10.1097/CEJ.0000000000000954

Huanhui Liu, Qian Zou, Hanjing Zhang, Xiaojie Ma

{"title":"Development of a prediction model based on Hemoglobin, Albumin, Lymphocyte count, and Platelet-score for lymph node metastasis in rectal cancer.","authors":"Huanhui Liu, Qian Zou, Hanjing Zhang, Xiaojie Ma","doi":"10.1097/CEJ.0000000000000954","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000954","url":null,"abstract":"This study aimed to evaluate the ability of the preoperative Hemoglobin, Albumin, Lymphocyte count, and Platelet (HALP) score to predict lymph node metastasis (LNM) in patients with rectal cancer (RC) and improve prediction accuracy by incorporating clinical parameters. Data from 263 patients with RC were analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value (OCV) for the HALP score in predicting LNM. Based on this cutoff value, patients were divided into two groups. A baseline analysis was conducted to identify independent factors linked to LNM. A support vector machine (SVM) prediction model was developed, and its performance was evaluated using ROC, calibration curves, decision curve analysis, and Kolmogorov-Smirnov curve. The OCV for HALP score was 45.979. Patients were then classified into a low HALP group (n = 182) and a high HALP group (n = 81). The analysis found 21 clinical factors significantly associated with LNM. Among them, the key risk factors included high inflammatory status, poor nutritional condition, and a low HALP score. The SVM model incorporated these factors and showed robust predictive performance, with area under the curve values of 0.897, 0.813, and 0.750 for the training, validation, and testing datasets, respectively. The HALP score was significantly associated with LNM in RC patients. A machine learning model integrating the HALP score and inflammatory markers may be an effective tool for predicting LNM in RC.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate-to-severe psoriasis: an observational monocentric study. 中重度牛皮癣患者的皮肤癌与抗il单克隆抗体治疗的相关性：一项观察性单中心研究

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-07 DOI: 10.1097/CEJ.0000000000000948

Flavia Manzo Margiotta, Cristian Fidanzi, Simone Pardossi, Alessandra Michelucci, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Riccardo Morganti, Salvatore Panduri, Giovanni Bagnoni, Marco Romanelli, Agata Janowska, Valentina Dini

{"title":"Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate-to-severe psoriasis: an observational monocentric study.","authors":"Flavia Manzo Margiotta, Cristian Fidanzi, Simone Pardossi, Alessandra Michelucci, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Riccardo Morganti, Salvatore Panduri, Giovanni Bagnoni, Marco Romanelli, Agata Janowska, Valentina Dini","doi":"10.1097/CEJ.0000000000000948","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000948","url":null,"abstract":"Our study aimed to investigate the correlation between skin cancer and anti-interleukin (IL) therapy in patients with moderate-to-severe psoriasis. This was an observational monocentric study in which we enrolled a total of 235 patients in which 127 patients were affected by moderate-to-severe psoriasis and treated with anti-IL monoclonal antibodies (mAbs) for at least 6 months, whereas 108 patients affected by mild psoriasis were treated with topical therapies. Afterward, we performed a dermatologic visit to all the subjects, collecting anamnestic information including risk factors for skin cancer. We examined the skin lesions on their entire body by polarized and nonpolarized dermoscopy. A total of 21 suspicious lesions in the first group and 17 in the second one were removed and histologically analyzed. Twelve (9.4%) cancerous or precancerous lesions were found in the first group: seven (5.5%) basal cell carcinoma (BCC) and five actinic keratosis. The mean time to cancer onset was identified as 22 months after the start of four therapy, with an SD of 18 months, suggesting an earlier onset with respect to the start of therapy in our population. On univariate analysis, age (P = 0.001) and age of psoriasis onset (0.009) were statistically significant. Nine of 17 were skin cancers in the second group. Our study provided real-life evidence of the percentage of patients with skin cancers during therapy with anti-IL mAbs, demonstrating a good safety profile of the investigated drugs.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0