European Journal of Cancer Prevention最新文献

{"title":"Incidence and prognosis of pediatric kidney malignant tumors diagnosed from 2010 to 2021: a Surveillance, Epidemiology, and End Results-based study.","authors":"Huyu Wang, Chengjun Yu, Zhengbai Li, Jie Zhang, Hanyu Xiao, Sheng Wen, Yi Hua","doi":"10.1097/CEJ.0000000000000976","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000976","url":null,"abstract":"<p><p>Pediatric kidney parenchymal malignant tumor (KPMT) is a common primary tumor. We conducted this study to characterize the incidence proportions and prognosis of Wilms tumor and non-Wilms tumors (NWTs). We collected 1739 patients under the age of 18 who were diagnosed with KPMT from the Surveillance, Epidemiology, and End Results database between 2010 and 2021, and divided them into two groups to analyze. The incidence rate of Wilms tumor (85.1%) is significantly higher than NWT (14.9%). The proportion of Wilms tumor decreases with age [odds ratio (OR) = 0.81, 95% confidence interval (CI) = 0.78-0.84], and is gradually replaced by NWT. Male (OR = 0.65, 95% CI = 0.47-0.90), Asian (vs. White, OR = 0.46, 95% CI = 0.26-0.81) had significantly lower odds of Wilms tumor. In addition, Wilms tumor had the lower odds of initial diagnosis at the regional stage (vs. localized, OR = 0.68, 95% CI = 0.47-0.98), bone metastasis (OR = 0.09, 95% CI = 0.03-0.24), and brain metastasis (OR = 0.007, 95% CI = 0.001-0.068) than NWT, but the higher odds of lung metastasis (OR = 3.07, 95% CI = 1.42-6.62) and larger size of tumor (OR = 1.009, 95% CI = 1.005-1.012). NWT is associated with a significantly higher mortality than Wilms tumor (P < 0.01). Patients with later stage and major organ involvement are significantly associated with a higher mortality (P < 0.01). Surgery significantly improved the prognosis of patients with Wilms tumor and NWT.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus vaccination, cervical cancer screening, and acceptability of self-sampling: a cross-sectional study in vulnerable women.","authors":"Ana Fernandes, Nuno Lunet","doi":"10.1097/CEJ.0000000000000975","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000975","url":null,"abstract":"<p><p>The burden of cervical cancer is heterogeneously distributed across regions and population groups, which is likely to reflect inequalities in the access and use of human papillomavirus (HPV) vaccination and cervical cancer screening (CCS). Groups with worse vulnerability indicators are at higher risk. We aimed to describe the awareness, access, and use of HPV vaccination and CCS, as well as the acceptability of self-sampling, in vulnerable population groups. We evaluated 222 women recruited in institutions that support homeless people, drug users, sex workers, Roma communities, migrants, and older women (>50 years old) from low socioeconomic contexts. For data analysis, women pertaining to more than one group were analyzed in each of them, except for the older women group, that only included women not classified in any of the other groups. Most women never heard about the HPV vaccine (60%) and, among those aware, 80% were not vaccinated. The majority heard about CCS (96%) and had been screened at least once (91%), with Roma women presenting the lowest adherence (84%). Most women were screened opportunistically (68%) and were screened at no fixed intervals (34%) or more often than recommended (46%). Regarding self-sampling, 80% considered they would be able to perform it, and 65% of the unscreened women reported they would be more likely to undergo screening based on self-sampling. Most women were not vaccinated against HPV but underwent CCS. Self-sampling was widely perceived as an acceptable option for CCS that could increase adherence in vulnerable groups.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and survival of third primary cancers in a population-based cohort of prostate cancer survivors.","authors":"Patrícia Sá, José Taveira-Barbosa, Samantha Morais, Teresa Garcia, Maria José Bento, Nuno Lunet","doi":"10.1097/CEJ.0000000000000977","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000977","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the long-term risk and survival of third primary cancers (TPCs) among prostate first primary cancer (FPC) survivors.</p><p><strong>Methods: </strong>A population-based cohort of 13 222 males with a prostate FPC diagnosed between 2000 and 2009, registered by the North Region Cancer Registry of Portugal, was followed until 2021 for TPCs and vital status. We estimated the cumulative incidence of TPCs and the risk of death among TPCs. TPCs were compared to matched patients with a second primary cancer (SPC) only (1:1, by age group, the time between FPC and SPC, and SPC site) for risk and adjusted hazard of death.</p><p><strong>Results: </strong>For a period of up to 22 years after a prostate cancer diagnosis, 169 TPCs were identified, predominantly, in digestive, intrathoracic, and urinary tract organs; this corresponds to 15- and 20-year cumulative incidences [95% confidence interval (CI)] of 1.2% (1.0-1.4%) and 1.5% (1.2-1.8%), respectively, among the FPCs, and 9.1% (7.6-10.5%) and 12.0% (8.2-15.9%), respectively, among the SPCs. The 15-year all-cause cumulative mortality was 88.2% (82.2-94.3%) among TPCs and 75.7% (69.6-81.7%) among SPC only patients; the corresponding age-adjusted hazard ratio (95% CI) was 1.79 (1.37-2.34).</p><p><strong>Conclusions: </strong>Among males with a prostate FPC that are diagnosed with an SPC, just over 10% are expected to be diagnosed with a TPC within 20 years, and these have a nearly two-fold higher death hazard than those with an SPC only.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and cost-effectiveness of lung cancer screening in France with low-dose computed tomography.","authors":"Henri Leleu, Quentin Berkovitch, Julia Bonastre, Caroline Caramella, Étienne Giroux-Leprieur, Lucile Lefèvre, Pernelle Lavaud, Andreea Todea, Marie Wislez, Paul Hofman","doi":"10.1097/CEJ.0000000000000973","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000973","url":null,"abstract":"<p><p>Lung cancer is the third most frequent cancer in France. It has a poor prognosis when patients are diagnosed at advanced stages. Low-dose computed tomography (LDCT) can detect early-stage cancer. In addition, blood-based biomarkers could help select patients for lung cancer screening or manage indeterminate lung nodules. The objective of this study is to assess the efficacy and cost-effectiveness of lung cancer screening in the French context including LDCT and biomarkers. A microsimulation model calibrated for France was used to compare four strategies: no screening, biennial LDCT, biennial LDCT followed by biomarkers, and biennial screening with biomarkers followed by LDCT. Screening eligibility included age (50-74) and smoking history (>15 cigarettes/day over 25 years, or 10 cigarettes/day over 30 years, or former smokers who quit less than 10 years ago). A 25% participation rate was assumed. Direct medical costs were estimated from the perspective of the French health system. Cost and outcomes were discounted at 2.5%. Screening decreased lifetime lung cancer mortality from 2 to 12% depending on the participation rate, leading to an increase in both life years and quality-adjusted life years (QALY). Considering cost effectiveness, LDCT screening was associated with an incremental cost-effectiveness ratio of €7629 per QALY in comparison to the absence of screening. Sensitivity analyses were all favorable to LDCT-based screening strategies. Biennial LDCT screening could be an effective and cost-effective strategy in France even at a 25% participation rate.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and clinical traits of HER2-low breast cancer patients and their relationship with neoadjuvant treatment effectiveness.","authors":"Wei Zhao, Mingxiang Zhang, Bohui Zhu, Yueyin Pan, Yiyuan Sun","doi":"10.1097/CEJ.0000000000000924","DOIUrl":"10.1097/CEJ.0000000000000924","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the clinical and molecular characteristics of different degrees of human epidermal growth factor receptor 2 (HER2) protein expression in HER2-negative breast cancer and the related factors affecting the efficacy of neoadjuvant chemotherapy in HER2-low breast cancer patients.</p><p><strong>Methods: </strong>The study endpoint was pathological complete remission (PCR). Blood specimens and fresh cancer tissue samples were collected before neoadjuvant chemotherapy for whole-exon sequencing (WES) and RNA sequencing (RNA-seq), and patients were divided into a human epidermal growth factor receptor 2 (HER2)-low group and a HER2-0 group according to their HER2 expression status via bioinformatics analysis.</p><p><strong>Results: </strong>A total of 409 HER2-negative breast cancer patients were included in the analysis, and HER2 status (HER2-0 vs. HER2-low) was significantly different between hormone receptor status, the Ki-67 index, and the PCR rate. A total of 18 patients who underwent WES and RNA testing were included, and the WES results suggested that the HER2-low group had a significantly higher rate of PIK3CA mutations and a greater frequency of PI3K pathway variants than the other groups and the HER2-low group had a greater number of concomitant mutations and reached statistical significance ( P  = 0.03). In terms of expression profiles, HER2-low and HER2-0 patients had different expression profiles. Overall, suggesting that the low PCR rate in the HER2-low group may also be related to chemoresistance.</p><p><strong>Conclusion: </strong>Our investigation highlights the possibility that HER2-low breast cancer may indicate a unique clinical and biological phenomenon.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"241-254"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Old age decreases the risk of lymph node metastasis in T1-2 hypopharynx squamous cell carcinoma patients.","authors":"Yujiao Li, Chaosu Hu","doi":"10.1097/CEJ.0000000000000945","DOIUrl":"10.1097/CEJ.0000000000000945","url":null,"abstract":"<p><p>Cervical lymph node metastasis (LNM) is an important prognostic factor for hypopharynx squamous cell carcinoma (SCC) patients, which can be detected in a large fraction of clinically diagnosed early hypopharynx SCC patients; however, the importance of knowing the risk of LNM in the younger/older patients has not been well defined. The objective of this study is to assess the effect of age and LNM in T1-2 hypopharynx SCC patients. Patients with T1-2 hypopharynx SCC were extracted from the Surveillance, Epidemiology and End Results database between 2005 and 2014. Univariate and multivariate logistic regression models were produced to recognize the association between age and risk factors of LNM. A total of 1018 patients were analyzed. Older patients have a lower risk of LNM compared with their younger peers ( P  < 0.01). In multivariate analyses, older age was associated with a significantly lower risk of LNM. Compared with patients aged 80-93 years old, the hazard ratios for patients aged 31-49, 50-59, 60-69, and 70-79 years old were 2.464 [95% confidence interval (CI): 1.338-4.537], 2.668 (95% CI: 1.638-4.346), 3.192 (95% CI: 1.957-5.205), and 1.564 (95% CI: 0.945-2.588), respectively. Subgroup analysis shows that the effect of older age was significantly associated with a higher risk of LNM in Caucasian male who harbored moderately/poorly differentiated tumors. Our study demonstrates that older patients with T1-2 hypopharynx SCC had a lower risk of LNM than their younger peers, especially males with moderately/poorly differentiated tumors. More accurate assessments of LNM and prophylactic neck dissection or prophylactic adjuvant radiation therapy to the neck will be imperative for reducing recurrence in younger T1-2 hypopharynx SCC.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"285-289"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between radiotherapy and the risk of second primary malignancies in breast cancer patients with different estrogen receptor statuses.","authors":"Chengshan Zhao, Yang Yu, Pi'ao Xiang, Jiahu Liao, Boyang Yu, Yifeng Xing, Guobing Yin","doi":"10.1097/CEJ.0000000000000915","DOIUrl":"10.1097/CEJ.0000000000000915","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most common cancer among women. Second primary malignancies (SPMs) related to radiotherapy are significant complications. This study aims to investigate the correlation between radiotherapy and the occurrence of SPMs in breast cancer patients with different estrogen receptor statuses.</p><p><strong>Methods: </strong>We used data from the Surveillance, Epidemiology, and End Results (SEER) database, selecting estrogen receptor(+) and estrogen receptor(-) breast cancer patients from 1990 to 2015, with SPMs as the outcome measure. Fine-Gray competing risks regression and Poisson regression were employed to analyze the relationship between radiotherapy and the risk of SPMs in different estrogen receptor status groups.</p><p><strong>Results: </strong>Radiotherapy was associated with an increased risk of lung cancer, melanoma, non-Hodgkin lymphoma, and leukemia in estrogen receptor(+) patients. In estrogen receptor(-) patients, radiotherapy was linked to an increased risk of brain cancer and leukemia. The cumulative incidence, standardized incidence ratio, and subgroup analyses showed consistent results. In the dynamic assessment of radiotherapy-related risks, estrogen receptor(+) patients aged 50-70 exhibited a higher risk of leukemia and melanoma. Lung cancer risk was highest during a latency period of 20-30 years, while melanoma, non-Hodgkin lymphoma, and leukemia risks peaked within the first 10 years. For estrogen receptor(-) patients, brain cancer risk was higher between ages 50 and 70, and leukemia risk was elevated between ages 20 and 50.</p><p><strong>Conclusion: </strong>Postoperative radiotherapy for breast cancer is associated with an increased risk of SPMs, with risks varying by estrogen receptor status and SPM type. Further research into the prevention of radiotherapy-related SPMs in different estrogen receptor status groups is crucial.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"255-263"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoablation of early breast cancer: the challenge towards de-escalation of surgical treatment.","authors":"Mattia Intra, Francesca Magnoni, Paolo Della Vigna, Luca Nicosia, Giovanni Mazzarol, Viviana Galimberti, Franco Orsi, Paolo Veronesi","doi":"10.1097/CEJ.0000000000000936","DOIUrl":"10.1097/CEJ.0000000000000936","url":null,"abstract":"","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"264-266"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic difference in the effect of organized programs on socioeconomic inequalities in breast cancer screening: ecological study in Switzerland.","authors":"Clement P Buclin, Martina von Arx, Vladimir Jolidon, José Luis Sandoval, Fabienne Buholzer-Mercier, Justine E Daverio, Bernadette W A van der Linden, Philippe Wanner, Idris Guessous, Delphine S Courvoisier, Stéphane Cullati","doi":"10.1097/CEJ.0000000000000914","DOIUrl":"10.1097/CEJ.0000000000000914","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to examine how the effect of organized mammography screening programs on breast cancer screening participation differ between socioeconomic strata and how this relationship may be modified by the context of linguistic differences. Switzerland, marked by its diverse linguistic landscape, reflects cultural variations alongside differences in public health strategies. The goal of this study was to assess potential socioeconomic differences in regional mammography screening programs effectiveness to improve breast cancer screening participation.</p><p><strong>Methods: </strong>Data on 14 173 women in the regionally adapted breast cancer screening age range was drawn from five cross-sectional waves of the nationally representative Swiss Health Interview Survey (1997-2017). Socioeconomic indicators included education, household income, and employment status. Poisson regression was used to estimate the adjusted prevalence ratios of up-to-date (last 2 years) mammography uptake. Inequality was assessed using relative index of inequality and the slope index of inequality.</p><p><strong>Results: </strong>Organized screening programs were generally effective and increased up-to-date mammography uptake by close to 20 percentage points in both regions. While in the Latin cantons, screening programs had no impact on socioeconomic inequalities in screening, it reduced inequalities for women with lower education in the German cantons. This modification effect of screening programs was not seen for income and employment-related inequalities and did not differ across linguistic regions.</p><p><strong>Conclusions: </strong>Public health agencies should consider the different cultural reception of programs as addressing these differences could help ensure that breast cancer screening initiatives are not only effective, but also culturally equitable across different socioeconomic groups.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"221-230"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival and risk factors of synchronous bone metastasis in oral tongue squamous cell carcinoma patients.","authors":"Yujiao Li, Chaosu Hu","doi":"10.1097/CEJ.0000000000000955","DOIUrl":"10.1097/CEJ.0000000000000955","url":null,"abstract":"<p><p>The objective of this study was to analyze the risk factors for synchronous bone metastases in patients with oral tongue squamous cell carcinomas (OTSCC). OTSCC patients were extracted from the Surveillance, Epidemiology and End Results database between 2014 and 2017. We examined the association between risk factors and synchronous bone metastases using Chi-squared tests. Predictors of survival rates were assessed using univariate and multivariate analyses. A total of 3902 patients were analyzed, which include 12 patients (0.3%) with synchronous bone metastases and 3890 patients without synchronous bone metastases (99.7%). Multivariate logistic regression analysis showed that highly differentiated disease, lower T classification, and lower N classification were associated with a significantly lower risk of bone metastases ( P  < 0.05, respectively). Unmarried and elderly patients who harbored with poorly differentiated disease, higher T or N classification, multiple sites of metastases, and no surgical therapy to primary tumor were more likely to influence patients' survival. By analyzing data from a large cohort, factors affecting bone metastases are primarily related to grade, T classification and N classification. Multivariable analysis showed that unmarried and elderly patients who harbored with poorly differentiated disease, higher T or N classification, multiple sites of metastases, and no surgical therapy to primary tumor were more likely to influence patients' survival. More accurate assessments of bone metastasis will be imperative for early diagnosis and treatment in poorly differentiated disease, higher T classification or N classification patients.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"279-284"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}