European Journal of Cancer Prevention最新文献

Accuracy of breath tests for colorectal neoplasms diagnosis: a meta-analysis. 呼吸试验对结直肠肿瘤诊断的准确性：一项荟萃分析。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2024-12-05 DOI: 10.1097/CEJ.0000000000000943

Lei Tian, Yizhe Wei, Yue Shi, Yiming Zhao, Jiang Chen, Xuan Liu, Bencheng Lin

{"title":"Accuracy of breath tests for colorectal neoplasms diagnosis: a meta-analysis.","authors":"Lei Tian, Yizhe Wei, Yue Shi, Yiming Zhao, Jiang Chen, Xuan Liu, Bencheng Lin","doi":"10.1097/CEJ.0000000000000943","DOIUrl":"10.1097/CEJ.0000000000000943","url":null,"abstract":"Early noninvasive and rapid screening for colorectal cancer critically influences treatment outcomes. Breath testing, as an emerging screening technology, allows for noninvasive and convenient screening for different biomarkers and is a reliable screening method for various diseases. In this study, a meta-analysis of the accuracy and current status of volatile organic compounds present in exhaled breath for colorectal cancer detection was performed. PubMed, Cochrane Library, and CNKI were searched for relevant studies. The quality of the studies was assessed using the QUADAS-2 criteria, and meta-analysis was performed using RevMan 5.3 and Stata 16. The pooled sensitivity is 90% [95% confidence interval (CI), 85-94%], the pooled specificity is 86% (95% CI, 72-93%), the pooled positive likelihood ratio is 6.3 (95% CI, 3.1-12.6), the negative likelihood ratio is 0.11 (95% CI, 0.07-0.17), and the diagnostic odds ratio is 56 (95% CI, 23-133). Summary receiver operating characteristic analysis revealed an area under the curve of 0.94 (95% CI, 0.91-0.95). The alteration of specific components of exhaled breath is associated with colorectal cancer development, and the selection of biomarkers and detection instruments influence the diagnostic value. What this paper adds to the literature: this meta-analysis provides a comprehensive evaluation of the diagnostic accuracy of volatile organic compounds in breath tests for colorectal cancer, highlighting the influence of biomarker selection and detection methods on screening efficacy.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"528-533"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptosporidiosis as an opportunistic infection in colorectal cancer patients. 隐孢子虫病在结直肠癌患者中的机会性感染。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2025-01-06 DOI: 10.1097/CEJ.0000000000000950

Can Muftuoglu, Tayfun Yoldas, Osman Bozbiyik, Ozlem Ulusan Bagci, Hamid Alizadeh, Ufuk Mert, Ayse Caner

{"title":"Cryptosporidiosis as an opportunistic infection in colorectal cancer patients.","authors":"Can Muftuoglu, Tayfun Yoldas, Osman Bozbiyik, Ozlem Ulusan Bagci, Hamid Alizadeh, Ufuk Mert, Ayse Caner","doi":"10.1097/CEJ.0000000000000950","DOIUrl":"10.1097/CEJ.0000000000000950","url":null,"abstract":"Cryptosporidium spp. is an opportunistic protozoan parasite that primarily affects immunocompromised individuals, including those with colorectal cancer (CRC). This study investigates the prevalence and clinical significance of Cryptosporidium spp. in CRC patients, including both the gastrointestinal and respiratory systems. A total of 108 CRC patients and 102 healthy controls were enrolled, and stool, sputum, and saliva samples were analyzed using both microscopy and qPCR methods. Cryptosporidium spp. were detected in 13% of CRC patients' stool samples, compared to 2% in the control group, demonstrating a statistically significant difference ( P = 0.0013). In contrast, there was no significant difference in Cryptosporidium spp. positivity between CRC patients and controls in sputum or saliva samples. Strikingly, one CRC patient had Cryptosporidium spp. in both sputum and saliva samples in addition to stool, suggesting potential secondary pulmonary involvement. The findings highlight the importance of screening for Cryptosporidium spp. in CRC patients, particularly those with respiratory symptoms, advanced-stage disease, or left-sided tumors, to ensure timely diagnosis and management of this opportunistic infection. Further research is needed to clarify the pathogen's role in colorectal carcinogenesis and the implications for patient outcomes.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"534-540"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate-to-severe psoriasis: an observational monocentric study. 中重度牛皮癣患者的皮肤癌与抗il单克隆抗体治疗的相关性：一项观察性单中心研究

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2025-01-07 DOI: 10.1097/CEJ.0000000000000948

Flavia Manzo Margiotta, Cristian Fidanzi, Simone Pardossi, Alessandra Michelucci, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Riccardo Morganti, Salvatore Panduri, Giovanni Bagnoni, Marco Romanelli, Agata Janowska, Valentina Dini

{"title":"Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate-to-severe psoriasis: an observational monocentric study.","authors":"Flavia Manzo Margiotta, Cristian Fidanzi, Simone Pardossi, Alessandra Michelucci, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Riccardo Morganti, Salvatore Panduri, Giovanni Bagnoni, Marco Romanelli, Agata Janowska, Valentina Dini","doi":"10.1097/CEJ.0000000000000948","DOIUrl":"10.1097/CEJ.0000000000000948","url":null,"abstract":"Our study aimed to investigate the correlation between skin cancer and anti-interleukin (IL) therapy in patients with moderate-to-severe psoriasis. This was an observational monocentric study in which we enrolled a total of 235 patients in which 127 patients were affected by moderate-to-severe psoriasis and treated with anti-IL monoclonal antibodies (mAbs) for at least 6 months, whereas 108 patients affected by mild psoriasis were treated with topical therapies. Afterward, we performed a dermatologic visit to all the subjects, collecting anamnestic information including risk factors for skin cancer. We examined the skin lesions on their entire body by polarized and nonpolarized dermoscopy. A total of 21 suspicious lesions in the first group and 17 in the second one were removed and histologically analyzed. Twelve (9.4%) cancerous or precancerous lesions were found in the first group: seven (5.5%) basal cell carcinoma (BCC) and five actinic keratosis. The mean time to cancer onset was identified as 22 months after the start of four therapy, with an SD of 18 months, suggesting an earlier onset with respect to the start of therapy in our population. On univariate analysis, age ( P = 0.001) and age of psoriasis onset (0.009) were statistically significant. Nine of 17 were skin cancers in the second group. Our study provided real-life evidence of the percentage of patients with skin cancers during therapy with anti-IL mAbs, demonstrating a good safety profile of the investigated drugs.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"571-580"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the threat of malignant melanoma in the UK still increasing? A comprehensive analysis of 30 years of historical data and Bayesian age-period-cohort model projections for 2030. 英国恶性黑色素瘤的威胁还在增加吗？综合分析30年的历史数据和贝叶斯年龄-时期-队列模型对2030年的预测。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2024-12-17 DOI: 10.1097/CEJ.0000000000000947

Hao Chen, Yangyang Wang

{"title":"Is the threat of malignant melanoma in the UK still increasing? A comprehensive analysis of 30 years of historical data and Bayesian age-period-cohort model projections for 2030.","authors":"Hao Chen, Yangyang Wang","doi":"10.1097/CEJ.0000000000000947","DOIUrl":"10.1097/CEJ.0000000000000947","url":null,"abstract":"Malignant melanoma, a highly aggressive skin cancer, though less common, significantly contributes to cancer-related mortality. In the UK, it is of growing concern with an aging population, making it crucial to analyze historical trends and forecast future burdens. We used Joinpoint regression and age-period-cohort models to analyze trends in incidence, prevalence, and mortality of malignant melanoma in the UK from 1990 to 2021. Bayesian age-period-cohort model was applied to predict the disease burden for different age groups by 2030. From 1991 to 2021, melanoma incidence and prevalence in the UK exhibited distinct temporal patterns: a significant upward trend until 2015, particularly pronounced in individuals aged 60 and older, followed by a downward trend after 2015. By 2030, incidence and prevalence are projected to decrease, particularly in younger and middle-aged populations, with incidence expected to fall from 20.78/100 000 in 2020 to 11.90/100 000, and prevalence from 167.80/100 000 to 80.13/100 000. Mortality is also expected to decrease. However, high-risk groups, especially those aged 85 and above, are predicted to maintain higher incidence and prevalence rates. Despite a historical rise, melanoma incidence, prevalence, and mortality have declined since 2015 and are projected to continue declining through 2030. However, the elderly population remains at higher risk, underscoring the need for targeted public health interventions.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"563-570"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global, regional, and national disease burden and risk factors of male breast cancer from 1990 to 2021: an analysis of the Global Burden of Disease Study. 1990年至2021年全球、区域和国家男性乳腺癌疾病负担和风险因素：对全球疾病负担研究的分析

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2025-02-14 DOI: 10.1097/CEJ.0000000000000952

Jia-Yan Qu, Jing-Bo Lu, Hui-Jun Sun, Cai-Ping Meng, Li-Yuan Rong

{"title":"The global, regional, and national disease burden and risk factors of male breast cancer from 1990 to 2021: an analysis of the Global Burden of Disease Study.","authors":"Jia-Yan Qu, Jing-Bo Lu, Hui-Jun Sun, Cai-Ping Meng, Li-Yuan Rong","doi":"10.1097/CEJ.0000000000000952","DOIUrl":"10.1097/CEJ.0000000000000952","url":null,"abstract":"Male breast cancer (MBC) contributes to approximately 1% of total breast cancer diagnoses, with rapidly rising incidence and mortality rates worldwide. Since most breast cancer research has focused on women, this study intended to report the incidence, mortality, and disability-adjusted life years (DALYs) of MBC to aid in its control and prevention. The data on the incidence, DALYs, deaths, and age-standardized rates of MBC between 1990 and 2021 in different countries and territories were sourced from the Global Burden of Disease (GBD) 2021 study. In 1990 and 2021, Eastern Sub-Saharan Africa had the highest incidence, DALYs, and mortality rates. Countries in the middle socio-demographic index quintile showed the fastest growth in age-standardized incidence rate, ASDR, and ASMR. From 1990 to 2021, the incidence, mortality rate, and DALYs of MBC increased worldwide. Alcohol use, dietary risks, and tobacco use were risk factors for ASMR, with dietary risks ranking first in all GBD regions. The rise in the number of cases of breast cancer in men places substantial stress on humans. Hence, policymakers should establish effective interventions and strategies for patients with MBC in accordance with the local situation.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"504-518"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of colorectal cancer screening by primary tumor location in a real-world setting in Japan. 在日本，原发肿瘤位置对结直肠癌筛查的影响。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2024-11-27 DOI: 10.1097/CEJ.0000000000000940

Takeshi Makiuchi, Ling Zha, Tetsuhisa Kitamura, Tomotaka Sobue, Toshio Ogawa

{"title":"Impact of colorectal cancer screening by primary tumor location in a real-world setting in Japan.","authors":"Takeshi Makiuchi, Ling Zha, Tetsuhisa Kitamura, Tomotaka Sobue, Toshio Ogawa","doi":"10.1097/CEJ.0000000000000940","DOIUrl":"10.1097/CEJ.0000000000000940","url":null,"abstract":"The objective of this retrospective observational study was to investigate the impact of fecal occult blood test (FOBT) as colorectal cancer (CRC) screening by primary tumor location. We compared the risk of requiring treatment for advanced disease and total medical costs per patient between CRC patients who underwent FOBT within 1 year before initial treatment for CRC and those who did not, using the JMDC Claims database, large-scale health insurance claims and checkup data in Japan. Treatment for advanced disease was defined as (1) nonendoscopic therapy or (2) chemotherapy or radiotherapy, performed during the follow-up period. A total of 1194 participants with CRC (right-sided, 22.2%; left-sided, 60.4%) who initiated treatment between 2010 and 2016 and underwent health checkups within 1 year before the initial treatment were enrolled and followed up for an average of 46.1 months. A significantly lowered risk ratio (RR) of chemotherapy or radiotherapy and total medical costs were observed in FOBT group for left-sided CRC [RR = 0.78 (95% confidence interval, 0.63-0.97), mean and median costs = 4.1 vs. 5.6 and 2.4 vs. 2.9 million JPY; P = 0.018], while they were not observed for right-sided CRC [RR = 0.88 (95% confidence interval, 0.61-1.28), mean and median costs = 4.0 vs. 4.1 and 2.7 vs. 2.9 million JPY; P = 0.995]. This study demonstrated the improved outcomes by FOBT for left-sided CRC, whereas its impact was limited for right-sided CRC.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"519-527"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between weight loss and survival outcomes in patients with gastric cancer: a meta-analysis. 胃癌患者体重减轻与生存结局之间的关系：一项荟萃分析

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2024-12-16 DOI: 10.1097/CEJ.0000000000000946

Heng Zhang, Xuan Tang, Junfang Zhang, Dapeng Jiang, Dandan Gong, Yu Fan

{"title":"Association between weight loss and survival outcomes in patients with gastric cancer: a meta-analysis.","authors":"Heng Zhang, Xuan Tang, Junfang Zhang, Dapeng Jiang, Dandan Gong, Yu Fan","doi":"10.1097/CEJ.0000000000000946","DOIUrl":"10.1097/CEJ.0000000000000946","url":null,"abstract":"Patients with gastric cancer often experience weight loss. A meta-analysis was conducted to evaluate the association between weight loss and survival outcomes in gastric cancer patients. We searched PubMed, Embase, and Web of Science according to the PECOS criteria: population (gastric cancer patients), exposure (weight loss), comparator (weight stable), outcomes [overall survival (OS) or recurrence-free survival], and study design (cohort studies). The prognostic value was expressed by combing the fully adjusted hazard ratio with 95% confidence interval (CI) for weight loss versus stable weight. Eighteen studies reporting on 16 articles involving 26 080 patients were identified. The pooled adjusted relative risk showed that weight loss was associated with shorter OS (hazard ratio 1.48; 95% CI: 1.32-1.66; I2 = 71.0%) and recurrence-free survival (hazard ratio 1.59; 95% CI: 1.17-2.16; I2 = 52.0%). The pooled adjusted hazard ratio of OS was 1.39 (95% CI: 1.14-1.70; I2 = 74.6%) among the studies that defined weight loss meeting the criteria for cancer cachexia. Moreover, stratified analysis revealed that weight loss significantly predicted OS, irrespective of patients' age, study design, tumor stage, timing of sampling weight loss, or follow-up duration. Weight loss significantly predicts OS and recurrence-free survival in gastric cancer patients. Monitoring weight changes can improve risk classification of gastric cancer, particularly in those with advanced disease.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"550-558"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral hygiene habits are risk factors of oral cavity cancer: a short communication. 口腔卫生习惯是口腔癌的危险因素：简短交流。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2025-10-01 DOI: 10.1097/CEJ.0000000000000966

Khanh Dang Nguyen, Truong Duc Hoang Nguyen, Nguyen Lam Vuong

{"title":"Oral hygiene habits are risk factors of oral cavity cancer: a short communication.","authors":"Khanh Dang Nguyen, Truong Duc Hoang Nguyen, Nguyen Lam Vuong","doi":"10.1097/CEJ.0000000000000966","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000966","url":null,"abstract":"Poor oral hygiene is a well-established risk factor for oral cavity cancer. However, the specific association between oral hygiene practices and oral cancer risk remains unclear. This study aimed to investigate the relationship between oral hygiene habits and the risk of oral cavity cancer. A case-control study was conducted involving 231 participants: 94 oral cavity cancer patients (case group) and 137 controls with other head and neck cancers. Oral health status was assessed using the Revised Oral Assessment Guide - Jönköping (ROAG-J), and a structured questionnaire was used to collect data on oral hygiene practices and lifestyle factors. The case group exhibited poorer oral hygiene practices, including lower rates of toothbrushing (68.1 vs. 90.5%) and food debris removal (38.3 vs. 63.5%), higher rates of smoking (66 vs. 11.7%) and alcohol consumption (58.5 vs. 14.6%), and poorer oral health (ROAG-J grade 2 or 3: 94.7 vs. 40.2%) compared with the control group. Multivariable logistic regression model has three independent risk factors for oral cavity cancer: smoking [odds ratio (OR): 9.77, 95% confidence interval (CI): 4.21-22.61], alcohol consumption (OR: 3.47, 95% CI: 1.48-8.10), and the presence of chronic diseases (OR: 2.90, 95% CI: 1.37-6.12), whereas food debris removal (OR: 0.25, 95% CI: 0.12-0.51) was a protective factor. Our findings highlight the importance of maintaining good oral hygiene practices in preventing oral cavity cancer. Future studies with larger sample sizes and collection of potential confounding factors are needed to confirm our findings.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":"34 6","pages":"559-562"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marital status as an independent prognostic factor for survival in women with vaginal cancer: evidence from the SEER database analysis. 婚姻状况是女性阴道癌患者生存期的独立预后因素：来自 SEER 数据库分析的证据。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2025-10-01 DOI: 10.1097/CEJ.0000000000000938

Yanhong Xu, Xinru Shu, Wenhuang Xu, Yiming Hu

{"title":"Marital status as an independent prognostic factor for survival in women with vaginal cancer: evidence from the SEER database analysis.","authors":"Yanhong Xu, Xinru Shu, Wenhuang Xu, Yiming Hu","doi":"10.1097/CEJ.0000000000000938","DOIUrl":"10.1097/CEJ.0000000000000938","url":null,"abstract":"This study aimed to evaluate the influence of marital status on the survival outcomes of women diagnosed with vaginal cancer, considering the potential role of sociodemographic factors in patient prognosis. Utilizing data from the Surveillance, Epidemiology, and End Results database, the study included 6046 women with primary vaginal cancer diagnosed between 2000 and 2020. The propensity score matching (PSM) method was employed to balance comparison groups and account for confounding factors. The primary outcomes were overall survival (OS) and cancer-specific survival (CSS), with Cox proportional-hazards regression models used for statistical analysis. Married patients exhibited better survival outcomes than their unmarried counterparts [OS: hazard ratio = 1.520, 95% confidence interval (CI) = 1.430-1.630, P < 0.001; CSS: hazard ratio = 1.380, 95% CI = 1.270-1.490, P < 0.001]. Subgroup analyses stratified by age and race highlighted a significant survival benefit for married individuals, particularly those aged 50-69 years and white patients. After PSM, the widowed subgroup within the unmarried category showed worse survival outcomes (OS: hazard ratio = 1.580, 95% CI = 1.430-1.750, P < 0.001; CSS: hazard ratio = 1.360, 95% CI = 1.200-1.530, P < 0.001). This study demonstrates that marital status serves as an independent prognostic factor for OS and CSS among patients with primary vaginal cancer, which supports that unmarried people need more individualized care strategies.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"483-492"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary polyunsaturated fatty acids and gastric cancer. 膳食多不饱和脂肪酸与胃癌。

IF 2.5 4区医学

European Journal of Cancer Prevention Pub Date : 2025-11-01 Epub Date: 2024-12-06 DOI: 10.1097/CEJ.0000000000000941

Ngoan Tran Le, Yen Thi-Hai Pham, Linh Thuy Le, Nguyen Ha Ta, Chung Thi-Kim Le, Xingyi Guo, Jennifer Cullen, Hung N Luu

{"title":"Dietary polyunsaturated fatty acids and gastric cancer.","authors":"Ngoan Tran Le, Yen Thi-Hai Pham, Linh Thuy Le, Nguyen Ha Ta, Chung Thi-Kim Le, Xingyi Guo, Jennifer Cullen, Hung N Luu","doi":"10.1097/CEJ.0000000000000941","DOIUrl":"10.1097/CEJ.0000000000000941","url":null,"abstract":"Polyunsaturated fatty acids (PUFAs) are fatty acids, containing more than one double bond and have both anti-inflammatory properties and inhibit tumor progression effects as well as carcinogenic properties. There is inconclusive evidence regarding the effect of PUFA intake on gastric cancer in diverse populations. We, therefore, aimed to determine the association between PUFA intake and risk of gastric cancer in a hospital-based case-control study comprising 1182 incident cases of gastric cancer and 2965 controls in Vietnam. A semiquantitative validated food frequency questionnaire was used to derive PUFA intake. Unconditional logistic regression model was applied to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer in relation to PUFA intake. Overall, there was a dose-response inverse association between PUFA intake and gastric cancer risk (OR per-SD increment = 0.72, 95% CI: 0.65-0.79; Ptrend < 0.001). Compared with quintile 1 (the lowest quintile), the ORs and respective 95% CIs of gastric cancer for quintiles 2, 3, 4, and 5 of the PUFA intake were 0.65 (0.52-0.80), 0.51 (0.41-0.64), 0.47 (0.37-0.59), and 0.37 (0.28-0.48), respectively. A similar pattern was observed in both sexes and individuals aged <60 years and those aged 60 years or older. In summary, we found a risk reduction of gastric cancer in individuals with a higher intake of PUFA in the Vietnamese population, regardless of sex or age. Our findings have great implications for the prevention and control programs against gastric cancer in low-middle-income countries and similar limited-resource settings.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"541-549"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0