European Journal of Cancer Prevention最新文献

{"title":"Invitation strategies for improving uptake in cervical, breast, and colorectal cancer screening: a systematic review.","authors":"Giacomo Scaioli, Maria Grazia Varì, Giulia Barbera, Alessandro Durbano, Sonia Pinto, Giuseppina Lo Moro, Fabrizio Bert, Roberta Siliquini","doi":"10.1097/CEJ.0000000000000985","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000985","url":null,"abstract":"<p><p>This systematic review focuses on the screening invitation process to identify the most effective methods for increasing participation in oncological cancer screening programs. The success of cancer screening programs heavily relies on the invitation process within a structured framework. This PRISMA-P compliant systematic review focuses on randomized controlled trials conducted worldwide between 2010 and 2021, with participation rates as the primary outcome. From the 7790 initially retrieved articles, 29 underwent quality assessment using the Cochrane Collaboration tool. The analysis revealed 13 studies with low risk, 11 with medium risk, and five with high risk of bias; the latter were excluded from further analysis. The review examined intervention types, control types, analysis approaches, and the effectiveness of various invitation methods. Different communication means, such as letters, text messages, phone calls, and face-to-face consultations, were evaluated along with the roles of various professionals. Specific invitation methods significantly increased participation rates, with multistep approaches using multiple communication channels proving more effective. Advanced notification techniques, interactive approaches such as phone calls and counseling sessions, and mailing fecal immunochemical test or fecal occult blood test kits directly with invitation letters demonstrated increased participation rates. In contrast, engaging general practitioners, attaching supplementary materials to invitation letters, sending reminders after the initial invitation, and applying behavioral theories showed limited impact on participation rates. The findings emphasize the importance of tailored, multistep invitation strategies incorporating various communication channels for optimal success in cancer screening programs.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global disease burden of laryngeal cancer attributable to smoking from 1990 to 2021.","authors":"Xiao Han, Shanchun Gong, Chao Wang, Yulin Zhang, Yufei Pan, Jing Li, Kai Liu, Zhenkun Yu","doi":"10.1097/CEJ.0000000000000984","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000984","url":null,"abstract":"<p><p>Smoking is a prominent risk factor for laryngeal cancer (LC). Understanding the impacts of smoking on the burden of LC is crucial for its prevention. Data were obtained from the Global Burden of Disease study 2021. A systematic analysis was conducted, assessing mortality and disability-adjusted life years (DALYs) burden, disaggregated by age, sex, region, and the Social Development Index (SDI). From 1990 to 2021, global burden of LC attributable to smoking decreased, while the number of death cases and DALYs increased by 20.80 and 11.53%, respectively. The disease burden has shifted from high-middle SDI regions to middle-low SDI regions. The South Asian and Southeast Asian regions exhibited the largest scale and growth rate of death cases and DALYs, respectively, while the high-income Asia Pacific region demonstrated the most significant decrease in age-standardized death rate [EAPC: -3.99, 95% uncertainty interval (UI), -4.17 to -3.81] and age-standardized DALYs rate (EAPC: -4.19, 95% UI, -4.36 to -4.03). The burden is significantly greater in men than in women, undergoing substantial significant sex differences. The burden decreased in all the age groups, while increasing with age, peaking in the 90-94-year age group. In the next 15 years, the number of LC-related deaths attributable to smoking is expected to continue increasing. The global burden of LC attributable to smoking has decreased from 1990 to 2021; however, it continues to vary by SDI, region, country, age and sex. Further strengthening smoking control and healthcare system is crucial for reducing the burden of LC.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid cancer in Asia: incidence, mortality in 2022, and future projections to 2050.","authors":"Mengxia Fu, Zhiming Peng, Min Wu","doi":"10.1097/CEJ.0000000000000983","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000983","url":null,"abstract":"<p><p>Thyroid cancer incidence has increased globally, with Asia bearing a major burden because of its large population and socioeconomic diversity. This study analyzed age-standardized incidence and mortality rates in Asia in 2022 and projected trends to 2050. This ecological, population-level study analyzed thyroid cancer data from 47 Asian countries using secondary data from the GLOBOCAN 2022. Spearman's correlation examined its association with the Human Development Index, while 2050 projections were derived from demographic trends. In 2022, Asia accounted for 72.7% of global thyroid cancer cases and 61.3% of related deaths, with 596.6 thousand new cases and 29.1 thousand deaths, including 50% of incidence and 25% of mortality in younger individuals. The age-standardized incidence and mortality rates were 10.7/100 000 and 0.5/100 000, respectively. Incidence rates rose faster in younger and male individuals. A significant correlation was found between the Human Development Index and cancer rates. South Korea had the highest incidence rate (7.6 per 100 000 males; 39.5 per 100 000 females), while the United Arab Emirates had the highest mortality rate (0.9/100 000 males and 13.9/100 000 females). In contrast, China had the largest absolute numbers of new cases and deaths, with 124.9 thousand new cases and 4.3 thousand deaths in males, and 341.2 thousand new cases and 7.2 thousand deaths in females. By 2050, 747.6 thousand new cases and 58.6 thousand deaths are expected in Asia. Targeted public health strategies addressing socioeconomic disparities, gender-specific risks, and emerging environmental factors may help reduce overdiagnosis and preventable deaths.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, prognosis, and prognostic factors of patients with second primary triple-negative breast cancer: a study based on Surveillance, Epidemiology, and End Results database.","authors":"Li Ding, Yan Xu, Chao Li, Xi Chen","doi":"10.1097/CEJ.0000000000000929","DOIUrl":"10.1097/CEJ.0000000000000929","url":null,"abstract":"<p><p>This study examined the characteristics of tumors, treatments, and survival outcomes, with a particular focus on the survival-related factors of second primary triple-negative breast cancer (TNBC) in comparison to first primary TNBC. The Surveillance, Epidemiology, and End Results database was utilized to identify and enroll patients diagnosed with TNBC between the years 2010 and 2015. The outcomes of this study were 3-year and 5-year breast cancer-specific survival (BCSS). The multivariate competing risk model was conducted to explore the association between the second primary cancer and BCSS and to estimate risk factors for BCSS of both first and second primary TNBC. The hazard ratio and 95% confidence interval (CI) were evaluation indices. Our study demonstrated that age, histological grade III/IV, high T stage, high N stage, and TNBC were associated with a decreased 3-year and 5-year BCSS in both first and second primary TNBC. Family income ≥$60 000 per year (hazard ratio: 0.68, 95% CI: 0.48-0.95, P  = 0.026) correlated with better 3-year BCSS in patients with second primary TNBC. Breast-conserving surgery, mastectomy, and the interval between two cancer diagnoses >3 years were associated with increased 3-year and 5-year BCSS in patients with second primary TNBC (all P  < 0.05). This paper reveals a worse survival of second primary TNBC. Great attention should be paid to the prognosis of patients with second primary TNBC.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"316-328"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbohydrate quality indices and lung cancer risk: a case-control study from Iran.","authors":"Milad Mohammadzadeh, Fatemeh Abdi, Melika Mamaghanian, Amin Paydareh, Alireza Bahrami, Zahra Sheikhi, Ehsan Hejazi","doi":"10.1097/CEJ.0000000000000913","DOIUrl":"10.1097/CEJ.0000000000000913","url":null,"abstract":"<p><p>Considering that carbohydrates play an important role in supplying the body with energy and exhibit diverse mechanisms that can either prevent or stimulate cancer, we hypothesize that the quality of carbohydrate intake may be associated with cancer risk, including lung cancer. This hospital-based case-control study was conducted on 135 newly diagnosed lung cancer patients, and 237 healthy age- and sex-matched hospitalized controls. We used a valid and reliable 148-item Food Frequency Questionnaire to collect the dietary intake of subjects. Multivariate logistic regression was used to estimate the association between carbohydrate quality indices and the odds of lung cancer. After adjustment for confounding variables, the high glycemic index appears to be an increased risk factor for lung cancer [odds ratio (OR) = 2.51, 95% confidence interval (CI): 1.28-4.91]. No statistically significant association was found between glycemic load and lung cancer (OR = 2.51, 95% CI: 0.98-6.43). In contrast, the carbohydrate quality index (OR = 0.23, 95% CI: 0.11-0.48) and low-carbohydrate diet score (OR = 0.17, 95% CI: 0.08-0.36), were associated with a decrease in the risk of lung cancer. In summary, our study showed that a high glycemic index is a risk factor for lung cancer, however carbohydrate quality index and low-carbohydrate diet score is a dietary approach to reduce the risk of lung cancer.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"357-362"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of stool DNA for colorectal cancer screening: a meta-analysis and systematic review.","authors":"Mariam Mostafa, Basant Eltaher, Hebat-Allah Egiza, Sugam Gouli, Amir Mahmoud, Himal Kharel, Harkarandeep Singh, Chengu Niu","doi":"10.1097/CEJ.0000000000000937","DOIUrl":"10.1097/CEJ.0000000000000937","url":null,"abstract":"<p><p>Colorectal cancer is the third most common malignancy in the USA and accounts for more than 1 million deaths worldwide with screening shown to reduce CRC mortality. This meta-analysis analyzed the use of stool DNA for screening average risk, asymptomatic subjects for colorectal cancer and advanced precancerous lesions and compared sDNA to FOBT tests (gFOBT and FIT). Eight studies were included from four different countries with a total of 39 665 subjects. Pooled sensitivity and specificity for sDNA for detecting CRC was 83.3% (95% CI: 60.8-94.2) and 92.4% (95% CI: 90.1-94.1), respectively, compared with FOBT, which had a lower sensitivity at 70.2% (95% CI: 45.5-86.9) but higher specificity 95.7% (95% CI: 95.1-96.2). Further analysis showed improved sensitivity of sDNA to 92.6% when only the studies employing sDNA tests that incorporate hemoglobin immunochemical test were used. Both sDNA and FOBT tests had low sensitivity for detecting advanced precancerous lesions. sDNA tests are sensitive and specific for the detection of CRC but show low sensitivity compared with colonoscopy for the detection of advanced precancerous lesions.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"309-315"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of the ketogenic diet on cancer treatment: a narrative review.","authors":"Qingxuan Deng, Ruyue Lv, Tangbin Zou","doi":"10.1097/CEJ.0000000000000918","DOIUrl":"10.1097/CEJ.0000000000000918","url":null,"abstract":"<p><p>Despite significant advances in therapy, cancer remains the top cause of death in parts of the globe. For many types of cancer, the typical treatment is a combination of surgery, chemotherapy, and radiotherapy. However, this conventional treatment is not successful on its own. As a consequence, innovative approaches that improve treatment efficacy are urgently needed. The ketogenic diet is a high-fat, moderate protein, and low-carbohydrate diet that appears to sensitize most cancers to conventional therapies by exploiting cancer cells' altered metabolism, making it an effective adjuvant cancer treatment alternative. This diet could decrease glucose metabolism while enhancing lipid metabolism, interfering with the Warburg effect, and inhibiting tumor cell proliferation. The anticancer impact of ketogenic diet has been established in numerous animal trials and clinical investigations on a wide range of tumor types, including glioblastoma, pancreatic cancer, head and neck cancer, breast cancer, invasive rectal cancer, ovarian cancer, and endometrial cancer. In this review, we discussed the various types of ketogenic diets, the mechanism of action for ketogenic diet as a cancer therapy, and the data gathered from continuing preclinical and clinical studies, intending to establish a solid theoretical foundation for future research.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"291-300"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV infection patterns and viral load distribution: implication on cervical cancer prevention in Western Kenya.","authors":"Ivy Akinyi, Ogol Japheth Ouma, Sylvester Ogutu, Eric Ogola, Jane Owenga, George Ayodo, Dicken Omondi, Shehu Shagari Awandu, Davy Vanden Broeck, Nina Redzic, Ana Rita Pereira, Johannes Bogers","doi":"10.1097/CEJ.0000000000000920","DOIUrl":"10.1097/CEJ.0000000000000920","url":null,"abstract":"<p><p>Human papillomavirus (HPV) coinfection remains common globally. However, its clinical significance compared to mono-infection remains controversial. Further, the epidemiology of HPV genotype combination in coinfection is not well studied in Kenya. . Between June and August 2023, a cross-sectional facility-based survey enrolled 434 women aged 16-68 years using purposive sampling strategy. Structured questionnaire was obtained from each woman regarding demographic and sexual behavior characteristics. Cervical specimen was collected from each participant and analyzed using RIATOL assay to determine HPV genotypes and viral load. Overall, HPV 52 was the most frequently detected HPV strain. The mean HPV viral load was elevated among coinfected women than those with mono-infection but there was no evidence to support differences in viral load in the two groups ( P  = 0.113). Mono-infection was common (58.52%). HPV 16 was noted to have a near equal presence both in mono-infection and coinfection (52.17% and 47. 83%), respectively. HPV 33 (alpha 9) and 45 (alpha 7) had the greatest preference for each other compared to all other HPV interactions. HPV 52 is the most prevalent HPV in the population supporting the need for the nonavalent HPV vaccine. Mono-infection with HPV 16 remains common corroborating the relevance of bivalent vaccine in resource limited setting where nonavalent vaccines may be unavailable. The frequent coinfection preference of HPV 33 and 45 (alpha 9 and alpha 7, respectively) pauses the need for further concurrent characterization. HPV vaccination and education on safe sexual behaviors is key in reducing HPV coinfection.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"329-336"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of antibiotics on immunotherapy in patients with metastatic nonsmall cell lung cancer.","authors":"Tao Hu, Li Li, Jinfeng Cui, Xiaoyu Song, He Zhu, Zhi Wei Hou, Shuanghu Yuan","doi":"10.1097/CEJ.0000000000000912","DOIUrl":"10.1097/CEJ.0000000000000912","url":null,"abstract":"<p><p>To investigate the effects of antibiotic exposure on the prognosis of patients with advanced metastatic non-small cell lung cancer (m-NSCLC) who received immune checkpoint inhibitors (ICIs). This study retrospectively included 199 patients diagnosed with m-NSCLC in Shandong Cancer Hospital and Institute from December 2017 to October 2021, all patients received ICIs for the first time. The basic clinical characteristics of patients before the first treatment of ICIs, whether antibiotics were used during treatment, progression-free survival (PFS), and overall survival (OS) were collected. The survival among different groups was compared by the Kaplan-Meier method. The median follow-up time of m-NSCLC patients was 33.79 months, mPFS was 11.67 months, and mOS was 21.55 months. Univariate analysis showed that antibiotic use, radiotherapy, and targeted drug resistance influenced PFS and OS ( P  < 0.05). Multivariate analysis showed that antibiotic use, radiotherapy, and targeted resistance remained independent factors of PFS, and targeted resistance was an independent factor of OS ( P  < 0.05). Subgroup analysis found that antibiotic use within 30 days before and after immunotherapy could decrease the PFS and OS ( P  < 0.05). Kaplan-Meier analysis showed that patients without radiotherapy had shorter PFS (mPFS, 12.89 vs. 8.13 months; P  = 0.0258) and OS (mOS, 26.94 vs. 16.43 months; P  = 0.0465). The mPFS (16.17 vs. 9.19 months; P  = 0.0151) and mOS (27.27 vs. 18.65 months; P  = 0.0437) of patients in the antibiotic group were shorter. Patients in the targeted drug-resistant group had shorter PFS (mPFS, 40.66 vs. 7.77 months, P  < 0.001) and OS (mOS, 41.98 vs. 16.89 months, P  < 0.001) compared with patients who did not receive targeted treatment. Antibiotics and radiation therapy are associated with the prognosis of m-NSCLC who are newly treated with ICIs. Effectively reducing antibiotic use in 1 month before and after ICIs treatment may help improve the immunotherapy efficacy of patients with m-NSCLC.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"363-371"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of BUBR1, MCM2, and GMNN as oral cancer biomarkers.","authors":"Naíza M M Abrahim, Roberta B Cavalcante, Maria Inês de M C Pardini, Silvia H B Rabenhorst, Adriana Camargo Ferrasi","doi":"10.1097/CEJ.0000000000000932","DOIUrl":"10.1097/CEJ.0000000000000932","url":null,"abstract":"<p><p>Oral cancer is a public health problem worldwide. Late diagnosis results in a low survival rate. However, this tumor can arise from oral precancerous lesions and identification of biomarkers in precursor lesions has the potential for early diagnosis, improving patient survival. In this context, proteins involved in the cell cycle control are potentially promising. This study aimed to evaluate the importance of immunohistochemical expression of BUBR1, MCM2, and GMNN as biomarkers of oral carcinogenesis considering different oral sites. Sixty-six samples of oral epithelial dysplasia (from 33 males and 33 females) and 63 samples of oral squamous cell carcinoma (from 44 males and 19 females) were subjected to immunohistochemistry to detect some human proteins. Ki67 expression was included as a marker of cell proliferation. Marker expression was quantified by manually counting at least 1000 cells, and the labeling index was used in all statistical analyses. GMNN, MCM2, BUBR1 (nuclear and cytoplasmic labeling), and Ki67 expression levels were higher in carcinomas than in dysplasia ( P  < 0.05). Cytoplasmic BUBR1 was a good marker of malignancy (AUC = 0.8525, P  < 0.05), but Ki67 was not (AUC = 0.5943, P  = 0.0713). GMNN, MCM2, BUBR1, and Ki67 had higher expression in carcinoma than in dysplasia, regardless of the site of the lesion. Cytoplasmic BUBR1 has the potential to be used as a marker of tumor progression.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"378-385"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}