European Journal of Cancer Prevention最新文献_第3页

Diverging trends in lung cancer: a 26-year analysis of sex-specific patterns and histological shifts in Northern Italy.

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-28 DOI: 10.1097/CEJ.0000000000000951

Luca Bertolaccini, Claudia Santucci, Carlo La Vecchia, Federica Toffolutti, Giovanni Corso, Lorenzo Spaggiari, Diego Serraino

{"title":"Diverging trends in lung cancer: a 26-year analysis of sex-specific patterns and histological shifts in Northern Italy.","authors":"Luca Bertolaccini, Claudia Santucci, Carlo La Vecchia, Federica Toffolutti, Giovanni Corso, Lorenzo Spaggiari, Diego Serraino","doi":"10.1097/CEJ.0000000000000951","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000951","url":null,"abstract":"Lung cancer is the leading cause of cancer-related mortality worldwide, and understanding its pathological patterns and trends is of interest for clinical and public health interventions. This study investigates the trends in lung cancer incidence rates from 1995 to 2021 in the Friuli Venezia Giulia (FVG) region in northeastern Italy, focusing on histological subtypes and sex-specific differences. Data were obtained from the population-based FVG Cancer Registry. Data on histological types of lung cancer were analyzed. Using census-based population estimates, age-standardized incidence rates (ASIRs) were calculated for three calendar periods (1995-2003, 2004-2012, 2013-2021). Joinpoint regression analysis was used to assess significant changes in trends, estimating annual percent change and average annual percent change (AAPC). A total of 24 519 lung cancer cases were recorded between 1995 and 2021, 70% in males. During 2013-2021, ASIRs were 31.9/100 000 males and 16.9/100 000 females. Adenocarcinoma accounted for the highest ASIRs in both sexes (15.2/100 000 males and 9.9/100 000 females). Over the 1995-2021 period, the overall incidence of lung cancer decreased in males (AAPC: -3.2%), whereas it increased in females (AAPC: +1.0%). Trends in adenocarcinoma were inconsistent for males but continued to rise in females. Squamous and small cell lung cancer incidence declined in males, while both increased in females. These trends underscore the importance of targeted prevention strategies, especially addressing smoking cessation in middle-aged females.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global, regional, and national burden of colorectal cancer attributable to smoking from 1990 to 2021: a population-based study. 1990年至2021年吸烟导致的全球、区域和国家结直肠癌负担：一项基于人群的研究

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-22 DOI: 10.1097/CEJ.0000000000000957

Shuai Wang, Tao Zhang, Dongming Li, Xueyuan Cao

{"title":"The global, regional, and national burden of colorectal cancer attributable to smoking from 1990 to 2021: a population-based study.","authors":"Shuai Wang, Tao Zhang, Dongming Li, Xueyuan Cao","doi":"10.1097/CEJ.0000000000000957","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000957","url":null,"abstract":"Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide, with smoking being a significant risk factor. Understanding the temporal and spatial patterns of the CRC burden attributable to smoking is crucial for global public health strategies. Data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 were used to calculate the number of deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR) per 100 000 population, and age-standardized disability-adjusted life year rate (ASDR). The average annual percentage change (AAPC) was calculated from 1990 to 2021 to analyze disease burden trends. Frontier analysis was conducted to assess efficiency, and predictions were made for the next decade. In 2021, the global death toll and DALYs attributable to smoking were 47 613 and 1 235 667, respectively. From 1990 to 2021, the absolute number of deaths and DALYs increased, while ASMR (AAPC: -1.20) and ASDR (AAPC: -1.22) showed a significant decline. The disease burden was notably higher in males than females. Analysis by the Social Development Index revealed that more developed regions had a higher burden than less developed areas. China ranked first in the number of deaths and DALYs, while Greenland had the highest ASMR and ASDR. From 1990 to 2021, the age-standardized burden of CRC attributable to smoking decreased globally. However, the absolute burden remains a significant public health challenge, requiring sustained and targeted interventions.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a prediction model based on Hemoglobin, Albumin, Lymphocyte count, and Platelet-score for lymph node metastasis in rectal cancer. 建立基于血红蛋白、白蛋白、淋巴细胞计数和血小板评分的直肠癌淋巴结转移预测模型。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-22 DOI: 10.1097/CEJ.0000000000000954

Huanhui Liu, Qian Zou, Hanjing Zhang, Xiaojie Ma

{"title":"Development of a prediction model based on Hemoglobin, Albumin, Lymphocyte count, and Platelet-score for lymph node metastasis in rectal cancer.","authors":"Huanhui Liu, Qian Zou, Hanjing Zhang, Xiaojie Ma","doi":"10.1097/CEJ.0000000000000954","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000954","url":null,"abstract":"This study aimed to evaluate the ability of the preoperative Hemoglobin, Albumin, Lymphocyte count, and Platelet (HALP) score to predict lymph node metastasis (LNM) in patients with rectal cancer (RC) and improve prediction accuracy by incorporating clinical parameters. Data from 263 patients with RC were analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value (OCV) for the HALP score in predicting LNM. Based on this cutoff value, patients were divided into two groups. A baseline analysis was conducted to identify independent factors linked to LNM. A support vector machine (SVM) prediction model was developed, and its performance was evaluated using ROC, calibration curves, decision curve analysis, and Kolmogorov-Smirnov curve. The OCV for HALP score was 45.979. Patients were then classified into a low HALP group (n = 182) and a high HALP group (n = 81). The analysis found 21 clinical factors significantly associated with LNM. Among them, the key risk factors included high inflammatory status, poor nutritional condition, and a low HALP score. The SVM model incorporated these factors and showed robust predictive performance, with area under the curve values of 0.897, 0.813, and 0.750 for the training, validation, and testing datasets, respectively. The HALP score was significantly associated with LNM in RC patients. A machine learning model integrating the HALP score and inflammatory markers may be an effective tool for predicting LNM in RC.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term survival and risk factors of synchronous bone metastasis in oral tongue squamous cell carcinoma patients. 口腔舌鳞癌患者同步骨转移的远期生存率及危险因素分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-17 DOI: 10.1097/CEJ.0000000000000955

Yujiao Li, Chaosu Hu

{"title":"Long-term survival and risk factors of synchronous bone metastasis in oral tongue squamous cell carcinoma patients.","authors":"Yujiao Li, Chaosu Hu","doi":"10.1097/CEJ.0000000000000955","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000955","url":null,"abstract":"The objective of this study was to analyze the risk factors for synchronous bone metastases in patients with oral tongue squamous cell carcinomas (OTSCC). OTSCC patients were extracted from the Surveillance, Epidemiology and End Results database between 2014 and 2017. We examined the association between risk factors and synchronous bone metastases using Chi-squared tests. Predictors of survival rates were assessed using univariate and multivariate analyses. A total of 3902 patients were analyzed, which include 12 patients (0.3%) with synchronous bone metastases and 3890 patients without synchronous bone metastases (99.7%). Multivariate logistic regression analysis showed that highly differentiated disease, lower T classification, and lower N classification were associated with a significantly lower risk of bone metastases (P < 0.05, respectively). Unmarried and elderly patients who harbored with poorly differentiated disease, higher T or N classification, multiple sites of metastases, and no surgical therapy to primary tumor were more likely to influence patients' survival. By analyzing data from a large cohort, factors affecting bone metastases are primarily related to grade, T classification and N classification. Multivariable analysis showed that unmarried and elderly patients who harbored with poorly differentiated disease, higher T or N classification, multiple sites of metastases, and no surgical therapy to primary tumor were more likely to influence patients' survival. More accurate assessments of bone metastasis will be imperative for early diagnosis and treatment in poorly differentiated disease, higher T classification or N classification patients.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate-to-severe psoriasis: an observational monocentric study. 中重度牛皮癣患者的皮肤癌与抗il单克隆抗体治疗的相关性：一项观察性单中心研究

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-07 DOI: 10.1097/CEJ.0000000000000948

Flavia Manzo Margiotta, Cristian Fidanzi, Simone Pardossi, Alessandra Michelucci, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Riccardo Morganti, Salvatore Panduri, Giovanni Bagnoni, Marco Romanelli, Agata Janowska, Valentina Dini

{"title":"Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate-to-severe psoriasis: an observational monocentric study.","authors":"Flavia Manzo Margiotta, Cristian Fidanzi, Simone Pardossi, Alessandra Michelucci, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Riccardo Morganti, Salvatore Panduri, Giovanni Bagnoni, Marco Romanelli, Agata Janowska, Valentina Dini","doi":"10.1097/CEJ.0000000000000948","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000948","url":null,"abstract":"Our study aimed to investigate the correlation between skin cancer and anti-interleukin (IL) therapy in patients with moderate-to-severe psoriasis. This was an observational monocentric study in which we enrolled a total of 235 patients in which 127 patients were affected by moderate-to-severe psoriasis and treated with anti-IL monoclonal antibodies (mAbs) for at least 6 months, whereas 108 patients affected by mild psoriasis were treated with topical therapies. Afterward, we performed a dermatologic visit to all the subjects, collecting anamnestic information including risk factors for skin cancer. We examined the skin lesions on their entire body by polarized and nonpolarized dermoscopy. A total of 21 suspicious lesions in the first group and 17 in the second one were removed and histologically analyzed. Twelve (9.4%) cancerous or precancerous lesions were found in the first group: seven (5.5%) basal cell carcinoma (BCC) and five actinic keratosis. The mean time to cancer onset was identified as 22 months after the start of four therapy, with an SD of 18 months, suggesting an earlier onset with respect to the start of therapy in our population. On univariate analysis, age (P = 0.001) and age of psoriasis onset (0.009) were statistically significant. Nine of 17 were skin cancers in the second group. Our study provided real-life evidence of the percentage of patients with skin cancers during therapy with anti-IL mAbs, demonstrating a good safety profile of the investigated drugs.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raising the bar: evaluating quality and consistency in clinical guidelines for surgical management of pulmonary carcinoid. 提高标准：评估肺类癌手术治疗临床指南的质量和一致性。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-07 DOI: 10.1097/CEJ.0000000000000949

Luca Bertolaccini, Claudia Bardoni, Giovanni Caffarena, Matteo Chiari, Cristina Diotti, Antonio Mazzella, Lavinia Benini, Francesca Spada, Giovanni Corso, Eleonora Pisa, Monica Casiraghi, Nicola Fazio, Lorenzo Spaggiari

{"title":"Raising the bar: evaluating quality and consistency in clinical guidelines for surgical management of pulmonary carcinoid.","authors":"Luca Bertolaccini, Claudia Bardoni, Giovanni Caffarena, Matteo Chiari, Cristina Diotti, Antonio Mazzella, Lavinia Benini, Francesca Spada, Giovanni Corso, Eleonora Pisa, Monica Casiraghi, Nicola Fazio, Lorenzo Spaggiari","doi":"10.1097/CEJ.0000000000000949","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000949","url":null,"abstract":"Leading societies have established guidelines that vary significantly regarding recommendations for the surgical management of pulmonary carcinoids (PC). We aimed to assess current guidelines and recommendations for PC surgical management, benchmark their methodological quality, and identify factors that may influence their effectiveness in guiding surgical practice. Literature was sought to identify relevant guidelines for the management of PC. Each guideline was evaluated using the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool and rated on a seven-point scale for items and domains. Five observers assessed four guidelines (developed by ENETS in 2015, ESMO in 2021, NANETS in 2021, and NCCN in 2020). In Scope and Purpose and Stakeholder Involvement, the NCCN guideline achieved the highest score. In Rigor of Development, NANETS and ENETS achieved the highest score. In Clarity of Presentation, ENETS guidelines scored the highest score. For applicability, NCCN received the highest score. All guidelines got the highest score in the Rigor of Development and Clarity of Presentation domains, whereas the Applicability domain received the lowest score. The methodological quality of guidelines on the surgical management of PC varies significantly. The findings underscore the need for future guidelines to prioritize practical implementation in clinical and surgical practice, ensuring that recommendations reflect best practices and effectively meet surgeons' needs. Based on our AGREE II appraisal, the ENETS and ESMO guidelines might be recommended as a model for developing future recommendations and guidelines.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human papillomavirus vaccination coverage in Italy. 意大利的人类乳头瘤病毒疫苗接种覆盖率。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.1097/CEJ.0000000000000896

Giorgio Bogani, Giovanni Scambia, Francesco Raspagliesi, Giovanni Corso

引用次数: 0

Conditional survival of male breast cancer. 男性乳腺癌的条件生存率。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-01 Epub Date: 2024-05-06 DOI: 10.1097/CEJ.0000000000000893

Yanshuai Fan, Chaoyue Ku, Ruizhe Wang, Binbin Wu, Man Cui, Juan Wang, Miao Deng, Li Liu, Zhiguang Ping

{"title":"Conditional survival of male breast cancer.","authors":"Yanshuai Fan, Chaoyue Ku, Ruizhe Wang, Binbin Wu, Man Cui, Juan Wang, Miao Deng, Li Liu, Zhiguang Ping","doi":"10.1097/CEJ.0000000000000893","DOIUrl":"10.1097/CEJ.0000000000000893","url":null,"abstract":"Background: The incidence of male breast cancer has been increasing in recent years; however, the long-term survival outcomes of diagnosed patients remain uncertain. This study was designed to evaluate the conditional survival of male breast cancer patients and to predict the future survival of patients through the conditional nomogram, to provide important suggestions for clinical decision-making.Methods: Retrospective data from the SEER database included 3600 male breast cancer patients, divided into training and validation groups (7 : 3 ratio). Overall survival rates were calculated using Kaplan-Meier analysis. Conditional survival analysis described survival at specific years. Time-dependent multivariate Cox analysis identified prognostic factors' impact. The conditional survival nomogram model predicted real-time survival rates.Results: Over time, the 5-year real-time survival rate of patients gradually improved, increasing from 70.5 to 74.8, 79.4, 85.8, and 92.9% (respectively, representing 5-year survival rates of 1-4 years after diagnosis). In addition, the improvement in conditional survival rate CS5 showed a nonlinear trend. After 5 years of diagnosis, age, tumor size, and tumor stage had a sustained impact on patient prognosis. Finally, a conditional survival nomogram was constructed to predict the 10-year survival rate in real time.Conclusion: Five years after diagnosis, the conditional survival rate of male patients with breast cancer has improved, but it is not nonlinear. In the first 5 years after diagnosis, patients with older age, larger tumor size, poorer tumor stage, and distant metastasis should be actively followed up and treated to improve their long-term survival.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"66-75"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncoplastic breast surgery: where are we now. 乳房肿瘤整形手术：我们现在在哪里？

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1097/CEJ.0000000000000923

Francesca De Lorenzi, Mario Alessandri-Bonetti

引用次数: 0

Physical activity and exercise health benefits: cancer prevention, interception, and survival. 体育活动和锻炼对健康的益处：癌症预防、拦截和生存。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2025-01-01 Epub Date: 2024-06-26 DOI: 10.1097/CEJ.0000000000000898

Adriana Albini, Carlo La Vecchia, Francesca Magnoni, Ornella Garrone, Danilo Morelli, Jaak Ph Janssens, Alain Maskens, Gad Rennert, Viviana Galimberti, Giovanni Corso

{"title":"Physical activity and exercise health benefits: cancer prevention, interception, and survival.","authors":"Adriana Albini, Carlo La Vecchia, Francesca Magnoni, Ornella Garrone, Danilo Morelli, Jaak Ph Janssens, Alain Maskens, Gad Rennert, Viviana Galimberti, Giovanni Corso","doi":"10.1097/CEJ.0000000000000898","DOIUrl":"10.1097/CEJ.0000000000000898","url":null,"abstract":"Physical activity (PA) has an established role in the promotion of health and fitness and the prevention of disease. Expected overall benefits include reduction of all-cause morbidity and death, weight control, improved quality of life, improved bone health and decreased falls of elderly subjects, , deeper cognition, and reduced risk of depression, anxiety, and sleeplessness. Currently, PA is a mainstay in the management of cardiovascular diseases, metabolic syndrome, diabetes, and bone health. Recently, the perception of its role in primary and secondary prevention, interception, and treatment of cancer, however, is also gaining importance. Regular walking, the simplest type of PA, is associated with reduced all-cause and cardiovascular disease mortality, and a role in cancer prevention is of increasing interest. Furthermore, PA improves the quality of life of cancer patients, attenuating side effects of chemotherapy, decreasing sarcopenia, increasing fitness, and inhibiting the recurrence and progression of some cancer types. It promotes emotional and psychological benefits in patients, inducing positive changes. While mechanisms, effective levels and useful amount of PA practice are well established in cardiology, they are yet to be fully determined in oncology. Nevertheless, PA is recommended to reduce cancer risk in the general population, and it has been introduced in programs for the prevention of second cancers. In perspective, it will help as integrative therapy in cancer patients and for cancer survivors. The number of beneficial effects in the cancer continuum is highlighted in this review.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"24-39"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0