European Journal of Cancer Prevention最新文献_第10页

Prognostic model for predicting the survival benefit of adjuvant chemotherapy for elderly patients with stage II colon cancer: a population-based study. 预测老年 II 期结肠癌患者辅助化疗生存获益的预后模型：一项基于人群的研究。

IF 2.4 4区医学

European Journal of Cancer Prevention Pub Date : 2024-03-01 Epub Date: 2023-08-25 DOI: 10.1097/CEJ.0000000000000836

Guanhua Yu, Ran Wei, Hengchang Liu, Yixiao Liu, Xu Guan, Xishan Wang, Zheng Jiang

{"title":"Prognostic model for predicting the survival benefit of adjuvant chemotherapy for elderly patients with stage II colon cancer: a population-based study.","authors":"Guanhua Yu, Ran Wei, Hengchang Liu, Yixiao Liu, Xu Guan, Xishan Wang, Zheng Jiang","doi":"10.1097/CEJ.0000000000000836","DOIUrl":"10.1097/CEJ.0000000000000836","url":null,"abstract":"Objectives: Adjuvant chemotherapy benefits in elderly patients with stage II colon cancer (CC) remain controversial. We aimed to construct a nomogram to estimate the chemotherapy survival benefits in elderly patients.Methods: The training and testing cohort were patients with stage II CC older than 70 years from the Surveillance, Epidemiology, and End Results (SEER) database, while the external validation cohort included patients from the National Cancer Center (NCC). Cox proportional hazard models were used to determine the covariates associated with overall survival (OS). Using the risk factors identified by Cox proportional hazards regression, a nomogram was developed to predict OS. Nomogram precision was assessed using receiver operating characteristic and calibration curves.Results: The present study recruited 42 097 and 504 patients from the SEER database and NCC, respectively. The OS of patients who underwent surgery plus adjuvant chemotherapy was considerably longer than patients who underwent surgery alone. The nomogram included variables related to OS, including age, year of diagnosis, sex, AJCC T stage, tumor location, tumor size, harvested lymph nodes, and chemotherapy. According to the nomogram score, the elderly patients were separated into high- and low-risk groups, with high-risk group nomogram scores being greater than the median value, and vice versa. Patients in the high-risk group witnessed worse prognosis and were more likely to benefit from postoperative chemotherapy.Conclusion: This nomogram can be regarded as a useful clinical tool for assessing the potential adjuvant chemotherapy benefits and for predicting survival in elderly patients with stage II CC.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":"33 2","pages":"105-114"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is phased implementation of HPV testing and triage with dual staining the way to transform organized cytology screening? 分阶段实施HPV检测和双染色分型是改变有组织细胞学筛查的方法吗？

IF 2.4 4区医学

European Journal of Cancer Prevention Pub Date : 2024-03-01 Epub Date: 2023-09-21 DOI: 10.1097/CEJ.0000000000000844

Jiří Sláma, Vladimír Dvořák, Markéta Trnková, Aleš Skřivánek, Karolína Hrabcová, Petra Ovesná, Martina Nováčková

{"title":"Is phased implementation of HPV testing and triage with dual staining the way to transform organized cytology screening?","authors":"Jiří Sláma, Vladimír Dvořák, Markéta Trnková, Aleš Skřivánek, Karolína Hrabcová, Petra Ovesná, Martina Nováčková","doi":"10.1097/CEJ.0000000000000844","DOIUrl":"10.1097/CEJ.0000000000000844","url":null,"abstract":"Objective: The substantial material and legislative investments in establishing and maintaining cytological screening in the Czech Republic represent barriers to a direct transition to primary HPV screening. Therefore, the LIBUSE project was implemented to test the efficacy of phasing in HPV DNA testing as a co-test to cytology in routine screening of women >30 years of age.Methods: Women aged 30 to 60 years who underwent regular annual Pap smears were co-tested for HPV DNA with selective 16/18 genotyping at 3-year intervals. All HPV 16/18-positive cases and/or cases with a severe abnormality in cytology were sent for colposcopy; HPV non-16/18-positive cases and LSILs were graded using p16/Ki67 dual-stain cytology, and positive cases were sent for colposcopy.Results: Overall, 2409 patients were included. After the first combined screening (year 'zero') visit, 7.4% of women were HPV-positive and 2.0% were HPV16/18-positive; only 8 women had severe Pap smear abnormalities. Triage by dual staining was positive in 21.9% of cases (28/128). Biopsy confirmed 34 high-grade precancer lesions. At the second combined visit (year 'three'), the frequency of HPV infection (5.3% vs. 7.4%) frequency of HPV16/18 (1.1% vs. 2.0%), referrals for colposcopy (35 vs. 83), and biopsy verified high-grade lesions (5 vs. 34) were significantly lower (all P ≤ 0.001).Conclusion: The addition of HPV DNA testing with selective genotyping of HPV16/18 to existing cytology screening significantly increased the safety of the program. The gradual introduction of HPV testing was well received by healthcare professionals and patients, and can facilitate transformation of the cytology-based screening. ClinicalTrials.gov Identifier: NCT05578833.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"168-176"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10833184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41136092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of interaction between interleukin-6 gene polymorphism and Helicobacter pylori infection on susceptibility to gastric cancer. 白细胞介素-6 基因多态性与幽门螺旋杆菌感染之间的相互作用对胃癌易感性的影响

IF 2.4 4区医学

European Journal of Cancer Prevention Pub Date : 2024-03-01 Epub Date: 2023-08-28 DOI: 10.1097/CEJ.0000000000000835

Longyue Wang, Shuaishuai Xiao, Yiming Zheng, Zefeng Gao, Fan Fan

{"title":"Impact of interaction between interleukin-6 gene polymorphism and Helicobacter pylori infection on susceptibility to gastric cancer.","authors":"Longyue Wang, Shuaishuai Xiao, Yiming Zheng, Zefeng Gao, Fan Fan","doi":"10.1097/CEJ.0000000000000835","DOIUrl":"10.1097/CEJ.0000000000000835","url":null,"abstract":"Objective: This study aimed to evaluate the association between four single nucleotide polymorphisms (SNPs) of the interleukin-6 (IL-6) gene and gastric cancer (GC), and impact of interaction between IL-6 SNPs and Helicobacter pylori (H. pylori ) infection on susceptibility to GC.Methods: Logistic regression was used to test the relationships between four SNPs of IL-6 gene and GC susceptibility. A generalized multifactor dimensionality reduction (GMDR) model was employed to assess the interaction effect between IL-6 gene and H. pylori infection on GC risk.Results: Logistic regression analysis indicated that the rs1800795-C allele was associated with increased GC risk, adjusted ORs (95% CI) were 1.80 (1.21-2.41) (CC vs. GG) and 1.68 (1.09-2.30) (C vs. G), respectively. The rs10499563-C allele was associated with decreased risk of GC, and adjusted ORs (95% CI) were 0.62 (0.31-0.93) (TC vs. TT), 0.52 (0.18-0.89) (CC vs. TT) and 0.60 (0.29-0.92) (C vs. T), respectively. GMDR methods found a two-dimensional model combination (including rs1800795 and H. pylori infection) was statistically significant. The selected model had testing balanced accuracy of 59.85% and the best cross-validation consistencies of 10/10 ( P = 0.0107). Compared with H. pylori -negative subjects with rs1800795- GG genotype, H. pylori -positive participants with GC or CC genotype had the highest risk of GC, the OR (95% CI) was 3.34 (1.78-4.97).Conclusion: The rs1800795-C allele was associated with increased GC risk and the rs10499563-C allele was associated with decreased GC risk. The interaction between rs1800795 and H. pylori infection was also correlated with increased risk of GC.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"136-140"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10217799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine cancer deaths certified as part unspecified: an unsolved issue. 子宫癌死亡证明部分未指明：一个悬而未决的问题。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-08-17 DOI: 10.1097/CEJ.0000000000000833

Giovanna Esposito, Claudia Santucci, Fabio Parazzini, Silvia Mignozzi, Matteo Malvezzi, Carlo La Vecchia, Eva Negri

{"title":"Uterine cancer deaths certified as part unspecified: an unsolved issue.","authors":"Giovanna Esposito, Claudia Santucci, Fabio Parazzini, Silvia Mignozzi, Matteo Malvezzi, Carlo La Vecchia, Eva Negri","doi":"10.1097/CEJ.0000000000000833","DOIUrl":"10.1097/CEJ.0000000000000833","url":null,"abstract":"Objective: A large percentage of uterine cancer deaths worldwide are not attributed to the cervix or corpus, but classified as uterus part 'unspecified'. We provided the trend for the proportion of uterine cancer deaths certified as 'unspecified' in selected countries.Methods: We derived the proportions of 'unspecified' uterine cancers for 20 selected high- and middle-income countries with reliable death certification over the period 1994-2021, using official mortality data from the WHO database coded according to the 10th Revision of the International Classification of Diseases.Results: For the earliest available year, the proportion of deaths classified as 'unspecified' uterine cancers ranged from 5.8% in Mexico to 65.6% in Italy. In some countries only, this proportion decreased over time. For 10 countries the proportion of 'unspecified' uterus in the most recent available year was around 20%. The proportion of deaths at 20-44 years registered as uterus 'unspecified' was lower for all countries during the study period.Conclusion: A substantial number of uterine cancer deaths worldwide coded as 'unspecified' was observed, also in high-income countries where death certification for other common neoplasms is accurate. Valid attribution of uterine cancer deaths to the cervix or corpus is feasible and should be adopted.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"1-4"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild renal impairment is associated with increased cardiovascular events and all-cause mortality following cancer diagnosis. 轻度肾功能损害与癌症诊断后心血管事件和全因死亡率的增加有关。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-07-03 DOI: 10.1097/CEJ.0000000000000828

Yonatan Moshkovits, Adam Goldman, Shmuel Tiosano, Alon Kaplan, Maia Kalstein, Gabriella Bayshtok, Shlomo Segev, Ehud Grossman, Amit Segev, Elad Maor

{"title":"Mild renal impairment is associated with increased cardiovascular events and all-cause mortality following cancer diagnosis.","authors":"Yonatan Moshkovits, Adam Goldman, Shmuel Tiosano, Alon Kaplan, Maia Kalstein, Gabriella Bayshtok, Shlomo Segev, Ehud Grossman, Amit Segev, Elad Maor","doi":"10.1097/CEJ.0000000000000828","DOIUrl":"10.1097/CEJ.0000000000000828","url":null,"abstract":"Background: The association between mildly decreased renal function and cardiovascular (CV) outcomes in cancer patients remains unestablished.Aims: We sought to explore this association in asymptomatic self-referred healthy adults.Method: We followed 25, 274 adults, aged 40-79 years, who were screened in preventive healthcare settings. Participants were free of CV disease or cancer at baseline. The estimated glomerular filtration rate (eGFR) was calculated according to the CKD Epidemiology Collaboration equation and categorized into groups [≤59, 60-69, 70-79, 80-89, 90-99, ≥100 (ml/min/1.73 m²)]. The outcome included a composite of death, acute coronary syndrome, or stroke, examined using a Cox model with cancer as a time-dependent variable.Results: Mean age at baseline was 50 ± 8 years and 7973 (32%) were women. During a median follow-up of 6 years (interquartile range: 3-11), 1879 (7.4%) participants were diagnosed with cancer, of them 504 (27%) develop the composite outcome and 82 (4%) presented with CV events. Multivariable time-dependent analysis showed an increased risk of 1.6, 1.4, and 1.8 for the composite outcome among individuals with eGFR of 90-99 [95% confidence interval (CI): 1.2-2.1 P = 0.01], 80-89 (95% CI: 1.1-1.9, P = 0.01) and 70-79 (95% CI: 1.4-2.3, P < 0.001), respectively. The association between eGFR and the composite outcome was modified by cancer with 2.7-2.9 greater risk among cancer patients with eGFR of 90-99 and 80-89 but not among individuals free from cancer ( Pinteraction < 0.001).Conclusion: Patients with mild renal impairment are at high risk for CV events and all-cause mortality following cancer diagnosis. eGFR evaluation should be considered in the CV risk assessment of cancer patients.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"11-18"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timely assessment of 5-year relative survival for patients with thyroid cancer from Taizhou, eastern China: a period analysis. 中国东部台州甲状腺癌患者5年相对生存率的及时评估：周期分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-07-19 DOI: 10.1097/CEJ.0000000000000830

Jiajia Huang, Jun Cao, Luyao Zhang, Meiyu Fang, Yongran Cheng, Da-Lin Lu, Liangyou Wang, Tianhui Chen

{"title":"Timely assessment of 5-year relative survival for patients with thyroid cancer from Taizhou, eastern China: a period analysis.","authors":"Jiajia Huang, Jun Cao, Luyao Zhang, Meiyu Fang, Yongran Cheng, Da-Lin Lu, Liangyou Wang, Tianhui Chen","doi":"10.1097/CEJ.0000000000000830","DOIUrl":"10.1097/CEJ.0000000000000830","url":null,"abstract":"Background: While timely assessment of long-term survival in thyroid cancer patients is critical for assessing early detection and screening programs for thyroid cancer, those data are sorely lacking in China. We aimed to timely and accurately assess the long-term survival of thyroid cancer patients in eastern China.Methods: Patients diagnosed with thyroid cancer during 2004-2018 from four cancer registries in Taizhou, eastern China were included. The 5-year relative survival was estimated by period analysis and stratified by sex, age at diagnosis, and region. The 5-year RS of thyroid cancer patients during 2019-2023 was also predicted using the model-based period analysis.Results: During 2014-2018, the overall 5-year relative survival of thyroid cancer patients was 87.7%, 91.2% for women and 79.4% for men. The 5-year RS decreased along with increasing age at diagnosis, decreasing from 94.9% for age <45 years to 81.3% for age >74 years, while 5-year RS was higher in urban areas than in rural areas (93.2% vs. 86.1%). The 5-year RS for thyroid cancer patients improved greatly between 2004-2008 to 2014-2018. The predicted overall 5-year RS could reach 91.4% over the upcoming 2019-2023 period.Conclusion: We provided, for the first time in China using period analysis, the most up-to-date 5-year RS for thyroid cancer patients from Taizhou, eastern China, which has important implications for timely evaluation on early detection and screening programs for patients with thyroid cancer in eastern China.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"62-68"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the incidence of thyroid cancer among US persons from 2000 to 2019. 2000 年至 2019 年美国甲状腺癌发病率趋势。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-07-12 DOI: 10.1097/CEJ.0000000000000827

Juebo Yu

{"title":"Trends in the incidence of thyroid cancer among US persons from 2000 to 2019.","authors":"Juebo Yu","doi":"10.1097/CEJ.0000000000000827","DOIUrl":"10.1097/CEJ.0000000000000827","url":null,"abstract":"Background: The incidence of thyroid cancer is increasing by 3% annually; however, the analysis was restricted to the period from 1973 to 2013, which could be changed in incidence trends over time. This study is to analyze trends in thyroid cancer incidence based on demographic and tumor characteristics at diagnosis using recent database.Methods: We used the Surveillance, Epidemiology, and End Results database to assess thyroid cancer incidence rates and trends from 2000 to 2019. We compared incidence rates for thyroid cancer among US persons by age, sex, race/ethnicity, and economic status (SES) and identified trends using Joinpoint software.Results: During 2000 to 2019, the overall thyroid cancer incidence was 13.22/100 000. This study found a decreasing trend in the incidence of thyroid cancer from 2014 to 2019 in the US with significant differences among age, sex, race and ethnicity, geographic region, SES, and tumor subtype. Specifically, the largest reduction in annual percentage changes in persons with all thyroid cancer and papillary thyroid cancer (PTC) in 55-69 years, female, Black, highest SES, urban region, and non-Hispanic ethnicity groups were identified.Conclusion: These results suggested that there is still a high epidemic of thyroid cancer in the US, whereas the rapidly increasing incidence rates of thyroid cancer have reversed since 2015, especially the incidence rates of PTC.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"5-10"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9836909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CDH1 hypermethylation: a potential molecular pathway for invasiveness in glioblastoma. CDH1 高甲基化：胶质母细胞瘤侵袭性的潜在分子途径。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-07-03 DOI: 10.1097/CEJ.0000000000000824

Daniel R Belut, Estela de O Lima, Marco A Zanini, Aline F Galvani, Fabiana B Furtado, Adriana C Ferrasi

引用次数: 0

Development of a nomogram for predicting survival in clinical T1N0M1 lung adenocarcinoma: a population-based study. 开发用于预测临床 T1N0M1 肺腺癌生存率的提名图：一项基于人群的研究。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-07-19 DOI: 10.1097/CEJ.0000000000000831

Xuejing Lin, Weicheng Tian, Ni Sun, Ziyang Xia, Pei Ma

{"title":"Development of a nomogram for predicting survival in clinical T1N0M1 lung adenocarcinoma: a population-based study.","authors":"Xuejing Lin, Weicheng Tian, Ni Sun, Ziyang Xia, Pei Ma","doi":"10.1097/CEJ.0000000000000831","DOIUrl":"10.1097/CEJ.0000000000000831","url":null,"abstract":"Objective: This study aimed to establish a prognostic model for clinical T1N0M1 (cT1N0M1) lung adenocarcinoma patients to evaluate the prognosis of patients in terms of overall survival (OS) rate and cancer-specific survival (CSS) rate.Methods: Data of patients with metastatic lung adenocarcinoma from 2010 to 2016 were collected from the Surveillance, Epidemiology and End Results database. Multivariate Cox regression analysis was conducted to identify relevant prognostic factors and used to develop nomograms. The receiver operating characteristic (ROC) curve and calibration curve are used to evaluate the predictive ability of the nomograms.Results: A total of 45610 patients were finally included in this study. The OS and CSS nomograms were constructed by same clinical indicators such as age (<60 years or ≥60 years), sex (female or male), race (white, black, or others), surgery, radiation, chemotherapy, and the number of metastatic sites, based on the results of statistical Cox analysis. From the perspective of OS and CSS, surgery contributed the most to the prognosis. The ROC curve analysis showed that the survival nomograms could accurately predict OS and CSS. According to the points obtained from the nomograms, survival was estimated by the Kaplan-Meier method, then cT1N0M1 patients were divided into three groups: low-risk group, intermediate-risk group, and high-risk group, and the OS ( P < 0.001) and CSS ( P < 0.001) were significantly different among the three groups.Conclusion: The nomograms and risk stratification model provide a convenient and reliable tool for individualized evaluation and clinical decision-making of patients with cT1N0M1 lung adenocarcinoma.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"37-44"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum uric acid and the risk of colorectal cancer: a meta-analysis. 血清尿酸与结直肠癌风险：一项荟萃分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-01-01 Epub Date: 2023-08-28 DOI: 10.1097/CEJ.0000000000000834

Wenqiang Liao, Yuxiang Wang, Wenpeng Zhang

{"title":"Serum uric acid and the risk of colorectal cancer: a meta-analysis.","authors":"Wenqiang Liao, Yuxiang Wang, Wenpeng Zhang","doi":"10.1097/CEJ.0000000000000834","DOIUrl":"10.1097/CEJ.0000000000000834","url":null,"abstract":"Background: A meta-analysis was performed in this study to evaluate the association between serum uric acid and the risk of colorectal cancer (CRC).Methods: Relevant observational studies observing the relationship between uric acid and the incidence of CRC were obtained by the search of electronic databases, including Medline, Embase, Cochrane Library and Web of Science . A randomized-effects model was selected to pool the data by incorporating the influence of potential heterogeneity.Results: Eight observational studies involving 1,226,379 adults were included. During a mean follow-up duration of 12.8 years, CRC was developed in 12349 (1.0%) participants. Pooled results showed that compared to those with the lowest category of serum uric acid at baseline, participants with the highest category of serum uric acid had an increased incidence of CRC during follow-up [risk ratio (RR), 1.28; 95% confidence interval (CI), 1.17-1.42; P < 0.001; I2 = 0%]. Sensitivity analysis limited to prospective cohort studies retrieved similar results (RR, 1.32; 95% CI, 1.19-1.47; P < 0.001; I2 = 0%). Subgroup analyses showed consistent results in men and women, in estimates of the incidence of colon cancer and rectal cancer and in studies with different follow-up durations and quality scores ( P for subgroup differences all > 0.05).Conclusion: Although the cutoff for defining a high uric acid varied among the included studies, results of the meta-analysis suggest that a high serum uric acid may be associated with an increased risk of CRC in an adult population.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"19-28"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10162008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0