Mesothelioma among seamen: a systematic review and meta-analysis.

IF 2.1 4区医学 Q3 ONCOLOGY

European Journal of Cancer Prevention Pub Date : 2024-09-01 Epub Date: 2024-03-15 DOI:10.1097/CEJ.0000000000000875

Matteo Rota, Angelo Viscardi, Francesca Maghin, Donatella Placidi, Adelaide Conti

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引用次数: 0

Abstract

Objectives: Navy personnel and seafarers live and work 24 h per day in the shipboard environment and they are exposed to asbestos fibers released into the confined spaces aboard ships. We conducted a systematic review and meta-analysis to quantify the mesothelioma risk of seamen working aboard ships, either commercial or naval vessels, as compared to that of the general population.

Methods: We carried out a literature search in MEDLINE through PubMed and EMBASE, from inception to 31 December 2021, of all studies on seamen working aboard ships, either commercial or naval vessels, characterized by exposure to asbestos and providing mesothelioma risk estimates. The Newcastle-Ottawa Scale was used to assess the quality of the studies included. The pooled standardized mortality ratio (SMR) was computed across eligible studies. The study protocol was registered on PROSPERO and reporting followed the preferred reporting items for systematic reviews and meta-analyses guidelines.

Results: A total of 10 studies published from 1990 to 2020 were considered eligible and included in the systematic review and meta-analysis. All the included studies were of good quality, with a median score of seven out of nine. Overall, there were 235 mesothelioma cases/deaths in the included studies versus 115.6 expected, with a pooled SMR of 2.11 (95% confidence intervals, 1.70-2.62), in the absence of a significant between-study heterogeneity ( I2 = 39%, P = 0.11).

Conclusion: A more than double excess risk for mesothelioma among seamen working aboard ships emerged from our meta-analysis.

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海员间皮瘤：系统回顾和荟萃分析。

目标：海军人员和海员每天 24 小时生活和工作在船上环境中，他们暴露于释放到船上密闭空间中的石棉纤维。我们进行了一项系统回顾和荟萃分析，以量化在商船或军舰上工作的海员与普通人群相比患间皮瘤的风险：我们通过 PubMed 和 EMBASE 在 MEDLINE 上检索了从开始到 2021 年 12 月 31 日的所有文献，包括所有关于在商船或军舰上工作的海员的研究，这些研究的特点是暴露于石棉并提供间皮瘤风险估计值。纽卡斯尔-渥太华量表用于评估纳入研究的质量。对所有符合条件的研究进行了汇总标准化死亡率（SMR）计算。研究方案在 PROSPERO 上注册，报告遵循系统综述和荟萃分析指南的首选报告项目：从 1990 年到 2020 年，共发表了 10 项符合条件的研究，并纳入了系统综述和荟萃分析。所有纳入的研究质量良好，中位数为 7 分（满分 9 分）。总体而言，纳入研究的间皮瘤病例/死亡数为235例，而预期为115.6例，汇总SMR为2.11（95%置信区间，1.70-2.62），研究间无显著异质性（I2 = 39%，P = 0.11）：我们的荟萃分析显示，在船上工作的海员罹患间皮瘤的超额风险超过一倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Cancer Prevention 医学-肿瘤学

CiteScore

4.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： European Journal of Cancer Prevention aims to promote an increased awareness of all aspects of cancer prevention and to stimulate new ideas and innovations. The Journal has a wide-ranging scope, covering such aspects as descriptive and metabolic epidemiology, histopathology, genetics, biochemistry, molecular biology, microbiology, clinical medicine, intervention trials and public education, basic laboratory studies and special group studies. Although affiliated to a European organization, the journal addresses issues of international importance.