European Journal of Cancer Prevention最新文献_第4页

The global gastric cancer consortium: an update from the Stomach cancer Pooling (StoP) project. 全球胃癌联盟：胃癌汇集（StoP）项目的最新进展。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-09-01 Epub Date: 2024-02-20 DOI: 10.1097/CEJ.0000000000000874

Claudio Pelucchi, Carlo La Vecchia, Rossella Bonzi, Eva Negri, Giovanni Corso, Stefania Boccia, Paolo Boffetta, M Constanza Camargo, Maria Paula Curado, Nuno Lunet, Jesus Vioque, Zuo-Feng Zhang

引用次数: 0

Association of metformin and statin uses with the prognosis of colon cancer: a meta-analysis. 二甲双胍和他汀类药物的使用与结肠癌预后的关系：一项荟萃分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-09-01 Epub Date: 2024-01-15 DOI: 10.1097/CEJ.0000000000000872

Yanyan Xu, Hao Che, Jiang Liu, Pingjiang Ye

{"title":"Association of metformin and statin uses with the prognosis of colon cancer: a meta-analysis.","authors":"Yanyan Xu, Hao Che, Jiang Liu, Pingjiang Ye","doi":"10.1097/CEJ.0000000000000872","DOIUrl":"10.1097/CEJ.0000000000000872","url":null,"abstract":"Background: Metformin and statins are commonly used globally for the treatment of type 2 diabetes mellitus and dyslipidemia, respectively. Recently, multiple novel pathways have been discovered, which may contribute to the treatment of various types of cancer. Several meta-analysis studies have reported that the use of metformin or statins is associated with a lower risk of colon cancer compared to nonusers. In this study, our aim was to perform a meta-analysis and investigate the prognostic roles of these two medications in colon cancer.Methods: To identify relevant articles, literature searches were performed in the PubMed and Web of Science databases using a combination of keywords related to metformin, statins and colon cancer prognosis until August 2023. The study utilized STATA 12.0 software (Stata Corporation, College Station, Texas, USA) to compute all the hazard ratios (HRs) and 95% confidence intervals (CIs) regarding the association between metformin or statin uses and prognostic-related outcomes.Results: Our analysis revealed that the use of metformin was associated with a significantly lower overall mortality of colon cancer (HR = 0.63; 95% CI = 0.51-0.77; I2 = 94.9%; P < 0.001), as well as lower cancer-specific mortality of colon cancer (HR = 0.68; 95% CI = 0.50-0.94; I2 = 91.9%; P < 0.001). Similarly, the use of statins was also associated with a lower overall mortality of colon cancer (HR = 0.68; 95% CI = 0.60-0.78; I2 = 93.8%; P < 0.001), as well as a lower cancer-specific mortality of colon cancer (HR = 0.74; 95% CI = 0.67-0.81; I2 = 82.2%; P < 0.001).Conclusion: Our meta-analysis study suggests that statins and metformin may have potential as adjuvant agents with significant benefits in the prognosis of colon cancer.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"414-424"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational exposure to diesel exhaust and head and neck cancer: a systematic review and meta-analysis of cohort studies. 职业暴露于柴油废气与头颈癌：队列研究的系统回顾和荟萃分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-09-01 Epub Date: 2024-03-15 DOI: 10.1097/CEJ.0000000000000876

Monireh Sadat Seyyedsalehi, Giulia Collatuzzo, Federica Teglia, Paolo Boffetta

{"title":"Occupational exposure to diesel exhaust and head and neck cancer: a systematic review and meta-analysis of cohort studies.","authors":"Monireh Sadat Seyyedsalehi, Giulia Collatuzzo, Federica Teglia, Paolo Boffetta","doi":"10.1097/CEJ.0000000000000876","DOIUrl":"10.1097/CEJ.0000000000000876","url":null,"abstract":"Exposure to diesel exhaust (DE) and other fossil fuels in the workplace can cause several health effects including cancer. We conducted a systematic review and meta-analysis of cohort studies examining the association between occupational DE exposure and the risk of head and neck cancer (HNC), including cancer of the oral cavity, pharynx and larynx. We included cohort studies mentioned in the Monograph of the International Agency for Research on Cancer, 2014, on DE. Forest plots of relative risk (RR) were constructed for HNC overall and its anatomical subtypes. A random-effects model was used to address heterogeneity between studies. Fifteen articles were included after removing duplicates and irrelevant reports. The summary RR for DE exposure was 1.08 [95% confidence interval (CI) = 1.01-1.17, P heterogeneity = <0.001] for HNC overall, 0.98 (95% CI = 0.87-1.11) for oral cavity, 1.05 (95% CI = 0.77-1.43) for pharyngeal, 1.15 (95% CI = 0.96-1.38) for oral cavity and pharyngeal combined, and 1.13 (95% CI = 1.03-1.24) for laryngeal cancer. There were elevated RRs for incidence studies of HNC (RR = 1.13; 95% CI = 1.05-1.22, P = 0.001), European studies (RR = 1.13; 95% CI = 1.05-1.23, P = 0.001), and female studies (RR = 1.77; 95% CI = 1.31-2.39, P = 0.003). Our study suggested an association between occupational DE exposure and the risk of HNC, particularly laryngeal cancer. Although residual confounding cannot be ruled out, our results support the importance of controlling occupational DE exposure.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"425-432"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV infection patterns and viral load distribution: implication on cervical cancer prevention in Western Kenya. HPV 感染模式和病毒载量分布：对肯尼亚西部宫颈癌预防的影响。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-29 DOI: 10.1097/CEJ.0000000000000920

Ivy Akinyi, Ogol Japheth Ouma, Sylvester Ogutu, Eric Ogola, Jane Owenga, George Ayodo, Dicken Omondi, Shehu Shagari Awandu, Davy Vanden Broeck, Nina Redzic, Ana Rita Pereira, Johannes Bogers

{"title":"HPV infection patterns and viral load distribution: implication on cervical cancer prevention in Western Kenya.","authors":"Ivy Akinyi, Ogol Japheth Ouma, Sylvester Ogutu, Eric Ogola, Jane Owenga, George Ayodo, Dicken Omondi, Shehu Shagari Awandu, Davy Vanden Broeck, Nina Redzic, Ana Rita Pereira, Johannes Bogers","doi":"10.1097/CEJ.0000000000000920","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000920","url":null,"abstract":"Human papillomavirus (HPV) coinfection remains common globally. However, its clinical significance compared to mono-infection remains controversial. Further, the epidemiology of HPV genotype combination in coinfection is not well studied in Kenya. . Between June and August 2023, a cross-sectional facility-based survey enrolled 434 women aged 16-68 years using purposive sampling strategy. Structured questionnaire was obtained from each woman regarding demographic and sexual behavior characteristics. Cervical specimen was collected from each participant and analyzed using RIATOL assay to determine HPV genotypes and viral load. Overall, HPV 52 was the most frequently detected HPV strain. The mean HPV viral load was elevated among coinfected women than those with mono-infection but there was no evidence to support differences in viral load in the two groups (P = 0.113). Mono-infection was common (58.52%). HPV 16 was noted to have a near equal presence both in mono-infection and coinfection (52.17% and 47. 83%), respectively. HPV 33 (alpha 9) and 45 (alpha 7) had the greatest preference for each other compared to all other HPV interactions. HPV 52 is the most prevalent HPV in the population supporting the need for the nonavalent HPV vaccine. Mono-infection with HPV 16 remains common corroborating the relevance of bivalent vaccine in resource limited setting where nonavalent vaccines may be unavailable. The frequent coinfection preference of HPV 33 and 45 (alpha 9 and alpha 7, respectively) pauses the need for further concurrent characterization. HPV vaccination and education on safe sexual behaviors is key in reducing HPV coinfection.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between radiotherapy and the risk of second primary malignancies in breast cancer patients with different estrogen receptor statuses. 不同雌激素受体状态的乳腺癌患者接受放疗与罹患第二原发性恶性肿瘤风险之间的关系。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-26 DOI: 10.1097/CEJ.0000000000000915

Chengshan Zhao, Yang Yu, Pi'ao Xiang, Jiahu Liao, Boyang Yu, Yifeng Xing, Guobing Yin

{"title":"Association between radiotherapy and the risk of second primary malignancies in breast cancer patients with different estrogen receptor statuses.","authors":"Chengshan Zhao, Yang Yu, Pi'ao Xiang, Jiahu Liao, Boyang Yu, Yifeng Xing, Guobing Yin","doi":"10.1097/CEJ.0000000000000915","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000915","url":null,"abstract":"Background: Breast cancer is the most common cancer among women. Second primary malignancies (SPMs) related to radiotherapy are significant complications. This study aims to investigate the correlation between radiotherapy and the occurrence of SPMs in breast cancer patients with different estrogen receptor statuses.Methods: We used data from the Surveillance, Epidemiology, and End Results (SEER) database, selecting estrogen receptor(+) and estrogen receptor(-) breast cancer patients from 1990 to 2015, with SPMs as the outcome measure. Fine-Gray competing risks regression and Poisson regression were employed to analyze the relationship between radiotherapy and the risk of SPMs in different estrogen receptor status groups.Results: Radiotherapy was associated with an increased risk of lung cancer, melanoma, non-Hodgkin lymphoma, and leukemia in estrogen receptor(+) patients. In estrogen receptor(-) patients, radiotherapy was linked to an increased risk of brain cancer and leukemia. The cumulative incidence, standardized incidence ratio, and subgroup analyses showed consistent results. In the dynamic assessment of radiotherapy-related risks, estrogen receptor(+) patients aged 50-70 exhibited a higher risk of leukemia and melanoma. Lung cancer risk was highest during a latency period of 20-30 years, while melanoma, non-Hodgkin lymphoma, and leukemia risks peaked within the first 10 years. For estrogen receptor(-) patients, brain cancer risk was higher between ages 50 and 70, and leukemia risk was elevated between ages 20 and 50.Conclusion: Postoperative radiotherapy for breast cancer is associated with an increased risk of SPMs, with risks varying by estrogen receptor status and SPM type. Further research into the prevention of radiotherapy-related SPMs in different estrogen receptor status groups is crucial.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular death risk in patients with solid tumors: a population-based study in the United States. 实体瘤患者的心血管死亡风险：一项基于美国人口的研究。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-26 DOI: 10.1097/CEJ.0000000000000921

Shuaijie Gao, Hao Zhu, Xinyu Chang, Xiting Cao, Zhenwei Wang, Xiaoxuan Chu, Lu Zhang, Xinhua Wang, Jie Lu

{"title":"Cardiovascular death risk in patients with solid tumors: a population-based study in the United States.","authors":"Shuaijie Gao, Hao Zhu, Xinyu Chang, Xiting Cao, Zhenwei Wang, Xiaoxuan Chu, Lu Zhang, Xinhua Wang, Jie Lu","doi":"10.1097/CEJ.0000000000000921","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000921","url":null,"abstract":"Background: Previous studies have focused on the risk of cardiovascular disease (CVD)-specific death in hematological cancers and in some single anatomical tumor sites, there remains a paucity of data on systematic analyses in solid tumors.Objective: The objective of this study is to evaluate the distribution, risk, and trends of CVD-specific death in patients with solid tumors.Methods: A total of 2 679 293 patients with solid tumors diagnosed between 1975 and 2019 were screened from the Surveillance, Epidemiology and End Results (SEER) program across 15 anatomical sites. Standardized mortality ratios (SMRs) and absolute excess risks (AERs) were used to describe the intensity of CVD-specific death, competing risk regression models were used to assess the risk of CVD-specific death, and restricted cubic spline analyses were employed to investigate the potential linear or nonlinear relationship between age and CVD death.Results: CVD-specific death in patients with solid tumors accounted for 48.95% of non-cancer deaths. Compared with the general population, patients with solid tumors had higher SMR and AER of CVD death (SMR: 1.15; AER: 21.12), heart disease-related death (SMR: 1.13; AER: 13.96), and cerebrovascular disease-related death (SMR: 1.20; AER: 4.85). Additionally, the SMR exhibited a decreasing trend with increasing time to diagnosis. Furthermore, a nonlinear relationship was observed between age and CVD-specific death in patients with solid tumors of different systems.Conclusion: CVD-specific death accounted for a large proportion of the cause of non-cancer deaths. Patients with solid tumors exhibit an elevated risk of CVD-specific death. Screening for CVD death and optimizing risk management in patients with solid tumors throughout anticancer treatment may be beneficial in preventing CVD death.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison analysis of the burden and attributable risk factors of early-onset and late-onset colorectal cancer in China from 1990 to 2019. 1990-2019年中国早发与晚发结直肠癌负担及可归因风险因素对比分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-20 DOI: 10.1097/CEJ.0000000000000907

Mingmin Gong, Tian Xia, Zefu Chen, Yuanyuan Zhu

{"title":"Comparison analysis of the burden and attributable risk factors of early-onset and late-onset colorectal cancer in China from 1990 to 2019.","authors":"Mingmin Gong, Tian Xia, Zefu Chen, Yuanyuan Zhu","doi":"10.1097/CEJ.0000000000000907","DOIUrl":"10.1097/CEJ.0000000000000907","url":null,"abstract":"Objectives: The project intended to analyze the impact of burden and related risk factors of late-onset colorectal cancer (LOCRC) and early-onset colorectal cancer (EOCRC) in China, thus offering essential references for optimizing prevention and control strategies.Method: Global Burden of Disease Study was employed to describe burden changes of EOCRC and LOCRC in China during 1990-2019, containing the numbers of incidence, deaths, prevalence, and disability-adjusted life years (DALYs), and to compare attributable deaths and DALYs risk factors in varying age and sex segments.Results: The numbers and corresponding crude rates of incidence, deaths, prevalence, and DALYs of EOCRC and LOCRC in China during 1990-2019 demonstrated an upward trend across all age categories, with males being dramatically predominant. Overall, over time, the impact of a low-calcium diet and a low-fiber diet on mortality and DALY rates decreased, while the impact of other risk factors increased. In terms of gender, the risk factors affecting males changed greatly, with smoking, inadequate milk intake, and the low whole-grain diet being the main factors in 2019, while in 1990, the main factors were the low-calcium diet, smoking, and inadequate milk intake.Conclusion: The burden of colorectal cancer in China is concerning. Patients grouped by diagnostic age exhibit different characteristics, indicating the need for high-quality research in the future to achieve personalized medicine tailored to different population characteristics.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis. 职业苯暴露与肾癌和膀胱癌的风险：系统回顾和荟萃分析。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-20 DOI: 10.1097/CEJ.0000000000000911

Monireh Sadat Seyyedsalehi, Mattia Bonetti, Darshi Shah, Vincent DeStefano, Paolo Boffetta

{"title":"Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis.","authors":"Monireh Sadat Seyyedsalehi, Mattia Bonetti, Darshi Shah, Vincent DeStefano, Paolo Boffetta","doi":"10.1097/CEJ.0000000000000911","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000911","url":null,"abstract":"Introduction: Benzene is recognized as leukemogenic. However, the association between it and solid cancers has been the subject of less investigation. We aim to conduct a systematic review and meta-analysis to evaluate the association between occupational exposure to benzene and the risk of urinary tract cancer, including kidney and bladder.Methods: We included 41 cohort and case-control studies listed in the most recent International Agency for Research on Cancer (IARC) Monograph on benzene exposure and the result of a literature review to identify more recent studies. Forest plots of relative risk (RR) were constructed for kidney, bladder, and urinary tract cancer overall. A random-effects model was used to address heterogeneity between studies. Stratified analyses were conducted to explore effect modification.Results: Our findings revealed an association between exposure to occupational benzene and kidney and unspecified urinary tract cancers (RR = 1.20, 95% confidence interval = 1.03-1.39), and an association of borderline statistical significance with bladder cancer (RR = 1.07, 95% confidence interval = 0.97-1.18). Publication bias was excluded for both kidney (P = 0.809) and bladder cancer (P = 0.748). Stratification analysis according to the selected study characteristics showed no difference except regarding the industry for kidney cancer (P < 0.000), with a stronger association in the chemical industry. An analysis by exposure level did not reveal any trend for kidney cancer, whereas there was a trend (P = 0.01) for bladder cancer.Conclusion: Our study found an association between occupational benzene exposure and kidney cancer and a dose-effect association between benzene exposure and bladder cancer.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the differential effect of participation in breast cancer screening program versus opportunistic screening or symptomatic detection on tumour characteristics. 比较参加乳腺癌筛查计划与机会性筛查或症状检测对肿瘤特征的不同影响。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-13 DOI: 10.1097/CEJ.0000000000000919

Celmira Laza-Vásquez, Montserrat Rué-Monné, José Luís Fougo, Bárbara Peleteiro

{"title":"Comparison of the differential effect of participation in breast cancer screening program versus opportunistic screening or symptomatic detection on tumour characteristics.","authors":"Celmira Laza-Vásquez, Montserrat Rué-Monné, José Luís Fougo, Bárbara Peleteiro","doi":"10.1097/CEJ.0000000000000919","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000919","url":null,"abstract":"Objectives: The success of a breast cancer screening program is highly dependent on adherence. We aimed to compare the differential effect of participation in breast cancer screening program versus opportunistic screening or symptomatic detection on tumour characteristics.Methods: We included women referred to our Breast Centre in 2015-2021: 321 from the breast cancer screening group (group 1) and 422 through opportunistic screening or due to symptomatic detection (group 2). We compared data on sociodemographics, breast cancer detection, clinical features and tumour characteristics.Results: A total of 10.6% of women in group 1 had breast symptoms and 63.8% had breast signs, with group 2 presenting higher proportions (57.6 and 77.8%, respectively, P < 0.001). The median tumour size in group 1 was smaller compared with group 2 (14 vs 17 mm, P < 0.001). A total of 8.7% of women in group 1 had nodal involvement whereas in group 2 the proportion corresponded to 19.0% (P < 0.001). No women in group 1 were diagnosed with metastasis, while metastases were found in 2.4% of those from group 2 (P = 0.005). There were no significant differences in molecular subtype of invasive tumours between the two groups.Conclusion: The tumour characteristics of women who participated in the breast cancer screening program showed in almost all characteristics more favourable results in comparison with the group who underwent opportunistic screening or sought care due to symptoms. The lower clinical stage observed in those referred from the organised program reaffirms that it is an effective measure for early detection, diagnosis, and treatment.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of body composition parameters, age, and tumor staging on gastric cancer prognosis. 身体成分参数、年龄和肿瘤分期对胃癌预后的影响。

IF 2.1 4区医学

European Journal of Cancer Prevention Pub Date : 2024-08-13 DOI: 10.1097/CEJ.0000000000000917

Wei Li, Hai Zhu, Hai-Zheng Dong, Zheng-Kun Qin, Fu-Ling Huang, Zhu Yu, Shi-Yu Liu, Zhen Wang, Jun-Qiang Chen

{"title":"Impact of body composition parameters, age, and tumor staging on gastric cancer prognosis.","authors":"Wei Li, Hai Zhu, Hai-Zheng Dong, Zheng-Kun Qin, Fu-Ling Huang, Zhu Yu, Shi-Yu Liu, Zhen Wang, Jun-Qiang Chen","doi":"10.1097/CEJ.0000000000000917","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000917","url":null,"abstract":"Background: Research studies on gastric cancer have not investigated the combined impact of body composition, age, and tumor staging on gastric cancer prognosis. To address this gap, we used machine learning methods to develop reliable prediction models for gastric cancer.Methods: This study included 1,132 gastric cancer patients, with preoperative body composition and clinical parameters recorded, analyzed using Cox regression and machine learning models.Results: The multivariate analysis revealed that several factors were associated with recurrence-free survival (RFS) and overall survival (OS) in gastric cancer. These factors included age (≥65 years), tumor-node-metastasis (TNM) staging, low muscle attenuation (MA), low skeletal muscle index (SMI), and low visceral to subcutaneous adipose tissue area ratios (VSR). The decision tree analysis for RFS identified six subgroups, with the TNM staging I, II combined with high MA subgroup showing the most favorable prognosis and the TNM staging III combined with low MA subgroup exhibiting the poorest prognosis. For OS, the decision tree analysis identified seven subgroups, with the subgroup featuring high MA combined with TNM staging I, II showing the best prognosis and the subgroup with low MA, TNM staging II, III, low SMI, and age ≥65 years associated with the worst prognosis.Conclusion: Cox regression identified key factors associated with gastric cancer prognosis, and decision tree analysis determined prognoses across different risk factor subgroups. Our study highlights that the combined use of these methods can enhance intervention planning and clinical decision-making in gastric cancer.","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0