European Journal of Cancer Prevention最新文献

{"title":"The accuracy of administrative data in identifying pulmonary metastases: a population-based study in Northern Italy.","authors":"Francesco Marinelli, Maria Barbara Braghiroli, Isabella Bisceglia, Francesca Roncaglia, Annamaria Pezzarossi, Fortunato Morabito, Antonino Neri, Paolo Giorgi Rossi, Lucia Mangone","doi":"10.1097/CEJ.0000000000000964","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000964","url":null,"abstract":"<p><strong>Objective: </strong>Lung cancer remains a highly prevalent and lethal disease, with the majority of tumors identified at advanced stages. Screening with low-dose CT was shown to be effective in reducing mortality through early diagnosis. Administrative data are increasingly utilized in clinical settings and research for identifying metastatic lung cancer, yet their accuracy and limitations require thorough evaluation.</p><p><strong>Methods: </strong>This study evaluated the use of administrative data to identify lung cancer metastases within the population-based cancer registry (CR) of Reggio Emilia by cross-referencing registry data with administrative hospital discharge records (HDRs). Distant metastases were identified using specific International Classification of Diseases, 9th revision codes, with medical records reviewed to validate and refine the identification process. Standardized incidence and mortality rates were calculated and analyzed using joinpoint regression.</p><p><strong>Results: </strong>Between 2018 and 2021, 1391 lung cancers exhibiting at least one HDR were identified. Of these, 383 (27.5%) cases had distant metastases, 80 (6%) had a second tumor, and 12 (1.5%) had unknown tumor sites. After a manual review of cases with codes 196 (secondary and unspecified malignant neoplasm of lymph nodes) and code 199 (malignant neoplasm without specification of the site), the number of identified metastatic tumors increased to 30.5%. Lung cancer metastases identified by the CR showed an HDR sensitivity equal to 32.6%.</p><p><strong>Conclusion: </strong>Administrative data, even with manual verification, achieved a positive predictive value of 30.5 for metastatic tumors. The scientific community and policymakers must be aware of these limitations and the need for additional resources to accurately screen to evaluate lung cancer.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for the response to neoadjuvant treatment in patients with stage II and III breast cancer.","authors":"Márcia Piccoli Fusieger Baratto, Larissa Franciele Piovesan, Luciano Fiorentin, Shaline Ferla Baptistella, Diego Carvalho, Luana Patrícia Marmitt, Antuani Rafael Baptistella","doi":"10.1097/CEJ.0000000000000967","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000967","url":null,"abstract":"<p><p>This study aimed to identify predictive factors for response to neoadjuvant treatment in patients with stage II and III breast cancer. A cross-sectional study evaluated the medical records of 440 patients treated in the Oncology Department of a University Hospital in Brazil between 2007 and 2022. Response to neoadjuvant treatment was classified into three groups: pathological complete response (pCR), partial response, and no response. Predictive factors were analyzed using multinomial regression. Most patients showed partial response (73.9%). Patients aged 39 years or younger were three times more likely to achieve pCR [relative risk (RR) = 3.04, 95% confidence interval (CI): 1.51-6.15]. Conversely, patients with luminal A and B subtypes had a lower likelihood of pCR (RR = 0.09, 95% CI: 0.04-0.18). The presence of diabetes (RR = 7.18, 95% CI: 2.43-21.1) and stage IIIB and IIIC (RR = 7.41, 95% CI: 1.48-37.0) increased the risk of no response by at least 7.4-fold. Besides age, molecular subtype, and staging, diabetes was significantly associated with the response to neoadjuvant chemotherapy, highlighting the importance of elucidating the mechanism by which diabetes may impair the response to neoadjuvant treatment, as well as the importance of prevention and management of diabetes before and during oncologic treatment.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing prognostic insights: myometrial invasion patterns in endometrial carcinoma, with emphasis on MELF pattern-a comprehensive review and meta-analysis.","authors":"Yuyuan Guo, Luying Li, Kaini Yang, Yuhan Song, Lu Xu, Fangyi Zhao, Wenting Li","doi":"10.1097/CEJ.0000000000000903","DOIUrl":"10.1097/CEJ.0000000000000903","url":null,"abstract":"<p><strong>Purpose: </strong>The microcystic, elongated, and fragmented (MELF) pattern, characterized by myxoid and inflamed stroma, is readily identifiable as a form of myometrial infiltration. This meta-analysis endeavors to assess the prognostic significance of MELF infiltration patterns in patients diagnosed with endometrial cancer.</p><p><strong>Methods: </strong>A comprehensive literature search, spanning until 11 October 2023, across PubMed , Embase , Cochrane , and Web of Science databases, identified 23 relevant studies involving 5199 patients. Data analysis was performed using Stata 16.0.</p><p><strong>Results: </strong>Analysis indicates that MELF infiltration predicts a higher risk of lymph node metastasis in endometrial cancer patients [hazard ratios (HR) = 5.05; 95% confidence interval (CI), 3.62-7.05; P  < 0.05]. Notably, this association remains consistent across various patient demographics, analytical approaches, study designs, and treatment modalities. However, MELF infiltration does not significantly correlate with recurrence (HR = 1.05; 95% CI, 0.73-1.52; P  > 0.05), overall survival (HR = 1.24; 95% CI, 0.91-1.68; P  > 0.05), or disease-free survival (HR = 1.40; 95% CI, 0.85-2.28; P  > 0.05).</p><p><strong>Conclusion: </strong>While MELF infiltration heightens the risk of lymph node metastasis in endometrial cancer, its impact on recurrence, overall survival, and disease-free survival remains statistically insignificant.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"173-184"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between folate level and cervical intraepithelial neoplasia risk: a systematic review and meta-analysis.","authors":"Run Chen, Chengcheng Ding, Dongyu Wang","doi":"10.1097/CEJ.0000000000000908","DOIUrl":"10.1097/CEJ.0000000000000908","url":null,"abstract":"<p><p>There were several studies about the association between folate level and the risk of cervical intraepithelial neoplasia (CIN). This meta-analysis was conducted to evaluate whether folate deficiency is related to a high risk of CIN and cervical cancer. Odds ratios (ORs)/relative risks and 95% confidence intervals (CIs) were summarized regarding the association between folate level and risk of CIN or cervical cancer. The meta-analysis indicated that higher serum folate levels (the second, third, and fourth quartiles of serum folate) were associated with a lower risk of CIN, as demonstrated by a random-effects model (OR = 0.42, 95% CI: 0.28-0.62). Conversely, no significant association was found between erythrocyte folate levels and the risk of CIN, as indicated by a random-effects model (OR = 0.69, 95% CI: 0.43-1.12). In addition, random-effects models demonstrated that higher serum folate levels (the second, third, and fourth quartiles of serum folate) were associated with lower risks of CIN grade 1 and CIN grades 2 or 3, compared with the lowest quartile of serum folate (CIN grade 1: OR = 0.52, 95% CI: 0.29-0.93; CIN grades 2 or 3: OR = 0.33, 95% CI: 0.19-0.58). Higher serum folate levels (the second, third, and fourth quartiles of serum folate) were associated with a lower risk of cervical cancer, compared with the lowest quartile of serum folate (OR = 0.53, 95% CI: 0.36-0.79). Serum low folate levels could increase the risk of CIN and cervical cancer, while erythrocyte folate concentration was not associated with the risk of CIN.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"185-192"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer burden among young women from 1990 to 2021: a global, regional, and national perspective.","authors":"Zhuojun Tang, Yiying Wei, Yanqing Liang, Xuexian Zhu, Junjie Tang, Yulin Sun, Qingyuan Zhuang","doi":"10.1097/CEJ.0000000000000909","DOIUrl":"10.1097/CEJ.0000000000000909","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer, the most prevalent tumor in women globally, significantly impacts young women, compromising their daily lives and overall well-being. Breast cancer represents a significant public health concern due to its extensive physical and psychological consequences.</p><p><strong>Material and methods: </strong>Data from the Global Burden of Disease (GBD) were used to assess the global, regional, and national burden of breast cancer in young women aged 20-39 from 1990 to 2021. This analysis focused on trends measured by the estimated annual percentage change (EAPC) and explored the socioeconomic impacts via the sociodemographic index (SDI).</p><p><strong>Results: </strong>During 1990-2021, the incidence and prevalence of breast cancer among young women increased globally, with annual rates of 0.82 and 0.87%, respectively. The mortality rate and disability-adjusted life years (DALYs) also rose annually by -0.12% and -0.05, respectively. A significant burden shift was observed towards regions with lower SDI, with diet high in red meat, alcohol use, and high fasting plasma glucose identified as prominent risk factors, particularly in lower SDI regions.</p><p><strong>Conclusion: </strong>Our findings underscore breast cancer in young women as an escalating global health challenge, with the burden increasingly shifting towards lower socioeconomic areas. This underscores the necessity for targeted prevention and control strategies for breast cancer, focusing on reducing the identified risk factors and ensuring equitable health resource distribution.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"130-139"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of atypical glandular cells on cytology: 10 years' experience of a colposcopic referral center.","authors":"Ermelinda Monti, Eugenia Di Loreto, Giada Libutti, Daniela Alberico, Giussy Barbara, Veronica Boero, Giulia Emily Cetera, Maria Pasquali Coluzzi, Sonia Cipriani, Fabio Parazzini","doi":"10.1097/CEJ.0000000000000910","DOIUrl":"10.1097/CEJ.0000000000000910","url":null,"abstract":"<p><strong>Introduction: </strong>'Atypical glandular cells' (AGC) is an uncommon cytological result of cervical Pap smears which includes a wide of histopathological diagnoses, from benign to premalignant and malignant cervical disorders, endometrial cancer and, occasionally, other genital malignancies. This study aims to provide a comprehensive overview of AGC, assessing risk factors and clinical and histological features in affected patients.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on a cohort of 239 women diagnosed with AGC between 2012 and 2022 at the 'Regional Referral Center for Prevention, Diagnosis and Treatment of HPV-related Genital Disorders', Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Following AGC detection, patients underwent colposcopy with endocervical sampling and endometrial assessment via pelvic ultrasound. Selective cases also received endometrial biopsies.</p><p><strong>Results: </strong>Among a total of 190 women who underwent both colposcopy and endometrial assessment, 116 (61%) had negative clinical and histopathological findings. The remainder displayed various abnormalities: 36 women (18.9%) were found to have endometrial or cervical polyps, 23 (12.1%) were diagnosed with preinvasive cervical neoplasia, and 21 (10.9%) with invasive cervical or endometrial disease. Menopause, multiparity, and older age were all significantly associated with endometrial cancer, but none of the abovementioned variables were significantly associated with cervical neoplasia.</p><p><strong>Conclusion: </strong>Our data confirm that AGC may reveal the presence of a wide range of histopathological conditions. Patients diagnosed with AGC should undergo a careful evaluation including both colposcopy with endocervical sampling and an endometrial assessment.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"106-112"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraprocessed foods and cancer risk: the importance of distinguishing ultraprocessed food groups.","authors":"Livia S A Augustin, Angela D'Angelo, Elvira Palumbo, Carlo La Vecchia","doi":"10.1097/CEJ.0000000000000901","DOIUrl":"10.1097/CEJ.0000000000000901","url":null,"abstract":"<p><p>Several case-control, cohort studies, and meta-analyses found a moderate association between ultraprocessed food consumption and the risk of colorectal and a few other cancers. The evidence is, however, not consistent. A reason for such inconsistence is that the NOVA classification of ultraprocessed foods may include unfavorable but also favorable dietary components, and it may vary across different populations.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"97-99"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description of lymphocyte and cytokine profiles in individuals with acute myeloid leukemia associated with FLT3-ITD and NPM1 mutation status.","authors":"Rogério Reis, Gabriel S Müller, Mariane M Santos, Allan S Santos, Herbert Santos, Lorene S Santos, Bruno A Lopes, Soraya C Trindade, Roberto J Meyer, Songelí M Freire","doi":"10.1097/CEJ.0000000000000905","DOIUrl":"10.1097/CEJ.0000000000000905","url":null,"abstract":"<p><p>The pathogenesis of acute myeloid leukemia (AML) involves mutations in genes such as FLT3 and NPM1 , which are also associated with the prognosis of the disease. The immune system influences disease progression, but the mechanisms underlying the interaction between the immune system and AML are not clear. In this study, the profiles of lymphocytes and cytokines were described in individuals with AML stratified by molecular changes associated with prognosis. The participants included in this study were newly diagnosed AML patients ( n  = 43) who were about to undergo chemotherapy. Subtypes of lymphocytes in peripheral blood, including B cells, T cells, and natural killer cells, and serum concentrations of cytokines, including Th1, Th2, and Th17, were studied by flow cytometry assays (BD FACSCanto II). The correlations between lymphocyte subsets, cytokines, and genetic/prognostic risk stratification (based on the FLT3 and NPM1 genes) were analyzed. The differences in B lymphocytes (%), T lymphocytes (%), plasmablasts (%), leukocytes (cells/µl), and tumor necrosis factor (pg/ml) were determined between groups with FLT3-ITD+ and FLT3-ITD- mutations. The presence of mutations in NPM1 and FLT3-ITD and age suggested changes in the lymphocyte and cytokine profile in individuals with AML.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"115-123"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between priori and posteriori dietary patterns and gastric cancer risk: an updated systematic review and meta-analysis of observational studies.","authors":"Meng-Zhao Luo, Long Shu, Xiao-Sen Ye","doi":"10.1097/CEJ.0000000000000900","DOIUrl":"10.1097/CEJ.0000000000000900","url":null,"abstract":"<p><p>An increasing number of epidemiological studies have explored the relationship between the risk of gastric cancer and specific dietary patterns, but the findings remain inconclusive. We, therefore, performed this comprehensive systematic review and meta-analysis to analyze the available evidence regarding the associations between a priori and a posteriori dietary patterns and the risk of gastric cancer. A systematic search of six electronic databases, including PubMed , Web of Science , EBSCO , Scopus , China National Knowledge Infrastructure ( CNKI ), and Wanfang Data , was carried out to retrieve the relevant articles published up to March 2024. Thirty-six studies (10 cohort and 26 case-control studies) with a total of 2 181 762 participants were included in the final analyses. Combining 15 effect sizes extracted from 12 articles, we observed a reduced risk of gastric cancer in the highest versus the lowest categories of the Mediterranean diet [relative risk (RR), 0.72; 95% confidence interval (CI), 0.61-0.85; P  < 0.001]. Combining 11 effect sizes from 10 articles (involving 694 240 participants), we found that the highest Dietary Inflammatory Index scores were significantly associated with an increased risk of gastric cancer (RR, 1.32; 95% CI, 1.11-1.57; P  < 0.001). A reduced risk of gastric cancer was shown for the highest compared with the lowest categories of healthy dietary pattern (RR, 0.78; 95% CI, 0.67-0.91; P  = 0.002). Conversely, the highest adherence to the Western dietary pattern was associated with an increased risk of gastric cancer (RR, 1.33; 95% CI, 1.19-1.49; P  < 0.001). Our study demonstrated that the Mediterranean diet and a healthy dietary pattern were associated with a decreased risk of gastric cancer. Conversely, the Dietary Inflammatory Index and Western dietary pattern were associated with an increased risk of gastric cancer.</p>","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":" ","pages":"157-172"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus oropharyngeal cancer and vaccine: present and future perspective.","authors":"Stefano Zorzi, Marta Tagliabue, Rita De Berardinis, Francesco Chu, Mohssen Ansarin","doi":"10.1097/CEJ.0000000000000944","DOIUrl":"https://doi.org/10.1097/CEJ.0000000000000944","url":null,"abstract":"","PeriodicalId":11830,"journal":{"name":"European Journal of Cancer Prevention","volume":"34 2","pages":"113-114"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}