Enhancing prognostic insights: myometrial invasion patterns in endometrial carcinoma, with emphasis on MELF pattern-a comprehensive review and meta-analysis.

IF 2.1 4区医学 Q3 ONCOLOGY

European Journal of Cancer Prevention Pub Date : 2024-06-03 DOI:10.1097/CEJ.0000000000000903

Yuyuan Guo, Luying Li, Kaini Yang, Yuhan Song, Lu Xu, Fangyi Zhao, Wenting Li

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引用次数: 0

Abstract

Purpose: The microcystic, elongated, and fragmented (MELF) pattern, characterized by myxoid and inflamed stroma, is readily identifiable as a form of myometrial infiltration. This meta-analysis endeavors to assess the prognostic significance of MELF infiltration patterns in patients diagnosed with endometrial cancer.

Methods: A comprehensive literature search, spanning until 11 October 2023, across PubMed, Embase, Cochrane, and Web of Science databases, identified 23 relevant studies involving 5199 patients. Data analysis was performed using Stata 16.0.

Results: Analysis indicates that MELF infiltration predicts a higher risk of lymph node metastasis in endometrial cancer patients [hazard ratios (HR) = 5.05; 95% confidence interval (CI), 3.62-7.05; P < 0.05]. Notably, this association remains consistent across various patient demographics, analytical approaches, study designs, and treatment modalities. However, MELF infiltration does not significantly correlate with recurrence (HR = 1.05; 95% CI, 0.73-1.52; P > 0.05), overall survival (HR = 1.24; 95% CI, 0.91-1.68; P > 0.05), or disease-free survival (HR = 1.40; 95% CI, 0.85-2.28; P > 0.05).

Conclusion: While MELF infiltration heightens the risk of lymph node metastasis in endometrial cancer, its impact on recurrence, overall survival, and disease-free survival remains statistically insignificant.

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提高预后洞察力：子宫内膜癌的子宫肌层侵袭模式，重点是MELF模式--全面回顾和荟萃分析。

目的：以肌样和炎性基质为特征的微囊状、拉长和碎裂（MELF）模式很容易被识别为子宫肌层浸润的一种形式。本荟萃分析旨在评估MELF浸润模式在确诊子宫内膜癌患者中的预后意义：截至 2023 年 10 月 11 日，在 PubMed、Embase、Cochrane 和 Web of Science 数据库中进行了全面的文献检索，共发现 23 项相关研究，涉及 5199 名患者。数据分析使用Stata 16.0进行：分析表明，MELF浸润可预测子宫内膜癌患者发生淋巴结转移的更高风险[危险比（HR）=5.05；95%置信区间（CI），3.62-7.05；P 0.05]、总生存期（HR = 1.24；95% CI，0.91-1.68；P > 0.05）或无病生存期（HR = 1.40；95% CI，0.85-2.28；P > 0.05）：结论：虽然MELF浸润会增加子宫内膜癌淋巴结转移的风险，但其对复发、总生存率和无病生存率的影响在统计学上并不显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Cancer Prevention 医学-肿瘤学

CiteScore

4.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： European Journal of Cancer Prevention aims to promote an increased awareness of all aspects of cancer prevention and to stimulate new ideas and innovations. The Journal has a wide-ranging scope, covering such aspects as descriptive and metabolic epidemiology, histopathology, genetics, biochemistry, molecular biology, microbiology, clinical medicine, intervention trials and public education, basic laboratory studies and special group studies. Although affiliated to a European organization, the journal addresses issues of international importance.