Environmental Toxicology and Chemistry最新文献

{"title":"Individual and combined toxicity of polystyrene nanoplastics and clothianidin toward Daphnia magna, Lemna minor, Chlamydomonas reinhardtii, and Microcystis aeruginosa.","authors":"Felipe Ogliari Bandeira, Paulo Roger Lopes Alves, Thuanne Braúlio Hennig, Vitor Pereira Vaz, Denice Schulz Vicentini, Philippe Juneau, David Dewez, William Gerson Matias","doi":"10.1093/etojnl/vgae029","DOIUrl":"https://doi.org/10.1093/etojnl/vgae029","url":null,"abstract":"<p><p>Nanoplastics (NPs) and neonicotinoids are common pollutants in aquatic ecosystems. Although their co-occurrence is expected in multiple environments, studies assessing their combined effects are still limited. This toxicological assessment investigated the potential effects of polystyrene NPs (PSNPs), clothianidin (CLO), and their mixtures on four aquatic species: the freshwater cladoceran Daphnia magna, the duckweed Lemna minor, the green algae Chlamydomonas reinhardtii, and the cyanobacteria Microcystis aeruginosa. Toxicological tests were performed following International Organization for Standardization and Organisation for Economic Co-operation and Development protocols. Acute, chronic (multigenerational) and swimming behavior tests were performed with D. magna, and growth inhibition tests were run with L. minor, C. reinhardtii, and M. aeruginosa. Abbott's model was used to predict the toxicological interactions of the mixtures for each one of the tested species. The D. magna immobility and swimming behavior tests revealed that the combined toxicities of PSNPs and CLO are decreased when the compounds are present as a mixture. Antagonistic interactions were also observed for C. reinhardtii growth, whereas for L. minor and M. aeruginosa, interactions ranged from antagonism to additivity. Chronic multigenerational tests with D. magna revealed that neonates obtained from the exposed parental generation showed a delay in the first brood during the recovery (nonexposure) phase, but this effect disappeared at the next generation, which indicates that microcrustaceans will probably be able to recover on a long-term scale if contamination is stopped. Our results provide new insights into the combined toxicity and ecological risk of NPs and neonicotinoids toward aquatic organisms.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"470-483"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of tissue morphometry on tissue mercury concentration in male and female virile crayfish (Faxonius virilis).","authors":"Tate E Libunao, Alan S Kolok","doi":"10.1093/etojnl/vgae043","DOIUrl":"https://doi.org/10.1093/etojnl/vgae043","url":null,"abstract":"<p><p>The objective of this study was to determine the influence of tissue morphometry on tissue total mercury concentration (THg) in male and female virile crayfish (Faxonius virilis). In 2023, 10 embryonized and nine stage IV female crayfish and 29 male virile crayfish were captured from Lake Roosevelt and the Spokane River Arm, in Washington, USA. Total mercury was analyzed in the adductor muscle, gills, and hepatopancreas for all individuals and the ovaries and eggs for females with developed ovaries and embryonized females, respectively. Tissue morphometrics and tissue THg were allometrically correlated to the clawless body mass of male virile crayfish. Furthermore, it was determined that in male size-adjusted virile crayfish, gill THg was significantly associated with hepatopancreas THg but not adductor muscle THg. In embryonized and reproductive developing female virile crayfish, there was evidence of considerable adductor muscle and hepatopancreas tissue atrophy; however, no significant differences in THg occurred. In both the adductor muscle and the hepatopancreas, THg was not bioamplified despite tissue atrophy, suggesting a net loss of mercury from the tissues into the hemolymph. Although the most plausible redistribution of mercury in females with developed ovaries would be from the hepatopancreas to the developing ovary, this redistribution does not completely explain the level of maternal transfer observed. Clearly, dietary mercury contributed to the body burden of mercury within the ovaries of the females in reproductive development.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"497-507"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial occurrence of emerging contaminants in rivers and wastewater. Analysis of environmental and human risks.","authors":"Carla Mariela Teglia, Fabiana Andrea Gutierrez, Selva Machado, Hérnan Ricardo Hadad, María Alejandra Maine, Héctor Casimiro Goicoechea","doi":"10.1093/etojnl/vgae075","DOIUrl":"10.1093/etojnl/vgae075","url":null,"abstract":"<p><p>This study assesses the occurrence of emerging contaminants (ECs) from agricultural and livestock production activities along the Salado River (Santa Fe province, Argentina). Of the 23 ECs studied, 8 were detected and quantified in river and wastewater samples, including ciprofloxacin, enrofloxacin, chlorpyrifos-methyl, albendazole, fenbendazole, levamisole, diazepam, and thiamethoxam. In river samples, the highest concentrations corresponded to ciprofloxacin, chlorpyrifos-methyl, and enrofloxacin. In wastewater samples, albendazole, fenbendazole, ciprofloxacin, enrofloxacin, and thiamethoxam were found. The detection frequency ranged from 4.2% to 54.2% in river samples and from 11.1% to 22.2% in wastewater samples. The spatial distribution of contaminants showed different concentrations, with higher levels often found near urban and agricultural areas, suggesting anthropogenic sources. Ecological risk assessments for different organisms were conducted. Ciprofloxacin posed the highest risk, especially affecting bacteria, cyanobacteria, and algae. Diazepam also was found to pose significant risks to algae, crustaceans, and fishes. Chlorpyrifos-methyl was identified as highly hazardous to multiple living organisms, which is in agreement with the fish mortality that occurred at the sampling sites. The risk assessment in humans showed differences among children, adolescents, and adults, with infants (6 months to 1 year) being at a higher risk than adults. Children may be at a higher daily intake of contaminants than adults, raising concerns about the long-term effects of exposure. This work underscores the critical need for monitoring and regulating ECs in aquatic environments. Further studies are necessary to fully understand their impact and to develop effective strategies for mitigating their presence in water systems.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"397-409"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of environmental radioactivity in road dust between a city and a megacity: geo-environmental evaluation, health risks, and potential remediation.","authors":"Rahat Khan, Sayma Zahan Akhi, Md Harunor Rashid Khan, Sadiya Sultana, Saad Aldawood, Md Samium Basir, Md Shohel Parvez, Kamrun Naher, Md Ahosan Habib, Abubakr M Idris, Dhiman Kumer Roy","doi":"10.1093/etojnl/vgae027","DOIUrl":"https://doi.org/10.1093/etojnl/vgae027","url":null,"abstract":"<p><p>This pioneering study represents a comprehensive comparative analysis of naturally occurring radioactive materials (NORMs: 226Ra (≈238U),232Th, 40K) on the roadside dust samples collected from a coastal city (Khulna) and a highly urban megacity (Dhaka), Bangladesh. The corresponding radioactivity was calculated based on Instrumental Neutron Activation Analysis of elemental abundances (uranium [U], thorium [Th], and potassium [K]). Averagen=30 radioactivity levels of 226Ra (≈238U), 232Th, and 40K in the road dust of Khulna city were 46.82 ± 24, 74.79 ± 25, and 541.14 ± 160.8, whereas in Dhaka city, they were 84.4 ± 13, 126 ± 11, and 549 ± 48 (Bq.kg-1), respectively. Khulna city had 1.3, 2.5, and 1.4 times greater 226Ra (≈238U), 232Th, and 40K radioactivity than the global average values, respectively. For Dhaka city, the following values were 2.42, 4.2, and 1.4 times elevated. The levels of radioactivity in Dhaka city are significantly higher than those in Khulna city; however, both cities have exceeded the world average values. The mechanisms for the enrichment and dispersion of NORMs from their fundamental source (surface soil) were studied, considering waterlogging, relative solubility-controlled leaching and translocation, climate conditions, and aerodynamic fractionations (dry and wet air deposition). The computation of standard radiological indices indicates risks to human health. Respiratory harm can be inflicted by α-particles originating from the radioactive decay products of 232Th and 238U. In addition to public awareness, policymakers should prioritize limiting the evolution of dust particles to mitigate the associated health risks.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"344-362"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial patterns of microplastics in freshwater bivalves (Bivalvia: Unionidae and Sphaeriidae) relative to municipal wastewater effluent discharges.","authors":"Emily L Robson, Karen A Kidd, Evlyn K Sun, Patricia L Gillis, Ryan S Prosser","doi":"10.1093/etojnl/vgae044","DOIUrl":"https://doi.org/10.1093/etojnl/vgae044","url":null,"abstract":"<p><p>Microplastics are discharged by municipal wastewater treatment plants (WWTPs); however, their uptake by filter-feeding freshwater bivalves is poorly understood. This study examined the abundance and characteristics of microplastics in wild bivalves from five locations along a 155 km stretch of the Grand River (Ontario, Canada) in 2021-2022, including upstream and downstream of three municipal WWTPs. At each site, fingernail clams (Sphaeriidae spp., n = 5 composites), freshwater mussels (Lasmigona costata, n = 10; gill, digestive gland, and hemolymph), and surface water (n = 3) were sampled at a single timepoint. Microplastics (particles >38 μm to 5 mm) were isolated and visualized via stereomicroscopy, and a subset chemically analyzed using Fourier transform infrared spectroscopy. Fingernail clams contained the highest total blank corrected microparticle counts (35.5 ± 29.4 g-1 [mean ± SD]), mussel tissues ranged from 4.3 ± 4.2 mL-1 in hemolymph to 6.5 ± 8.1 g-1 in digestive gland, and water contained 5.5 ± 2.8 L-1. Fibers were the dominant morphology across all samples, most particles were between 80 μm and 2 mm in length and, of those analyzed chemically, 30.0% were a plastic polymer. At sites downstream of WWTP outfalls, elevated counts were only seen in mussel gills and not in other bivalve tissues or water compared with upstream samples. Although microplastics were found across all sites in both biotic and abiotic compartments, results suggest little impact of WWTP discharges on their uptake in downstream bivalves.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"508-523"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence, removal, and risks of psychopharmaceuticals in wastewater streams.","authors":"Charlie J E Davey, Anne Kiki Hartelust, Rick Helmus, Antonia Praetorius, Annemarie P van Wezel, Thomas L Ter Laak","doi":"10.1093/etojnl/vgae042","DOIUrl":"10.1093/etojnl/vgae042","url":null,"abstract":"<p><p>Psychopharmaceuticals are used to treat psychological disorders and other conditions relating to the nervous system and are known to affect nontarget organisms at low concentrations. Their occurrence in the water cycle remains an understudied topic, with data lacking for many compounds, and risks not accounted for in removal targets. Therefore, this study aimed to provide insights into the presence, removal, and risks of psychopharmaceuticals in wastewater. Furthermore, the use of risk assessment in the context of proposed legislation is discussed. Thirty highly used psychopharmaceuticals were studied during 1 week in the wastewater of the Amsterdam West Wastewater Treatment Plant (WWTP) using solid phase extraction and ultra high performance liquid chromatography-quadrupole time of flight-high resolution mass spectrometry. Twenty target compounds were detected in the influent (17 ng-99 µg/L) and 16 in the effluent (34 ng/L-17 µg/L). Removal efficiencies during treatment ranged from 24% to >99%. Paracetamol, amphetamine, fluoxetine, levetiracetam, phenacetin, and sertraline demonstrated almost complete removal, whereas tramadol, lidocaine, lamotrigine, fluvoxamine, and carbamazepine had removals below 50%, with lidocaine demonstrating the lowest removal (24%). Utilizing existing ecotoxicity data, a preliminary risk assessment was performed to contextualize the calculated removal efficiencies. Here, sertraline and ibuprofen still demonstrated a potential risk, despite high removal efficiencies of both compounds. This study highlights that wastewater contains abundant numbers and ecotoxicologically relevant concentrations of psychopharmaceuticals that are insufficiently removed by the WWTP. The implementation of risk-based removal targets in legislation is discussed to facilitate the reduction in emissions of psychopharmaceuticals, for example, by adequate WWTP upgrades with advanced treatments to ensure a toxic-free environment.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"375-385"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced tolerance to narcosis in starved Daphnia magna neonates.","authors":"Sophie Steigerwald, Yves Saladin, Gastón Alurralde, Sebastian Abel, Anna Sobek, Ann-Kristin Eriksson Wiklund, Elena Gorokhova","doi":"10.1093/etojnl/vgae010","DOIUrl":"https://doi.org/10.1093/etojnl/vgae010","url":null,"abstract":"<p><p>Guidelines for ecotoxicity testing with Daphnia magna specify particular feeding protocols during the exposure, yet standardization for preexposure feeding remains ambiguous despite its recognized significance in affecting organismal metabolic capacity and tolerance. This ambiguity may contribute to disparate responses and heightened uncertainty in determining the effect concentrations of test chemicals, particularly those inducing metabolic effects through narcosis. Here, we address this gap through a three-step dose-response experiment with neonates of D. magna subjected to two alternative feeding regimes in the preexposure phase: starved and moderately fed during the first 24 hr after birth. Following this treatment, the daphnids were exposed to narcosis-inducing substances (polycyclic aromatic hydrocarbons; PAHs) for 72 hr before being transferred to clean media with algal food ad libitum for a 48 hr recovery phase. Daphnid survivorship, individual protein content, and body size at the end of each experiment phase-pre-exposure, postexposure and postrecovery-were compared between the treatments. Significant treatment effects were observed, including lower and less variable protein content in the starved daphnids entering the PAH exposure phase, yet higher survivorship and greater recovery potential in these daphnids compared with the fed individuals. Our findings underscore the importance of early-life food access and advocate for mandatory reporting of pre-exposure feeding regimes, particularly when testing substances acting via nonpolar narcosis.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"410-419"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of seasonality on mercury concentrations, polyunsaturated fatty acids, and stable isotopes: implications for the use of tetragnathid spiders as sentinels.","authors":"Jessica Landaverde, Connor Olson, Mario Montesdeoca, Madeline Hannappel, Ryan R Otter","doi":"10.1093/etojnl/vgae052","DOIUrl":"10.1093/etojnl/vgae052","url":null,"abstract":"<p><p>Riparian spiders are used in ecotoxicology as sentinels of bioavailable contaminants that are transferred from aquatic to terrestrial habitats via emergent aquatic insects. Spiders in the family Tetragnathidae are particularly of interest because a high proportion of their diet consists of emergent aquatic insects and their contaminant loads reflect the amount transferred through the food web to riparian predators. The transfer of contaminants can be determined through food web tracers such as stable isotopes and polyunsaturated fatty acids; however, it is unclear how contaminants and tracers vary over the course of a year. The objective of this study was to determine whether seasonality affected size, carbon and nitrogen stable isotopes, polyunsaturated fatty acid biomarkers, mercury, and other trace metal concentrations in tetragnathid spiders. Spiders were sampled fortnightly from a single site on the Stones River in Tennessee, USA, for an entire active season (April through October). Spider mass and length steadily increased from April to September to a maximum average value of 0.078 ± 0.03 g, then decreased in October. Seasonal trends were observed for carbon and nitrogen stable isotopes, with significantly decreased signatures occurring late in the active season. Overall, methyl mercury concentrations (range: 12.1-134.4 ng/g) and the methyl-total mercury ratio (range: 49%-98%) increased throughout the active season, with higher variability observed at the end of the active season. Collectively, our results indicate that seasonality affected several important endpoints and that spiders collected during the end of the active season may not be representative of spiders during the entire active season.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"534-541"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of developmental methylmercury exposure on avian embryonic development, hatchling growth, and survival.","authors":"James C Leaphart, Sarah M Chinn, James C Beasley","doi":"10.1093/etojnl/vgae032","DOIUrl":"https://doi.org/10.1093/etojnl/vgae032","url":null,"abstract":"<p><p>Methylmercury (MeHg) is a globally ubiquitous and persistent environmental toxicant that negatively affects animal behavior, health, and reproduction. In birds, MeHg is transferred from female to egg, contaminating embryos during sensitive stages of early embryonic development and growth. This toxic exposure in the prenatal environment not only induces mortality but also possible lasting impacts on physiology, health, and survival, even once hatched. The purpose of our study was to further elucidate the negative effects of MeHg exposure during avian embryonic development and explore how such exposure can impact offspring development, growth, and survival, both in ovo and posthatch. To assess this, we experimentally dosed fertile mallard and wood duck eggs with MeHg II chloride and reared developing embryos and ducklings to various endpoints. We found that embryos not only readily accumulated MeHg throughout incubation, but they also displayed varying dose-dependent disparities in body mass and morphometrics, with control individuals being larger during early and late embryonic stages of development (p < 0.05). Furthermore, hatched offspring exposed to MeHg exhibited increasingly slower growth rates between 7 to 10 and 10 to 15 days posthatch (p < 0.05), and were found to have lower survival probabilities both under controlled laboratory conditions (p < 0.005), and in the natural environment (p < 0.05). Our findings on the detrimental effects of MeHg on avian embryos and hatchlings emphasize the need for more proactive means of environmental protection and remediation to protect vulnerable avian populations and the ecosystems they inhabit.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"432-443"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of soil organic matter content on the toxicity of pesticides to the springtail Folsomia candida.","authors":"Bart G van Hall, Christopher J Sweeney, Melanie Bottoms, Cornelis A M van Gestel","doi":"10.1093/etojnl/vgae048","DOIUrl":"10.1093/etojnl/vgae048","url":null,"abstract":"<p><p>The European environmental risk assessment (ERA) of pesticides to soil invertebrates applies a correction factor (CF) of 2 to endpoints derived from toxicity tests with lipophilic pesticides (log Kow > 2) to correct for differences in organic matter (OM) content between artificial soil (AS) and natural soils. Because the applicability of this CF to springtails has never been assessed, this study investigated the influence of soil OM content on the toxicity of five pesticide active substances differing in lipophilicity to the springtail Folsomia candida. Toxicity tests following Organisation for Economic Cooperation and Development guideline 232 were conducted in AS containing 10%, 5%, and 2.5% peat and a natural soil (LUFA 2.2) with 4.5% OM. For all pesticides, toxicity (median lethal and median effect concentrations [LC50s, EC50s]) differed significantly between soils and strongly negatively correlated with soil OM content in AS (r2 > 0.88). Utilizing the regression equations derived from the data, LC50s and EC50s were calculated for soils with 10% and 5% OM. For EC50s, the differences in model-estimated toxicity between these soils ranged from 1.85 to 3.23, sometimes exceeding the CF of 2. To identify differences between species, data from a sister paper on the earthworm Eisenia andrei was used. Although ratios between model-estimated EC50s in soils containing 10% and 5% OM were similar between species (2.08-3.24 for earthworms), pesticide-specific toxicity-OM relationships differed in some cases. Non-lipophilic pesticides were influenced by soil OM content in a similar manner as the lipophilic pesticides, showing that the influence of soil properties on non-lipophilic pesticides may currently be overlooked. Overall, this study shows that the CF of 2 suffers from erroneous assumptions concerning lipophilicity, OM content, and toxicity. Further research is required to improve our mechanistic understanding of the relationship between toxicity and soil OM content, ultimately increasing the ecological relevance of CFs used in ERAs.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"44 2","pages":"524-533"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}