Environmental Toxicology and Chemistry最新文献

{"title":"Recent Developments in Sediment Toxicity Testing","authors":"Michiel T. O. Jonker, Alan J. Jones","doi":"10.1002/etc.5942","DOIUrl":"10.1002/etc.5942","url":null,"abstract":"<p>Sediment is an important environmental compartment inhabited by many different aquatic species, including benthic plants, vertebrates, and invertebrates. These species rely on the sediment for rooting, shelter, and/or feeding. Unfortunately, sediments also act as an important sink of certain anthropogenic contaminants, such as heavy metals and hydrophobic organic chemicals, which tend to accumulate in this aquatic compartment. Because many of these contaminants are toxic, they can potentially impact natural processes or habitat quality and thereby be harmful to aquatic ecosystems. Sediment toxicity tests have been developed to investigate potential toxicity to benthic species; these assays typically test the survival (or other response) of organisms after exposure to sediments collected from the field or contaminated in the laboratory. The array of sediment toxicity tests originally developed has gone through several iterations, resulting in the current use of standardized assays that employ standard test organisms and simple, easily quantifiable responses (e.g., death or reproduction). However, the field of sediment toxicity testing continues to evolve through new assays, test organisms, and dosing strategies.</p><p>In early 2022, a (virtual) workshop was organized as part of a European Chemical Industry Council–funded project (Cefic-LRI ECO43). Although the ECO43 project specifically focused on improving sediment toxicity testing with difficult-to-test, highly hydrophobic organic substances, the scope of the workshop reached beyond this focus. Approximately 40 people from academia, industry, and the regulatory field discussed the current status and future challenges and needs of sediment toxicity testing for plant protection products, substances of unknown or variable composition, complex reaction products and biological materials (UVCBs), offshore chemicals, and field sediments, as well as modeling and regulatory aspects of sediment toxicity. After the workshop, the idea arose to write critical reviews on the topics discussed during the workshop, combine these with manuscripts resulting from the Cefic-LRI ECO43 project, stimulate colleagues to write other manuscripts on sediment toxicity testing, and publish the collection of manuscripts in a special series in <i>Environmental Toxicology and Chemistry</i>. To identify colleagues who would be interested in jointly submitting manuscripts on sediment toxicity testing, forces were joined with the Society of Environmental Toxicology and Chemistry Sediment Interest Group, which has been active in the field of sediment research for many years, with sediment toxicity being one of its core topics. Despite the busy schedule of all our sediment toxicity colleagues, we managed to put together a collection of eight interesting scientific papers, all dealing with sediment toxicity testing, and particularly focusing on recent developments in this important field of environmental research.</p><p>In the fir","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 8","pages":"1695-1696"},"PeriodicalIF":3.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Cover","authors":"","doi":"10.1002/etc.5664","DOIUrl":"https://doi.org/10.1002/etc.5664","url":null,"abstract":"","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 7","pages":"C1"},"PeriodicalIF":3.6,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141488638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board and Table of Contents","authors":"","doi":"10.1002/etc.5663","DOIUrl":"https://doi.org/10.1002/etc.5663","url":null,"abstract":"","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 7","pages":"1459-1462"},"PeriodicalIF":3.6,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141488639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogenic, Genotoxic, and Antibacterial Effects of Chemicals from Cryogenically Milled Tire Tread","authors":"Alan J. Bergmann,&nbsp;T. Masset,&nbsp;F. Breider,&nbsp;W. Dudefoi,&nbsp;K. Schirmer,&nbsp;B. J. D. Ferrari,&nbsp;E. L. M. Vermeirssen","doi":"10.1002/etc.5934","DOIUrl":"10.1002/etc.5934","url":null,"abstract":"<p>Tire and road wear particles (TRWP) contain complex mixtures of chemicals and release them to the environment, and potential toxic effects of these chemicals still need to be characterized. We used a standardized surrogate for TRWP, cryogenically milled tire tread (CMTT), to isolate and evaluate effects of tire-associated chemicals. We examined organic chemical mixtures extracted and leached from CMTT for the toxicity endpoints genotoxicity, estrogenicity, and inhibition of bacterial luminescence. The bioassays were performed after chromatographic separation on high-performance thin-layer chromatography (HPTLC) plates. Extracts of CMTT were active in all three HPTLC bioassays with two estrogenic zones, two genotoxic zones, and two zones inhibiting bacterial luminescence. Extracts of CMTT artificially aged with thermooxidation were equally bioactive in each HPTLC bioassay. Two types of aqueous leachates of unaged CMTT, simulating either digestion by fish or contact with sediment and water, contained estrogenic chemicals and inhibitors of bacterial luminescence with similar profiles to those of CMTT extracts. Of 11 tested tire-associated chemicals, two were estrogenic, three were genotoxic, and several inhibited bacterial luminescence. 1,3-Diphenylguanidine, transformation products of <i>N</i>-(1,3-dimethylbutyl)-<i>N′</i>-phenyl-<i>p</i>-phenylenediamine, and benzothiazoles were especially implicated through comparison to HPTLC retention factors in the CMTT samples. Other bioactive bands in CMTT samples did not correspond to any target chemicals. Tire particles clearly contain and can leach complex mixtures of toxic chemicals to the environment. Although some known chemicals contribute to estrogenic, genotoxic, and antibacterial hazards, unidentified toxic chemicals are still present and deserve further investigation. Overall, our study expands the understanding of potential adverse effects from tire particles and helps improve the link between those effects and the responsible chemicals. <i>Environ Toxicol Chem</i> 2024;43:1962–1972. © 2024 The Authors. <i>Environmental Toxicology and Chemistry</i> published by Wiley Periodicals LLC on behalf of SETAC.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 9","pages":"1962-1972"},"PeriodicalIF":3.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioconcentration of Per- and Polyfluoroalkyl Substances and Precursors in Fathead Minnow Tissues Environmentally Exposed to Aqueous Film-Forming Foam–Contaminated Waters","authors":"Nicholas I. Hill,&nbsp;Jitka Becanova,&nbsp;Simon Vojta,&nbsp;Larry B. Barber,&nbsp;Denis R. LeBlanc,&nbsp;Alan M. Vajda,&nbsp;Heidi M. Pickard,&nbsp;Rainer Lohmann","doi":"10.1002/etc.5926","DOIUrl":"10.1002/etc.5926","url":null,"abstract":"<p>Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with toxicity in wildlife and negative health effects in humans. Decades of fire training activity at Joint Base Cape Cod (MA, USA) incorporated the use of aqueous film-forming foam (AFFF), which resulted in long-term PFAS contamination of sediments, groundwater, and hydrologically connected surface waters. To explore the bioconcentration potential of PFAS in complex environmental mixtures, a mobile laboratory was established to evaluate the bioconcentration of PFAS from AFFF-impacted groundwater by flow-through design. Fathead minnows (<i>n</i> = 24) were exposed to PFAS in groundwater over a 21-day period and tissue-specific PFAS burdens in liver, kidney, and gonad were derived at three different time points. The ∑PFAS concentrations in groundwater increased from approximately 10,000 ng/L at day 1 to 36,000 ng/L at day 21. The relative abundance of PFAS in liver, kidney, and gonad shifted temporally from majority perfluoroalkyl sulfonamides (FASAs) to perfluoroalkyl sulfonates (PFSAs). By day 21, mean ∑PFAS concentrations in tissues displayed a predominance in the order of liver &gt; kidney &gt; gonad. Generally, bioconcentration factors (BCFs) for FASAs, perfluoroalkyl carboxylates (PFCAs), and fluorotelomer sulfonates (FTS) increased with degree of fluorinated carbon chain length, but this was not evident for PFSAs. Perfluorooctane sulfonamide (FOSA) displayed the highest mean BCF (8700 L/kg) in day 21 kidney. Suspect screening results revealed the presence of several perfluoroalkyl sulfinate and FASA compounds present in groundwater and in liver for which pseudo-bioconcentration factors are also reported. The bioconcentration observed for precursor compounds and PFSA derivatives detected suggests alternative pathways for terminal PFAS exposure in aquatic wildlife and humans. <i>Environ Toxicol Chem</i> 2024;43:1795–1806. © 2024 The Author(s). <i>Environmental Toxicology and Chemistry</i> published by Wiley Periodicals LLC on behalf of SETAC.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 8","pages":"1795-1806"},"PeriodicalIF":3.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tissue-Specific Eco-Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions","authors":"Jaylen L. Sims,&nbsp;Alexander R. Cole,&nbsp;Zachary S. Moran,&nbsp;Charles M. Mansfield,&nbsp;Bianca Possamai,&nbsp;Macarena Rojo,&nbsp;Ryan S. King,&nbsp;Cole W. Matson,&nbsp;Bryan W. Brooks","doi":"10.1002/etc.5931","DOIUrl":"10.1002/etc.5931","url":null,"abstract":"<p>Though bioaccumulation of pharmaceuticals by aquatic organisms continues to receive scientific attention, the internal disposition of these contaminants among different tissue compartments of fish species has been infrequently investigated, particularly among fish at different trophic positions. We tested a human to fish biological read-across hypothesis for contaminant disposition by examining tissue-specific accumulation in three understudied species, longnose gar (<i>Lepisosteus osseus</i>; piscivore), gizzard shad (<i>Dorosoma cepedianum</i>; planktivore/detritivore), and smallmouth buffalo (<i>Ictiobus bubalus</i>; benthivore), from a river influenced by municipal effluent discharge. In addition to surface water, fish plasma, and brain, gill, gonad, liver, and lateral muscle fillet tissues were analyzed via isotope dilution liquid chromatography tandem mass spectrometry. Caffeine and sucralose, two common effluent tracers, were quantitated at low micrograms per liter levels in surface water, while an anticonvulsant, carbamazepine, was observed at levels up to 37 ng/L. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and primary metabolites were detected in at least one tissue of all three species at low micrograms per kilogram concentrations. Within each species, brain and liver of select fish contained the highest levels of SSRIs compared to plasma and other tissues, which is generally consistent with human tissue disposition patterns. However, we observed differential accumulation among specific tissue types and species. For example, mean levels of sertraline in brain and liver tissues were 13.4 µg/kg and 1.5 µg/kg in gizzard shad and 1.3 µg/kg and 7.3 µg/kg in longnose gar, respectively. In contrast, smallmouth buffalo did not consistently accumulate SSRIs to detectable levels. Tissue-specific eco-exposome efforts are necessary to understand mechanisms associated with such marked bioaccumulation and internal dispositional differences among freshwater fish species occupying different trophic positions. <i>Environ Toxicol Chem</i> 2024;43:1894–1902. © 2024 The Author(s). <i>Environmental Toxicology and Chemistry</i> published by Wiley Periodicals LLC on behalf of SETAC.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 8","pages":"1894-1902"},"PeriodicalIF":3.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ET&C Best Paper of 2023","authors":"","doi":"10.1002/etc.5933","DOIUrl":"10.1002/etc.5933","url":null,"abstract":"&lt;p&gt;WINNER OF THE 2023 BEST PAPER AWARD:&lt;/p&gt;&lt;p&gt;Genes-to-Pathways Species Conservation Analysis: Enabling the Exploration of Conservation of Biological Pathways and Processes Across Species&lt;/p&gt;&lt;p&gt;&lt;i&gt;Claudia Rivetti, Jade Houghton, Danilo Basili, Geoff Hodges, and Bruno Campos&lt;/i&gt;&lt;/p&gt;&lt;p&gt;DOI:doi.org/10.1002/etc.5600&lt;/p&gt;&lt;p&gt;The development of the Genes-to-Pathways Species Conservation Analysis (G2P-SCAN), a novel R package designed to enhance the understanding of cross-species conservation of biological pathways, is a major leap forward towards integrating computational biology approaches into safety assessments. By integrating data from multiple databases and focusing on gene orthologs, protein families, entities, and reactions, G2P-SCAN offers a comprehensive tool for analyzing the conservation of biological processes across various species. This methodology supports the reduction of animal testing by enabling more accurate species extrapolation and risk assessment.&lt;/p&gt;&lt;p&gt;The paper's significance lies in its potential to improve the accessibility and synthesis of genomic data, thus facilitating the application of mechanistically based data in ecological risk assessments. The authors demonstrate the utility of G2P-SCAN through five case studies, validating its effectiveness in identifying conservation and susceptibility at the pathway level across different species. This work not only advances scientific understanding but also aligns with global regulatory shifts towards new approach methodologies (NAMs), promoting the use of computational and cell-based approaches in safety assessments.&lt;/p&gt;&lt;p&gt;REFERENCE&lt;/p&gt;&lt;p&gt;Rivetti, C., Houghton, J., Basili, D., Hodges, G., &amp; Campos, B. (2023), Genes-to-pathways species conservation analysis: Enabling the exploration of conservation of biological pathways and processes across species. &lt;i&gt;Environmental Toxicology and Chemistry&lt;/i&gt;, &lt;i&gt;42&lt;/i&gt;, 1152–1166.&lt;/p&gt;&lt;p&gt;Jana Asselmann&lt;/p&gt;&lt;p&gt;&lt;i&gt;Ghent University&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Ghent, Belgium&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;Best Paper Award winner Claudia Rivetti.&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;Models used to predict chemical bioaccumulation in fish from in vitro biotransformation rates require accurate estimates of blood–water partitioning and chemical volume of distribution&lt;/p&gt;&lt;p&gt;&lt;i&gt;Leslie J. Saunders and John W. Nichols&lt;/i&gt;&lt;/p&gt;&lt;p&gt;DOI:10.1002/etc.5503&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;Arsenic and mercury distribution in an aquatic food chain: Importance of femtoplankton and picoplankton filtration fractions&lt;/p&gt;&lt;p&gt;&lt;i&gt;Abdullah M. Alowaifeer, Scott Clingenpeel, Jinjun Kan, Patricia E. Bigelow, Masafumi Yoshinaga, Brian Bothner, and Timothy R. McDermott&lt;/i&gt;&lt;/p&gt;&lt;p&gt;DOI:10.1002/etc.5516&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;Sublethal exposure of per- and polyfluoroalkyl substances of varying chain length and polar functionality results in distinct metabolic responses in &lt;i&gt;Daphnia magna&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Lisa M. Labine, Erico A. Oliveira Pereira, Sonya Kleywegt, Karl J. Jobst, André J. Simpson, and Myrna J. Simpson&lt;/i&gt;&lt;/p&gt;&lt;p&gt;DOI:10.1002/etc.5517&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;Priorit","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 7","pages":"1463-1465"},"PeriodicalIF":3.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Short-Term Mussel Test for Estimating Toxicity","authors":"Ning Wang,&nbsp;James L. Kunz,&nbsp;Christopher D. Ivey,&nbsp;Danielle Cleveland,&nbsp;Jeffery A. Steevens","doi":"10.1002/etc.5935","DOIUrl":"10.1002/etc.5935","url":null,"abstract":"<p>Effect concentrations of ammonia, nickel, sodium chloride, and potassium chloride from short-term 7-day tests were compared to those from standard chronic 28-day toxicity tests with juvenile mussels (fatmucket, <i>Lampsilis siliquoidea</i>) to evaluate the sensitivities of the 7-day tests. The effect concentrations for nickel (59 µg Ni/L), chloride (316–519 mg Cl/L, a range from multiple tests), and potassium (15 mg K/L) obtained from the 7-day tests were within a range of effect concentrations for each corresponding chemical in the 28-day tests (41–91 µg Ni/L, 251–&gt;676 mg Cl/L, 15–23 mg K/L), whereas the 7-day ammonia effect concentration (0.40 mg/L total ammonia nitrogen; TAN) was up to 3.3-fold greater than the 28-day effect concentrations (0.12–0.36 mg TAN/L) but with overlapped 95% confidence limits. These results indicate that the 7-day tests produced similar estimates compared to the 28-day tests. Further studies are needed to evaluate the 7-day test sensitivity using additional chemicals with different modes of toxic action. <i>Environ Toxicol Chem</i> 2024;43:2020–2025. Published 2024. This article is a U.S. Government work and is in the public domain in the USA.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 9","pages":"2020-2025"},"PeriodicalIF":3.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Cadmium and Nickel Mixtures on Multiple Endpoints of the Microalga Raphidocelis subcapitata","authors":"Larissa Luiza dos Reis,&nbsp;Cínthia Bruno de Abreu,&nbsp;Renan Castelhano Gebara,&nbsp;Giseli Swerts Rocha,&nbsp;Elson Longo,&nbsp;Adrislaine da Silva Mansano,&nbsp;Maria da Graça Gama Melão","doi":"10.1002/etc.5927","DOIUrl":"10.1002/etc.5927","url":null,"abstract":"<p>It is crucial to investigate the effects of mixtures of contaminants on aquatic organisms, because they reflect what occurs in the environment. Cadmium (Cd) and nickel (Ni) are metals that co-occur in aquatic ecosystems, and information is scarce on their joint toxicity to Chlorophyceae using multiple endpoints. We evaluated the effects of isolated and combined Cd and Ni metals on multiple endpoints of the chlorophycean <i>Raphidocelis subcapitata</i>. The results showed that Cd inhibited cell density, increased reactive oxygen species (ROS) production (up to 308% at 0.075 mg L⁻¹ of Cd), chlorophyll <i>a</i> (Chl <i>a</i>) fluorescence (0.050–0.100 mg L⁻¹ of Cd), cell size (0.025–0.100 mg L⁻¹ of Cd), and cell complexity in all concentrations evaluated. Nickel exposure decreased ROS production by up to 25% at 0.25 mg L⁻¹ of Ni and Chl <i>a</i> fluorescence in all concentrations assessed. Cell density and oxygen-evolving complex (initial fluorescence/variable fluorescence [<i>F</i>₀/<i>F</i>_v]) were only affected at 0.5 mg L⁻¹ of Ni. In terms of algal growth, mixture toxicity showed antagonism at low doses and synergism at high doses, with a dose level change greater than the median inhibitory concentration. The independent action model and dose-level–dependent deviation best fit our data. Cadmium and Ni mixtures resulted in a significant increase in cell size and cell complexity, as well as changes in ROS production and Chl <i>a</i> fluorescence, and they did not affect the photosynthetic parameters. <i>Environ Toxicol Chem</i> 2024;43:1855–1869. © 2024 SETAC</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 8","pages":"1855-1869"},"PeriodicalIF":3.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Freshwater Ecotoxicity of More Than 9000 Chemicals by Combining Different Levels of Available Measured Test Data with In Silico Predictions","authors":"Mélanie Douziech,&nbsp;Susan Anyango Oginah,&nbsp;Laura Golsteijn,&nbsp;Michael Zwicky Hauschild,&nbsp;Olivier Jolliet,&nbsp;Mikołaj Owsianiak,&nbsp;Leo Posthuma,&nbsp;Peter Fantke","doi":"10.1002/etc.5929","DOIUrl":"10.1002/etc.5929","url":null,"abstract":"<p>Ecotoxicological impacts of chemicals released into the environment are characterized by combining fate, exposure, and effects. For characterizing effects, species sensitivity distributions (SSDs) estimate toxic pressures of chemicals as the potentially affected fraction of species. Life cycle assessment (LCA) uses SSDs to identify products with lowest ecotoxicological impacts. To reflect ambient concentrations, the Global Life Cycle Impact Assessment Method (GLAM) ecotoxicity task force recently recommended deriving SSDs for LCA based on chronic EC10s (10% effect concentration, for a life-history trait) and using the 20th percentile of an EC10-based SSD as a working point. However, because we lacked measured effect concentrations, impacts of only few chemicals were assessed, underlining data limitations for decision support. The aims of this paper were therefore to derive and validate freshwater SSDs by combining measured effect concentrations with in silico methods. Freshwater effect factors (EFs) and uncertainty estimates for use in GLAM-consistent life cycle impact assessment were then derived by combining three elements: (1) using intraspecies extrapolating effect data to estimate EC10s, (2) using interspecies quantitative structure–activity relationships, or (3) assuming a constant slope of 0.7 to derive SSDs. Species sensitivity distributions, associated EFs, and EF confidence intervals for 9862 chemicals, including data-poor ones, were estimated based on these elements. Intraspecies extrapolations and the fixed slope approach were most often applied. The resulting EFs were consistent with EFs derived from SSD-EC50 models, implying a similar chemical ecotoxicity rank order and method robustness. Our approach is an important step toward considering the potential ecotoxic impacts of chemicals currently neglected in assessment frameworks due to limited test data. <i>Environ Toxicol Chem</i> 2024;43:1914–1927. © 2024 The Author(s). <i>Environmental Toxicology and Chemistry</i> published by Wiley Periodicals LLC on behalf of SETAC.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":"43 8","pages":"1914-1927"},"PeriodicalIF":3.6,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/etc.5929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}