Environmental Toxicology and Chemistry最新文献_第10页

Significant research needs for defensible hazard assessment of UV filters in aquatic ecosystems part 2: analytical methods of organic UV filters. 水生生态系统中紫外线过滤器可防御危害评估的重要研究需求。第2部分：有机紫外线过滤器的分析方法。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-04-01 DOI: 10.1093/etojnl/vgaf019

William Matthew Henderson, Cheryl Hankins, Sandy Raimondo

引用次数: 0

Trade-offs of different types of dose-responses following temporal gradients of Pb stress in Tillandsia usneoides. 铅胁迫时间梯度下不同类型剂量反应的权衡。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-04-01 DOI: 10.1093/etojnl/vgaf023

Zhen Tang, Yuanyuan Liu, Evgenios Agathokleous, Shuo Han, Guiling Zheng, Peng Li

{"title":"Trade-offs of different types of dose-responses following temporal gradients of Pb stress in Tillandsia usneoides.","authors":"Zhen Tang, Yuanyuan Liu, Evgenios Agathokleous, Shuo Han, Guiling Zheng, Peng Li","doi":"10.1093/etojnl/vgaf023","DOIUrl":"10.1093/etojnl/vgaf023","url":null,"abstract":"The dose-response relationship between toxicants and organisms is the most fundamental principle in toxicological risk assessment. However, multiphasic nonlinear responses are poorly understood, and the underlying mechanisms remain elusive. In this study, we subjected the indicator plant Tillandsia usneoides to 5 or 10 time gradients of 1 mM Pb and assessed the response patterns of five damage markers and eight resistance markers in the leaves. The results showed that in the assay with five time gradients, 10 out of 13 biomarkers showed biphasic responses and two biomarkers showed multiphasic responses. In the assay with 10 time gradients, six biomarkers showed biphasic responses and five biomarkers showed multiphasic responses. The results confirmed that increasing the number of dose gradients facilitates the detection of multiphasic dose responses. Additionally, the occurrence of nonlinear responses was found to be a common phenomenon. Further analysis of the frequency of trade-offs showed that the occurrence frequency of trade-off 2 (toxicants do not affect one marker but stimulate other markers) was always higher than that of trade-off 1 (toxicants worsen one marker while stimulating other markers) for both damage and resistance markers, and that trade-off 2 was more likely to appear in resistance markers. This suggests that as the duration of stress increases, the body produces more resistance substances, which coordinate with one another to maintain internal balance. This study suggests that the trade-off theory can be effectively used to elucidate the complex relationship between a toxicant and T. usneoides.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1066-1079"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic effects of atrazine on freshwater mussels (Elliptio complanata). 阿特拉津对淡水贻贝的毒性作用。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-04-01 DOI: 10.1093/etojnl/vgaf010

Manna Job, Miryam Makutonin, Jerome Job, Vaduod Niri, Suresh Nimmagadda, James A MacKenzie, Poongodi Geetha-Loganathan

{"title":"Toxic effects of atrazine on freshwater mussels (Elliptio complanata).","authors":"Manna Job, Miryam Makutonin, Jerome Job, Vaduod Niri, Suresh Nimmagadda, James A MacKenzie, Poongodi Geetha-Loganathan","doi":"10.1093/etojnl/vgaf010","DOIUrl":"10.1093/etojnl/vgaf010","url":null,"abstract":"Atrazine (ATR) is a commonly found herbicide contaminant in water bodies across the United States. In this study, native freshwater mussels (Elliptio complanata) were investigated to determine histopathological effects and bioaccumulation of ATR under laboratory conditions. Mussels were collected from the Rice Creek Field Station, Oswego, NY, and were exposed to two different concentrations of ATR (15 and 150 μg/L) for 4 weeks. Histopathological phenotypes induced by ATR include reduced or no ciliary epithelium, ciliary cells merged or completely absent, skeletal rods and connective tissue reduced, causing malformed gill filaments; inhibition of condensation of spermatogenic cells and induced necrosis in spermatocytes in testis; disintegration of acini, oocytes, follicles, and epithelium of the duct, disintegration of the yolk and stalk connecting acini to the follicular wall in ovaries. There were no apparent ATR-mediated histopathological effects in the mantle tissue. Liquid chromatography-mass spectrometry was used to quantify the levels of bioaccumulation of ATR in the tissues where the teratogenic effects are observed from the histological analysis. Bioaccumulation of ATR was observed in gills (0.11 µg/g in the ATR 15 µg/L group and 0.51 µg/g in the ATR 150 µg/L group) and visceral tissues (0.11 µg/g in the ATR 15 µg/L group and 0.63 µg/g in the ATR 150 µg/L), correlating with the histopathological phenotypes. ATR's action mechanism is identified as induced apoptosis in the cells. Further investigation is warranted to elucidate the biochemical response and determine the derivates of ATR in this species.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1007-1019"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycoremediation of Louisiana sweet crude oil with Pleurotus ostreatus and nutrient amendments. 利用平菇和营养添加剂对路易斯安那州低硫原油进行微修复。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-04-01 DOI: 10.1093/etojnl/vgae078

Summer S Crescent, Emily C Pisarski, Ed F Wirth, Richard A Long

{"title":"Mycoremediation of Louisiana sweet crude oil with Pleurotus ostreatus and nutrient amendments.","authors":"Summer S Crescent, Emily C Pisarski, Ed F Wirth, Richard A Long","doi":"10.1093/etojnl/vgae078","DOIUrl":"10.1093/etojnl/vgae078","url":null,"abstract":"Oyster mushrooms (Pleurotus ostreatus) are known to metabolize polycyclic aromatic hydrocarbons in petroleum crude oil, making them candidates for oil spill remediation studies. This work aimed to assess P. ostreatus for its hydrocarbon degradation potential in estuarine conditions. In vitro experiments evaluated nutrient amendments based on P. ostreatus carbon: nitrogen: phosphorous (C: N: P) ratios to optimize mycelium growth, increase degradation efficiencies, and reduce potential nutrient runoff in broader applications. Image analysis was used to track mycelium growth response to various salinities, nutrient amendments, and oil types. Subsequent evaluation of alterations within the saturate, aromatic, resin, and asphaltene (SARA) fractions constituting Louisiana sweet crude (LSC) was conducted via SARA analysis. Results indicate that P. ostreatus mycelium tolerates estuarine salinities, with maximum growth between 5 and 15‰. Relative to 0‰, growth was reduced at salinities >25‰, but positive growth was still observed. Nutrient amendments significantly increased growth over 7 days relative to untreated samples (p < 0.0001). The combination of ammonium chloride and potassium phosphate yielded optimal mycelium growth after 7 days. Mycelium and nutrients significantly altered saturate (p = 0.0015) and asphaltene (p = 0.0124) fractions in LSC. This study suggests that mycelium growth is viable under estuarine salinities and can be enhanced with nutrient amendments. Introducing nutrient factors was shown to influence oil degradation. Results also indicate that mycelium can reduce recalcitrant oil fractions. Thus, this study highlights the adaptability of P. ostreatus to estuarine conditions and its response to nutrient amendments, all while offering a promising approach to crude oil bioremediation.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1154-1163"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composition, source appointment, and biomigration of per- and polyfluoroalkyl substances in the Fu River of Wuhan, China. 武汉府河中全氟烷基和多氟烷基物质的组成、来源确定及生物迁移

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-04-01 DOI: 10.1093/etojnl/vgaf008

Si Shi, Zijie Zhang, Rong Wang, Shiji Xue, Wanyu Fei, Yue'e Peng

{"title":"Composition, source appointment, and biomigration of per- and polyfluoroalkyl substances in the Fu River of Wuhan, China.","authors":"Si Shi, Zijie Zhang, Rong Wang, Shiji Xue, Wanyu Fei, Yue'e Peng","doi":"10.1093/etojnl/vgaf008","DOIUrl":"10.1093/etojnl/vgaf008","url":null,"abstract":"In this study, a detailed analysis of 20 per- and polyfluoroalkyl substances (PFAS) was conducted, in different environmental media of the Fu River, the main sewage storage body, located near the Tianhe Airport in Wuhan, China. The PFAS included 13 perfluorocarboxylic acids (C4-C18), four perfluorosulfonic acids (C4, C6, C8, C10), and three PFAS. In the surface water samples, short-chain PFAS perfluorobutanesulfonic acid (PFBS) and perfluorobutanoic acid were the most prevalent and highest concentrations, 168 ng/L and 49.7 ng/L, respectively. However, in the sediment samples, PFBS and perfluorooctane sulfonate (PFOS) were the most prevalent and highest concentrations, 840 ng/kg and 1,510 ng/kg, respectively. In addition, PFOS was the most prevalent substance, with the highest concentrations measured at 23.3 μg/kg in egg yolk and 28.1 μg/kg in fish, accounting for proportions of 82% and 88%, respectively. Two new short-chain substitutes of PFOS, 6:2 clorinated polyfluoroalykyl ether sulfonate and 8:2 clorinated polyfluoroalykyl ether sulfonate, emerged in sediment and fish. The PFAS in eggs, fish, and vegetables of the Fu River Basin poses a potential health risk to residents according to the suggested values of the European Food Safety Agency.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"926-934"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pollution fast-track to the Arctic: how southern wintering areas contribute to organochlorine loads in a migrant seabird breeding in the Arctic. 污染进入北极的快速通道：南方越冬区如何影响在北极繁殖的候鸟体内的有机氯负荷。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-04-01 DOI: 10.1093/etojnl/vgaf016

Jan Ove Bustnes, Bård-Jørgen Bårdsen, Børge Moe, Dorte Herzke, Rob S A van Bemmelen, Ingrid Tulp, Hans Schekkerman, Sveinn-Are Hanssen

{"title":"The pollution fast-track to the Arctic: how southern wintering areas contribute to organochlorine loads in a migrant seabird breeding in the Arctic.","authors":"Jan Ove Bustnes, Bård-Jørgen Bårdsen, Børge Moe, Dorte Herzke, Rob S A van Bemmelen, Ingrid Tulp, Hans Schekkerman, Sveinn-Are Hanssen","doi":"10.1093/etojnl/vgaf016","DOIUrl":"10.1093/etojnl/vgaf016","url":null,"abstract":"This study examines how southern wintering areas may contribute to organochlorine (OCs) loads in arctic seabirds during breeding. Light-sensitive geolocators (GLS loggers) were deployed on Arctic skuas (Stercorarius parasiticus) in one high arctic and two subarctic colonies. Hexcahlorobenzene (HCB), chlordanes, mirex, p,p'-dichlorodiphenyldichloro-ethylene (p,p'-DDE), and polychlorinated biphenyls (PCBs) were measured in the blood of breeding adults at the nest (58 individuals, a total of 128 samples) in northern Norway and Svalbard between 2009 and 2015. We compared OC concentrations and OC profiles among nesting skuas wintering in five Atlantic regions, determined by the GLS loggers: the coast of Argentina, the Caribbean, off West Africa, off the coast of southern Africa, and the Mediterranean Sea. As predicted, HCB, which is semi-volatile and has high long-range transport potential, showed high prevalence in birds wintering in all regions except the Mediterranean. Mirex showed the highest prevalence in birds wintering off the coasts of Argentina and southern Africa, in accordance with high background levels previously documented in the Southern Ocean. Chlordanes were particularly prevalent in skuas wintering off southern Africa, whereas p,p'-DDE seemed relatively evenly distributed among wintering areas. As predicted, the prevalence of PCBs was much higher in birds wintering in the Mediterranean Sea than in birds from other regions. This study thus suggests that the Mediterranean Sea and the mid- and southern Atlantic are essential sources of different OCs in the blood of Arctic skuas breeding in the European Arctic.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1020-1028"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-induced degradation of single-use polyethylene terephthalate (PET) microplastics under laboratory and outdoor environmental conditions. 在实验室和室外环境条件下光诱导降解一次性聚对苯二甲酸乙二醇酯（PET）微塑料。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-03-28 DOI: 10.1093/etojnl/vgaf084

Zachery A Kasuske, Kailash Arole, Micah J Green, Todd A Anderson, Jaclyn E Cañas-Carrell

{"title":"Photo-induced degradation of single-use polyethylene terephthalate (PET) microplastics under laboratory and outdoor environmental conditions.","authors":"Zachery A Kasuske, Kailash Arole, Micah J Green, Todd A Anderson, Jaclyn E Cañas-Carrell","doi":"10.1093/etojnl/vgaf084","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf084","url":null,"abstract":"There is a lack of knowledge regarding the mechanisms that induce microplastic fragmentation and degradation within the environment. This research aimed to quantify the combined degradative effects that mechanical abrasion in conjunction with photo-oxidation and hydrolysis, have on polyethylene terephthalate (PET) microplastics. To accomplish this, common routes of degradation were evaluated. Degradation was assessed using three indices indicative of polymer degradation: Carbonyl Index (CI), Carbon-to-Oxygen Index (COI), and Hydroxyl Index (HI). This study assessed the effects that mechanical abrasion (MA), photo-oxidation, and various simulated environmental conditions: aqueous (Aq), aqueous + ultraviolet (UV), and UV only within two distinct settings (lab vs outdoor) have on PET microplastic degradation. Photo-oxidation exposure across a 60-d period induced significant degradation on PET microplastics resulting in a 1-22% increase in carbonyl groups across all treatments except UV and Aq. + UV Chamber (MA). A 6-214% increase in hydroxyl groups across all treatments. A 1-10% decrease in carbon-to-oxygen groups in all treatments except the Chamber Aqueous and Outdoor UV (MA). Mechanical abrasion seemed to accelerate this degradation in combination with both UV and aqueous treatments. Using simulated environmental conditions to induce degradation upon PET microplastics, in both lab and simulated environmentally relevant settings, revealed that the combined effects of hydrolysis and photo-oxidation can accelerate the process, especially in conjunction with mechanical abrasion. The novel findings presented here provide insight into the complex relationship between various polymer degradation pathways and the effects that mechanical abrasion can have on them, while also providing additional data for an understudied yet prevalent plastic polymer.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gap between hypothesis-based test results and point-estimates in freshwater chronic toxicity tests: a meta-analysis. 弥合淡水慢性毒性试验中基于假设的试验结果与点估计值之间的差距：一项荟萃分析。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-03-28 DOI: 10.1093/etojnl/vgaf066

James R Justice, Brian Schnitker, Kathryn Gallagher

{"title":"Bridging the gap between hypothesis-based test results and point-estimates in freshwater chronic toxicity tests: a meta-analysis.","authors":"James R Justice, Brian Schnitker, Kathryn Gallagher","doi":"10.1093/etojnl/vgaf066","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf066","url":null,"abstract":"There has been a history of debate within the ecotoxicological community on the use of point estimates (e.g., effect concentration for 20% of test organisms; EC20) versus effect levels determined through hypothesis-based testing, such as the no observed effect concentration (NOEC) and lowest observed effect concentration (LOEC). This study provides analyses of the percent effect that is expected to occur at the NOEC, LOEC, and maximum acceptable toxicant concentration (MATC) based on available chronic data but does not debate the merits of point estimates versus hypothesis-based test results. We also developed adjustment factors that can be applied to NOECs, LOECs, MATCs, EC20, and EC10 values to equate them to EC5 values, which generally represent an effect level that is within the variability of control responses (e.g., NOEC/Adjustment Factor = Approximate EC5). Our analyses showed median percent effect occurring at the NOEC (8.5%), LOEC (46.5%), and MATC (23.5%) was not strongly influenced by chemical or taxon type (invertebrate vs. vertebrate). The median NOEC, LOEC, and MATC to EC5 adjustment factors were 1.2, 2.5, and 1.8, respectively. The median EC20 to EC5 adjustment factor was 1.7, and the median EC10 to EC5 adjustment factor was 1.3. Adjustment factors were not strongly influenced by chemical or taxon type, suggesting they can be applied across chemicals and taxa. Our results provide context to the use of hypothesis-based testing results. The adjustment factors developed could be considered in efforts to streamline screening-level ecological risk assessments and individual-level endangered species evaluations by providing an approach that could be used to adjust commonly reported toxicity test results (i.e., NOEC, LOEC, MATC, EC20, EC10) into approximate EC5 values.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake and elimination of per-and polyfluoroalkyl substances in earthworms exposed to spiked artificial soil or aqueous medium. 蚯蚓在人工土壤或水介质中吸收和消除全氟烷基和多氟烷基物质。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-03-27 DOI: 10.1093/etojnl/vgaf083

Guilherme Lotufo, Robert E Boyd, Paige M Krupa, Zhao Yang, Jennifer E Guelfo, Michael Simini, Roman G Kuperman

{"title":"Uptake and elimination of per-and polyfluoroalkyl substances in earthworms exposed to spiked artificial soil or aqueous medium.","authors":"Guilherme Lotufo, Robert E Boyd, Paige M Krupa, Zhao Yang, Jennifer E Guelfo, Michael Simini, Roman G Kuperman","doi":"10.1093/etojnl/vgaf083","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf083","url":null,"abstract":"We investigated the accumulation of per- and polyfluoroalkyl substances (PFAS) in earthworms (Eisenia andrei). Uptake kinetics and bioaccumulation factors (BAFs) were determined using a mixture of 16 PFAS by exposing earthworms to spiked artificial soil for up to 28 d. Two treatments were used, with the low treatment targeting environmentally relevant concentrations. The concentrations of PFAS remained relatively unchanged during the exposures and statistically significant rates of uptake were estimated for most individual PFAS. For the 0.01 mg/kg treatment (target concentration of each PFAS), steady state was reached for all PFAS except PFHpS, PFHxS, PFOS, PFTeDA, and PFTrDA. For the 0.01 mg/kg treatment, bioaccumulation factors (BAF; kg/kg-dry wt.) ranged from 4 to 49 for most PFAS, but were higher for PFHxS (72), PFTeDA (271), and PFUnA (299). Organic-carbon-normalized BAFs were within the range of published values. The BAF values increased with increasing length of the alkyl chain for perfluoroalkyl carboxylic acids (PFCAs), but not for perfluoroalkyl sulfonic acids (PFSAs). Uptake rates and BAFs were lower for the 1 mg/kg treatment, typically by over one order of magnitude, likely because of sublethal physiological impairment. Fast and steep decreases in tissue concentrations of PFAS occurred when earthworms were transferred to clean soil, even for long chain PFAS, overall agreeing with previous reports. However, measured elimination rates were faster than predicted from the uptake experiments and the causes remain unknown. Bioaccumulation of PFAS was also investigated in exposures to aqueous medium for up to 7 d to derive bioconcentration factors (BCFs). Comparison of BCFs and BAFs suggests that uptake from soil may have higher relevance compared to dermal uptake from porewater for long-chain PFCAs and PFSAs.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diclofenac activates antioxidant defenses and affects ovarian growth in the freshwater shrimp Macrobrachium borellii. 双氯芬酸激活淡水虾的抗氧化防御系统并影响其卵巢生长

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-03-26 DOI: 10.1093/etojnl/vgaf070

Marina Zanitti, Ariel Calabró López, Ismael E Lozano, Daniel A Medesani, Ariadna G Battista, Laura S López Greco, Enrique M Rodríguez

{"title":"Diclofenac activates antioxidant defenses and affects ovarian growth in the freshwater shrimp Macrobrachium borellii.","authors":"Marina Zanitti, Ariel Calabró López, Ismael E Lozano, Daniel A Medesani, Ariadna G Battista, Laura S López Greco, Enrique M Rodríguez","doi":"10.1093/etojnl/vgaf070","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf070","url":null,"abstract":"Ovigerous females of the freshwater shrimp Macrobrachium borellii were exposed to three sublethal concentrations (0.01, 0.1, and 1 mg/L) of diclofenac sodium salt, for 74 d, in order to measure several variables related to both reproductive success and oxidative stress. Although no differences (p > 0.05) were noted in either the egg incubation time or the postlarvae survival, the number of hatched postlarvae (actual fecundity) decreased to some extent, together with a low percentage of abnormal larvae. At the end of the assay, the ovarian size of re-maturating shrimps exposed to 1 mg/L of diclofenac was significantly (p < 0.05) higher than that of controls, showing an acceleration of ovarian growth by the effect of this drug. Taken together, though, these results showed no evident increase of the reproductive output. Concerning oxidative stress, both the reduced glutathione level and total antioxidant capacity were enhanced without altering glutathione-S-transferase activity and lipid peroxidation. Concomitantly, no damage to the hepatopancreas structure was observed in females. We conclude that diclofenac caused an imbalance in gonadal growth, likely by affecting the endocrine control exerted by prostaglandins, while oxidative stress could be efficiently controlled by the induction of antioxidant defenses.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0