Environmental Toxicology and Chemistry最新文献_第10页

Evaluation of Neurotoxicity of Neonicotinoid Insecticides Using Lipidomics. 脂质组学评价新烟碱类杀虫剂的神经毒性。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-09 DOI: 10.1093/etojnl/vgaf203

Tomoya Koike, Anri Hirai, Kei Nomiyama, Akihumi Eguchi, Nobuhiko Hoshi, Tetsushi Hirano, Collins Nimako, Yared Beyene Yohannes, Mai Tamba, Shouta M M Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka

{"title":"Evaluation of Neurotoxicity of Neonicotinoid Insecticides Using Lipidomics.","authors":"Tomoya Koike, Anri Hirai, Kei Nomiyama, Akihumi Eguchi, Nobuhiko Hoshi, Tetsushi Hirano, Collins Nimako, Yared Beyene Yohannes, Mai Tamba, Shouta M M Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka","doi":"10.1093/etojnl/vgaf203","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf203","url":null,"abstract":"Neonicotinoid (NN) pesticides are widely used globally, but recent studies suggest that even non-toxic doses can induce anxiety-like behaviors and alter brain monoamine neurotransmitter levels in mice. Current neurotoxicity assays may fail to detect subtle toxic effects, such as higher brain function abnormalities caused by small molecule disruptions. These findings highlight the need for highly sensitive and reproducible neurotoxicity testing methods. The brain, a lipid-rich organ, relies on lipids for various functions, and disturbances in lipid homeostasis are linked to numerous diseases. This study uses lipidomics to analyze the cerebral cortex of mice exposed to the NN acetamiprid (ACE), aiming to identify lipid biomarkers of neurotoxicity. Thirty 12-week-old male C57BL/6J mice were randomly divided into control (0 mg/kg), low dose (65 mg/kg), and high dose (130 mg/kg) groups, with 10 mice in each group. Mice were euthanized, and cerebral cortex samples were collected 30 minutes after oral ACE administration. Lipids were extracted and analyzed using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (LC/Q-TOF/MS). A total of 358 lipids were annotated. Fifteen lipids exhibited a fold change > 2.0 and significant differences between control and high-dose groups, with an AUC ≥ 0.900 in ROC analysis. Increased levels of seven fatty acids (e.g., palmitic acid) and five Fatty Acyl Esters of Hydroxy Fatty Acids (e.g., FAHFA 22:6_22:5) were observed, suggesting roles in neurodegenerative diseases and inflammation. These findings identify a promising lipid biomarker linked to NN-induced neurotoxicity and contribute to detecting neurotoxic effects from acute exposure to such substances.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of different size suspended particles on the bioaccumulation of polycyclic aromatic hydrocarbons in zebrafish tissues. 不同粒径悬浮颗粒对斑马鱼组织中多环芳烃生物积累的影响。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-09 DOI: 10.1093/etojnl/vgaf206

Yawei Zhai, Yuting Yang, Shuai He

{"title":"Effect of different size suspended particles on the bioaccumulation of polycyclic aromatic hydrocarbons in zebrafish tissues.","authors":"Yawei Zhai, Yuting Yang, Shuai He","doi":"10.1093/etojnl/vgaf206","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf206","url":null,"abstract":"Polycyclic aromatic hydrocarbons (PAHs) are easily bound with suspended particles (SPS) in rivers, and this will further affect their bioaccumulation. However, it is unclear whether SPS will affect the PAH bioaccumulation in different fish tissues. In the present work, we studied the effect of different size SPS on the PAH bioaccumulation in different zebrafish tissues. The results showed that PAH concentrations in the different zebrafish tissues increased with time and the bioaccumulation steady-state reached in less than 16 days. In addition, the PAH steady-state concentrations were not affected significantly by the SPS (p > 0.05), but the PAH concentrations in different tissues of the zebrafish cultured with SPS were higher than that without SPS at the initial bioaccumulation stage. Meanwhile, it was found that the effect of SPS on the PAH bioaccumulation was relevant with the particle size, for example, the uptake rates of pyrene in the muscle tissue increased respectively by 45% ± 5%, 38% ± 8%, and 20% ± 4% for the zebrafish cultured with <20 μm SPS, 20-63 μm SPS, and 63-106 μm SPS. Moreover, the small size SPS performed much stronger effect than the large size SPS on the PAH bioaccumulation in the digestive tract and gill tissues, and this might further affect the PAH bioaccumulation in other zebrafish tissues. The present study is favorable to understand the bioaccumulation of the PAHs bound with the SPS in turbid rivers.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Environmental Variation Impacts 2,4-D Fate and Metabolism in Urban Landscapes. 季节环境变化对城市景观2,4- d命运和代谢的影响

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-08 DOI: 10.1093/etojnl/vgaf205

Amarilys E González Vázquez, Ming Yi Chou, Kurt R Hockemeyer, Maiyia Vang, Paul L Koch

{"title":"Seasonal Environmental Variation Impacts 2,4-D Fate and Metabolism in Urban Landscapes.","authors":"Amarilys E González Vázquez, Ming Yi Chou, Kurt R Hockemeyer, Maiyia Vang, Paul L Koch","doi":"10.1093/etojnl/vgaf205","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf205","url":null,"abstract":"The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is commonly applied to urban landscapes such as turfgrass lawns. Though 2,4-D's degradative pathway has been extensively researched, the interaction of soil microbiota with 2,4-D under varying seasonal conditions remains unclear. This study aimed to assess the role of seasonal environmental conditions on the soil bacterial community and the resulting impact on the degradation of 2,4-D and the formation of its major transformation product, 2,4-dichlorophenol (2,4-DCP). Field and controlled environment studies were conducted near Madison, WI, USA in 2018 and 2019 and demonstrated that 2,4-D concentrations steadily declined in both the soil and leaves in the 10 days following application. The metabolite 2,4-DCP was only detected in the controlled environment study and was always below the limit of quantification. The impact of seasonal environmental variations on bacterial community structure, function, and composition were also assessed. Distinct bacterial communities were observed between season-simulated temperatures, soil depths, field sites, and 2,4-D treatment application timings. These findings emphasize that environmental variations shift the soil bacterial community over the course of a growing season with potentially important implications for the degradation of 2,4-D in urban landscapes.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Toxicity of Lithium to the Fingernail Clam Pisidium dubium and the Water Flea Daphnia pulex. 锂对蛤蚌和水蚤的慢性毒性研究。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-08 DOI: 10.1093/etojnl/vgaf204

A M M A Ouedraogo, C J Rickwood, P Huntsman, C L Proulx, F Pick, R R Goulet

{"title":"Chronic Toxicity of Lithium to the Fingernail Clam Pisidium dubium and the Water Flea Daphnia pulex.","authors":"A M M A Ouedraogo, C J Rickwood, P Huntsman, C L Proulx, F Pick, R R Goulet","doi":"10.1093/etojnl/vgaf204","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf204","url":null,"abstract":"Lithium (Li) is used in batteries and pharmaceutical applications. The growing use raises concerns about impacts on aquatic ecosystems and the need for better source management. The study objective was to investigate Li chronic toxicity and bioaccumulation using two native freshwater species to allow water quality guideline derivation. We conducted toxicity tests in which the fingernail clam Pisidium dubium (28-day exposure) and the water flea Daphnia pulex (21-day exposure) were exposed to a control and six environmentally relevant nominal concentrations of Li ranging from 0.05 to 10 mg/L and 0.5 to 3 mg/L Li, respectively. Solubility and partitioning tests indicated that Li readily dissolved in water and did not sorb onto particles as filtered and unfiltered Li concentrations were similar. Results for Pisidium dubium revealed EC50,10 values of 1.59 and 0.99 mg/L for burrowing behavior and LC50,10 values of 1.37 and 0.77 mg/L for survival. Soft tissue Li content in Pisidium dubium was similar across all exposures at the end of the tests suggesting clams control internal Li concentrations despite increased exposure. Daphnia pulex was less sensitive to Li than P. dubium. Li exposure affected reproduction (EC50 = 1.77 mg/L, EC10 = 1.42 mg/L) and somatic growth based on body size changes (EC50 = 3.01 mg/L, EC10 = 1.97 mg/L). Updated species sensitivity distribution using our new data suggests a Li water quality guideline of 0.034 mg/L. This value falls within the range of lithium concentrations near contaminated areas, underscoring the need for adequate controls to mitigate ecological risk. Future research should better characterize how Na, Ca, and pH influence Li toxicity at both the organismal and molecular levels.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Effects of Sediments Contaminated by Industrial Discharges to a Unionid Mussel (Fatmucket, Lampsilis siliquoidea) and a Common Test Benthic Organism (Amphipod, Hyalella azteca). 工业排放物污染沉积物对一种统一贻贝（Fatmucket, Lampsilis siliquoidea）和一种常见底栖生物（Amphipod, Hyalella azteca）的影响评价。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-07 DOI: 10.1093/etojnl/vgaf200

Chris D Ivey, Jeffery A Steevens, Ning Wang, Kathleen Patnode, James L Kunz, John Besser

{"title":"Evaluation of the Effects of Sediments Contaminated by Industrial Discharges to a Unionid Mussel (Fatmucket, Lampsilis siliquoidea) and a Common Test Benthic Organism (Amphipod, Hyalella azteca).","authors":"Chris D Ivey, Jeffery A Steevens, Ning Wang, Kathleen Patnode, James L Kunz, John Besser","doi":"10.1093/etojnl/vgaf200","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf200","url":null,"abstract":"Freshwater mussels are among the most sensitive species to a variety of chemicals in water exposures. However, few studies have been conducted to evaluate the effect of toxicants in sediments on mussels. Industrial discharges containing polyaromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), and metals entered the Kanawha River surrounding Blaine Island, South Charleston, West Virginia, USA; a river which supports eight federally endangered mussel species. We collected sediment samples from a highly contaminated site, a nearby upstream site, and a further upstream reference site to assess the effects of contaminated sediment on the survival and growth of a unionid mussel (fatmucket, Lampsilis siliquoidea) and a commonly tested benthic organism (amphipod, Hyalella azteca) using standard 28-d sediment toxicity tests. We also determined mussel toxicity in a serial dilution of the highly contaminated sediment. Results showed that concentrations of PAHs, VOCs, and metals in the contaminated sediment were consistently greater than the other two sites. The mean survival of mussels and amphipods in the reference sediment was 100% and 95%, respectively, whereas the mean survival of both test species in the contaminated sediment was 0%. In the sediment dilution study, mean survival and biomass of mussels in the ≥6.25% treatment were significantly reduced relative to the control, with a 25% inhibition concentration of 4.1% for survival and 3.6% for biomass. We used sediment screening values and equilibrium partitioning sediment benchmarks to determine that nickel, mercury, and PAH mixture were likely responsible for the toxicity observed to mussels and amphipods and will provide critical data to identify and mitigate the sources of the mixture in contaminated sediment.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstrated Laboratory Effectiveness of an Anthelmintic Medicated Feed for the Treatment of Oxyspirura petrowi Infections in Northern Bobwhite (Colinus virginianus). 驱虫药饲料治疗北山齿鹑（Colinus virginianus）刺毛螺旋体感染的实验室有效性。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-06 DOI: 10.1093/etojnl/vgaf198

Hannah N Suber, Timothy B Arlowe, Henry Valencia, Ashley Kaskocsak, Kaya Kinsey, John Guerra, Sarah Colette, Anna Summers, James G Surles, Ronald J Kendall

{"title":"Demonstrated Laboratory Effectiveness of an Anthelmintic Medicated Feed for the Treatment of Oxyspirura petrowi Infections in Northern Bobwhite (Colinus virginianus).","authors":"Hannah N Suber, Timothy B Arlowe, Henry Valencia, Ashley Kaskocsak, Kaya Kinsey, John Guerra, Sarah Colette, Anna Summers, James G Surles, Ronald J Kendall","doi":"10.1093/etojnl/vgaf198","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf198","url":null,"abstract":"May 2024, a medicated anthelmintic feed was approved by the United States Food and Drug Administration (FDA) to treat parasitic infection in wild quail following evidence linking parasites to Northern bobwhite (Colinus virginianus) population impacts. During the FDA approval process, it was confirmed that the feed significantly reduced parasite burdens in wild bobwhite populations after three weeks of treatment. However, no studies were conducted on the drug's efficacy in individual bobwhite in a controlled laboratory setting. In this study, we infected pen-reared bobwhite with Oxyspirura petrowi, an eyeworm commonly found in wild bobwhite. We treated the birds with anthelmintic feed for three weeks at different frequencies (0x, 2x, and 5x/week) to determine the optimal feed amount and feeding frequency for parasite control. One-third of the birds were euthanized weekly and examined for O. petrowi. A stepwise Poisson regression revealed that the total amount of feed eaten was the strongest predictor of the number of live O. petrowi found. None of the categorical variables assessed, including feeding frequency, impacted the predicted parasite reduction. All birds that consumed ≥ 38.887 g of feed were parasite-free, though this may be a liberal estimate, as 15 of the 48 worms were not recovered from birds not given anthelmintic feed. In addition to the feed, other factors like the bobwhites' innate immune responses or potential unnoticed worm injuries likely contributed to the reduced O. petrowi numbers. Regardless, this study determined that a medicated anthelmintic feed effectively reduces O. petrowi infection intensity in individual bobwhite. Additional findings include observing O. petrowi migration between eyes and determining O. petrowi tissue is either resorbed or expelled after parasite death.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the World Health Organization Toxic Equivalency Factors of Polychlorinated Dibenzo-p-dioxins, Dibenzofurans, and Biphenyls for Applicability to Amphibians using an In Vitro Ah Receptor Transactivation Assay. 使用体外Ah受体反激活试验评估多氯二苯并对二恶英、二苯并呋喃和联苯对两栖动物适用性的世界卫生组织毒性等效因子。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-06 DOI: 10.1093/etojnl/vgaf199

Cameron H Collins, Nonnie E Cook, Wade H Powell, Jon A Doering

{"title":"Evaluating the World Health Organization Toxic Equivalency Factors of Polychlorinated Dibenzo-p-dioxins, Dibenzofurans, and Biphenyls for Applicability to Amphibians using an In Vitro Ah Receptor Transactivation Assay.","authors":"Cameron H Collins, Nonnie E Cook, Wade H Powell, Jon A Doering","doi":"10.1093/etojnl/vgaf199","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf199","url":null,"abstract":"The World Health Organization (WHO) coordinated an expert meeting to streamline ecological risk assessments for complex mixtures of dioxin-like compounds (DLCs) by establishing 2,3,7,8-tetrachlorodibenzo-p-dixoin (2,3,7,8-TCDD) equivalency factors (TEFs) for mammals, fishes, and birds. No TEFs exist for amphibians, nor have any studies investigated whether the existing TEFs for mammals, fishes, or birds are suitable estimates of DLC potency for this taxon. Therefore, the objective of the present study was to determine the relative potency (ReP) for DLCs to assess the need for amphibian-specific TEFs. A total of 15 DLCs in addition to 2,3,7,8-TCDD were assessed in a standardized in vitro transactivation assay using COS-7 cells transfected with an expression construct for the aryl hydrocarbon receptor 1 (AHR1) from Xenopus laevis, a model amphibian. Two AHR1 paralogs (AHR1α/ahr.L and AHR1β/ahr.S) are expressed in X. laevis with comparable patterns of expression and comparable sensitivity to activation by DLCs, which suggests that RePs are independent of the specific AHR1 paralog. Compared to the corresponding WHO TEFs, 73% of RePs generated in this study for X. laevis are within 10-fold of the WHO TEFs for birds, which was more similar than comparisons to the WHO TEFs for mammals (33%) and fishes (33%). Three key amino acid residues (N325, A354, and A370) within the ligand binding domain of AHR1 are conserved at homologous positions in all 21 amphibian species with known AHR1 sequences, suggesting that RePs for X. laevis are likely applicable to most, if not all, other amphibians. Overall, this study suggests risk assessors can refer to WHO TEFs for birds when evaluating the toxicity of DLC mixtures to amphibians.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withdrawal Period and Elimination Half-life of Enrofloxacin, and Assessment of Its Impact on Bioresponses of Oreochromis niloticus Using Integrated Biomarker Response. 恩诺沙星停药期、消除半衰期及综合生物标志物评价对尼罗褐虾生物反应的影响

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-06 DOI: 10.1093/etojnl/vgaf202

Ratnapriya Das, Thangapalam Jawahar Abraham, Arya Sen, Ravindran Rajisha, Ranjit Kumar Nadella, Prasanna Kumar Patil

{"title":"Withdrawal Period and Elimination Half-life of Enrofloxacin, and Assessment of Its Impact on Bioresponses of Oreochromis niloticus Using Integrated Biomarker Response.","authors":"Ratnapriya Das, Thangapalam Jawahar Abraham, Arya Sen, Ravindran Rajisha, Ranjit Kumar Nadella, Prasanna Kumar Patil","doi":"10.1093/etojnl/vgaf202","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf202","url":null,"abstract":"In intensive aquaculture, the outbreaks of infectious diseases are increasing, which demand improved disease management. This study assessed the effects of dietary enrofloxacin (ENF) on Oreochromis niloticus at the recommended (10 mg) and overdose (30 mg/kg biomass/day) for 5 days using integrated biomarker response (IBR). The ENF-fed fish were observed for mortality, residue deposition, oxidative stress, plasma biochemistry, and histopathological anomalies. The withdrawal period and elimination half-life of ENF were estimated. The dosing groups experienced 0.67-2.67% mortalities. An increase in glucose, transaminases, alkaline phosphatase, and creatinine, alongside a decrease in calcium and chloride, indicated altered physiology. The liver and kidney tissues exhibited signs of oxidative stress, as indicated by alterations in malondialdehyde, ferric reducing antioxidant power, total nitric oxide, glutathione S-transferase and catalase levels. Maximum residual accumulation of ENF and its metabolite ciprofloxacin (CIP) was in the liver, followed by muscle+skin, kidney, and plasma. Residues of ENF+CIP persisted in the muscle+skin and kidney at day 42 post-dosing. The projected withdrawal period at a 95% confidence limit was 22 days for the recommended dose group. The elimination half-life followed the kidney> muscle+skin> liver> plasma trend. The IBR scores of the liver were comparatively higher than those of the kidney, indicating that the liver tissues are more prone to oxidative damage. The liver and kidney histopathology revealed dose-dependent damage, which partially recovered after ENF withdrawal. While the recommended dose induced reversible effects, the findings emphasised the need for stringent regulation and adherence to withdrawal to mitigate potential risks to fish and consumers.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake and transformation of arsenic by Acidomyces acidophilus isolated from acidic mine tailings and its toxigenic implications. 从酸性尾矿中分离的嗜酸菌对砷的吸收转化及其产毒意义。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-01 DOI: 10.1093/etojnl/vgaf121

Mariana Umpierrez-Failache, Arshath Abdul Rahim, Lorena Betancor, Subhasis Ghoshal

{"title":"Uptake and transformation of arsenic by Acidomyces acidophilus isolated from acidic mine tailings and its toxigenic implications.","authors":"Mariana Umpierrez-Failache, Arshath Abdul Rahim, Lorena Betancor, Subhasis Ghoshal","doi":"10.1093/etojnl/vgaf121","DOIUrl":"10.1093/etojnl/vgaf121","url":null,"abstract":"Adequate treatment and safe disposal of high-acidity effluents generated during mining containing elevated concentrations of heavy metals and metalloids, such as arsenic, are a critical environmental challenge. In this work, we isolated and characterized an acidophilic fungus from acid mine drainage-affected tailings pond sludge containing high levels of heavy metals. This fungus was identified as Acidomyces acidophilus strain MSS1 and was characterized by its capacity to tolerate and metabolize As(V) and As(III). Our results show that As tolerance and removal capacity by this fungus is highly dependent on pH, being more effective at pH 3.0 than pH 5.4. The biotransformation mechanism involves internalization of As species, As(V) reduction to As(III), and possible biomethylation. It is also capable of oxidizing As(III) in the medium to As(V) to a lesser extent. Arsenite methyltransferase expression was upregulated in the presence of As(III), increasing approximately 25-fold at pH 3 and approximately 14-fold at pH 5.4, compared with fungus not exposed to As. However, in the presence of As(V), it only increased approximately five-fold at pH 5.4; thus, methylation of As is highly dependent on pH and the type of As species present. Additionally, As was removed by biosorption to the fungal biomass. Overall, our results suggest that A. acidophilus can be considered as a potential As bioremediation agent for the removal of As, in particular As(III), in highly acidic effluents, due to its remarkable tolerance to low pH and high metal concentrations.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"2376-2387"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of pesticides in Oregon coastal waters. 俄勒冈州沿海水域农药的发生。

IF 2.8 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-08-01 DOI: 10.1093/etojnl/vgaf117

Bria M Bleil, Elise F Granek, Michelle L Hladik

{"title":"Occurrence of pesticides in Oregon coastal waters.","authors":"Bria M Bleil, Elise F Granek, Michelle L Hladik","doi":"10.1093/etojnl/vgaf117","DOIUrl":"10.1093/etojnl/vgaf117","url":null,"abstract":"Pesticides are used globally for a wide range of applications including agricultural, forestry, roadsides, freshwater systems, and personal use. Although pesticides have ensured efficient crop production, they are frequently transported away from application sites and are found in almost all terrestrial and aquatic environments. Pesticides are frequently detected in watersheds and rivers, but there is limited research on pesticide presence in United States (U.S.) marine environments. To address these data gaps, this study documents pesticide occurrence in U.S. coastal waters, providing new understanding of pesticide contamination in offshore environments. Polar organic chemical integrative samples were deployed at five sites along the Oregon, U.S. coast to examine the occurrence of pesticides. Between two and seven different pesticides were detected at every site, with herbicides diuron and atrazine, and fungicides carbendazim, propiconazole, and tebuconazole being the most frequently detected at three sites. The prevalence of herbicides and fungicides in coastal waters indicates a connection between terrestrial pesticide practices and marine contamination. These findings provide new insights into the presence of pesticides in coastal nearshore and offshore waters and suggest that a comprehensive monitoring effort could enhance our understanding of sources, transport, and pesticide risks for marine species both nearshore and offshore.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"2098-2107"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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