Environmental Toxicology and Chemistry最新文献_第4页

Amphibian studies to investigate the endocrine-disrupting properties of chemicals through the thyroid modality: a comparison of their statistical power. 两栖动物研究通过甲状腺形态调查化学物质的内分泌干扰特性：其统计能力的比较。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf067

Simone Rizzuto, Franco Maria Neri, Valeria Ercolano, Alessio Ippolito, Alberto Linguadoca, Laura Villamar Bouza, Maria Arena

{"title":"Amphibian studies to investigate the endocrine-disrupting properties of chemicals through the thyroid modality: a comparison of their statistical power.","authors":"Simone Rizzuto, Franco Maria Neri, Valeria Ercolano, Alessio Ippolito, Alberto Linguadoca, Laura Villamar Bouza, Maria Arena","doi":"10.1093/etojnl/vgaf067","DOIUrl":"10.1093/etojnl/vgaf067","url":null,"abstract":"Amphibians are the current model species for investigating the endocrine-disrupting (ED) properties through the thyroid modality in non-mammalian species. A recurrent question in the European Union (EU) regulatory endocrine assessment of pesticide active substances (2018/605) is whether the positive results from an in vivo screening test, that is, Amphibian Metamorphosis Assay (AMA), can be considered sufficient to conclude on the ED properties of a pesticide active substance or whether the larval amphibian growth and developmental assay (LAGDA) is a necessary step to further clarify the concerns identified in the AMA. Another one is the consideration of the extended AMA (EAMA). To further clarify some of the uncertainties around the use of the LAGDA and to help further consideration of the EAMA in a regulatory context, the statistical power of the three test designs was tested for all the parameters entailed to be measured in the respective study design (except for thyroid histopathology) by using data from real experimental studies. Our findings showed that the statistical power of the EAMA is in line with other Organisation for Economic Co-operation and Development standardized tests, that is, AMA, LAGDA. Our results also confirmed that the LAGDA is more powerful to detect effects on relevant parameters, that is, time to reach metamorphosis, compared to other in vivo tests. However, the difference in power was small, questioning its contribution to an overall weight of evidence already supporting the identification of a substance as an ED. These findings should be considered only in the context of hazard-based endocrine assessment of active substances (i.e., EU regulatory ED assessment of pesticide active substances, 2018/65), while they may not be fully applicable for a risk assessment-based approach.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1435-1447"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of a lambda-cyhalothrin formulation residues on larval Apis mellifera: examining midgut and fat body morphological response to insecticide chronic exposure. 高效氯氟氰菊酯制剂残留物对蜜蜂幼虫的影响：检测杀虫剂慢性暴露的中肠和脂肪体形态反应。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf049

Pedro Henrique Ambrosio Nere, Rebecca Rey-Chai Kern, Lenise Silva Carneiro, Bárbara Soares Amoroso Lima, Diego Dos Santos Souza, José Eduardo Serrão

{"title":"Impact of a lambda-cyhalothrin formulation residues on larval Apis mellifera: examining midgut and fat body morphological response to insecticide chronic exposure.","authors":"Pedro Henrique Ambrosio Nere, Rebecca Rey-Chai Kern, Lenise Silva Carneiro, Bárbara Soares Amoroso Lima, Diego Dos Santos Souza, José Eduardo Serrão","doi":"10.1093/etojnl/vgaf049","DOIUrl":"10.1093/etojnl/vgaf049","url":null,"abstract":"Pollination by honey bees (Apis mellifera) is crucial for maintaining biodiversity and crop yields. However, the widespread use of pesticides may threaten bees' survival by contaminating their resources. Lambda-cyhalothrin, a neurotoxic insecticide commonly used in agricultural pest control, poses particular risks. In insects, the midgut and fat body serve as primary barriers against xenobiotics, and exposure to these chemicals during larval development can impact adult bees. This study aimed to assess whether the residual concentration of lambda-cyhalothrin in pollen grains affects the midgut and fat body of larval A. mellifera workers after chronic exposure. The midgut epithelium of larvae exposed to a lambda-cyhalothrin-based insecticide (λ-CBI) exhibited autophagic vacuoles, apical cell protrusions, apocrine secretion, nuclear pyknosis, and high levels of polysaccharides and glycoconjugates in the cytoplasm, with smaller amounts in the brush border. Histochemical analysis revealed areas of vacuolation and damage to cell integrity in the midgut. In fat body cells, the insecticide increased polysaccharide storage and decreased lipid droplet diameter. Despite the histopathological damage, no effects were found in the larval development and adult emergence. These findings suggest the occurrence of apoptosis and autophagy in midgut cells and alterations in nutrient storage in the fat body of A. mellifera larvae exposed to the λ-CBI, potentially impacting the physiology and development of this pollinator with possible effects on adult workers.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1422-1434"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant metal accumulation in fish in a metal-contaminated river without detectable effects on fish and macroinvertebrate communities. 在受金属污染的河流中，鱼类体内的大量金属积累对鱼类和大型无脊椎动物群落没有可检测到的影响。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf047

Yuichi Iwasaki, Tomoko Oguri, Kazutoshi Ueda, Kentaro Morita

{"title":"Significant metal accumulation in fish in a metal-contaminated river without detectable effects on fish and macroinvertebrate communities.","authors":"Yuichi Iwasaki, Tomoko Oguri, Kazutoshi Ueda, Kentaro Morita","doi":"10.1093/etojnl/vgaf047","DOIUrl":"10.1093/etojnl/vgaf047","url":null,"abstract":"Excess metal accumulation in organisms can result in adverse impacts at the levels of the individual, population, and community. A detectable increase of metal concentrations in organisms does not necessarily imply that there are such impacts, but to our knowledge, no field study has directly tested this hypothesis. To test this hypothesis, we investigated the accumulation of six elements (Cu, Zn, Cd, Pb, As, and Se) in masu salmon (Oncorhynchus masou, Salmonidae) at nine study sites in a metal-contaminated river receiving mine discharge and in a nearby reference river. Multiple fish community surveys in 2018 and 2019 consistently indicated that the abundance and condition factors of the four dominant fish species, including masu salmon, were comparable in the two rivers. In contrast, despite sample sizes of only five individuals per site, statistically significant increases in the concentrations of Cu, Cd, Pb, As, and Se in the muscle of masu salmon were observed at multiple sites in the metal-contaminated river, where no detectable impacts on the abundance or condition factor of the fish were observed. The muscle concentrations of Cu, Zn, Cd, Pb, As, and Se at these sites were 1.4-2.5, 1.5-1.9, 188-520, 4.6-68.0, 1.1-3.9, and 2.8-3.5 times, respectively, the mean concentrations at the reference sites, although the increase of the Zn concentration in muscle at these metal-contaminated river sites was not significant. These results provide clear empirical evidence that a detectable increase in metal accumulation does not necessarily imply that population and community-level impacts are simultaneously occurring in the environment.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1228-1234"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecotoxicity assessment of phthalic acid di-alkyl ester mixtures toward aquatic organisms based on results from a series of subchronic toxicity tests. 基于一系列亚慢性毒性试验结果的邻苯二甲酸二烷基酯混合物对水生生物的生态毒性评估。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgae072

Yusuke Oda, Machi Kawano, Haruna Watanabe, Takahiro Yamagishi, Hiroshi Yamamoto

{"title":"Ecotoxicity assessment of phthalic acid di-alkyl ester mixtures toward aquatic organisms based on results from a series of subchronic toxicity tests.","authors":"Yusuke Oda, Machi Kawano, Haruna Watanabe, Takahiro Yamagishi, Hiroshi Yamamoto","doi":"10.1093/etojnl/vgae072","DOIUrl":"10.1093/etojnl/vgae072","url":null,"abstract":"Phthalic acid di-alkyl esters (PAEs) constitute a class of industrial compounds with a wide range of carbon chain lengths and physicochemical properties that are predominantly used as plasticizers. Although multiple PAEs co-occur in water environments, which poses a combined exposure risk to aquatic organisms, no studies have quantitatively demonstrated the mixture ecotoxicity of multicomponent PAEs. This study performed a series of subchronic toxicity tests on three aquatic organisms (green alga Raphidocelis subcapitata, daphnid Ceriodaphnia dubia, and fish Danio rerio), using a total of 12 PAEs with the number of carbons in the alkyl chains ranging from C1 to C11 to determine their toxicity profiles and the combined effects. Shorter-chain PAEs (C1-C6) generally exhibited increasing toxicity associated with a logarithm of the octanol-water partition coefficient (log KOW), whereas for fish, C5 and C6 PAEs deviated from the log KOW-toxicity relationship. Longer-chain PAEs (C8-C11) were nontoxic below their solubility limits. Mixture toxicity tests with six shorter-chain PAEs at the equivalent toxic unit (calculated by exposure concentration/50% inhibition concentration) demonstrated good agreement between the observed concentration-response curves and predicted curves using the concentration addition (CA) model across all test organisms. These results provide a practical dataset to assess the mixture toxicity of multiple PAEs as well as insights into the applicability of the CA model to chemical groups based on structural similarities and toxicity profiles.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1247-1258"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of source contributions and seasonal variations on particle-associated polycyclic aromatic hydrocarbons and cancer risks in a rapidly urbanizing South American City (Fortaleza, Brazil). 在一个快速城市化的南美城市，源贡献和季节变化对颗粒相关多环芳烃和癌症风险的影响（巴西福塔莱萨）。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf011

Íthala S Saldanha, Camille A Rocha, Fernanda Pontes, Rafael P Santos, Ronaldo F Nascimento, Ana B Costa, Bruno Bertoncini, Rivelino M Cavalcante

{"title":"Influence of source contributions and seasonal variations on particle-associated polycyclic aromatic hydrocarbons and cancer risks in a rapidly urbanizing South American City (Fortaleza, Brazil).","authors":"Íthala S Saldanha, Camille A Rocha, Fernanda Pontes, Rafael P Santos, Ronaldo F Nascimento, Ana B Costa, Bruno Bertoncini, Rivelino M Cavalcante","doi":"10.1093/etojnl/vgaf011","DOIUrl":"10.1093/etojnl/vgaf011","url":null,"abstract":"Particulate matter (PM) was recently classified as a Group 1 (carcinogen to humans), marking a significant step forward in prioritizing the monitoring of airborne particles in urban environments. In this sense, the primary objective was to evaluate the cancer risk associated with PM10 and polycyclic aromatic hydrocarbons (PAHs) levels, with a focus on the contribution of different source types and seasonal variations in a highly urbanized city located in the tropical semiarid region of South America, where air quality studies and understanding remain scarce. The PM was collected using a Hivol sampler, and the PAHs contained within were extracted using Soxhlet extraction and analyzed by gas chromatograph with mass spectrometery. The PM10 levels ranged from 8.9 to 33.3 µg/m³ and from 17.2 to 33.2 µg/m³, in the rainy and dry season, respectively, while the ΣPAHs ranged from 0.18 to 2.03 ng/m³ (wet season) and from 0.14 to 0.64 ng/m³ (dry season). The ratio of PM10 levels between wet and dry periods remained relatively stable throughout the year, consistently staying below 1 across most parts of the city. However, in areas with higher traffic flow, classified as moderate to deep urban canyon zones, levels were significantly higher during the dry period. The sources appointment indicates that the contribution of the vehicle fleet is geographically predominant, followed by contributions from the burning of coal and wood, and, more succinctly, the influence of the existing industrial sectors in the region. Compared to other urban and industrial regions worldwide, Fortaleza's risk levels are moderate to relatively low. However, the relative cancer risk is approximately 22% higher for smokers compared to nonsmokers.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1378-1388"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of realistic pesticide mixtures on the springtail Folsomia candida. 真实农药混合对假丝叶虫的影响。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf057

Paula S Tourinho, Zuzana Hochmanová, Petr Kukučka, Olukayode Jegede, Vera Silva, Virginia Aparicio, Jakub Hofman

{"title":"Effects of realistic pesticide mixtures on the springtail Folsomia candida.","authors":"Paula S Tourinho, Zuzana Hochmanová, Petr Kukučka, Olukayode Jegede, Vera Silva, Virginia Aparicio, Jakub Hofman","doi":"10.1093/etojnl/vgaf057","DOIUrl":"10.1093/etojnl/vgaf057","url":null,"abstract":"The application of multiple pesticides over the last decades has resulted in their frequent and in some cases long-term presence in soils as complex mixtures. This work assessed the toxicity of realistic pesticide mixtures to the springtail Folsomia candida observed in 11 case study sites. Each mixture was composed of five pesticides (as active substances or metabolites), chosen based on their occurrence in soil and expected risk to soil invertebrates. Reproduction tests were conducted in natural agricultural soil, and the springtails were exposed to three concentrations of the selected pesticides: the median environmental concentration (MEC), the predicted environmental concentration (PEC), and five times PEC (5PEC). No significant effect was observed at MEC exposure in any case study sites; however, effects on reproduction, adult survival, and adult size were observed at PEC and 5PEC exposures in five case study sites. Risk quotients (RQs) of individual pesticides were calculated by dividing the exposure concentrations (MEC, PEC, and 5PEC) by the no observed effect concentration values from the literature, and the sum of the five pesticides was calculated as ∑RQ in each case study site. The toxicity at PEC exposure was higher than expected based on the ∑RQ in two case study sites, indicating a possible synergistic mixture effect. This work provides new information on the effects of realistic pesticide mixtures. Further research is required to clarify whether the current risk assessment of individual pesticides adequately protects soil species from exposure to multiple pesticide residues that may occur in even more complex mixtures.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1347-1356"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The behavioral, physiological, and biochemical responses of Lumbriculus variegatus exposed to cannabidiol and its metabolites. 大麻二酚（CBD）及其代谢物对杂交虫行为、生理生化反应的影响。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf048

Benjamin S Williams, Georgeena Jomy, Megan Flanagan, Julanta J Carriere, Grace E Labdon, Grace S Hawkes, James McRobbie-Aston, Melisa J Wallace, Claire L Price, Nia A Davies, Aidan Seeley

{"title":"The behavioral, physiological, and biochemical responses of Lumbriculus variegatus exposed to cannabidiol and its metabolites.","authors":"Benjamin S Williams, Georgeena Jomy, Megan Flanagan, Julanta J Carriere, Grace E Labdon, Grace S Hawkes, James McRobbie-Aston, Melisa J Wallace, Claire L Price, Nia A Davies, Aidan Seeley","doi":"10.1093/etojnl/vgaf048","DOIUrl":"10.1093/etojnl/vgaf048","url":null,"abstract":"Cannabidiol (CBD) is a major non-psychoactive cannabinoid that has been detected in environmental samples, but the ecotoxicological effects remain unknown. In this study, Lumbriculus variegatus were exposed to CBD and its metabolites 7-hydroxy-cannabidiol (7-OH-CBD) and 7-carboxy-cannabidiol (7-COOH-CBD). In this study, toxicity, tactile stimulation to elicit stereotypical behaviors, and locomotor activity were measured after 24-hr exposure of L. variegatus to CBD and its metabolites. We describe the impacts on dorsal blood vessel pulsation and oxygen consumption after 24-hr exposure to CBD and 7-OH-CBD and the effects on regenerative capacity and total energy reserves after 72 hr of exposure to CBD and 7-OH-CBD. We observed that CBD, 7-OH-CBD, and 7-COOH-CBD displayed toxicity in 50% of test populations at 14.12 µM, 11.29 µM, and 15.36 µM, respectively. A 24-hr exposure to CBD decreased tactile stimulation response to elicit body reversal at ≥ 2.5 µM and helical swimming at ≥ 0.5 µM and reduced locomotor activity. Lumbriculus variegatus oxygen consumption was not affected by CBD, but ≥ 2.5 µM significantly reduced dorsal blood vessel pulse rate. We observed that exposure to 7-OH-CBD did not affect the regenerative capacity of L. variegatus whereas CBD was shown to reduce regeneration. Exposure to CBD also resulted in a significant decrease in carbohydrates, increased lipids, and no effect on protein levels in L. variegatus. We determined that CBD can reduce L. variegatus behaviors, decrease pulse rates and regenerative capacity, and disrupt energy reserves. Our findings show that CBD is toxic to this common aquatic organism and the increased availability and use of CBD and related substances warrants further study of their environmental impact.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1297-1309"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of transcriptomics concentration-response modeling for prioritization of contaminants detected in tributaries of the North American Great Lakes. 转录组学浓度响应模型在北美五大湖支流中检测到的污染物优先级的应用。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf050

Jenna E Cavallin, Kendra Bush, Steve Corsi, Laura DeCicco, Kevin Flynn, Alex Kasparek, Monique Hazemi, Erin Maloney, Peter Schumann, Daniel L Villeneuve

{"title":"Application of transcriptomics concentration-response modeling for prioritization of contaminants detected in tributaries of the North American Great Lakes.","authors":"Jenna E Cavallin, Kendra Bush, Steve Corsi, Laura DeCicco, Kevin Flynn, Alex Kasparek, Monique Hazemi, Erin Maloney, Peter Schumann, Daniel L Villeneuve","doi":"10.1093/etojnl/vgaf050","DOIUrl":"10.1093/etojnl/vgaf050","url":null,"abstract":"As part of the Great Lakes Restoration Initiative, chemical monitoring and surveillance efforts have detected approximately 330 chemicals in surface water of Great Lakes tributaries. There were 140 chemicals for which no empirical toxicity data were available. The aim of this study was to generate transcriptomic points of departure (tPODs) for 10 of these compounds and demonstrate how they could be applied in a screening-level prioritization. Organisms representing three trophic levels of the aquatic food web (Pimephales promelas, Daphnia magna, and Raphidocelis subcapitata) were exposed for 24 hr to a half-log dilution series of nominal exposure concentrations typically ranging from 66.7-0.021 µM of each chemical. In addition to observations of apical effects (e.g., survival and morphology), whole body transcriptomic responses (tPODs) to each chemical were evaluated with targeted analysis using TempO-seq for P. promelas and D. magna and nontargeted RNA-seq for R. subcapitata. The tPODs ranged from 0.18-10.8 µM for P. promelas and 0.32-29 µM for D. magna, with the most potent of the chemicals tested being fipronil carboxamide for both species. For R. subcapitata, the tPODs ranged from 0.04-1.77 µM, with gabapentin as the most potent chemical tested. Empirically derived tPODs from these data-poor chemicals were compared with concentrations detected in the Great Lakes basin. Environmental concentrations were less than the tPODs except for R. subcapitata and 3,4-dichlorophenyl isocyanate. Similarly, tPODs from previously tested data-rich chemicals were compared with environmental concentrations, in which case tPODs from several chemicals overlapped environmental concentrations. This work demonstrates the potential utility of emerging ecological high-throughput transcriptomics assays to support screening and prioritization of data-poor environmental contaminants.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1310-1321"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of omics technology in ecotoxicology of arthropod in farmland. 组学技术在农田节肢动物生态毒理学研究中的应用。

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf040

Zhongyuan Li, Cuimei Gao, Zhuoman Wang, Siqi Huang, Zijian Jiang, Jing Liu, Huilin Yang

{"title":"Application of omics technology in ecotoxicology of arthropod in farmland.","authors":"Zhongyuan Li, Cuimei Gao, Zhuoman Wang, Siqi Huang, Zijian Jiang, Jing Liu, Huilin Yang","doi":"10.1093/etojnl/vgaf040","DOIUrl":"10.1093/etojnl/vgaf040","url":null,"abstract":"Arthropods, abundant in farmland, have unique biological traits that make them valuable for studying the ecotoxicological impacts of pollutants. Recent advancements in multi-omics technologies have enhanced their use in assessing pollution risks and understanding toxicity mechanisms. This article reviews recent developments in applying omics technologies-genomics, transcriptomics, proteomics, metabolomics, and meta-omics-to ecotoxicological research on farmland arthropods. Agricultural arthropods manage genes and proteins, such as metallothioneins, antioxidant enzyme systems, heat shock proteins, cytochrome P450, carboxylesterases, and glutathione S-transferases, for detoxification and antioxidant purposes. They adjust amino acid, sugar, and lipid metabolism to counteract pollutant-induced energy drain and modify gut microbiota to aid in detoxification. This study advocates for enhanced analysis of compound pollution and emerging pollutants using multi-omics, especially meta-omics, to clarify the toxicological mechanisms underlying arthropod responses to these pollutants. Furthermore, it underscores the urgent need for subsequent gene function mining and validation to support biological control strategies and promote sustainable agricultural practices. The findings of this research provide significant insights into the toxicological impacts and mechanisms of pollutants within farmland ecosystems, thereby contributing to the preservation of arthropod diversity.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1187-1208"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metallothionein expression in Eastern mosquitofish (Gambusia holbrooki) exposed to 137Cs and lead: implications for using metallothionein as a metal exposure biomarker. 金属硫蛋白（MT）在137Cs和铅环境下的表达：MT作为金属暴露生物标志物的意义

IF 3.6 4区环境科学与生态学

Environmental Toxicology and Chemistry Pub Date : 2025-05-01 DOI: 10.1093/etojnl/vgaf055

Kathryn A Quinlin, James C Beasley, Xiaoyu Xu

{"title":"Metallothionein expression in Eastern mosquitofish (Gambusia holbrooki) exposed to 137Cs and lead: implications for using metallothionein as a metal exposure biomarker.","authors":"Kathryn A Quinlin, James C Beasley, Xiaoyu Xu","doi":"10.1093/etojnl/vgaf055","DOIUrl":"10.1093/etojnl/vgaf055","url":null,"abstract":"Given the range of threats facing aquatic ecosystems, it is critical we have monitoring tools to quickly and efficiently identify stressors within ecosystems. Metallothionein's (MTs) are a group of proteins widely used as biomarkers of metal exposure; however, their suitability has been questioned due to their influenceable nature and ability to be induced by various stressors. Through our study, we sought to (1) evaluate induction of MT in eastern mosquitofish (Gambusia holbrooki) exposed to a radionuclide (137Cs) and metal (Pb), (2) assess the influence of in situ 137Cs pre-exposure on Pb-induced MT expression, and (3) quantify changes in MT concentrations during Pb depuration. We conducted our experiment in three phases using mosquitofish as a model species: Phase I-pre-exposure to 137Cs in the field, Phase II-exposure to Pb in the lab immediately following 137Cs exposure, and Phase III-depuration in the laboratory. We quantified MT concentrations over time and assessed differences among treatments. We did not find in situ exposure of mosquitofish to 137Cs to induce MT, nor did pre-exposure to 137Cs appear to influence induction of MT following Pb exposure. Metallothionein was rapidly induced in mosquitofish following Pb exposure; however, MT induction was also observed in control fish. Additionally, there was no apparent relationship between MT and Pb body burdens. During depuration, we found MT concentrations to be highly variable among fish demonstrating no clear response. Our study demonstrates the high variability exhibited by MT, the need for further validation of MT as a metal exposure biomarker, and the value in additional research on these proteins under varying exposure scenarios, particularly environmentally realistic concentrations.","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"1322-1333"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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