Environmental Health and Preventive Medicine最新文献

{"title":"Interaction between the oxidative balance score and serum per- and poly-fluoroalkyl substances (PFASs) on liver health: analysis of the NHANES 2007-2018 dataset.","authors":"Ren Zhou, Fei Chen, Lei Zhang, Yu Sun, Hong Jiang, Rong Hu, Jia Yan","doi":"10.1265/ehpm.24-00159","DOIUrl":"10.1265/ehpm.24-00159","url":null,"abstract":"<p><strong>Background: </strong>Per- and poly-fluoroalkyl substances (PFASs) are pervasive synthetic compounds, prompting investigations into their intricate interactions with lifestyle factors and health indicators because of their enduring environmental presence and bioaccumulation. This study aimed to explore the effects of the oxidative balance score (OBS) and PFAS on liver-related indices.</p><p><strong>Methods: </strong>Twenty dietary and lifestyle factors were used to calculate the OBS. The serum concentrations of PFASs were measured, and their sum was calculated for analysis. The levels of liver markers were also evaluated. Linear regression models and interaction analyses were used to assess the associations between OBS, PFAS concentrations, and liver indices.</p><p><strong>Results: </strong>The results revealed an inverse association between high OBS and perfluorooctane sulfonic acid concentration, as well as the sum of PFAS concentrations. OBS was positively associated with liver markers. The PFAS concentrations were positively associated with total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. Interaction analyses revealed significant interactions between OBS and specific PFASs for alkaline phosphatase (interaction P < 0.05). Possible interactions were also found between OBS and specific PFASs for ALT, and AST levels (interaction P < 0.10).</p><p><strong>Conclusions: </strong>This study clarified the association between total PFAS and OBS. This association was significant mainly for diet-related OBS. PFAS and OBS are associated with liver-related indicators in the blood.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"51"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A suspected case of \"itai-itai disease\" in a cadmium-polluted area in Akita prefecture, Japan.","authors":"Toru Sasaki, Hyogo Horiguchi, Takehisa Matsukawa, Momoko Kobayashi, Yuki Omori, Etsuko Oguma, Atsushi Komatsuda","doi":"10.1265/ehpm.24-00063","DOIUrl":"10.1265/ehpm.24-00063","url":null,"abstract":"<p><strong>Background: </strong>Itai-itai disease is the most severe case of chronic cadmium (Cd) toxicity, which was endemic in Cd-polluted areas in the Jinzu River basin in Toyama prefecture, Japan. Akita prefecture also has Cd-polluted areas, but there have been no cases of \"itai-itai disease\".</p><p><strong>Case presentation: </strong>An elderly female farmer with Cd nephropathy residing in a Cd-polluted area in the northern part of the Akita prefecture was identified through hospital-based screening at Akita Rosai Hospital in Odate city. She had chronic renal failure with a high Cd exposure level and advanced renal tubular dysfunction. The shortening of height, bone deformities and fractures, abnormal bone metabolism suggesting osteomalacia, and renal anemia were also noted. Therefore, \"itai-itai disease\", similar to cases in the Jinzu River basin, was suspected.</p><p><strong>Conclusion: </strong>This is the first case of \"itai-itai disease\" in a Cd-polluted area in Akita prefecture.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"40"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral hygiene status and vascular aging in schoolchildren and their mothers.","authors":"Shogo Nakane, Yuki Ito, Kayo Kaneko, Sayaka Kato, Kyoko Minato, Takeshi Ebara, Shinji Saitoh, Mayumi Sugiura-Ogasawara, Yasuyuki Shibuya, Michihiro Kamijima","doi":"10.1265/ehpm.24-00093","DOIUrl":"10.1265/ehpm.24-00093","url":null,"abstract":"<p><strong>Background: </strong>Poor oral hygiene, generally manifesting as dental caries, gingivitis, or periodontitis, is a common chronic condition among both children and adults worldwide and has been reportedly associated with hypertension and arterial stiffness mainly in adult patients. However, these associations have not been well-studied in children and adults in the general population. Therefore, we conducted this cross-sectional study to clarify the associations between oral hygiene indices and high blood pressure (BP)/hypertension and arterial stiffness as assessed by the cardio-ankle vascular index (CAVI) in children along with their mothers. The association between maternal oral hygiene and high BP in children was also examined based on the hypothesis that maternal awareness of oral hygiene is related to their children's oral hygiene.</p><p><strong>Methods: </strong>This study was conducted as an Adjunct Study of the Aichi Regional Sub-Cohort of the Japan Environment and Children's Study. Participating children (n = 220, 85-104 months old) and their mothers (n = 217, 29-52 years old) underwent dental/intra-oral examination and BP and CAVI assessment. High BP in children and hypertension in mothers were diagnosed according to corresponding American guidelines. Logistic regression analysis or analysis of covariance was used to examine the associations of poor oral hygiene indices with BP and CAVI.</p><p><strong>Results: </strong>Maternal dental caries ≥1 was associated with their hypertension (adjusted odds ratio [aOR]: 2.72, 95% confidence interval (CI): 1.12-6.61). Maternal dental plaque ≥1/3 was associated with maternal hypertension and children's high BP (aOR, 95% CI: 4.71, 1.33-16.73 and 5.67, 1.22-25.04, respectively). Maximum pocket depth ≥4 mm was associated with children's high BP (aOR: 6.85, 95% CI: 1.24-38.01). No associations were observed between oral hygiene indices and CAVI in children; however, there was a significant association between dental plaque and CAVI in mothers (F = 5.62, p < 0.01).</p><p><strong>Conclusions: </strong>The small sample size, especially the case number, made it necessary to refrain from drawing unambiguous conclusion. The hypothesis that warrants further investigation based on the present study results is that poor oral hygiene is associated with high BP in children and hypertension and arterial stiffness in mothers, and maternal oral hygiene is associated with high BP in children.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"42"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mammographic density and exposure to air pollutants in premenopausal women: a cross-sectional study.","authors":"Tamara Jiménez, Alejandro Domínguez-Castillo, Nerea Fernández de Larrea-Baz, Pilar Lucas, María Ángeles Sierra, Sergio Maeso, Rafael Llobet, Marina Nieves Pino, Mercedes Martínez-Cortés, Beatriz Pérez-Gómez, Marina Pollán, Virginia Lope, Javier García-Pérez","doi":"10.1265/ehpm.24-00209","DOIUrl":"10.1265/ehpm.24-00209","url":null,"abstract":"<p><strong>Background: </strong>Mammographic density (MD) is a well-established risk factor for breast cancer. Air pollution is a major public health concern and a recognized carcinogen. We aim to investigate the association between MD and exposure to specific air pollutants (SO₂, CO, NO, NO₂, NO_x, PM_2.5, PM₁₀, and O₃) in premenopausal females.</p><p><strong>Methods: </strong>This cross-sectional study, carried out in Spain, included 769 participants who attended their gynecological examinations. Hourly concentrations of the pollutants were extracted from the Air Quality Monitoring System of Madrid City over a 3-year period. Individual long-term exposure to pollutants was assessed by geocoding residential addresses and monitoring stations, and applying ordinary kriging to the 3-year annual mean concentrations of each pollutant to interpolate the surface of Madrid. This exposure variable was categorized into quartiles. In a first analysis, we used multiple linear regression models with the log-transformed percent MD as a continuous variable. In a second analysis, we used MD as a dichotomous variable (\"high\" density (MD > 50%) vs. \"low\" density (MD ≤ 50%)) and applied multiple logistic regression models to estimate odds ratios (ORs). We also analyzed the correlation among the pollutants, and performed a principal component analysis (PCA) to reduce the dimensionality of this set of eight correlated pollutants into a smaller set of uncorrelated variables (principal components (PCs)). Finally, the initial analyses were applied to the PCs to detect underlying patterns of emission sources.</p><p><strong>Results: </strong>The first analysis detected no association between MD and exposure to any of the pollutants. The second analysis showed non-statistically significant increased risks (OR_Q4; IC95%) of high MD were detected in women with higher exposure to SO₂ (1.50; 0.90-2.48), and PM_2.5 (1.27; 0.77-2.10). In contrast, non-significant ORs < 1 were found in all exposure quartiles for NO (OR_Q2 = 0.72, OR_Q3 = 0.68, OR_Q4 = 0.78), and PM₁₀ (OR_Q2 = 0.69, OR_Q3 = 0.82, OR_Q4 = 0.72). PCA identified two PCs (PC1: \"traffic pollution\" and PC2: \"natural pollution\"), and no association was detected between MD and proximity to these two PCs.</p><p><strong>Conclusions: </strong>In general, our results show a lack of association between residential exposure to specific air pollutants and MD in premenopausal females. Future research is needed to confirm or refute these findings.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"65"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of heat waves and cold spells on blood parameters: a cohort study of blood donors in Tianjin, China.","authors":"Yutong Gao, Yifan Liu, Jiayu He, Yin Zhang, Ting Wang, Lin Wu, Naixiu Sun, Tiange Fang, Hongjun Mao, Nai-Jun Tang, Xi Chen","doi":"10.1265/ehpm.24-00023","DOIUrl":"https://doi.org/10.1265/ehpm.24-00023","url":null,"abstract":"<p><strong>Background: </strong>With the increasing occurrence of extreme temperature events due to climate change, the attention has been predominantly focused on the effects of heat waves and cold spells on morbidity and mortality. However, the influence of these temperature extremes on blood parameters has been overlooked.</p><p><strong>Methods: </strong>We conducted a cohort study involving 2,752 adult blood donors in Tianjin, China, between January 18, 2013, and June 25, 2021. The generalized additive mixed model was used to investigate the effects and lagged effects of heat waves and cold spells on six blood parameters of blood donors, including alanine aminotransferase (ALT), white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HB), hematocrit (HCT), and platelet count (PLT). Subgroup analyses were stratified by sex, age, and BMI.</p><p><strong>Results: </strong>Heat waves and cold spells are associated with changes in blood parameters, particularly HB and PLT. Heat waves increased HB and PLT, while cold spells increased HB and decreased PLT. The effect of heat waves is greater than that of cold spells. The largest effect of heat waves on HB and PLT occurred at lag1 with 2.6 g/L (95% CI: 1.76 to 3.45) and lag7 with 9.71 × 10^9/L (95% CI: 6.26 to 13.17), respectively, while the largest effect of cold spells on HB and PLT occurred at lag0 with 1.02 g/L (95% CI: 0.71 to 1.33) and lag2 with -3.85 × 10^9/L (95% CI: -5.00 to -2.70), respectively. In subgroup analysis, the effect of cold spells on ALT was greater in the 40-49 age group.</p><p><strong>Conclusion: </strong>We indicated that heat waves and cold spells can impact hemoglobin and platelet counts in the human body. These findings provide evidence linking heat waves or cold spells to diseases and may reduce health risks caused by extreme temperature events.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"25"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between stair climbing and modifiable cardiovascular disease risk factors: the Suita Study.","authors":"Ahmed Arafa, Yuka Yasui, Yuka Kato, Chisa Matsumoto, Yoshihiro Kokubo","doi":"10.1265/ehpm.23-00323","DOIUrl":"10.1265/ehpm.23-00323","url":null,"abstract":"<p><strong>Background: </strong>Stair climbing is a readily available form of physical activity with potential cardiovascular benefits. This study aimed to investigate the association between stair climbing and numerous modifiable cardiovascular disease (CVD) risk factors.</p><p><strong>Methods: </strong>In this cross-sectional study, we used data from 7282 Japanese people (30-84 years) residing in Suita City, Osaka. CVD risk factors and stair climbing frequency were assessed during the Suita Study health examination. Logistic regressions were used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for CVD risk factors across stair climbing frequencies.</p><p><strong>Results: </strong>After adjustment for age, sex, lifestyle, and medical conditions, stair climbing >60% of the time, compared to <20% of the time, was inversely associated with obesity, smoking, physical inactivity, and stress: ORs (95% CIs) = 0.63 (0.53, 0.75), 0.81 (0.69, 0.96), 0.48 (0.41, 0.55), and 0.67 (0.58, 0.78), respectively (p-trends < 0.05).</p><p><strong>Conclusion: </strong>Stair climbing was inversely associated with obesity, smoking, physical inactivity, and stress; suggesting a potential role for cardiovascular disease prevention.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"26"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11111291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in vascular dehydration risk: insights from the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) study.","authors":"Tomofumi Nishikawa, Naomi Miyamatsu, Aya Higashiyama, Yoshimi Kubota, Yoko Nishida, Takumi Hirata, Aya Hirata, Junji Miyazaki, Daisuke Sugiyama, Kazuyo Kuwabara, Sachimi Kubo, Yoshihiro Miyamoto, Tomonori Okamura","doi":"10.1265/ehpm.24-00132","DOIUrl":"10.1265/ehpm.24-00132","url":null,"abstract":"<p><strong>Background: </strong>Dehydration, a risk factor for ischemic cerebrovascular diseases, is common in summer; however, the incidence of ischemic diseases is not necessarily higher in summer. Therefore, this study aimed to clarify the relationships between serum osmolarity, hematocrit, daily non-alcohol drink (NAD) intake and factors such as season and age as risk factors for dehydration.</p><p><strong>Method: </strong>Participants (703 women and 306 men) in the follow-up survey, in 2012 and 2013, of the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) Study, consisting of healthy individuals living in Kobe, Japan, were categorized into two groups based on the examination month: the warmer and colder seasons. Multivariate analyses were conducted to examine disparities in serum osmolarity, hematocrit, and NAD intake between these two groups.</p><p><strong>Results: </strong>The colder season was found to be negatively correlated with serum osmolarity and NAD intake, but positively correlated with hematocrit, even after adjusting for relevant factors. Age was independently associated with serum osmolarity, but not with hematocrit and NAD intake.</p><p><strong>Conclusions: </strong>This study suggests that intra-vascular volume depletion is more likely in the colder season despite lower serum osmolarity compared to the warmer season. Age-related increases in serum osmolarity without a corresponding rise in water intake may contribute to this. These findings support the importance of addressing dehydration in the colder season, particularly in older adults.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"62"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear isomer but not branched isomers of perfluorooctane sulfonate in plasma is associated with eicosapentaenoic acid, a seafood consumption biomarker.","authors":"Zhaoqing Lyu, Kouji H Harada, Mariko Harada Sassa, Yukiko Fujii","doi":"10.1265/ehpm.24-00140","DOIUrl":"10.1265/ehpm.24-00140","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS) are global contaminants. Seafood consumption is a possible PFAS exposure route to humans while the isomer specific analysis has not been conducted.</p><p><strong>Methods: </strong>Perfluorooctane sulfonate (PFOS), perfluoroheptane sulfonate (PFHpS) and perfluorohexane sulfonate (PFHxS) were investigated in residents of Kyoto, Japan (n = 51). The relationship between plasma PFAS and seafood consumption biomarker, the ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA) was examined by multiple regression analysis.</p><p><strong>Results: </strong>Linear PFOS concentrations showed a significant positive correlation with the EPA/AA ratio in plasma samples (β = 6.80, p = 0.0014). Linear PFHpS was marginally associated with EPA/AA ratio (β = 0.178, p = 0.0874). Branched PFOS isomers and PFHxS had no associations with EPA/AA ratios.</p><p><strong>Conclusion: </strong>Seafood intake may be a significant exposure pathway for PFAS, such as PFOS but the isomers differ.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"35"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between working hours and sleep quality with consideration to effect modification by work style: a community-based cross-sectional study.","authors":"Aya Yoshida, Keiko Asakura, Haruhiko Imamura, Sachie Mori, Minami Sugimoto, Takehiro Michikawa, Yuji Nishiwaki","doi":"10.1265/ehpm.23-00252","DOIUrl":"10.1265/ehpm.23-00252","url":null,"abstract":"<p><strong>Background: </strong>Although longer working hours are associated with lower sleep quality, it is still necessary to work a certain number of hours to make a living. In this study, we investigated the relationship between working hours and sleep quality in a community setting. We then explored how to manage work style while maintaining the sleep quality of workers without markedly reducing working hours.</p><p><strong>Methods: </strong>4388 day-time workers in various occupations living in Ota ward in Tokyo were included in the analysis. The relationship between working hours and sleep quality measured by the Athens Insomnia Scale was examined by ANOVA and linear regression models. Effect modification by work style (work end time, shift in working start and end time, current work from home status, change in work place) on the relationship between working hours and sleep quality was investigated by multivariate linear regression models.</p><p><strong>Results: </strong>Longer working hours were significantly associated with lower sleep quality. The magnitude of the relationship between long working hours and low sleep quality was significantly larger when work end time was later (p for trend of interaction < 0.01) and when working start and end time were shifted later (vs no change, p for interaction = 0.03). The relationship was marginally greater when the proportion of work from home was increased (vs no change, p for interaction = 0.07).</p><p><strong>Conclusions: </strong>A relationship between longer working hours and lower sleep quality was observed among workers. Leaving work earlier or optimizing the work environment at home may diminish the adverse effect of long working hours on sleep quality.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"19"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gabapentin improves neuropathic pain in Minamata disease model rats.","authors":"Masatake Fujimura","doi":"10.1265/ehpm.24-00035","DOIUrl":"10.1265/ehpm.24-00035","url":null,"abstract":"<p><strong>Background: </strong>Methylmercury (MeHg), the causative agent of Minamata disease, damages the cranial nervous system and causes specific sensory disturbances, especially hypoesthesia, in the extremities. However, recent reports demonstrate that patients with chronic Minamata disease conversely develop neuropathic pain in the lower extremities. Studies on our established Minamata disease model rats showed that MeHg-mediated neurodegeneration might induce neuropathic pain by over time through inducing rewiring with neuronal activation in the somatosensory cortex via microglial activation in the spinal dorsal horn.</p><p><strong>Methods: </strong>In this study, the effects of gabapentin, a potentially effective treatment for neuropathic pain, was evaluated using this Minamata disease model rats. To further elucidate the mechanism of its medicinal effects, histochemical and biochemical analyses of the nervous system of Minamata disease model rats were conducted.</p><p><strong>Results: </strong>Gabapentin treatment restored the reduction in the pain threshold caused by MeHg exposure in rats. Histochemical and biochemical analyses revealed that gabapentin showed no effect on MeHg-induced neurodegeneration in entire nervous system and microglial activation in the spinal dorsal horn. However, it was shown that gabapentin may reduce excessive synaptogenesis through its antagonist action on the alpha2-delta-1 subunit of calcium channels in the somatosensory cortex.</p><p><strong>Conclusions: </strong>These results indicate that gabapentin may alleviated neuropathic pain in MeHg poisoning, as typified by Minamata disease, by reversibly modulation synaptic rewiring in the somatosensory cortex.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"31"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}