Environmental Health and Preventive Medicine最新文献

{"title":"Is Japan at low risk for PFAS immunotoxicity?: human biomonitoring study in contaminated areas in Japan.","authors":"Zhaoqing Lyu, Kouji H Harada, Junko Kimura-Kuroda, Yasuharu Tokuda","doi":"10.1265/ehpm.24-00047","DOIUrl":"10.1265/ehpm.24-00047","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS) are now considered global contaminants posing health risks. Recent human biomonitoring data in Japan are presented.</p><p><strong>Methods: </strong>Human biomonitoring data from Japan, dating back to 2000, were reviewed. In addition, 399 serum samples collected in a primary care clinic in Urayasu City, Okinawa Island-one of the highest PFAS-exposed areas in Japan-between 2021 and 2022 were analyzed. Serum levels of four PFAS were compared with risk levels based on the assessment by Sonne et al. and the European Food Safety Agency.</p><p><strong>Results: </strong>The PFAS levels in the general population from various areas other than Hokkaido (16.1-43.5 ng/mL) are classified at moderate to severe risk for immunotoxicity based on the assessment.</p><p><strong>Conclusions: </strong>A portion of the Japanese population has had high exposure to PFAS and was at high risk of immunotoxicity, and this situation remained in PFAS-contaminated areas in the 2020s.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"37"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between blood cadmium and depression varies by age and smoking status in US adult women: a cross-sectional study from NHANES 2005-2016.","authors":"Yewei Ji, Jinmin Wang","doi":"10.1265/ehpm.24-00050","DOIUrl":"10.1265/ehpm.24-00050","url":null,"abstract":"<p><strong>Background: </strong>Cadmium, a toxic metal, is widely encountered in diverse environmental contexts. Despite its pervasive exposure, there is limited research on the association between blood cadmium levels and depression, especially among females. This study aimed to investigate the relationship between blood cadmium levels and depression in adult women.</p><p><strong>Methods: </strong>Data spanning 2005-2016 from the National Health and Nutrition Examination Survey (NHANES) were selected. Depression was diagnosed with the Patient Health Questionnaire (PHQ-9, score ≥10). Multiple logistic regression, multiple linear regression, and smoothed curve fitting were used to investigate the relationship between blood cadmium and depression. Subgroup analyses and interaction tests were performed to evaluate the stability of this association across populations.</p><p><strong>Results: </strong>A total of 1,173 individuals were diagnosed with depression. The heightened prevalence of depression was linked to increased blood cadmium levels, a trend that persisted even after quartering blood cadmium. In the fully adjusted model, each incremental unit of blood cadmium was associated with a 33% rise in the prevalence of depression (OR = 1.33, 95% CI: 1.21-1.45). Participants in the highest quartile were 63% more likely to experience depression compared to those in the lowest quartile of blood cadmium (OR = 1.63, 95% CI: 1.15-2.30), and PHQ-9 score increased by 0.73 (β = 0.73, 95% CI: 0.30-1.17). This positive association may be relevant to the general population.</p><p><strong>Conclusions: </strong>Blood cadmium levels are associated with depression in adult women, and this association varies by age and smoking status.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"32"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal for nationwide registration of injuries or fatalities in wheelchair user motor vehicle passengers in Japan.","authors":"Masahito Hitosugi, Ayumu Kuwahara, Mami Nakamura","doi":"10.1265/ehpm.24-00160","DOIUrl":"10.1265/ehpm.24-00160","url":null,"abstract":"<p><p>One consequence of population aging is an increase in the number of older wheelchair users. They often board the motor vehicle from the rear for moving. Recently, wheelchair user vehicle passengers have involved in motor vehicle collisions and died. A three-point seatbelt does not adequately fit most wheelchair user passengers because of the way that the wheelchair is constructed. Therefore, owing to the movement of the body immediately after the collision, the wheelchair user passengers attacked their body to the interior of the vehicle or suffered from the intrusion of the lap belt into the abdomen, subsequently suffered from severe head, chest or abdominal injuries. According to the review of all fatal motor vehicle collisions in Shiga Prefecture, Japan, which has a population of approximately 1.4 million, from 2017 to 2022, the rate of wheelchair users in fatal motor vehicle passenger increased from 3.6% in 2017 to 2019 to 7.8% in 2020 to 2022. Therefore, there is a risk that substantial numbers of wheelchair user passengers involved in motor vehicle collisions will die. However, in Japan, there are no official statistics on the involvement of wheelchair user passengers in motor vehicle collisions. Therefore, we propose a nationwide registration of injuries and fatalities in wheelchair user passengers. Investigating the mechanisms of injury in wheelchair user passengers would contribute to the development of safety measures, especially for restraint systems. Established preventive measure would contribute to the decrease of fatally or severely injured motor vehicle collision passengers.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"45"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial light at night and risk of depression: a systematic review and meta-analysis.","authors":"Manman Chen, Yuankai Zhao, Qu Lu, Zichen Ye, Anying Bai, Zhilan Xie, Daqian Zhang, Yu Jiang","doi":"10.1265/ehpm.24-00257","DOIUrl":"10.1265/ehpm.24-00257","url":null,"abstract":"<p><strong>Background: </strong>Artificial light at night (ALAN) has been increasingly recognized as a potential environmental risk factor for mental health issues. However, no meta-analyses have been conducted to summarize the findings. This study aimed to evaluate the pooled associations between outdoor and indoor ALAN exposures and the risk of depression.</p><p><strong>Methods: </strong>Adhering to the PRISMA guideline, we conducted systematic searches across PubMed, Web of Science, EMBASE, Cochrane, and Ovid databases for studies published before May 1st, 2024.</p><p><strong>Results: </strong>A total of 7 studies (5 for outdoor ALAN and 2 for indoor ALAN) with a combined total of 560,219 participants were included in the meta-analysis. Specifically, a 1 nW/cm²/sr increase in outdoor ALAN was associated with a 0.43% (95% CI: 0.21%, 0.65%) increase in depression risk. Meanwhile, a 1 lux increase in indoor ALAN was associated with a 3.29% (95% CI: 0.85%, 5.79%) increase in depression risk. No potential heterogeneity was observed for outdoor ALAN exposure and indoor ALAN exposure. Subgroup analyses for outdoor ALAN indicated that development level, sample size, age group, sex, study design, modality of depression assessment, or adjustment of sleep-related variables in models may not be potential sources of heterogeneity. Sensitivity analyses confirmed the robustness of the findings, while evidence of publication bias was observed for studies on outdoor ALAN.</p><p><strong>Conclusions: </strong>Our findings suggest that both outdoor and indoor ALAN exposures are associated with increased risk of depression. These results underscore the importance of considering outdoor and indoor ALAN in public health strategies aimed at reducing depression risk. Nevertheless, further studies with prospective design are still warranted considering the limited study numbers.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"73"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a test battery for workers' well-being: the first wave of the Tsukuba Salutogenic Occupational Cohort Study.","authors":"Shotaro Doki, Daisuke Hori, Tsukasa Takahashi, Kei Muroi, Mami Ishitsuka, Asako Matsuura, Hotaka Tsukada, Wakako Migaki, Norishige Kanai, Yu Ikeda, Soshi Takao, Ichiyo Matsuzaki, Shin-Ichiro Sasahara","doi":"10.1265/ehpm.23-00372","DOIUrl":"10.1265/ehpm.23-00372","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been a diversification of working styles. The concept of workers' well-being is no longer limited to material wealth, such as how satisfied they are with their wages. Psychological enrichment, encompassing factors like motivation and interpersonal relationships, is also important. This study was established to develop a scale to evaluate the well-being of workers, named the Abundance Index for Workers (AIW). This new concept proposed by the authors comprehensively considers both job-related resources and personal and societal resources.</p><p><strong>Methods: </strong>This study was carried out as part of the Tsukuba Salutogenic Occupational Cohort Study (T-SOCS). We utilized data from a survey targeting workers affiliated with institutions under the Tsukuba Science City Network, examining aspects of their daily life, work, and mental health. The deviation scores for each survey item were averaged to calculate an overall score. The correlations of the comprehensive score with the Patient Health Questionnaire-9 (PHQ-9) index for depression and the Single-item Presenteeism Question (SPQ) index for presenteeism were analyzed to determine criterion-related validity.</p><p><strong>Results: </strong>The number of participants analyzed was 2,745. Factor analysis categorized the data into three factors: workplace mental health, societal resources, and lifestyle habits. Cronbach's α coefficient was 0.688. There were correlations of -0.363 (p < 0.001) between the total score and SPQ, and -0.558 (p < 0.001) between the total score and PHQ-9, suggesting a degree of criterion-related validity.</p><p><strong>Conclusions: </strong>In this study, we designed a test battery that assesses workers' well-being based on job-related resources and the richness of societal resources. The internal consistency of this battery was not as high as expected due to the broad scope of well-being. Although it is difficult to evaluate workers' well-being on a single scale, we believe that the AIW functions well as a test battery by combining scales with different attributes, which enables well-being to be captured from as many different perspectives as possible. This tool is designed to assist individuals in evaluating their own well-being and recognizing factors that can enhance it.</p><p><strong>Trial registration: </strong>Not applicable; this study is not an intervention trial.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"39"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration and mortality in patients with chronic noncommunicable disease: a population-based cohort study.","authors":"Lin Wu, Ruyi Chen, Yuqin Zhang, Huiying Pan, Ying Wang, Xiaowen Wang","doi":"10.1265/ehpm.23-00249","DOIUrl":"10.1265/ehpm.23-00249","url":null,"abstract":"<p><strong>Background: </strong>Inadequate sleep behaviors may confer a higher risk of premature death, however, evidence in patients with chronic noncommunicable disease (NCD) is scarce. To investigate the relationship between sleep duration and mortality from all-cause and heart diseases in NCD patients from a prospective cohort.</p><p><strong>Methods: </strong>Totally, 14,171 participants with at least one NCD, including 8275 with hypertension, 7547 with high cholesterol, 4065 with diabetes, and 5815 with chronic renal failure were enrolled from the National Health and Nutrition Examination Survey during 2005-2014. Cox proportional hazard models were performed to estimate the hazard ratio (HR) for sleep duration and mortality after adjusting for potential confounding factors.</p><p><strong>Results: </strong>After a median follow-up of 9 years, 2514 all-cause deaths were identified. Compared with sleeping 7-8 h/day, sleeping over 8 h/day was significantly associated with a higher risk of all-cause mortality, where the multivariable-HRs were 1.29 (1.11, 1.50) for hypertension, 1.23 (1.01, 1.51) for high cholesterol, 1.44 (1.13, 1.82) for diabetes, and 1.36 (1.10, 1.68) for chronic renal failure. Similar patterns were observed for heart disease mortality. A nonlinear association was detected between sleep duration and mortality in patients with NCD. Age modified the association in patients with hypertension (P-interaction: 0.036). Trouble sleeping modified the association in patients with diabetes (P-interaction: 0.042).</p><p><strong>Conclusions: </strong>Long sleep duration was associated with higher risks of all-cause and heart disease mortality in patients with chronic NCD. Our findings highlight that improving sleep behaviors may decrease the risk of premature deaths and help to NCD tertiary prevention.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"9"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Comparison of the inward leakage rate between N95 filtering facepiece respirators and modified surgical masks during the COVID-19 pandemic.","authors":"Kazunari Onishi, Masanori Nojima","doi":"10.1265/ehpm.24-00196","DOIUrl":"10.1265/ehpm.24-00196","url":null,"abstract":"","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"38"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the feasibility of using toenails as biomarkers for estimating inorganic arsenic exposure in Japanese adults.","authors":"Tomoko Oguri, Naohide Shinohara, Shoji F Nakayama","doi":"10.1265/ehpm.24-00073","DOIUrl":"10.1265/ehpm.24-00073","url":null,"abstract":"<p><strong>Background: </strong>Long-term exposure to inorganic arsenic (InAs) through arsenic (As)-contaminated drinking water poses serious health risks. However, epidemiological studies focusing on low-level dietary exposure to InAs are lacking. Furthermore, although toenail clippings are used as biomarkers for assessing As exposure in areas with contaminated drinking water, to date, no method has been developed for using toenails as a biomarker of long-term InAs exposure in individuals with lower exposure levels, e.g., from dietary sources including fish and seaweeds. Therefore, this study aimed to assess the feasibility of using toenails as biomarkers for estimating InAs exposure in Japanese adults.</p><p><strong>Methods: </strong>Three sets of 7-day diet records and toenail clipping samples were collected from 39 healthy adult participants at intervals of 1-6 months over 4-8 months, spanning from June 2019 to March 2020. The analysis sample sets comprised 113 sample sets obtained from 38 subjects: 56 samples from 19 males and 57 samples from 19 females. The speciation of As species in the toenail samples was performed using high-performance liquid chromatography-inductively coupled plasma mass spectrometry. The sum of the InAs and monomethylarsonic acid (MMA) or sum of As species (sum-As) concentrations in toenail samples was used as an index of InAs exposure.</p><p><strong>Results: </strong>The geometric mean (GM) concentration of InAs + MMA or sum-As in toenails was 0.180 µg As/g or 0.284 µg As/g. The estimated GM of daily dietary InAs exposure was 0.147 µg/kg/day. Log-transformed InAs + MMA or sum-As concentrations in toenails did not predict dietary InAs exposure levels from rice and hijiki consumption in both males and females. Similarly, toenail InAs + MMA or sum-As concentrations showed no correlation with dietary InAs exposure levels from rice or hijiki consumption.</p><p><strong>Conclusions: </strong>Our findings indicate that human toenail clippings are not a suitable biomarker for assessing long-term InAs exposure levels in Japanese individuals based on the observed range of InAs and its metabolite concentrations in toenails.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"59"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long working hours and preventive oral health behaviors: a nationwide study in Korea (2007-2021).","authors":"Seong-Uk Baek,Jin-Ha Yoon,Yu-Min Lee,Jong-Uk Won","doi":"10.1265/ehpm.24-00102","DOIUrl":"https://doi.org/10.1265/ehpm.24-00102","url":null,"abstract":"BACKGROUNDThis study explored the association between working hours and preventive oral health behaviors.METHODSIn total, 48,599 workers (22,992 females) were included from the Korea National Health and Nutrition Examination Survey (2007-2021). Weekly working hours were self-reported. The following three preventive oral health behaviors were set as outcomes: participation in annual dental check-ups; adherence to the recommended toothbrushing frequency (≥twice a day); and use of interdental cleaning devices. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression.RESULTSIn male workers, the adjusted OR (95% CI) of the association between working ≥55 h/week and each outcome was 0.84 (0.77-0.92) for dental check-ups, 0.82 (0.72-0.94) for toothbrushing ≥twice a day, and 0.83 (0.76-0.92) for utilization of interdental cleaning device when compared to 35-40 h/week. In female workers, the adjusted OR (95% CI) of the association between working ≥55 h/week and each outcome was 0.79 (0.70-0.89) for dental check-ups, 0.88 (0.70-1.11) for toothbrushing ≥twice a day, and 0.80 (0.71-0.90) for utilization of interdental cleaning device when compared to 35-40 h/week. Additionally, low socio-economic status, such as low educational attainment, low income level, and blue-collar occupations, were major risk factors associated with non-adherence to preventive oral health behaviors in both male and female workers.CONCLUSIONSOur study suggests that individuals who work long hours are more likely to exhibit undesirable oral health behaviors.","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"57 1","pages":"48"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of hub genes and key pathways in arsenic-treated rice (Oryza sativa L.) based on 9 topological analysis methods of CytoHubba.","authors":"Zhen Yu, Rongxuan Wang, Tian Dai, Yuan Guo, Zanxuan Tian, Yuanyuan Zhu, Juan Chen, Yongjian Yu","doi":"10.1265/ehpm.24-00095","DOIUrl":"10.1265/ehpm.24-00095","url":null,"abstract":"<p><strong>Background: </strong>Arsenic is a toxic metalloid that can cause acute and chronic adverse health problems. Unfortunately, rice, the primary staple food for more than half of the world's population, is generally regarded as a typical arsenic-accumulating crop plant. Evidence indicates that arsenic stress can influence the growth and development of the rice plant, and lead to high concentrations of arsenic in rice grain. But the underlying mechanisms remain unclear.</p><p><strong>Methods: </strong>In the present research, the possible molecules and pathways involved in rice roots in response to arsenic stress were explored using bioinformatics methods. Datasets that involving arsenic-treated rice root and the \"study type\" that was restricted to \"Expression profiling by array\" were selected and downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between the arsenic-treated group and the control group were obtained using the online web tool GEO2R. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed to investigate the functions of DEGs. The protein-protein interactions (PPI) network and the molecular complex detection algorithm (MCODE) of DEGs were analyzed using STRING and Cystoscope, respectively. Important nodes and hub genes in the PPI network were predicted and explored using the Cytoscape-cytoHubba plug-in.</p><p><strong>Results: </strong>Two datasets, GSE25206 and GSE71492, were downloaded from Gene Expression Omnibus (GEO) database. Eighty common DEGs from the two datasets, including sixty-three up-regulated and seventeen down-regulated genes, were then selected. After functional enrichment analysis, these common DEGs were enriched mainly in 10 GO items, including glutathione transferase activity, glutathione metabolic process, toxin catabolic process, and 7 KEGG pathways related to metabolism. After PPI network and MCODE analysis, 49 nodes from the DEGs PPI network were identified, filtering two significant modules. Next, the Cytoscape-cytoHubba plug-in was used to predict important nodes and hub genes. Finally, five genes [Os01g0644000, PRDX6 (Os07g0638400), PRX112 (Os07g0677300), ENO1(Os06g0136600), LOGL9 (Os09g0547500)] were verified and could serve as the best candidates associated with rice root in response to arsenic stress.</p><p><strong>Conclusions: </strong>In summary, we elucidated the potential pathways and genes in rice root in response to arsenic stress through a comprehensive bioinformatics analysis.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"41"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}