Environmental Health and Preventive Medicine最新文献

{"title":"Association of mixed polycyclic aromatic hydrocarbons exposure with cardiovascular disease and the mediating role of inflammatory indices in US adults.","authors":"Tingwei Du, Xiaoli Shen, Runqing Zhan","doi":"10.1265/ehpm.24-00091","DOIUrl":"10.1265/ehpm.24-00091","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is the leading cause of death worldwide. Few studies have investigated the effects of mixed polycyclic aromatic hydrocarbon (PAH) exposure on CVD prevalence. We aimed to evaluate the association between mixed PAHs exposure and CVD and determine the extent to which these links are mediated by inflammatory indices.</p><p><strong>Methods: </strong>We used National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2016. Adults with a diagnosis of CVD and seven monohydroxylated PAH metabolites (OH-PAHs) in their urine samples were included. Multivariate logistic regression and Bayesian kernel machine regression (BKMR) models were used to estimate the association between single and mixed PAHs exposure and CVD. Mediation analysis was used to evaluate the mediating effect of inflammatory indices on the association between PAHs mixtures and CVD.</p><p><strong>Results: </strong>Here, 9136 individuals were included and 10.5% had CVD. Multivariate logistic regression analysis with all the OH-PAHs included that 2-hydroxyfluorene was found positively associated with increased odds of CVD. The BKMR analysis revealed that the overall effect of the seven PAH mixtures was positively associated with CVD. The univariate exposure-response function showed that 2-hydroxyfluorene was positively associated with CVD. Moreover, mediation analysis demonstrated that neutrophil-to-lymphocyte ratio and systemic immune inflammation index mediated the association between PAHs and CVD.</p><p><strong>Conclusions: </strong>Our findings highlight the complexity of the association between mixed PAHs exposure and CVD. At the same time, our study provides insight into the potential mechanisms of inflammation as a mediator between exposure to PAH mixtures and CVD.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"70"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long Internet use during pregnancy and low birth weight: a retrospective cohort study.","authors":"Aya Sakakihara, Chiyori Haga, Aya Kinjo, Yoneatsu Osaki","doi":"10.1265/ehpm.24-00279","DOIUrl":"10.1265/ehpm.24-00279","url":null,"abstract":"<p><strong>Background: </strong>Low birth weight (LBW) is an important public health issue that affects development and health over a long period. However, there has been no sufficient decrease in the prevalence of LBW, and it is important to identify preventable factors for LBW which remain to be clarified. The purpose of this study was to clarify the association between Internet use for many hours during pregnancy and LBW.</p><p><strong>Methods: </strong>The subjects were mothers who had submitted the pregnancy notification form in Matsue City between April 2016 and September 2017 and their children. The data provided by Matsue City authorities consisted of 2,465 records. We analyzed 2,089 records, excluding untraceable records, those with insufficient information, those on multiple pregnancy, and those on pregnant smokers. Logistic regression analysis was performed using LBW as a dependent variable, Internet use for many hours during pregnancy as an independent variable, and the child's sex, mother's age at the time of pregnancy, unmarried status on pregnancy, first childbirth, mother's job during pregnancy, and weeks of pregnancy on the notification as covariates.</p><p><strong>Results: </strong>The results of analysis showed that Internet use for many hours during pregnancy accounted for 4.4%, and that LBW accounted for 7.2%. Internet use for many hours during pregnancy was associated with LBW (adjusted odds ratio = 2.16 (95%CI: 1.13-4.13)).</p><p><strong>Conclusions: </strong>This study suggested that there is an association between Internet use for many hours during pregnancy and LBW. It is necessary to provide appropriate support to pregnant women who use the Internet for many hours during pregnancy after confirming the presence or absence of risk factors for LBW.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"72"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Suicide-Risk Factor - Data Query Tool (SURF-DQT): easy and handy access to the exhaustive base of highest evidence suicide risk factors.","authors":"C-E Notredame, M Ford, N Jabari, O Bhuiyan, S Richard-Devantoy","doi":"10.1265/ehpm.24-00113","DOIUrl":"10.1265/ehpm.24-00113","url":null,"abstract":"<p><p>The extensive number of publications on suicide risk factors presents a practical challenge for clinicians, policy makers, and researchers to translate the research findings from academia to the improvement of individual suicide predictions and collective prevention. The Suicide Risk-Factor - Data Query Tool (SURF-DTQ) is a web application that collates organized data and helps with meta-analysis of suicidality data. Through a process of systematic review of literature according to PRISMA standards, screening and extracting studies with designs of a high level of evidence, and multi-level data synthesis, information is presented in the SURF database in a summarized, structured, and immediately relevant form. SURF allows users to search by risk factor, population, date, and indicator filters, enabling users to quickly access the most up to date and empirically grounded general or specific knowledge about suicide-related risk factors.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"69"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A population-based urinary and plasma metabolomics study of environmental exposure to cadmium.","authors":"Yoshiki Ishibashi, Sei Harada, Yoko Eitaki, Ayako Kurihara, Suzuka Kato, Kazuyo Kuwabara, Miho Iida, Aya Hirata, Mizuki Sata, Minako Matsumoto, Takuma Shibuki, Tomonori Okamura, Daisuke Sugiyama, Asako Sato, Kaori Amano, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Toru Takebayashi","doi":"10.1265/ehpm.23-00218","DOIUrl":"10.1265/ehpm.23-00218","url":null,"abstract":"<p><strong>Background: </strong>The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma for the detection of relatively low-level cadmium (Cd) exposure in large population-based studies.</p><p><strong>Method: </strong>We analyzed 123 urinary metabolites and 94 plasma metabolites detected in fasting urine and plasma samples collected from 1,412 men and 2,022 women involved in the Tsuruoka Metabolomics Cohort Study. Regression analysis was performed for urinary N-acetyl-beta-D-glucosaminidase (NAG), plasma, and urinary metabolites as dependent variables, and urinary Cd (U-Cd, quartile) as an independent variable. The multivariable regression model included age, gender, systolic blood pressure, smoking, rice intake, BMI, glycated hemoglobin, low-density lipoprotein cholesterol, alcohol consumption, physical activity, educational history, dietary energy intake, urinary Na/K ratio, and uric acid. Pathway-network analysis was carried out to visualize the metabolite networks linked to Cd exposure.</p><p><strong>Result: </strong>Urinary NAG was positively associated with U-Cd, but not at lower concentrations (Q2). Among urinary metabolites in the total population, 45 metabolites showed associations with U-Cd in the unadjusted and adjusted models after adjusting for the multiplicity of comparison with FDR. There were 12 urinary metabolites which showed consistent associations between Cd exposure from Q2 to Q4. Among plasma metabolites, six cations and one anion were positively associated with U-Cd, whereas alanine, creatinine, and isoleucine were negatively associated with U-Cd. Our results were robust by statistical adjustment of various confounders. Pathway-network analysis revealed metabolites and upstream regulator changes associated with mitochondria (ACACB, UCP2, and metabolites related to the TCA cycle).</p><p><strong>Conclusion: </strong>These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"22"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study.","authors":"Lei Liu, Changfa Wang, Zhongyang Hu, Shuwen Deng, Saiqi Yang, Xiaoling Zhu, Yuling Deng, Yaqin Wang","doi":"10.1265/ehpm.23-00289","DOIUrl":"10.1265/ehpm.23-00289","url":null,"abstract":"<p><strong>Background and aim: </strong>Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD.</p><p><strong>Methods: </strong>This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD.</p><p><strong>Results: </strong>After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31-1.67 for quintile 2; HR 2.07, 95%CI 1.85-2.33 for quintile 3; HR 2.55, 95%CI 2.27-2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95-6.05 for quintile 2; HR 4.25, 95%CI 2.44-7.40 for quintile 3; HR 6.29, 95%CI 3.59-10.99 for quintile 4), compared with the quintile 1.</p><p><strong>Conclusion: </strong>Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"5"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scale development and validation of perimenopausal women disability index in the workplace.","authors":"Kyoko Nomura, Kisho Shimizu, Fumiaki Taka, Melanie Griffith-Quintyne, Miho Iida","doi":"10.1265/ehpm.23-00239","DOIUrl":"10.1265/ehpm.23-00239","url":null,"abstract":"<p><strong>Background: </strong>Menopausal disorders include obscure symptomatology that greatly reduce work productivity among female workers. Quantifying the impact of menopause-related symptoms on work productivity is very difficult because no such guidelines exist to date. We aimed to develop a scale of overall health status for working women in the perimenopausal period.</p><p><strong>Methods: </strong>In September, 2021, we conducted an Internet web survey which included 3,645 female workers aged 45-56 years in perimenopausal period. We asked the participants to answer 76 items relevant to menopausal symptomatology, that were created for this study and performed exploratory and confirmatory factor analyses for the scale development. Cronbach's alpha, receiver operating characteristic analysis, and logistic regression analysis were used to verify the developed scale.</p><p><strong>Results: </strong>Approximately 85% participants did not have menstruation or disrupted cycles. Explanatory factor analysis using the maximum likelihood method and Promax rotation identified 21 items with a four-factor structure: psychological symptoms (8 items, α = 0.96); physiological symptoms (6 items, alpha = 0.87); sleep difficulty (4 items, alpha = 0.92); human relationship (3 items, alpha = 0.92). Confirmatory factor analyses found excellent model fit for the four-factor model (RMSR = 0.079; TLI = 0.929; CFI = 0.938). Criterion and concurrent validity were confirmed with high correlation coefficients between each of the four factors, previously validated menopausal symptom questionnaire, and Copenhagen Burnout Inventory scales, respectively (all ps < 0.0001). The developed scale was able to predict absenteeism with 78% sensitivity, 58% specificity, and an AUC of 0.727 (95%CI: 0.696-0.757). Higher scores of each factor as well as total score of the scale were more likely to be associated with work absence experience due to menopause-related symptoms even after adjusting for Copenhagen Burnout Inventory subscales (all ps < 0.0001).</p><p><strong>Conclusion: </strong>We found that the developed scale has high validity and reliability and could be a significant indicator of absenteeism for working women in perimenopausal period.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"4"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential impact of SARS-CoV-2 infection during different outbreak periods on incident diabetes in Japan: a matched cohort study utilizing health insurance claims.","authors":"Akiko Matsumoto, Sachiko Kodera, Tatsuya Matsuura, Yoko Takayama, Yuya Yamada, Akimasa Hirata","doi":"10.1265/ehpm.24-00191","DOIUrl":"10.1265/ehpm.24-00191","url":null,"abstract":"<p><strong>Background: </strong>An increased risk of diabetes after COVID-19 exposure has been reported in Caucasians during the early phase of the pandemic, but the effects across viral variants and in non-Caucasians have not been evaluated.</p><p><strong>Methods: </strong>To address this gap, survival analyses were performed for five outbreak periods. From an anonymized health insurance database REZULT for the employees and their dependents of large companies or government agencies in Japan, 5 matched cohorts were generated based on age, sex, area of residence (47 prefectures), and 7 ranges of medical bills (COVID-19 exposed:unexposed = 1:4). Observation of each matching group began on the same day. Incident diabetes type 1 (T1D) and type 2 (T2D) were defined as the first claim during the target period, including at least 1 year before the start of observation.</p><p><strong>Results: </strong>T1D accounted for 0.8% of incident diabetes after the first COVID-19 exposure, similar to the non-exposed cohort. Most T2D in the COVID-19 cohort was observed within a few weeks. After further adjustment for the number of days from the start of observation to hospitalization (a time-dependent variable), the hazard ratio for incident T2D ranged from 14.1 to 20.0, with 95% confidence intervals (95%CI) of 8.7 to 32.0, during the 2-month follow-ups from the original strain outbreak to the Delta variant outbreak (by September 2021), and decreased to 2.0, with a 95%CI of 1.6 to 2.5, during the Omicron outbreak (by March 2022). No association was found during the BA.4/5 outbreak (until September 2022). Males had a higher risk, and the trend toward higher risk in older age groups was inconsistent across the periods.</p><p><strong>Conclusions: </strong>Our large dataset, covering 2019-2023, reports for the first time the impact of COVID-19 on incident diabetes in non-Caucasians. The risk intensity and attributes of post-COVID-19 T2D were inconsistent across outbreak periods, suggesting diverse biological effects of different SARS-CoV-2 variants.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"52"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential mechanism of atrazine-induced dopaminergic neurotoxicity based on integration strategy.","authors":"Ling Qi, Jingran Yang, Jianan Li","doi":"10.1265/ehpm.24-00079","DOIUrl":"10.1265/ehpm.24-00079","url":null,"abstract":"<p><strong>Background: </strong>Atrazine (ATR), a commonly used herbicide, is linked to dopaminergic neurotoxicity, which may cause symptoms resembling Parkinson's disease (PD). This study aims to reveal the molecular regulatory networks responsible for ATR exposure and its effects on dopaminergic neurotoxicity based on an integration strategy.</p><p><strong>Methods: </strong>Our approach involved network toxicology, construction of protein-protein interaction (PPI) networks, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, as well as molecular docking techniques. Subsequently, we validated the predicted results in PC12 cells in vitro.</p><p><strong>Results: </strong>An integrated analysis strategy indicating that 5 hub targets, including mitogen-activated protein kinase 3 (Mapk3), catalase (Cat), heme oxygenase 1 (Hmox1), tumor protein p53 (Tp53), and prostaglandin-endoperoxide synthase 2 (Ptgs2), may play a crucial role in ATR-induced dopaminergic injury. Molecular docking indicated that the 5 hub targets exhibited certain binding activity with ATR. Cell counting kit-8 (CCK8) results illustrated a dose-response relationship in PC12 cells. Real-time quantitative polymerase chain reaction (RT-qPCR) displayed notable changes in the expression of hub targets mRNA levels, with the exception of Mapk3. Western blotting results suggested that ATR treatment in PC12 cells resulted in an upregulation of the Cat, Hmox1, and p-Mapk3 protein expression levels while causing a downregulation in Tp53, Ptgs2, and Mapk3.</p><p><strong>Conclusion: </strong>Our findings indicated that 5 hub targets identified could play a vital role in ATR-induced dopaminergic neurotoxicity in PC12 cells. These results provide preliminary support for further investigation into the molecular mechanism of ATR-induced toxicity.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"46"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11391274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between short-term exposure to ambient air pollutants and biomarkers indicative of inflammation and oxidative stress: a cross-sectional study using KoGES-HEXA data.","authors":"Ji Hyun Kim, Hae Dong Woo, Jane J Lee, Dae Sub Song, Kyoungho Lee","doi":"10.1265/ehpm.23-00199","DOIUrl":"10.1265/ehpm.23-00199","url":null,"abstract":"<p><strong>Background: </strong>Air pollution-induced systemic inflammation and oxidative stress are hypothesized to be the major biological mechanisms underlying pathological outcomes. We examined the association between short-term exposure to ambient air pollutants and biomarkers of inflammation and oxidative stress in 2199 general middle-aged Korean population residing in metropolitan areas.</p><p><strong>Methods: </strong>Serum levels of inflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-10, and tumor necrosis factor [TNF]-α) and urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. Daily concentrations of a series of air pollutants (particulate matter [PM]₁₀, PM_2.5, SO₂, NO₂, CO, and O₃) were predicted using the Community Multiscale Air Quality modeling system, and participant-level pollutant exposure was determined using geocoded residential addresses. Short-term exposure was defined as the 1- to 7-day moving averages.</p><p><strong>Results: </strong>The multivariable-adjusted linear models controlling for the sociodemographic, lifestyle, temporal, and meteorological factors identified positive associations of PM with IL-1β, IL-8, IL-10, TNF-α, and 8-OHdG levels; SO₂ with IL-10 levels, CO with IL-1β, IL-10, and TNF-α levels; and O₃ with IL-1β, IL-8, and 8-OHdG levels. O₃ levels were inversely associated with IL-10 levels. For each pollutant, the strongest associations were observed for the 7-day average PM and CO with IL-1β (per 10-µg/m³ increase in PM₁₀: 2.7%, 95% confidence interval [CI] = 0.6-4.8; per 10-µg/m³ increase in PM_2.5: 6.4%, 95% CI = 2.4-10.5; per 0.1-ppm increase in CO: 3.3%, 95% CI = 0.3-6.5); the 2-day average SO₂ with IL-10 levels (per 1-ppb increase in SO₂: 1.1%, 95% CI = 0.1-2.1); and the 7-day average O₃ with IL-8 levels (per 1-ppb increase in O₃: 1.3%, 95% CI = 0.7-1.9).</p><p><strong>Conclusions: </strong>Short-term exposure to ambient air pollutants may induce oxidative damage and pro-inflammatory roles, together with counter-regulatory anti-inflammatory response.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"17"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.","authors":"Kazuyoshi Furukawa, Kahori Okamoto-Matsuda, Kouji H Harada, Mutsuko Minata, Toshiaki Hitomi, Hatasu Kobayashi, Akio Koizumi","doi":"10.1265/ehpm.23-00284","DOIUrl":"10.1265/ehpm.23-00284","url":null,"abstract":"<p><strong>Background: </strong>Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown.</p><p><strong>Methods: </strong>In this study, two ABC transporters, ABCB1 and ABCB4, were examined in mice with single intravenous PFOA administration (3.13 µmol/kg). To identify candidate renal PFOA transporters, we used a microarray approach to evaluate changes in gene expression of various kidney transporters in Abcb4 null mice.</p><p><strong>Results: </strong>Biliary PFOA concentrations were lower in Abcb4 null mice (mean ± standard deviation: 0.25 ± 0.12 µg/mL) than in wild-type mice (0.87 ± 0.02 µg/mL). Immunohistochemically, ABCB4 expression was confirmed at the apical region of hepatocytes. However, renal clearance of PFOA was higher in Abcb4 null mice than in wild-type mice. Among 642 solute carrier and ABC transporters, 5 transporters showed significant differences in expression between wild-type and Abcb4 null mice. These candidates included two major xenobiotic transporters, multidrug resistance 1 (Abcb1) and organic anion transporter 3 (Slc22a8). Abcb1 mRNA levels were higher in Abcb4 null mice than in wild-type mice in kidney. In Abcb4 null mice, Abcb1b expression was enhanced in proximal tubules immunohistochemically, while that of Slc22a8 was not. Finally, in Abcb1a/b null mice, there was a significant decrease in the renal clearance of PFOA (0.69 ± 0.21 vs 1.1 mL ± 0.37/72 h in wild-type mice). A homology search of ABCB1 showed that several amino acids are mutated in humans compared with those in rodents and monkeys.</p><p><strong>Conclusions: </strong>These findings suggest that, in the mouse, Abcb4 and Abcb1 are excretory transporters of PFOA into bile and urine, respectively.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"21"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}