Kaviya Vijayalakshmi Babunagappan, Subastri Ariraman, Jann Harberts, Vimalraj Selvaraj, Mukilarasi Bedatham, Narendran Sekar, Nicolas H Voelcker, Roey Elnathan, Swathi Sudhakar
{"title":"Nanoinjection Platform for Drug Delivery in Breast Cancer Therapeutics","authors":"Kaviya Vijayalakshmi Babunagappan, Subastri Ariraman, Jann Harberts, Vimalraj Selvaraj, Mukilarasi Bedatham, Narendran Sekar, Nicolas H Voelcker, Roey Elnathan, Swathi Sudhakar","doi":"10.1002/admi.202500323","DOIUrl":"https://doi.org/10.1002/admi.202500323","url":null,"abstract":"<p>Conventional nanomaterial-based drug delivery systems are often limited by rapid burst release, poor cellular uptake, drug degradation, and high local drug concentrations, reducing therapeutic efficacy. To address these challenges, a dual strategy is presented, integrating i) doxorubicin encapsulation within thermostable nanoarchaeosomes (NAs), derived from archaeal lipids, and ii) silicon nanotubes (SiNTs)-based nanoinjection for intracellular delivery. This approach enables efficient transport of nanoarchaeosome-loaded doxorubicin (NAD) into MCF-7 breast cancer cells, inducing membrane perturbation and achieving controlled drug release over 700 h. NAD–SiNTs exhibit potent cytotoxicity, with an IC<sub>5</sub>₀ of 60 n<span>m,</span> 23-fold lower than free doxorubicin, while maintaining high biocompatibility in NIH-3T3 fibroblasts. Fluorescence-activated cell sorting (FACS) analysis revealed 44% necrosis in MCF-7 cells post-treatment with NAD–SiNTs. Moreover, chick embryo assays and angiogenesis gene expression studies confirm that NAD–SiNTs suppress tumor vasculature genes, effectively inhibiting angiogenesis. These findings position NAD–SiNTs as a promising drug delivery platform, enabling sustained and targeted breast cancer therapy.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaviya Vijayalakshmi Babunagappan, Subastri Ariraman, Jann Harberts, Vimalraj Selvaraj, Mukilarasi Bedatham, Narendran Sekar, Nicolas H Voelcker, Roey Elnathan, Swathi Sudhakar
{"title":"Nanoinjection Platform for Drug Delivery in Breast Cancer Therapeutics","authors":"Kaviya Vijayalakshmi Babunagappan, Subastri Ariraman, Jann Harberts, Vimalraj Selvaraj, Mukilarasi Bedatham, Narendran Sekar, Nicolas H Voelcker, Roey Elnathan, Swathi Sudhakar","doi":"10.1002/admi.202500323","DOIUrl":"https://doi.org/10.1002/admi.202500323","url":null,"abstract":"<p>Conventional nanomaterial-based drug delivery systems are often limited by rapid burst release, poor cellular uptake, drug degradation, and high local drug concentrations, reducing therapeutic efficacy. To address these challenges, a dual strategy is presented, integrating i) doxorubicin encapsulation within thermostable nanoarchaeosomes (NAs), derived from archaeal lipids, and ii) silicon nanotubes (SiNTs)-based nanoinjection for intracellular delivery. This approach enables efficient transport of nanoarchaeosome-loaded doxorubicin (NAD) into MCF-7 breast cancer cells, inducing membrane perturbation and achieving controlled drug release over 700 h. NAD–SiNTs exhibit potent cytotoxicity, with an IC<sub>5</sub>₀ of 60 n<span>m,</span> 23-fold lower than free doxorubicin, while maintaining high biocompatibility in NIH-3T3 fibroblasts. Fluorescence-activated cell sorting (FACS) analysis revealed 44% necrosis in MCF-7 cells post-treatment with NAD–SiNTs. Moreover, chick embryo assays and angiogenesis gene expression studies confirm that NAD–SiNTs suppress tumor vasculature genes, effectively inhibiting angiogenesis. These findings position NAD–SiNTs as a promising drug delivery platform, enabling sustained and targeted breast cancer therapy.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joachim Döring, Vadym Voropai, Alexander Thielecke, Gunnar Meichsner, Oliver Maiß, Matthias Hackert-Oschätzchen, Christoph H. Lohmann, Jessica Bertrand
{"title":"Reduction of Micro-Motion at the Tapered Connection of Hip Endoprostheses with an Adapted Deep Rolling Process of CoCrMo Inner Tapers","authors":"Joachim Döring, Vadym Voropai, Alexander Thielecke, Gunnar Meichsner, Oliver Maiß, Matthias Hackert-Oschätzchen, Christoph H. Lohmann, Jessica Bertrand","doi":"10.1002/admi.202500404","DOIUrl":"https://doi.org/10.1002/admi.202500404","url":null,"abstract":"<p>Modular hip joint replacements typically comprise a metal stem, a metal or ceramic ball, a polyethylene or ceramic acetabular cup inlay and a metal shell. Nevertheless, it is evident that this modularity represents a multitude of advantages and disadvantages. Implants retrieved from revision surgery showed evidence of abrasion and corrosion. Increased wear processes may occur. It is possible that these wear mechanisms could be reduced by functionalization of the surface. One potential method for inducing the transformation is through the utilization of a deep rolling process. As the metallic femoral heads are primarily composed of CoCrMo wrought alloy, this study employs a novel deep rolling tool to machine the inner conical bore (inner taper) of the femoral head. The resulting changes in mechanical and physical properties are investigated, as well as their influence on the clamping situation. A considerable enhancement is observed in the mechanical properties and a distinct reduction in surface irregularities, resulting in smoother morphologies after the deep rolling process. Along with the augmented mechanical properties, an improved clamping behavior is also achieved through the augmentation of torsional resistance, which subsequently reduces wear processes in the tapered connection and thus improves the implant.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joachim Döring, Vadym Voropai, Alexander Thielecke, Gunnar Meichsner, Oliver Maiß, Matthias Hackert-Oschätzchen, Christoph H. Lohmann, Jessica Bertrand
{"title":"Reduction of Micro-Motion at the Tapered Connection of Hip Endoprostheses with an Adapted Deep Rolling Process of CoCrMo Inner Tapers","authors":"Joachim Döring, Vadym Voropai, Alexander Thielecke, Gunnar Meichsner, Oliver Maiß, Matthias Hackert-Oschätzchen, Christoph H. Lohmann, Jessica Bertrand","doi":"10.1002/admi.202500404","DOIUrl":"https://doi.org/10.1002/admi.202500404","url":null,"abstract":"<p>Modular hip joint replacements typically comprise a metal stem, a metal or ceramic ball, a polyethylene or ceramic acetabular cup inlay and a metal shell. Nevertheless, it is evident that this modularity represents a multitude of advantages and disadvantages. Implants retrieved from revision surgery showed evidence of abrasion and corrosion. Increased wear processes may occur. It is possible that these wear mechanisms could be reduced by functionalization of the surface. One potential method for inducing the transformation is through the utilization of a deep rolling process. As the metallic femoral heads are primarily composed of CoCrMo wrought alloy, this study employs a novel deep rolling tool to machine the inner conical bore (inner taper) of the femoral head. The resulting changes in mechanical and physical properties are investigated, as well as their influence on the clamping situation. A considerable enhancement is observed in the mechanical properties and a distinct reduction in surface irregularities, resulting in smoother morphologies after the deep rolling process. Along with the augmented mechanical properties, an improved clamping behavior is also achieved through the augmentation of torsional resistance, which subsequently reduces wear processes in the tapered connection and thus improves the implant.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zorik Shamish, Krishna K. Yadav, Haya Kornweitz, Moshe Zohar, Dror Shamir, Raz Jelinek, Ariela Burg
{"title":"Harnessing the Potential of Dip-Pen Nanolithography to Pattern Meta-Chemical Surfaces with Glutathione Inks: An Electrochemical Sensor for Pb(II) and Hg(II)","authors":"Zorik Shamish, Krishna K. Yadav, Haya Kornweitz, Moshe Zohar, Dror Shamir, Raz Jelinek, Ariela Burg","doi":"10.1002/admi.202500295","DOIUrl":"10.1002/admi.202500295","url":null,"abstract":"<p>Traditional methods are complex and unsuitable for on-site detection of heavy metals, which become ubiquitous in groundwater contamination. This research introduces a novel approach for creating meta-chemical surfaces using dip-pen nanolithography with glutathione-based ink, which can be used as an affordable and portable electrochemical sensor. The sensitivity, which is quantified by LoD value (0.84 ppb and 0.99 ppb for Pb(II) and Hg(II), respectively), is influenced by the exposed gold surface, the pattern pitch, and the binding strength between the ligand and the cations. The results indicate that the LoD values are almost unaffected by the presence of the two cations in solution, which can be explained by DFT calculations. In addition to the efficient sensor developed in this study, the finding that the pattern pitch affects the fill factor, which in turn affects the sensor's sensitivity, is significant and novel. Thus, the sensor's sensitivity can be regulated by altering the pattern pitch, which has far-reaching implications in the field of sensing.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 17","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Direct-Write Laser Patterning of PDMS/Graphite Composites for Dual-Functional Surfaces with Tunable Conductivity and Wettability (Adv. Mater. Interfaces 15/2025)","authors":"Hsiang-Wei Chuang, Chun-Ru Hsu, Hong-Ren Jiang","doi":"10.1002/admi.70104","DOIUrl":"https://doi.org/10.1002/admi.70104","url":null,"abstract":"<p><b>Surface Engineering</b></p><p>In article 2500243, Hong-Ren Jiang and co-workers present a novel direct-write laser approach for creating multifunctional PDMS surfaces with tunable properties. The black laser-induced graphene controls electrical conductivity, while white SiO<sub>2</sub> particles regulate wettability. By incorporating graphite as anchoring points, this blue laser method offers a versatile single-step platform for flexible electronics, microfluidics, and smart materials.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 15","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the Role of Copper Oxidation State on a TiO2/ZSM-5 Catalyst for Photocatalytic CO2 Reduction to Methanol (Adv. Mater. Interfaces 15/2025)","authors":"Wibawa Hendra Saputera, Adhi Satriyatama, Ignatius Dozy Mahatmanto Budi, Adhitya Gandaryus Saputro, Muhammad Haris Mahyuddin, Wahyu Prasetyo Utomo, Siska Mutiara, Hoi Ying Chung, Arramel, Fatwa Firdaus Abdi, Dwiwahju Sasongko","doi":"10.1002/admi.70101","DOIUrl":"https://doi.org/10.1002/admi.70101","url":null,"abstract":"<p><b>Photocatalytic CO<sub>2</sub> Reduction to Methanol</b></p><p>In article 2500010 by Wibawa Hendra Saputera and co-authors explore the effect of copper (Cu) oxidation states in a TiO<sub>2</sub>/ZSM-5 catalyst system for the photocatalytic conversion of CO<sub>2</sub> to methanol. The study highlights the synergistic roles of Cu<sup>δ+</sup>, Ti<sup>3+</sup> sites, and the ZSM-5 framework in enhancing charge separation and CO<sub>2</sub> adsorption, resulting in a significant boost in methanol production. This work represents a promising step toward sustainable solar-driven fuel production and carbon utilization. Art by the team of INMYWORK Studio.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 15","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Classification and Characterization Methods for Heterojunctions (Adv. Mater. Interfaces 15/2025)","authors":"Zhenyu Han, Yundong Song, Yibing Jia, Yalin Wang, Jiale Shi, Xiaochun Liu, Liangliang Yu, Zhan Li, Yangyang Cheng, Hongna Zhang, Hai-Ying Jiang","doi":"10.1002/admi.70103","DOIUrl":"https://doi.org/10.1002/admi.70103","url":null,"abstract":"<p><b>Type II Heterojunction</b></p><p>In order to avoid the misuse and confusion of the classification and naming of different types of heterojunction in photocatalysis, this review categorizes Type II heterojunctions into O-scheme, Z-scheme and S-scheme heterojunctions according to different transfer paths of photocarriers. More details can be found in article 2500191 by Hongna Zhang, Hai-Ying Jiang, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 15","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiba Aljayyousi, Jongmin Kim, Serdal Kirmizialtin, Yong-Ak Song
{"title":"Investigating the Mechanism of Ion Concentration Polarization Within Nanofluidic Hydrogel Membranes: Experiment and Simulation (Adv. Mater. Interfaces 15/2025)","authors":"Hiba Aljayyousi, Jongmin Kim, Serdal Kirmizialtin, Yong-Ak Song","doi":"10.1002/admi.70105","DOIUrl":"https://doi.org/10.1002/admi.70105","url":null,"abstract":"<p><b>Ion Concentration Polarization</b></p><p>In article 2401018, Serdal Kirmizialtin, Yong-Ak Song combine an experimental approach and molecular dynamics simulation to investigate ion concentration polarization (ICP) near the hydrogel membrane inside a nanofluidic system. RNA trapping is optimized at intermediate ionic strength and high ion-selective hydrogel membrane surface charge, driven by coupled electrostatic and hydrodynamic effects. The findings support the design of ICP-enhanced biosensing platforms. Image credit: INMYWORK Studio.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 15","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah E. Bamford, Wil Gardner, Rongjie Sun, David A. Winkler, Benjamin W. Muir, Jeffrey L. Pura, Paul J. Pigram
{"title":"Tracking UV Degradation of Inkjet Prints Using ToF-SIMS and Machine Learning","authors":"Sarah E. Bamford, Wil Gardner, Rongjie Sun, David A. Winkler, Benjamin W. Muir, Jeffrey L. Pura, Paul J. Pigram","doi":"10.1002/admi.202500118","DOIUrl":"10.1002/admi.202500118","url":null,"abstract":"<p>Inkjet printing is widely deployed in a variety of commercial and consumer contexts and is an excellent reference system for exploring complex and subtle changes that occur in response to ageing and environmental exposure. This study describes a robust and unbiased assessment of changes in inkjet ink chemistry in response to real-world environmental exposure (sunlight and ambient heat). Over a period of 21 weeks, commercial inks are exposed to solar UV light and monitored for chemical changes via time-of-flight secondary ion mass spectrometry (ToF-SIMS). Self-organizing map with relational perspective mapping (SOM-RPM), hierarchical cluster analysis (HCA), and partial least squares (PLS) regression are used to analyze the ToF-SIMS data and elucidate chemical changes both spectrally and spatially over time. Ultraviolet (UV) light is found to cause significant changes to ink chemistry. Each of the inks (black, cyan, magenta and yellow) react in a unique manner, with the black and yellow inks being most affected. This study exemplifies how machine learning can pinpoint subtle changes in hyperspectral data and provide insight into the long-term thermal and UV degradation of inkjet inks.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 17","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}