Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology最新文献_第8页

[[Features of Pharmacological Correction of Alcoholic Fatty Liver Disease in Patients with Acute Ethanol Intoxication].] 急性乙醇中毒患者酒精性脂肪肝的药理纠正特点

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

G A Livanov, I A Shikalova, A N Lodyagin, S Glushkov, B V Batotsyrenov, A T Loladze, A L Kovalenko

{"title":"[[Features of Pharmacological Correction of Alcoholic Fatty Liver Disease in Patients with Acute Ethanol Intoxication].]","authors":"G A Livanov, I A Shikalova, A N Lodyagin, S Glushkov, B V Batotsyrenov, A T Loladze, A L Kovalenko","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the study was to increase the efficiency of the treatment of acute ethanol intoxication in patients with alcoholic fatty liver disease. The article presents the results which received during the investigation and treatment of 166 patients with acute ethanol in- toxication on the background of alcoholic fatty liver disease Patients were assessed by the severity scale APACHE-Il. Were studied the dynamics of clinical, laboratory, biochemical parameters, the state of the antioxidant system activity and lipid peroxidation. The study found the effect of the combination hepatoprotective drug remaxol on the many links of metabolism, which was confirmed by the dynamics of biochemical parameters. There was a quick correction of hyperlactatemia, an effective reduction of ALT activity, the absence of reduction of albumin and urea concentration in the somatic period of ethanol poisoning. Period of using remaxol there was improvement in the clinical course of the disease, which manifested by the reduce the incidence of delirium tremens and shorten the duration of treatment of patients.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35088829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[SERRATED COLORECTAL ADENOCARCINOMA]. [锯齿状结直肠腺癌]。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

A M Nechipay, K V Shishkin, M V Zobnina, L M Cherkasova, V A Krivopuskov

{"title":"[SERRATED COLORECTAL ADENOCARCINOMA].","authors":"A M Nechipay, K V Shishkin, M V Zobnina, L M Cherkasova, V A Krivopuskov","doi":"","DOIUrl":"","url":null,"abstract":"The aim: To present a clinical case of serrated colon adenocarcinoma. To demonstrate morphological and genetic features of these tumors and to determine their clinical management.Key points: Described case shows diagnostics of serrated colon adenocarcinoma. A 67-year-old woman presented for colonoscopy because of long constipation besides abdominal pain and distention have appeared recently. Colonoscopy was performed and she was found to have a 3.0 x 3.0-cm tumor next to hepatic flexure and pedunculated 1.2x0.7 cm polyp in sigmoid colon (type lp according to Paris classification). Endoscopic biopsies of these lesions were consistent with serrated adenocarcinoma and tubulovillous adenoma with foci of severe dysplasia. Additional diagnostic methods revealed no distant metastases. Patient was under went right hemicolectomy with D3 lymphodissection, lesion in sigmoid colon was removed using snare with electrocautery. Final pathology revealed no residual tissue in margins and no malignant cells in removed lymph nodes. Genetic diagnostics by PCR found high level of microsatellite instability and positive CpG island methylator phenotype (CIMP+) in tumor tissue.Conclusions: According to WHO classification serrated lesion are considered to have malignant potential. They serve as the precursors for approximately 10% to 15% of sporadic colorectal cancer developed through the serrated pathway. These tumors were named serrated adenocarcinoma and had special morphological criteria that allow us to differentiate them with colorectal adenocarcinomas developed through the traditional pathway. Serrated adenocarcinoma has high level of microsatellite instability and positive CpG island methylator phenotype (CIMP+). Presence of microsatellite instability in tumor determines its more favorable prognosis because of tumor immunogenicity. Besides this type of cancer is more often responding to therapy with fluoropyrimidines.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34641839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ACTIVITY ACTUAL INTESTINAL ENZYMES OF PANCREATIC ENZYMES AND ISCHEMIA OF THE SMALL INTESTINE (EXPERIMENTAL STUDY)]. [胰腺酶的实际肠酶活性与小肠缺血(实验研究)]。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

L P Khoroshinina

{"title":"[ACTIVITY ACTUAL INTESTINAL ENZYMES OF PANCREATIC ENZYMES AND ISCHEMIA OF THE SMALL INTESTINE (EXPERIMENTAL STUDY)].","authors":"L P Khoroshinina","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of the study: To study the activity of carbohydrase in model experimented on dogs.Material and methods: The research was carried out on 20 adult mongrel dogs of both sexes weighing from 12 before 22 kg and consisted of two series of experiments. The first one was 12 animals with 50% wrap-retirement stenosis of the celiac trunk. In the second series of experiments consisted of 8 animals with 50% compression stenosis of the cranial brizee Noi artery. The activity of amidalas and sucrase were determined to wrap-retirement narrowing of the arteries and through 114-173 after stenosis.Results: In conditions of chronic ischemia of the small intestine revealed as an increase in the activity of one, and unchanged levels of other Carbo-hydras: in biopsies of the mucosa of the proximal small intestine experienced dogs activity of pancreatic alpha-amylase stress-Valas is on average 13 times the original values, the activity of one membrane enzymes--gamma-amylase was increased by 4 times, the activity of another membrane enzyme sucrase remained without changes.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34468425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[THE CENTURY OF WAGNER PERM STATE MEDICAL UNIVERSITY]. [瓦格纳彼尔姆州立医科大学的世纪]。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

A V Tuev, O V Khlynova

引用次数: 0

ELECTROPHYSIOLOGICAL ANALYSIS OF EXPERIMENTAL ULCERATION STAGES IN RATS. 大鼠实验性溃疡分期的电生理分析。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

I L Privalova, E T Kamal

{"title":"ELECTROPHYSIOLOGICAL ANALYSIS OF EXPERIMENTAL ULCERATION STAGES IN RATS.","authors":"I L Privalova, E T Kamal","doi":"","DOIUrl":"","url":null,"abstract":"Research objective - to conduct electrophysiological analysis for experimental ulceration stages in rats studying changes in the electrical activity (EA) frequency characteristics (FCH) (frequency response) of the stomach and duodenum.Materials and methods: The study was conducted in 5 experimental groups of outbred albino rats weighing 250-300 g with acetate stomach ulcerative injury (SUl). Using the method of direct multi-channel electrocardiography, we recorded the EA of gastric corpus (SB), its pyloric (PO) and the entry part of duodenum. We analyzed the frequency response of EA smooth muscles of stomach and duodenum during the period of seven days after the simulation SUI. The obtained by Shapiro-Wilk test data was distributed in accordance with statistically significant differences between samples - using the Student's t test. Correlation analysis was performed basing on the calculation of Pearson correlation coefficient.Results: The average value of the frequency EA and TJ PO increased on the second day of the experiment 55.7% (p <0.01) and 53.0% (p <0.01), respectively, were down on the fourth day and then increased from 5 to 7 day of the experiment by 87.6% (p <0.01) in TJ and 89.8% (p <0.01) in the PO. The frequency EA LDK increased on the seventh day of the experiment 32,4% (p <0.05). The frequency EA LDK increased on the seventh day of the experiment 32.4% (p <0.05). Frequency EA inter-correlation among all the components of the gastroduodenal complex (GC) were the closest on the fourth day after inflicting the stomach ulcerative injury.Conclusion: Frequency EA changes in correlation of components GC can serve as functional markers its integral condition in the process of experimental ulceration.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMMUNOMODULATORY EFFECT OF ALLOGENEIC MESENCHYMAL STEM CELLS OF RATS. 大鼠同种异体间充质干细胞的免疫调节作用。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

I E Trubitsyna, N A Onishchenko, A V Lyundup, O V Knyazev, A S Gulyaev, O S Vasnev, Z M Abdulatipova, A V Smirnova, Yu M Orlova, G A Drozdova

{"title":"IMMUNOMODULATORY EFFECT OF ALLOGENEIC MESENCHYMAL STEM CELLS OF RATS.","authors":"I E Trubitsyna, N A Onishchenko, A V Lyundup, O V Knyazev, A S Gulyaev, O S Vasnev, Z M Abdulatipova, A V Smirnova, Yu M Orlova, G A Drozdova","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Recently, more and more attracted the attention of cell therapy, which requires a study of the efficacy and safety of allogeneic MSCs transplantation in acute and chronic inflammatory reactions. The aim of our study was to examine the effectiveness of transplantation of allogeneic mesenchymal bone marrow stromal cells for the healing of surgical wounds the glandular stomach in rats.Material and methods: Using white Wistar rats. Producing cell transplantation mononuclear fraction derived from rat bone marrow aspirate. Injected cells 8 and 9 th passage. The dose of cells administered to 3-th and / or 7-th days 3,5h106 cells / ml twice or 5,0h106 cells / ml dose. Autopsy on day 10-th and 17-th. The serum ELISA determined the content of the pro- and anti-inflammatory cytokines IL1β, TNFα, IFNy, IL-4.Results and discussion: Introduction MSCs contributed to the decline of the immune mediators of inflammation IL1P, TNFa, IFNy, increase anti-inflammatory IL4. Quality improved healing.Conclusion: Rapid curative effect of stem cells may be associated with the formation of blood immune cells (macrophages) that produce substances that restore damaged tissue. They restore the balance between Th1 and Th2.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ROLE OF BILE ACIDS IN THE REGULATION OF LIPID AND CARBOHYDRATE METABOLISM IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND DIABETES TYPE2. 胆汁酸在非酒精性脂肪肝和2型糖尿病患者脂质和碳水化合物代谢调节中的作用

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

L A Zvenigorodskaya, A V Petrakov, T V Nilova, G G Varvanina, A E Lychkova

引用次数: 0

CHOLESTASIS OF PREGNANCY. 妊娠期胆汁淤积。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

I O Marinkin, T M Sokolova, T V Kiseleva, V M Kuleshov, K Yu Makarov, A V Yakimova

引用次数: 0

[[New in the Development of Medical Education in Russia: Continuity and Specialists' Accreditation].] 俄罗斯医学教育发展的新进展:连续性与专家资格认证。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

Z Z Balkizov, G E Ulumbekova, S A Palevskaya

引用次数: 0

[[Clinical Relevance Helicobacter Pylori Genotypes in Patients with Chronic Pancreatitis and Concomitant Infections Helicobacter Pylori].] 慢性胰腺炎患者幽门螺杆菌基因型与幽门螺杆菌合并感染的临床相关性[j]。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

A S Sarsenbaeva, E V Domracheva, M N Rustamov

{"title":"[[Clinical Relevance Helicobacter Pylori Genotypes in Patients with Chronic Pancreatitis and Concomitant Infections Helicobacter Pylori].]","authors":"A S Sarsenbaeva, E V Domracheva, M N Rustamov","doi":"","DOIUrl":"","url":null,"abstract":"Relevance: Currently, there is a need to study the genetic diversity of H.pylori in patients with variety of acid-related dis- eases to develop new strategies for the treatment of patients with H.pylori to predict high efficiency of treatment.Objective: To assess the effectiveness of schemes of eradication therapy in patients with chronic pancreatitis and concom- itant H.pylori infection.Materials and methods: The study included 108 patients with H.pylori infection: 63 patients had chronic pancreatitis and were concomitant with H.pylori-infection and 45 patients were without chronic pancreatitis and had H.pylori infection with a chronic gastritis. All patients were determined by factors of pathogenicity of H.pylori by immunoblotting. After forming the group randomized patients received eradication therapy scheme I and the scheme I with inclusion of bismuth tripotassium dicitrate.Conclusions: The effectiveness of H.pylori eradication therapy is dependent on the genetic component of H.pylori. In the presence of H.pylori pathogenicity factors p33, p30, p26, p19, p17 in order to increase the effectiveness of treatment the scheme of eradication therapy I line drugs bismuth tri dicitrate should be included.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35088826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0