Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology最新文献

{"title":"Laennec (Human placenta hydrolyzate) in monotherapy of mixed etiology of steatohepatitis","authors":"I. Yu. Pirogova, T. V. Neuimina, O. V. Suchkova, M. N. Flegontova, S. P. Gogoleva, N. M. Gulyants, V. K. Sorokina","doi":"10.31146/1682-8658-ecg-216-8-37-47","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-37-47","url":null,"abstract":"Liver regeneration is an important task in the treatment of any liver diseases. The key point is the restoration of the liver structure, regression of fibrosis and steatosis of the liver. Difficulties in the treatment of patients with steatohepatitis of metabolic and alcoholic etiology are associated with comorbidity and multicomponent drug load, problems of lifestyle modification. The use of a complex parenteral drug in the treatment of this group of patients increases patient compliance, minimizes the risks of drug interactions. The aim of the study: to evaluate the effect of course treatment with Laennec on insulin resistance, dyslipidemia, systemic inflammatory response, activity of inflammatory process in the liver, steatosis and liver fibrosis. Materials and methods. The study included 50 patients with steatohepatitis of mixed etiology with the presence of biochemical activity, obesity, dyslipidemia, insulin resistance, are having liver steatosis and liver fibrosis of at least stage 1 (determined by liver fibroscopy). 32 patients received Laennec 6 ml intravenously 3 times a week, then 6 ml intramuscularly once every 10 days up to 24 weeks, 18 patients took Omega 3 PUFAs orally 2000 mg per day for 24 weeks. Results. Significant differences (p<0.05) in the estimated parameters in the group of patients treated with Laennec: decreased activity of the inflammatory process-ALT-21% AST -24%, CRP -21%; GGTP cholestasis syndrome -26%; insulin resistance index -13%; correction of LDL dyslipidemia -17%, triglycerides -17%, CA -18%; liver steatosis- 20%. There was an 8% decrease in triglycerides (p<0,05) in the group receiving Omega 3 PUFAs. Conclusions. The use of Laennec in patients with steatohepatitis initiates a decrease in the activity of the inflammatory process in liver tissue, improves metabolic parameters and liver structure.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The debut of autoimmune hepatitis after a new coronavirus infection (COVID-19) in an 11-month-old child","authors":"T. N. Lebedeva, A. U. Marchukova, K. G. Bondar","doi":"10.31146/1682-8658-ecg-216-8-191-196","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-191-196","url":null,"abstract":"In many countries fix cases of severe liver damage in children are recorded. A previous or existing coronavirus infection leads to a disruption in the body’s immune response to infections, which can lead to severe inflammation that caused liver damage. This article describes a clinical case of type 2 autoimmune hepatitis, a high degree of biochemical activity, that debuted in an 11-month-old child after a new coronavirus infection (COVID-19). The presented clinical example demonstrates the need for a thorough and comprehensive examination of children with the first clinical manifestations of liver damage and timely prescription of therapy","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the development of experimental liver steatosis in laboratory rats","authors":"I. A. Bulatova, T. P. Shevlyukova, I. L. Gulyaeva","doi":"10.31146/1682-8658-ecg-216-8-127-133","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-127-133","url":null,"abstract":"The aim. To study functional-morphological and biometric changes in the liver and lipid spectrum in an experiment in male and female laboratory rats when modeling fructose-induced liver steatosis. Materials and methods. The experimental study was conducted on 44 non-inbred sexually mature white rats, of which 20 were males aged 8-9 months with a body weight of 400-530 g. and 24 females aged 9-10 months with a body weight of 320-480 g. Modeling of liver steatosis was carried out for 28 days by adding fructose to drinking water throughout the experiment using 15%-th solution of fructose instead of drinking water. At the end of the experiment, body weight was measured, liver sampling for morphometric and histological studies and blood sampling for laboratory studies (transaminase, glucose and lipid spectrum levels) were performed. Results. When comparing body weight before the experiment and after its completion, a statistically significant increase in this indicator was found in females with experimental steatosis (p = 0.031), which indicates the formation of general obesity in them. The mass coefficient of the liver in the experimental groups of males and females with steatosis was significantly higher than in the controls (p= 0.009 and p = 0.009, respectively). During histological examination of liver tissue, the number of hepatocytes with steatosis in males and females in experimental models was significantly higher than in control groups and corresponded to the II-III degree of steatosis. A comparative analysis of the lipidogram parameters revealed that dyslipidemia developed during the formation of liver steatosis in animals of both groups with fructose-induced liver steatosis. Conclusion. In experimental modeling of fructose-induced liver steatosis in animals, regardless of gender, morphological changes in liver tissue are manifested by fatty dystrophy and hepatomegaly, dyslipidemia is registered. At the same time, males develop fermentemia, hyperglycemia without the formation of general obesity. In females, the course of experimental steatosis is accompanied by an increase in body weight without functional changes in the liver.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcolic liver disease: what’s new in the current decade?","authors":"D. I. Trukhan","doi":"10.31146/1682-8658-ecg-216-8-167-175","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-167-175","url":null,"abstract":"Alcoholic liver disease (ALD) - damage to the liver parenchyma under the influence of ethanol consumption, which can manifest itself in several ways: steatosis, alcoholic hepatitis (steatohepatitis), fibrosis and cirrhosis of the liver. The present review considers publications of recent years (2020-2023) in the Pubmed and Scopus information databases devoted to the study of various aspects of the current state of the problem of alcohol-associated liver pathology. New data on the epidemiology and burden of ALD have been obtained; the pandemic of a new coronavirus infection has had a certain impact on the course of ALD. The study of individual links in the pathogenesis of ALD is actively continuing, a large number of publications are devoted to the participation and role in the pathogenesis of alcohol-associated liver diseases of the “gut-liver” axis. New therapeutic strategies for alcohol-associated liver disease are classified based on their mode of action: (1) anti-inflammatory therapies, (2) antioxidants, (3) therapies that modulate the gut-liver axis, and (4) therapies that enhance liver regeneration. At the same time, the often unfavorable prognosis and insufficient effectiveness of therapy require further study of alcohol-associated liver diseases.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development of liver cirrhosis in a patient taking long-term weight loss supplements","authors":"T. V. Goma, N. M. Kozlova, K. S. Boldyreva","doi":"10.31146/1682-8658-ecg-216-8-176-183","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-176-183","url":null,"abstract":"Dietary supplements are often self-administered by patients for weight loss. However, the hepatotoxicity of such supplements remains underestimated. Liver damage is diverse: from asymptomatic reversible course to lethal fulminant hepatitis. In the case of a long unrecognized course and prolonged use of dietary supplements, irreversible structural and functional damage to the organ occurs. We present a retrospective analysis of the case histories of a patient with liver cirrhosis, who has a long history of using dietary supplements of Thai and Chinese origin, hellebore extract, during 5 years of follow-up. Despite the discontinuation of weight loss drugs, regular complex therapy, the patient has a steady progressive course of the disease. Obese patients with an increased risk of liver damage require a dynamic assessment of liver function, not only when prescribing drugs, but also when using various dietary supplements.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blebbing of the plasma membrane of lymphocytes as a marker of endothelial dysfunction in the development of post-resection insufficiency in patients with focal liver lesions","authors":"S. S. Dunayevskaya, N. A. Malinovskaya, A. A. Kosik","doi":"10.31146/1682-8658-ecg-216-8-110-115","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-110-115","url":null,"abstract":"Purpose of the study. To evaluate the intensity of blebbing of the plasma membrane of lymphocytes and the formation of microparticles of lymphocytic origin in patients with postresection hepatic failure. Material and methods. The study involved 54 patients with focal liver diseases. The study involved 32 (59%) women, 22 (41%) men. The average age was 59.5 [49.75; 66,00]. Patients were divided into groups, 1 group - 10 patients with developed acute liver failure and 2 group - 44 patients with a favorable course of postoperative period. The following surgical interventions were performed: 36 (67%) patients underwent surgery - laparotomy, segmental liver resection, 10 (18%) - left-sided hemihepatectomy and 8 (15%) - right-sided hemihepatectomy. Results. Predictors of early postoperative hepatic failure are a decrease in initial blebbing and an increase in terminal blebbing and free microparticles of lymphocytic origin. Conclusions. Thus, changes in lymphocyte blebbing and the presence of free microparticles of lymphocytic origin are due to the development of endothelial insufficiency and apoptosis of lymphocytes in the context of liver failure and are determined by the reduced function of residual liver volume.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional gastrointestinal disorders in patients with chronic opisthorchiasis and rosacea","authors":"S. A. Khardikova, M. L. Aripova, O. I. Urazova, Yu. V. Kolobovnikova","doi":"10.31146/1682-8658-ecg-216-8-79-85","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-79-85","url":null,"abstract":"Introduction. Rosacea is a very common disease among dermatological diagnoses, it is from 5% to 20%. Dysfunctional disorders of the gastrointestinal tract are described in rosacea and chronic opisthorchiasis (HO). The study of gastrointestinal pathology as a factor aggravating the course and manifestation of rosacea on the background of HO, is of practical interest. Purpose of research. To study the features of the gastrointestinal tract in patients with rosacea in combination with HO. Materials and methods. 144 patients were examined, including the 1st group consisted of 80 patients with rosacea without opisthorchiasis, the 2nd group-64 patients with rosacea in combination with HO. 3rd control group - 20 healthy volunteers. Patients underwent duodenal intubation with microscopy of bile; ultrasound examination of abdominal cavity; FGDS with the use of endoscope “Olympys” with biopsy of fondling and pyloric stomach; the complex of histological and histochemical methods; the index of the SHDOR to determine the severity of rosacea. Results. Clinical manifestations of rosacea in patients with HO were more pronounced, as evidenced by a high index of SHDOR 11.3 (6;16) points compared to group 1 (p<0.001). In most patients of group 2, according to ultrasound data, changes in the hepatobiliary system (85.9%) and according to the data of the FGDS (96.8%), pathology of the upper gastrointestinal tract (p<0.001) were detected, which was significantly higher than in patients of group 1 and due to the presence of HO. In patients of group 2, histological changes in the stomach were inflammatory-degenerative. Summary. Examination of the gastrointestinal tract (duodenal sounding with microscopy of bile, ultrasound, FGDS) in patients with rosacea in combination with HO is recommended in practical health care, which will contribute to timely deworming, and as a consequence, positive dynamics in the clinical course of rosacea.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Hyperammonemia and Cognitive Impairment in post-COVID patients","authors":"D. D. Mukhametova, E. N. Belousova, Z. I. Fashieva, M. G. Nazarova, M. V. Knyazeva, D. I. Abdulganieva","doi":"10.31146/1682-8658-ecg-216-8-66-72","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-66-72","url":null,"abstract":"The paper presents the results of an assessment cognitive function and ammonium levels in individuals who have had a novel coronavirus infection (COVID-19). The study included 60 people: 41 - confirmed COVID-19 during last 3 months and 19 - the control group. There have been performed clinical examination, psychometric test - connect-the-numbers test (CNT) and Mini-Mental State Examination (MMSE). Blood ammonium level has been determined. Post-COVID-19 syndrome (PCS) was diagnosed in 70.7% of patients, which was manifested by complaints of memory loss, weakness and anxiety. In patients who underwent COVID-19, cognitive impairment was detected on the MMSE scale in 27 people (45%), and the changes were more pronounced in the group with PCS. In the post-COVID group, 66% of the subjects had an increase CNT result. The cognitive impairment according to the MMSE correlated with the CNT results. Hyperammonemia was found in 54% of COVID-19 survivors, with higher values observed in the PCS group. No correlation was found between hyperammonemia and cognitive impairment.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperammonemia in patients with stable angina pectoris and nonalcoholic fatty liver disease at the steatosis stage","authors":"E. J. Zykina, Zh. G. Simonova","doi":"10.31146/1682-8658-ecg-216-8-57-65","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-57-65","url":null,"abstract":"The aim. To assess the severity of hyperammoniemia in patients with non-alcoholic fatty liver disease at the steatosis stage in conditions of comorbidity with stable angina. Research materials and methods. During the clinical trial, three groups of patients with stable angina were formed. Group I (n = 43) consisted of patients with NAFLD at the stage of hepatic steatosis in combination with obesity and a stable form of CHD. Group II (n = 41) - patients with NAFLD at the stage of hepatic steatosis against the background of normal body weight and stable CHD. Group III (control) (n = 42) - patients with stable angina without NAFLD, with normal body weight. The results of laboratory examination (clinical and biochemical blood tests, lipidograms, insulin levels (calculated by HOMA-IR), glycosylated hemoglobin (HbAlc)) were evaluated; non-invasive markers for the diagnosis of liver injury. Hyperammonemia was evaluated by quantitative rapid ammonia analysis using a Pocket Chem TM BA PA-4140 analyzer. All patients underwent ultrasound of the liver using Philips Epiq 5 (USA). Results. In all patients with stable angina (group I and II), the diagnosis of non-alcoholic fatty liver disease, steatosis stage, was confirmed. The lipid profile of patients in Groups I and II showed more significant hypertriglyceridemia compared to those in the control group, with no statistical difference in Groups I and II. The mean ammonium level in patients with NAFLD in combination with stable CHD (group I, II) was above the threshold and was 87 (57-127.5) and 79 (57-97) μmol/L, respectively, and did not differ significantly (p &gt; 0.05). In patients of group III (without liver disease), the mean values of ammonia in the blood were in the target range. According to the results of correlation analysis, we established the relationship of ammonium with liver enzymes, calculated steatosis indices and basic metabolic indicators. Conclusion. Patients with non-alcoholic fatty liver disease in the steatosis stage with a combination of stable angina have more severe hyperammonemia compared to patients with stable CHD without concomitant liver injury.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical aspects in treatment of gallblader parenchymatous polyps","authors":"O. V. Galimov, V. U. Sataev, V. O. Khanov, D. O. Galimov","doi":"10.31146/1682-8658-ecg-216-8-116-119","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-216-8-116-119","url":null,"abstract":"Aim of this work is to pay attention to tactical approaches to patients with gallbladder polyps. Materials and methods. Authors analyze the experience of surgical treatment of 84 patients with gallbladder polyps for the period 2015-2021 yy. at the University Clinic. Results. Histological examination showed that hyperplastic polyps met most frequently in 47.6%, adenomatous polyps occurred in 45.3% and cholesterol (cholesterosis) in 7.1%. Conclusions. Gallbladder polyps have no specific symptoms. The potential for malignant transformation implies an active surgical approach, which leads to an increase in the number of surgical benefits. At the same time, minimally invasive, videoendoscopic technologies have sufficient capabilities for the radical removal of gallbladder polyps.","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}