在局灶性肝病变患者切除术后功能不全的发展中,淋巴细胞质膜起泡作为内皮功能障碍的标志

S. S. Dunayevskaya, N. A. Malinovskaya, A. A. Kosik
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引用次数: 0

摘要

研究目的:目的:探讨肝衰竭患者淋巴细胞质膜泡的强度及淋巴细胞源性微粒的形成。材料和方法。该研究涉及54例局灶性肝病患者。该研究涉及32名(59%)女性和22名(41%)男性。平均年龄59.5岁[49.75岁;66,00)。患者分为两组,1组10例出现急性肝功能衰竭,2组44例术后病程良好。采取以下手术干预措施:36例(67%)患者接受手术-剖腹手术,肝节段切除术,10例(18%)-左侧半肝切除术,8例(15%)-右侧半肝切除术。结果。术后早期肝功能衰竭的预测因子是初始水泡减少,终末水泡和淋巴细胞来源的游离微粒增加。结论。因此,淋巴细胞起泡的变化和淋巴细胞来源的自由微粒的存在是由于肝衰竭背景下内皮功能不全和淋巴细胞凋亡的发展,并由剩余肝容量功能降低决定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Blebbing of the plasma membrane of lymphocytes as a marker of endothelial dysfunction in the development of post-resection insufficiency in patients with focal liver lesions
Purpose of the study. To evaluate the intensity of blebbing of the plasma membrane of lymphocytes and the formation of microparticles of lymphocytic origin in patients with postresection hepatic failure. Material and methods. The study involved 54 patients with focal liver diseases. The study involved 32 (59%) women, 22 (41%) men. The average age was 59.5 [49.75; 66,00]. Patients were divided into groups, 1 group - 10 patients with developed acute liver failure and 2 group - 44 patients with a favorable course of postoperative period. The following surgical interventions were performed: 36 (67%) patients underwent surgery - laparotomy, segmental liver resection, 10 (18%) - left-sided hemihepatectomy and 8 (15%) - right-sided hemihepatectomy. Results. Predictors of early postoperative hepatic failure are a decrease in initial blebbing and an increase in terminal blebbing and free microparticles of lymphocytic origin. Conclusions. Thus, changes in lymphocyte blebbing and the presence of free microparticles of lymphocytic origin are due to the development of endothelial insufficiency and apoptosis of lymphocytes in the context of liver failure and are determined by the reduced function of residual liver volume.
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