Functional gastrointestinal disorders in patients with chronic opisthorchiasis and rosacea

Abstract

Introduction. Rosacea is a very common disease among dermatological diagnoses, it is from 5% to 20%. Dysfunctional disorders of the gastrointestinal tract are described in rosacea and chronic opisthorchiasis (HO). The study of gastrointestinal pathology as a factor aggravating the course and manifestation of rosacea on the background of HO, is of practical interest. Purpose of research. To study the features of the gastrointestinal tract in patients with rosacea in combination with HO. Materials and methods. 144 patients were examined, including the 1st group consisted of 80 patients with rosacea without opisthorchiasis, the 2nd group-64 patients with rosacea in combination with HO. 3rd control group - 20 healthy volunteers. Patients underwent duodenal intubation with microscopy of bile; ultrasound examination of abdominal cavity; FGDS with the use of endoscope “Olympys” with biopsy of fondling and pyloric stomach; the complex of histological and histochemical methods; the index of the SHDOR to determine the severity of rosacea. Results. Clinical manifestations of rosacea in patients with HO were more pronounced, as evidenced by a high index of SHDOR 11.3 (6;16) points compared to group 1 (p<0.001). In most patients of group 2, according to ultrasound data, changes in the hepatobiliary system (85.9%) and according to the data of the FGDS (96.8%), pathology of the upper gastrointestinal tract (p<0.001) were detected, which was significantly higher than in patients of group 1 and due to the presence of HO. In patients of group 2, histological changes in the stomach were inflammatory-degenerative. Summary. Examination of the gastrointestinal tract (duodenal sounding with microscopy of bile, ultrasound, FGDS) in patients with rosacea in combination with HO is recommended in practical health care, which will contribute to timely deworming, and as a consequence, positive dynamics in the clinical course of rosacea.