急性乙醇中毒患者酒精性脂肪肝的药理纠正特点

G A Livanov, I A Shikalova, A N Lodyagin, S Glushkov, B V Batotsyrenov, A T Loladze, A L Kovalenko
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引用次数: 0

摘要

本研究的目的是提高酒精性脂肪性肝病患者急性乙醇中毒的治疗效率。本文对166例酒精性脂肪肝急性乙醇中毒患者进行了调查和治疗,并采用APACHE-Il严重程度量表对患者进行了评估。分别研究了临床、实验室动态、生化参数、抗氧化系统活性和脂质过氧化状态。本研究发现联合保肝药物利美索对代谢的多个环节的影响,并通过生化参数的动力学证实了这一点。在乙醇中毒的躯体期,高乳酸血症得到快速纠正,ALT活性有效降低,白蛋白和尿素浓度没有降低。在使用利马索期间,患者的临床病程有所改善,表现为震颤谵妄的发生率降低,患者的治疗时间缩短。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[[Features of Pharmacological Correction of Alcoholic Fatty Liver Disease in Patients with Acute Ethanol Intoxication].]

The aim of the study was to increase the efficiency of the treatment of acute ethanol intoxication in patients with alcoholic fatty liver disease. The article presents the results which received during the investigation and treatment of 166 patients with acute ethanol in- toxication on the background of alcoholic fatty liver disease Patients were assessed by the severity scale APACHE-Il. Were studied the dynamics of clinical, laboratory, biochemical parameters, the state of the antioxidant system activity and lipid peroxidation. The study found the effect of the combination hepatoprotective drug remaxol on the many links of metabolism, which was confirmed by the dynamics of biochemical parameters. There was a quick correction of hyperlactatemia, an effective reduction of ALT activity, the absence of reduction of albumin and urea concentration in the somatic period of ethanol poisoning. Period of using remaxol there was improvement in the clinical course of the disease, which manifested by the reduce the incidence of delirium tremens and shorten the duration of treatment of patients.

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