Digestive Diseases and Sciences最新文献

{"title":"Correction to: Fecal Immunochemical Test Positivity Thresholds: An International Survey of Population‑Based Screening Programs.","authors":"Graeme P Young, Sally C Benton, Robert S Bresalier, Han-Mo Chiu, Evelien Dekker, Callum G Fraser, Marieke A M Frasa, Stephen P Halloran, Michael Hoffmeister, Susan Parry, Kevin Selby, Carlo Senore, Harminder Singh, Erin L Symonds","doi":"10.1007/s10620-025-08961-9","DOIUrl":"https://doi.org/10.1007/s10620-025-08961-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Research Trends in Alcoholic Liver Disease: A Bibliometric Perspective.","authors":"Salvatore Pezzino, Sergio Castorina","doi":"10.1007/s10620-025-08948-6","DOIUrl":"https://doi.org/10.1007/s10620-025-08948-6","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors, Clinical Course, and Management of Delayed Perforation After Colorectal Endoscopic Submucosal Dissection: A Large-Scale Multicenter Study.","authors":"Naohisa Yoshida, Ryohei Hirose, Ken Inoue, Yoshikazu Inagaki, Yutaka Inada, Takayuki Motoyoshi, Ritsu Yasuda, Hikaru Hashimoto, Hiroyuki Yoriki, Toshifumi Tsuji, Kohei Fukumoto, Daisuke Hasegawa, Yasutaka Morimoto, Takaaki Murakami, Reo Kobayashi, Naoto Iwai, Osamu Dohi, Elsayed Ghoneem, Yoshito Itoh","doi":"10.1007/s10620-025-08949-5","DOIUrl":"https://doi.org/10.1007/s10620-025-08949-5","url":null,"abstract":"<p><strong>Introduction: </strong>Delayed perforation (DP) remains a significant complication of colorectal endoscopic submucosal dissection (ESD). This study analyzed the risk factors, clinical course, and management for DP following colorectal ESD.</p><p><strong>Methods: </strong>We retrospectively reviewed 4,632 consecutive colorectal ESD cases from 13 institutions between January 2006 and May 2024. DP cases were identified, and the incidence rate, along with patient/lesion characteristics (as tumor size, location, and severe fibrosis) were assessed. The clinical course, including onset timing, initial treatments, need for surgery, and risk factors were examined.</p><p><strong>Results: </strong>DP occurred in 18 cases, with an incidence rate of 0.39% [95% confidence interval (CI): 0.24-0.62]. The mean tumor size was 49.7 ± 35.7 mm. The rates of right-sided colon lesions and severe fibrosis were observed in 77.8 and 61.2%, respectively. DP occurred on post-procedure day 1 in 55.8% of cases, day 2 in 22.2%, and on day 3 or later in 22.2%. Initial DP management included conservative treatment in five cases (27.8%), endoscopic closure in six (33.3%), and surgery in seven cases (38.9%). Among the six cases managed endoscopically, five (83.3%) were successfully managed without surgery. Finally, surgery was required in 11 cases (61.1%). Multivariate analysis (odds ratio [95%CI]) identified severe fibrosis (4.61 [1.50-14.20], p = 0.007), and long procedure time (1.01 [1.00-1.02], p = 0.042), as significant risk factors for DP, while complete closure was inversely correlated with DP risk (0.12 [0.01-0.96], p = 0.046).</p><p><strong>Conclusions: </strong>This study identified DP incidence and risk factors after colorectal ESD, with some cases requiring surgery. Endoscopic treatment may prevent surgery.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic Colitis of the Ascending Colon Following Bowel Preparation with Oral Sulfate Solution.","authors":"Chaohui Zhu, Min Min","doi":"10.1007/s10620-025-08968-2","DOIUrl":"https://doi.org/10.1007/s10620-025-08968-2","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Chromosome 12 Open Reading Frame 49 Promotes Tumor Growth and Predicts Poor Prognosis in Colorectal Cancer.","authors":"Yiming Tao, Jia Luo, Hongyi Zhu, Yi Chu, Lei Pei","doi":"10.1007/s10620-025-08901-7","DOIUrl":"https://doi.org/10.1007/s10620-025-08901-7","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It's a Women's World: A New Look at Sex Differences in Patients with the Irritable Bowel Syndrome.","authors":"Madison R Heath, Zlatan Mujagic, Yuying Luo, Daniel Keszthelyi","doi":"10.1007/s10620-025-08965-5","DOIUrl":"10.1007/s10620-025-08965-5","url":null,"abstract":"<p><p>Irritable bowel syndrome (IBS) exhibits significant sex differences. The female predominance in its worldwide prevalence and variations in symptomatology, treatment efficacy, and adverse effects all may arise from differences in pathophysiology. Due to entrenched historical biases, only recently have studies considered biological differences between the sexes that could affect the understanding of IBS. In this commentary, inspired by a study published in the Digestive Diseases and Sciences, the authors not only focus on different aspects of sexual dimorphism in IBS but also elaborate on the challenges that arise from studying female physiology and its temporal changes in relation to disease characteristics and treatment outcomes.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Life Expectancy in Patients with Acute and Chronic Pancreatitis.","authors":"Satish Munigala, Divya S Subramaniam, Dipti P Subramaniam, Hong Xian, Sarah M Munigala, Krishna C Kottapalli, Thomas E Burroughs, Sunil G Sheth","doi":"10.1007/s10620-025-08944-w","DOIUrl":"10.1007/s10620-025-08944-w","url":null,"abstract":"<p><strong>Background and aims: </strong>Population-based data on the life expectancy and mortality for acute (AP) and chronic pancreatitis (CP) in the United States are limited. This study evaluates the life expectancy, mortality rates and the cause of death in AP and CP patients.</p><p><strong>Methods: </strong>Using the nationwide Veterans Administration database from 1999 to 2015, we identified AP and CP patients (using ICD-9 codes) and non-pancreatitis patients (controls). Age at the time of death was used as a surrogate indicator of life expectancy. Life expectancy in AP and CP patients was compared with the controls, using Cox-proportional hazards model. The mortality rates and cause of death for AP, CP, and controls were also assessed.</p><p><strong>Results: </strong>Overall, we selected 35,550 AP and 12,545 CP patients and 100,000 controls. The life expectancy was significantly lower for both AP (69 years) and CP (71 years) patients compared to the controls (81 years, p < 0.001). The risk of mortality was higher for AP (adjusted hazard ratio (aHR) 1.61, 95% CI 1.58-1.65, p < 0.001) and CP (aHR 1.64, 95% CI 1.59-1.68, p < 0.001) than in controls. Approximately forty-two percent of all patients died during the follow-up (AP-44.3%, CP-52.1% and controls-39.7%). Circulatory disorders, neoplasms, and respiratory disorders were the leading causes of death in AP and CP patients.</p><p><strong>Conclusions: </strong>Acute and chronic pancreatitis are associated with decreased life span and higher mortality emphasizing their clinical importance. Although the deaths due to gastrointestinal/digestive system disorders were significantly higher, most of the deaths in AP and CP patients were primarily due to non-gastrointestinal causes.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"tRF-Pro-CGG Suppresses Cell Proliferation and Promotes Apoptosis in Pancreatic Cancer.","authors":"Jikuan Zhu, Xudong Zhang, Tianping Luo, Cailin Xue, Jiadeng Chao, Jun Li, Bei Zhu, Lei Jin, Chunfu Zhu, Xihu Qin","doi":"10.1007/s10620-025-08943-x","DOIUrl":"10.1007/s10620-025-08943-x","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the role of tRNA-derived RNA fragment tRF-Pro-CGG in pancreatic cancer (PC), focusing on its expression levels in PC tissues and cell lines, and its effects on cell proliferation, clonality, migration, invasion, and apoptosis. Additionally, the study explored the potential of tRF-Pro-CGG as a diagnostic biomarker and therapeutic target in PC.</p><p><strong>Methods: </strong>The expression levels of tRF-Pro-CGG in PC tissues and cell lines were analyzed using next-generation sequencing and quantitative real-time PCR (qRT-PCR). Functional assays, including cell proliferation (CCK-8), colony formation, migration (Transwell), invasion (Matrigel), and apoptosis (flow cytometry), were conducted on PC cell lines (SW1990 and PANC-1) transfected with tRF-Pro-CGG mimic or inhibitor. Dual luciferase reporter assays and Western blotting were used to identify and validate the target gene of tRF-Pro-CGG, CSF1, and its involvement in the PI3K-AKT signaling pathway.</p><p><strong>Results: </strong>tRF-Pro-CGG was significantly downregulated in PC tissues and cell lines compared to normal tissues and cells. Overexpression of tRF-Pro-CGG in SW1990 cells inhibited cell proliferation, clonality, migration, and invasion, while promoting apoptosis. Conversely, inhibition of tRF-Pro-CGG in PANC-1 cells had the opposite effects. Dual luciferase assays confirmed CSF1 as a direct target of tRF-Pro-CGG, and Western blot analysis showed that tRF-Pro-CGG negatively regulated CSF1 expression. Furthermore, tRF-Pro-CGG was found to modulate the PI3K-AKT signaling pathway, with downstream effects on key molecules such as AKT, P-AKT, and PTEN.</p><p><strong>Conclusion: </strong>tRF-Pro-CGG acts as a tumor suppressor in pancreatic cancer by inhibiting cell proliferation, migration, invasion, and promoting apoptosis, likely through targeting CSF1 and regulating the PI3K-AKT signaling pathway. These findings suggest that tRF-Pro-CGG could serve as a potential diagnostic biomarker and therapeutic target for pancreatic cancer.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Gastrointestinal Motility in Adults with Type 1 and Type 2 Diabetes Using Wireless Motility Capsule.","authors":"Samita Garg, Sara Valencia, Hareem Syed, Baila Elkin, Ravi Shah, James Bena, Shannon Morrison, Anthony Lembo, Michael Cline","doi":"10.1007/s10620-025-08954-8","DOIUrl":"https://doi.org/10.1007/s10620-025-08954-8","url":null,"abstract":"<p><strong>Purpose: </strong>Gastrointestinal motility disorders are common in diabetes, though their prevalence and distribution have not been evaluated. The Wireless Motility Capsule (WMC) assesses transit times and pressures of the entire gastrointestinal (GI) tract in a single study. This study aimed to evaluate the prevalence and patterns of GI transit abnormalities using WMC in patients with diabetes.</p><p><strong>Methods: </strong>This retrospective study included adult patients with Type 1 (T1D) and Type 2 Diabetes (T2D) who underwent WMC testing. Whole gut transit time (WGTT), gastric emptying time (GET), small bowel transit time (SBTT) and colon transit time (CTT) were analyzed. Univariate and multivariable analyses identified risk factors for delayed transit. The rates of diabetic complications were assessed. Kaplan-Meier estimates of mortality rates at 1, 3, and 5 years were compared for patients with T1D and T2D.</p><p><strong>Results: </strong>A total of 475 patients (mean age of 54.4 years, 74% female) were included. Of these, 25.9% had T1D and 74.1% had T2D. Mean diabetes duration was 11.4 years. Patients with T1D had a higher mean disease duration of 21.7 years and those with T2D of 7.7 years. More than 35% of patients had HbA1c > 8 and 34% of patients had an HgbA1c between 6.5 and 7.99%. T1D patients had a higher mean HbA1c of 8.6% compared to 7.5% in T2D. Mean BMI was 32.3 in T2D and 26.5 in T1D. Mean BMI was higher in those with normal motility (32.9) than delayed motility (30.1). Delayed transit was observed in 75.8% with delayed GET (58.8%) being the most common abnormality. T2D had shorter median GET (4.4) than T1D (6.1) and longer CTT (95.9) than T1D (79.3). SBTT had an inverse correlation with HbA1c (-0.16). Microvascular complications were greater in T1D including neuropathy in 64.2%, retinopathy in 35% and nephropathy in 31.7% compared to T2D which were: neuropathy 50.3%, retinopathy 11.1% and nephropathy 19%. 7.3 and 1.1% of patients with T1D and T2D had kidney or pancreas transplants respectively. Kaplan-Meier analysis showed no significant difference in mortality in T1D vs T2D.</p><p><strong>Conclusion: </strong>This study reports the prevalence of GI motility abnormalities in patients with longer duration of diabetes, higher HbA1c, lower BMI and associated diabetes microvascular complications. Delayed gastric emptying was the most common finding with greater prevalence of GET delay in T1D vs. T2D. T2D had shorter GET but longer CTT. Mean diabetes duration was 11.4 years and > 70% of patients with diabetes had suboptimal glucose control. Microvascular complications and pancreas/kidney transplant were higher in patients with T1D. Mortality rates were not different in T1D vs T2D. Identifying GI motility disorders in diabetes can guide management to improve outcomes.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Rs12039395 Variant Influences the Expression of hsa‑miR‑181a‑5p and PTEN Toward Colorectal Cancer Risk.","authors":"Wael A El-Korany, Walid E Zahran, Mohamed A Alm El-Din, Hanan A Al-Shenawy, Ahmed F Soliman","doi":"10.1007/s10620-025-08962-8","DOIUrl":"10.1007/s10620-025-08962-8","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}