Digestive Diseases and Sciences最新文献

{"title":"Impact of Diet and Body Mass Index on the Development of Pouchitis in the First Year After Ileal Pouch-Anal Anastomosis.","authors":"Sophia Goldbeck, Chelsea Anderson, Jennifer Barr, Jordan Axelrad, Millie D Long, Hans H Herfarth, Edward Barnes","doi":"10.1007/s10620-026-10102-9","DOIUrl":"10.1007/s10620-026-10102-9","url":null,"abstract":"<p><strong>Background: </strong>Although pouchitis is the most common complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), the influence of diet on pouchitis is poorly understood. Thus, evidence-based dietary recommendations after IPAA are limited.</p><p><strong>Aims: </strong>We evaluated dietary intake in the period after the final stage of IPAA for UC and Body Mass Index (BMI) to identify potential associations with pouchitis.</p><p><strong>Methods: </strong>We used the Dietary Screener Questionnaire (DSQ) to assess dietary intake among patients in a prospective cohort enrolled within 2 weeks of the final stage of IPAA for UC. We compared food group and fiber intake of those who developed pouchitis within 12 months of the final stage of IPAA with those who did not. These were also compared to the United States Department of Agriculture (USDA) recommended daily goals.</p><p><strong>Results: </strong>Among 89 patients, there was no significant difference in individual fiber intake when comparing those who developed pouchitis and those who did not. In comparison with USDA guidelines, both groups (pouchitis and no pouchitis) exhibited decreased intake of several food groups, such as fruits, vegetables, fiber, and dairy. Patients who developed pouchitis had a significantly higher median body mass index (BMI) at the time of surgery compared to patients who did not develop pouchitis (median 29.2 vs. 24.8, P = 0.022).</p><p><strong>Conclusions: </strong>In a prospective cohort, we identified no association between dietary intake and development of pouchitis within the first year after IPAA. However, elevated BMI may represent a unique target for intervention to prevent pouchitis occurrence.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5473-5479"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MASLD Clinical Trials: Increasing Enrollment, Diversity and Generalizability.","authors":"Sobia Laique","doi":"10.1007/s10620-026-10104-7","DOIUrl":"10.1007/s10620-026-10104-7","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5292-5295"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIPS Prior to Liver Transplantation: Timely, Temporizing, and Temporary?","authors":"Ali Emre Bardak, Nazli Begum Ozturk, Eda Yildiz, Ahmet Gurakar","doi":"10.1007/s10620-026-10131-4","DOIUrl":"10.1007/s10620-026-10131-4","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5302-5304"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Four Dietary Approaches on Symptom Severity and Quality of Life in Irritable Bowel Syndrome: A Randomized Controlled Trial.","authors":"Nezihe Otay Lule, Mine Yurttagul, Abdullah Emre Yildirim, Kemal Ozan Lule","doi":"10.1007/s10620-026-10126-1","DOIUrl":"10.1007/s10620-026-10126-1","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder in which dietary interventions play a pivotal role in symptom management. Although traditional dietary advice, the low-FODMAP diet (LFD), and the gluten-free diet (GFD) are commonly employed in clinical practice, comparative evidence regarding their relative efficacy-particularly when applied in combination-remains limited.</p><p><strong>Methods: </strong>This randomized controlled trial with blinded outcome assessment was conducted in the gastroenterology outpatient clinic of a university hospital. Adult patients aged 19-65 years with IBS diagnosed according to the Rome IV criteria were randomized using a minimization method to one of four dietary interventions administered for four weeks: traditional diet (TD), LFD, GFD or a combined low-FODMAP gluten-free diet (LFGFD). Participants were blinded to the specific name of the dietary intervention, and outcome assessors were blinded to group allocation. The primary outcomes were changes in the IBS Symptom Severity Score (IBS-SSS) and the IBS Quality of Life questionnaire (IBS-QOL). Secondary outcomes included changes in FODMAP and gluten intake frequency scores, Bristol Stool Scale, body mass index (BMI), and responder rates.</p><p><strong>Results: </strong>Baseline demographic and clinical characteristics were comparable across the four groups. IBS-SSS decreased significantly within all groups following dietary intervention (p ≤ 0.004), with significantly greater reductions observed in the LFD and LFGFD groups compared with the TD group (p = 0.002). IBS-QOL scores improved significantly within all groups (p ≤ 0.003); however, no significant between-group differences were detected (p = 0.082). Clinically meaningful symptom improvement, defined as a reduction of at least 50 points in IBS-SSS, was achieved by all participants in the LFD, GFD, and LFGFD groups, compared with 8 of 13 participants (61.5%) in the TD group (p = 0.001). Changes in BSS and BMI did not differ significantly between groups.</p><p><strong>Conclusions: </strong>LFD and LFGFD diets were more effective than traditional dietary advice in reducing IBS symptom severity, whereas all dietary approaches yielded significant within-group improvements in quality of life, with no significant between-group difference detected, indicating that no single dietary strategy demonstrated a clear advantage in this domain. These findings, which reflect the restriction phase only, support a stepwise, individualized dietary management strategy in IBS that balances symptom control with quality-of-life considerations.</p><p><strong>Clinical trial number: </strong>NCT04853381.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5654-5665"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Clarify the Independent Role of Digital Learning and Nurse Support in the Self-Management of Inflammatory Bowel Disease.","authors":"Hang Chen, Han Zhang","doi":"10.1007/s10620-026-10158-7","DOIUrl":"10.1007/s10620-026-10158-7","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"6135-6136"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What a Placebo Arm Measures: Biopsy Misclassification and Embedded Lifestyle Care in Pooled Cirrhosis Incidence for Fibrotic MASH.","authors":"Chetan Raameshh Kalal, Samriddhi Poyekar, Harshad Joshi, Shankar Zanwar, Ameet Mandot, Piyush Gupta","doi":"10.1007/s10620-026-10155-w","DOIUrl":"10.1007/s10620-026-10155-w","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"6141-6142"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inaugural Rome Foundation Research into the Epidemiology of All Disorders of Gut-Brain Interaction: The 1993 U.S. Householder Survey in Digestive Diseases and Sciences, a High-Cite Classic.","authors":"Nicholas J Talley","doi":"10.1007/s10620-026-10143-0","DOIUrl":"10.1007/s10620-026-10143-0","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"6123-6127"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Readability, Quality, Understandability, and Actionability of ChatGPT-Generated GI Patient Education Versus AGA Patient Center\".","authors":"Wania Kauser, Muhammad Faizan Khan","doi":"10.1007/s10620-026-10144-z","DOIUrl":"10.1007/s10620-026-10144-z","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"6139-6140"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chewing the Fat: Reconsidering Treatment Goals in Hypertriglyceridemia-Associated Acute Pancreatitis.","authors":"Mohamed Abuelazm, Mohamed S Elgendy, Abdelrahman Awad","doi":"10.1007/s10620-026-10181-8","DOIUrl":"10.1007/s10620-026-10181-8","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5322-5323"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemostatic Efficacy and Safety of the Hybrid Injector ClearCoajet in Endoscopic Mucosal Resection of Large Colorectal Polyps: A Multicenter Randomized Trial.","authors":"Youngkyeong Nam, Han Hee Lee, Jin Lee, Seung In Seo, Seung Han Kim, Yunho Jung, Dae Young Cheung, Bo-In Lee, Tae Oh Kim, Jin Il Kim, Hyun Seok Lee","doi":"10.1007/s10620-026-10163-w","DOIUrl":"10.1007/s10620-026-10163-w","url":null,"abstract":"<p><strong>Background and aims: </strong>We aimed to evaluate the effectiveness and safety of ClearCoajet, a device that combines the hemostatic function of a heat probe with an injector, for hemostasis of intraprocedural bleeding (IPB) during colon endoscopic mucosal resection.</p><p><strong>Methods: </strong>This multicenter, randomized clinical trial, conducted from October 2022 to April 2025, enrolled patients undergoing EMR for non-pedunculated colorectal polyps measuring ≥ 15 mm. This study evaluated and compared the efficacy and safety of hemostasis for IPB by comparing a snare-tip-only strategy (control group) with a strategy in which hemostasis could be performed using either the snare tip or ClearCoajet at the endoscopist's discretion (Coajet group).</p><p><strong>Results: </strong>A total of 220 lesions were included in the study, with 106 and 114 lesions assigned to the Coajet and control groups, respectively. IPB occurred in 24.1% of EMR procedures, the majority of which were classified as mild cases. Hemostasis was attempted using the assigned interventions for each group. The hemostasis success rate was slightly higher in the Coajet group (96.4% [27/28]) than in the control group (84.0% [21/25]), although the difference was not statistically significant (P = 0.176). The risk difference in hemostasis success was 12.4 percentage points (95% CI, - 4.7 to 31.3). Among the 27 successful cases in the Coajet group, 17 were controlled using ClearCoajet and 10 using the snare tip. No significant differences were observed between the two groups in terms of hemostasis time, post-polypectomy syndrome, or delayed bleeding.</p><p><strong>Conclusions: </strong>In this trial, a ClearCoajet-available strategy was non-inferior to a snare-tip-only strategy, with ClearCoajet effectively controlling most bleeding episodes in that group without additional hemostatic devices. Given the smaller-than-planned sample, this finding should be confirmed in an adequately powered trial.</p><p><strong>Trial registration: </strong>www.</p><p><strong>Clinicaltrials: </strong>gov NCT05737017.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5930-5938"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}