Digestive Diseases and Sciences最新文献

{"title":"Dosing 5-ASA for Ulcerative Colitis: Is the Maximum Optimum?","authors":"Nai-Yu Chen, Chiao-Hsiung Chuang","doi":"10.1007/s10620-026-09874-x","DOIUrl":"https://doi.org/10.1007/s10620-026-09874-x","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymptomatic Isolated IgG4-related Colopathy.","authors":"Jin-Ping Zhang, Ting-Ting Zhou, Lei Liu, Wei Liu","doi":"10.1007/s10620-026-09876-9","DOIUrl":"https://doi.org/10.1007/s10620-026-09876-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: From Surgery to Strength: The Case for Mental Health Integration in Ileostomy Care.","authors":"Marie Atallah","doi":"10.1007/s10620-026-09884-9","DOIUrl":"https://doi.org/10.1007/s10620-026-09884-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coal Dust Nanoparticles Induce Colitis-Like Lesions in Rats via Gut Microbiota Dysbiosis and P53/SCO2/SLC7A11-Mediated Epithelial Ferroptosis.","authors":"Yazhen Zhang, Yuhan Ma, Cancan Jiang, Yao Liu, Yao Xu, Qiuxue Yang, Yuting Huang, Xinkuang Liu, Shuping Zhou, Yinci Zhang","doi":"10.1007/s10620-026-09867-w","DOIUrl":"https://doi.org/10.1007/s10620-026-09867-w","url":null,"abstract":"<p><strong>Purpose: </strong>Advanced mining technologies have increased the generation and exposure risk of coal dust nanoparticles (CD-NPs). While CD-NPs are known to cause lung damage, their effects on intestinal tissues following respiratory exposure remain unclear. Here, we investigated the damaging effects of CD-NPs on colonic tissues and the underlying mechanisms.</p><p><strong>Methods: </strong>Rats were exposed to CD-NPs for 3, 6, and 9 weeks (n = 6 per group). Assessments included intestinal pathology, inflammatory status, barrier integrity, gut microbiota (16S rRNA sequencing), colonic transcriptomics (RNA-Seq), and cellular functional validation of ferroptosis pathways.</p><p><strong>Results: </strong> : CD-NPs exposure caused significant colonic damage, elevated interleukin-6 / interleukin-17a levels, and reduced expression of tight junction proteins (Zonula occludens-1, Occludin, Claudin-1; all P < 0.05). The gut microbiota exhibited decreased alpha diversity, distinct beta separation, enriched pro-inflammatory taxa, and depleted anti-inflammatory commensals. Transcriptomics revealed downregulated oxidative phosphorylation and enriched ferroptosis (both P < 0.01). Functional experiments confirmed ferroptosis characteristics: reduced glutathione peroxidase 4, increased long-chain acyl-CoA synthetase 4, oxidative stress, mitochondrial dysfunction, Fe²⁺ accumulation, and activation of the tumor protein 53 (P53)/synthesis of cytochrome C oxidase 2 (SCO2)/solute carrier family 7 member 11 (SLC7A11) pathway.</p><p><strong>Conclusion: </strong>Respiratory exposure to CD-NPs induces colitis-like lesions via gut microbiota dysbiosis and P53/SCO2/SLC7A11-mediated epithelial ferroptosis, impairing the intestinal barrier. These findings provide new insights into the health risks associated with coal dust exposure.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Fecal Elastase-1: A Non-negligible Factor in Functional Dyspepsia Patients.","authors":"Jiao Liu, Tian He, Linglong Ji, Ling Liu","doi":"10.1007/s10620-025-09500-2","DOIUrl":"10.1007/s10620-025-09500-2","url":null,"abstract":"<p><strong>Background and aim: </strong>Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders. The occurrence of dyspepsia has been reported to be associated with a deficiency or dysfunction of digestive enzymes. Although the pancreas plays a critical role in secreting digestive enzymes, the relationship between FD and pancreatic exocrine insufficiency (PEI) remains unclear. This study aims to evaluate the prevalence of low Fecal elastase-1 (FE-1) level, a recognized indicator of PEI, in FD patients and explore potential risk factors contributing to this condition.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 76 FD patients. The FE-1 level was measured using a commercial ELISA kit. An FE-1 level below 200 μg/g stool was defined as abnormal. Clinical characteristics and gut microbiota composition were compared between FD patients with low FE-1 level (FE-L) and those with normal FE-1 level (FE-N). Logistic regression analysis was used to identify independent risk factors for low FE-1 level in FD patients.</p><p><strong>Results: </strong>The prevalence of low FE-1 level among FD patients was 19.7%. Compared to the FE-N group, the FE-L group exhibited higher gastrointestinal symptoms scores, anxiety scores and lower quality of life scores (P < 0.05). Logistic regression analysis revealed that male gender and anxiety state were independent risk factors for low FE-1 level. Gut microbiota analysis demonstrated that Prevotella were significantly enriched, while Bacteroides and Bifidobacterium were decreased in the FE-L group (LDA > 3, P < 0.05).</p><p><strong>Conclusions: </strong>The present study suggests that a subset of patients with FD have FE-1 secretion insufficiency and might benefit from pancreatic enzyme supplementation therapy.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1406-1415"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma and Chronic Obstructive Pulmonary Disease Are Associated with an Increased Risk of Developing Fecal Incontinence.","authors":"Aditya Ashok, Raphaëlle Varraso, Keming Yang, Orianne Dumas, Andrew T Chan, Carlos A Camargo, Kyle Staller","doi":"10.1007/s10620-025-09484-z","DOIUrl":"10.1007/s10620-025-09484-z","url":null,"abstract":"<p><strong>Background: </strong>Fecal incontinence (FI) is a common condition associated with aging. Asthma and chronic obstructive pulmonary disease (COPD) are obstructive lung diseases associated with both urinary incontinence and increased intraabdominal pressures.</p><p><strong>Objective: </strong>We sought to evaluate whether these obstructive lung diseases increase the risk of developing FI.</p><p><strong>Methods: </strong>We prospectively examined the association between asthma, COPD and asthma/COPD overlap and risk of FI among women from the Nurses' Health Study (NHS). We defined incident FI as ≥ 1 liquid or solid FI episode/month during four years of follow-up using self-administered, biennial questionnaires (2008-2012). Validated self-report of asthma and COPD were used from 1988 to 2008. We used Cox proportional hazards models to calculate multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for FI risk associated with obstructive lung diseases.</p><p><strong>Results: </strong>We documented 6,091 cases of incident FI in the asthma cohort (n = 54,444, with asthma 6,100, without asthma 48,344). Compared to women without asthma, the aHR for FI in those with asthma was 1.18 (95%CI 1.09-1.27). We documented 5,834 cases of incident FI in the COPD cohort (n = 51,837, with COPD 3,484, without COPD 48,353). Compared to women without COPD, the aHR for FI in those with COPD was 1.16 (95%CI 1.05-1.27). We documented 5,773 cases of incident FI in the asthma/COPD cohort (n = 51,156, with asthma/COPD overlap 2,803, without 48,353). Compared to women without asthma/COPD overlap, the aHR for FI in those with asthma/COPD overlap was 1.28 (95%CI 1.16-1.42).</p><p><strong>Conclusion: </strong>Asthma and COPD are associated with increased risk of developing FI. Further studies are needed to elucidate the pathophysiology driving this association.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1454-1463"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colon Perforation Induced by a Toothpick.","authors":"Yingxin Chen, Ran Ma, Yange Zhao, Kun Ma, Shaoxuan Wang","doi":"10.1007/s10620-025-09488-9","DOIUrl":"10.1007/s10620-025-09488-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1147-1148"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholangioscopy to the Rescue: Transpapillary Drainage for Contained Gallbladder Perforation.","authors":"Shubham Kumar, Ritesh Acharya, Pankaj Gupta, Rajesh Gupta, Surinder Singh Rana","doi":"10.1007/s10620-025-09489-8","DOIUrl":"10.1007/s10620-025-09489-8","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1153-1154"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anal Fistula-Associated Triple Malignant Lesions.","authors":"Hao Tan, Yamei Zhang, Ping Li, Weiming Liu, Chengdong Yu","doi":"10.1007/s10620-025-09478-x","DOIUrl":"10.1007/s10620-025-09478-x","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1149-1152"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Hospitalized Patients with Severe UC from 1997 to 2021 in a Large Regional Healthcare System in the US.","authors":"Katie Williams, Lauren A Sussman, Prasanna Challa, Emily W Lopes, Jonathan Downie, Michaela Tracy, Gregory Fricker, Erik Hasenoehrl, Rachel Irengo, Jenny Gurung, Cecilia Woo, Negin Amouei, Yueting Lu, Artemis Trikola, Marc Sherman, Liliana Bordeianou, Rocco Ricciardi, Tracey Simon, Hamed Khalili","doi":"10.1007/s10620-025-09544-4","DOIUrl":"10.1007/s10620-025-09544-4","url":null,"abstract":"<p><strong>Background: </strong>Disease course following hospitalization for severe ulcerative colitis (UC) is poorly understood. Here, we evaluate the outcomes of hospitalized patients with severe UC defined using endoscopic activity across the Mass General Brigham (MGB) health system over a 24-year period.</p><p><strong>Methods: </strong>We developed and internally validated a natural language processing (NLP) algorithm to derive endoscopic disease severity. We included all hospitalized patients with UC across MGB from 1997 to 2021 and used the NLP algorithm to identify those with severe disease activity, defined using the Mayo Endoscopic Score. We used Cox proportional hazards modeling to estimate the risk of 90-day colectomy and rehospitalization across three calendar periods (1997-2005, 2006-2015, and 2016-2021) for patients hospitalized with severe UC.</p><p><strong>Findings: </strong>The NLP algorithm had excellent performance for identifying endoscopic features, with high Cohen's Kappa scores between the algorithm's prediction and the reviewers' consensus for derived Mayo endoscopic score (k = 0.92). We identified 279 independent hospitalizations for severe UC using our NLP algorithm and manual validation methods from 1997 to 2021. The 90-day cumulative incidence of colectomy were 17.9% in 1997-2005, 18.3% in 2006-2015 and 24.4% in 2016-2021. In contrast, rates of biologic medication use increased from 10.7% in 1997-2005 to 70.2% in 2016-2021. Compared to the 1997-2005 period, the adjusted hazard ratios (aHRs) for 90-day colectomy were 1.1 (95% CI 0.4-2.8) in 2006-2015 and 1.5 (95% CI 0.6-3.9) in 2016-2021 (P_trend = 0.225). Similarly, we did not observe any differences in rates of 90-day rehospitalizations (P_trend = 0.624).</p><p><strong>Interpretation: </strong>Here, we present an NLP algorithm for extracting features of endoscopic severity in patients with UC. Using this algorithm, we showed that the outcomes, including colectomy and rehospitalization, of patients hospitalized for severe UC in a large health system in the US have not significantly changed over the past 24 years.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1425-1433"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}