Digestive Diseases and Sciences最新文献

{"title":"Ustekinumab Dose Optimization in Ulcerative Colitis: Is More Always Better?","authors":"Thanaboon Chaemsupaphan, Julajak Limsrivilai","doi":"10.1007/s10620-025-09108-6","DOIUrl":"10.1007/s10620-025-09108-6","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"2916-2917"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Crohn's Disease-Not Your Typical Brain-Gut Connection.","authors":"Nicholas P Valle, Sephr Hamidi, Fausto Rodriguez, Berkeley N Limketkai","doi":"10.1007/s10620-025-09150-4","DOIUrl":"10.1007/s10620-025-09150-4","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"3010-3013"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concise Commentary: Gray Area-Underappreciated HCC Risk in Untreated \"Gray Zone\" and Immune-Tolerant CHB Patients.","authors":"Won-Mook Choi","doi":"10.1007/s10620-025-09147-z","DOIUrl":"10.1007/s10620-025-09147-z","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"2910-2911"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financing Digestive Innovation-Energy from Synergy: A Concise Commentary.","authors":"Yichen Wang, Yuting Huang","doi":"10.1007/s10620-025-09146-0","DOIUrl":"10.1007/s10620-025-09146-0","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"2912-2913"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putting a Fine Edge on the Diagnosis of Pancreatic Cystic Lesions: How EUS-FNB Is Reshaping Their Management.","authors":"Fumitaka Niiya","doi":"10.1007/s10620-025-09113-9","DOIUrl":"10.1007/s10620-025-09113-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"2932-2933"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Post-polypectomy Bleeding After Colorectal Endoscopic Mucosal Resection in Patients with Chronic Kidney Disease: A Propensity-Matched Analysis of the US Collaborative Network.","authors":"Azizullah Beran, Khaled Elfert, Feenalie N Patel, Mouhand Mohamed, Daryl Ramai, Almaza Albakri, Nasir Saleem, Faisal Kamal, Andrew Canakis, Khaled Srour, Danial H Shaikh, Shyam Thakkar, Douglas K Rex, Indira Bhavsar-Burke, John J Guardiola","doi":"10.1007/s10620-025-09122-8","DOIUrl":"10.1007/s10620-025-09122-8","url":null,"abstract":"<p><strong>Background: </strong>Studies evaluating the risk of post-polypectomy bleeding (PPB) after colorectal endoscopic mucosal resection (EMR) in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) are limited.</p><p><strong>Methods: </strong>This retrospective cohort study utilized the U.S. Collaborative Network to assess the risk of PPB after colorectal EMR in patients with CKD compared to controls. Using one-to-one propensity score matching (PSM), the primary outcome measured was PPB within 30 days after colorectal EMR. The PPB risk was further stratified by CKD severity: non-advanced CKD and advanced CKD.</p><p><strong>Results: </strong>After PSM, each cohort included 9,196 patients. Overall, CKD was associated with increased risk of PPB following colorectal EMR (5.4% vs. 3.8%, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.25-1.66, p < 0.001). The PPB risk was significantly higher in patients with advanced CKD (8.1% vs. 4%, OR 2.09, 95% CI 1.65-2.65, p < 0.001), while those with non-advanced CKD showed modest increase in risk of PPB (4.7% vs. 4%, OR 1.20, 95% CI 1.01-1.41, p = 0.03).</p><p><strong>Conclusion: </strong>Patients with CKD had higher risk of PPB than patients without CKD. The PPB risk was notably increased in patients with advanced CKD. Optimizing patients with CKD, especially advanced CKD, before colorectal EMR and monitoring for post-procedure bleeding remains important.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"3102-3109"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Von Willebrand Disease-Induced Gastrointestinal Bleeding: Report of a Rare Case.","authors":"Bangfa Xiong, Tiansong Fan, Qianfeng Wei, Qian Liu, Erqing Chai","doi":"10.1007/s10620-025-09132-6","DOIUrl":"10.1007/s10620-025-09132-6","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"2894-2895"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Effect of Prior Lesion Manipulation on Colorectal Endoscopic Submucosal Dissection Outcomes: A Retrospective Cohort Study.","authors":"Daryl Ramai, Abdulrahman Qatomah, Hiroyuki Aihara","doi":"10.1007/s10620-025-09102-y","DOIUrl":"10.1007/s10620-025-09102-y","url":null,"abstract":"<p><strong>Introduction: </strong>Endoscopic submucosal dissection (ESD) is a minimally invasive technique for en-bloc resection of superficial gastrointestinal lesions. However, the influence of prior manipulations, such as tattooing or endoscopic mucosal resection (EMR), on ESD outcomes is not well understood.</p><p><strong>Methods: </strong>This retrospective cohort study evaluated 763 patients (mean age 64 years, 52% female) who underwent colorectal ESD at Brigham and Women's Hospital between 2014 and 2024. Outcomes included rates of en-bloc, R0, curative resection, and adverse events. Multivariable regression analysis identified factors associated with unsuccessful outcomes.</p><p><strong>Results: </strong>The mean lesion diameter was 50 mm, with 54.4% located in the right colon. Prior tattooing occurred in 7% of cases while prior EMR was reported in 17% of lesions. En-bloc resection was achieved in 95% of cases, R0 resection in 89%, and curative resection in 88%. The mean procedure time was 64 min, with adverse events including delayed bleeding (3.3%), muscle injury (0.9%), and perforation (0.8%). Factors linked to unsuccessful en-bloc resection were prior tattooing (OR 0.30, 95% CI 0.09-0.98; P = 0.047), prior EMR (OR 0.31, 95% CI 0.12-0.82; P = 0.017), and submucosal fibrosis (OR 0.20, 95% CI 0.07-0.53; P = 0.001). Submucosal fibrosis also reduced R0 and curative resection rates. No statistically significant associations between procedural adverse events and fibrosis, prior EMR, or tattooing were found.</p><p><strong>Conclusions: </strong>These findings highlight the importance of avoiding unnecessary pre-procedural manipulations and emphasize the need for urgent planning to optimize ESD outcomes.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"3097-3101"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E2F2/MUC1 Enhances Cell Stemness of Hepatocellular Carcinoma by Regulating the Notch Signaling Pathway.","authors":"Yao Huang, Jianxing Zeng, Teng Liu, Qingyi Xu, Xianglin Song, Jinhua Zeng","doi":"10.1007/s10620-025-09148-y","DOIUrl":"10.1007/s10620-025-09148-y","url":null,"abstract":"<p><strong>Background: </strong>The fifth most prevalent cancer in the world, hepatocellular carcinoma (HCC), has a significant fatality rate. A cell surface mucin protein known as MUC1 is widely expressed in different cancer types. Its function in HCC has not, however, been completely investigated. The purpose of this study was to look at biological role of MUC1 in HCC.</p><p><strong>Methods: </strong>Bioinformatics analysis investigated E2F2 expression in HCC tissues. Immunohistochemistry was used to detect the expression of MUC1 in HCC tissues and paracancerous tissues. qRT-PCR detected E2F2 and MUC1 expression in HCC cells. Dual-luciferase and ChIP assays verified regulatory relationship. CCK-8 assays tested cell viability. Western blot detected stem cell markers and Notch pathway-related proteins. Colony formation assays tested cell proliferation, and sphere formation assays tested the number of cell spheres formed.</p><p><strong>Results: </strong>MUC1 was significantly upregulated in HCC tissues and cells. Knockdown of MUC1 reduced cell proliferation, expression of stem cell surface markers, the number of cell spheres formed, and Notch signaling pathway-related proteins. Bioinformatics analysis predicted that E2F2 was an upstream transcription factor of MUC1 and was substantially increased in HCC. Dual-luciferase and ChIP assays confirmed the mutual binding relationship between E2F2 and MUC1. Further reversion experiments showed that further silencing of MUC1 reversed the stimulatory effect of overexpressed E2F2 on cell stemness.</p><p><strong>Conclusion: </strong>In summary, E2F2 could upregulate the expression of MUC1 to regulate Notch signaling pathway and promote stemness of HCC cells. This study revealed a potential regulatory pathway of MUC1-mediated HCC progression, providing new ideas for HCC therapy.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"3056-3065"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Efficacy of Repeated Endoscopic Incision Combined with Triamcinolone Injection in Patients with Recurrent Benign Esophageal Stricture.","authors":"Hongyu Chen, Ying Liu, Mengnan Xu, Rui Guo, Jing Zhang, Manhua Li, Xiaopeng Zhang, Xin Yin, Bairong Li, Tao Sun, Chongxi Fan, Yanglin Pan, Shoubing Ning","doi":"10.1007/s10620-025-09101-z","DOIUrl":"10.1007/s10620-025-09101-z","url":null,"abstract":"<p><strong>Background and aims: </strong>Endoscopic incision (EI) combined with triamcinolone (TAA) injection has emerged as an effective method for treating benign esophageal stricture (BES). However, a single EI and TAA injection seems to be insufficient for long-term relief of BES in some patients, especially those with recurrent BES. Here, we aimed to investigate the long-term efficacy and safety of repeated EIs and TAA injections in patients with recurrent BES.</p><p><strong>Methods: </strong>Patients with recurrent BES who previously underwent endoscopic dilation or EI were enrolled in this retrospective study. All patients underwent multiple EIs and TAA injections. Patients were followed for at least 12 months. The primary outcome was the rate of re-stricture at 6 months after repeated EIs and TAA injections. The secondary outcomes included the symptom relief rate, the change in Stooler's dysphagia score (0, normal swallowing; 1, semidry food intake only; 2, soft food intake only; 3, fluid only; and 4, no oral intake) and body mass index (BMI) at 6 months, and overall adverse events (AEs). The risk factors for 6-month re-stricture were identified using logistic regression analysis.</p><p><strong>Results: </strong>A total of 73 patients were enrolled in this study, including 30 (41.1%) with esophagogastric anastomotic strictures, 15 (20.5%) with caustic injury-related strictures, 14 (19.2%) who developed strictures after ESD, 5 (6.8%) with esophagojejunal anastomotic strictures and 9 (12.3%) with other types of strictures. A total of 264 EIs and TAA injections were performed, with 3 (IQR: 2, 5) treatments for each patient. The 6-month re-stricture rate was 53.4%, and the 2-month, 3-month, and 12-month re-stricture rates were 43.8%, 48.0%, and 54.8%, respectively. The 2-month, 3-month, 6-month, and 12-month dysphagia relief rates were 75.3%, 65.8%, 56.2%, and 54.8%, respectively. At 6 months after treatments, the median Stooler's dysphagia score had decreased from 4 (IQR: 4, 4) to 2 (IQR: 0, 4) (P < 0.001), and the median BMI had increased from 19.6 (IQR: 16.9, 21.8) kg/m² to 20.8 (IQR: 17.4, 22.6) kg/m² (P < 0.001). Bile reflux (OR 9.90, 95% CI: 0.99-98.43) and the number of EIs (OR 1.68, 95% CI: 1.17-2.41) were independently associated with 6-month re-stricture after repeated EIs and TAA injections. Four EI-related perforations were successfully treated with a covered metal stent (n = 3) and rescue surgery (n = 1).</p><p><strong>Conclusions: </strong>Repeated EIs and TAA injections were effective and reasonably safe in managing recurrent BES. However, the long-term efficacy remains suboptimal, thus further investigations are needed.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"3077-3088"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}