Digestive Diseases and Sciences最新文献_第8页

Predictors for Achieving Textbook Outcomes After Endoscopic Resection of Giant Submucosal Tumors in the Esophagus and Cardia. 内镜下食管和贲门巨大粘膜下肿瘤切除术后达到教科书预后的预测因素。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-05 DOI: 10.1007/s10620-025-09377-1

Wei Su, Yun Wang, Haihan Xu, Ji-Yuan Zhang, Xi-Guo Fang, Hao Hu, Quan-Lin Li, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Ping-Hong Zhou, Sheng-Li Lin

{"title":"Predictors for Achieving Textbook Outcomes After Endoscopic Resection of Giant Submucosal Tumors in the Esophagus and Cardia.","authors":"Wei Su, Yun Wang, Haihan Xu, Ji-Yuan Zhang, Xi-Guo Fang, Hao Hu, Quan-Lin Li, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Ping-Hong Zhou, Sheng-Li Lin","doi":"10.1007/s10620-025-09377-1","DOIUrl":"https://doi.org/10.1007/s10620-025-09377-1","url":null,"abstract":"Background and aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate the predictors of TO for giant SMTs with a long diameter ≥ 7 cm or a transverse diameter ≥ 3.5 cm.Methods: A retrospective review was conducted for endoscopic resection of consecutive patients with giant SMTs in the esophagus and cardia between July 2017 and February 2022 at the Endoscopy center of Zhongshan Hospital, Fudan University. TO was mainly defined as absences of major adverse events, piecemeal resection, and prolonged hospital stay. Clinicopathologic, procedural characteristics, adverse events, and follow-up outcomes were analyzed.Results: A total of 109 patients who completed endoscopic resection were analyzed. The median long and transverse diameter of the tumors were 7.5 cm (range, 4-15 cm) and 4 cm (range, 1.5-7 cm), respectively. The en bloc resection rate was 78.9%. Transverse diameter < 4.5 cm and regular shape were independent predictors for TO. Major adverse events (mAEs) occurred in 14 patients (12.8%). Long diameter ≥ 9 cm and piecemeal resection were significantly associated with mAEs. During a median follow-up of 33.5 months, there was no tumor recurrence or metastasis.Conclusion: Giant esophageal or cardia SMTs with a long diameter < 9 cm and transverse diameter < 4.5 cm indicated a safe and credible outcome for endoscopic resection.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Submucosal Dissection Followed by Endoscopic Full-Thickness Resection for Hidden Major Duodenal Papillary Neoplasm (with Video). 内镜下粘膜夹层及内镜下全层切除术治疗隐藏的十二指肠乳头状肿瘤（附视频）。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-05 DOI: 10.1007/s10620-025-09365-5

Ning Su, Jiyu Zhang, Qingfen Zheng, Lixia Zhao, Bingrong Liu

引用次数: 0

Beyond Identification: Operationalizing Frailty and Sarcopenia Assessment for Pre-transplant Optimization. 超越识别：移植前优化的虚弱和肌肉减少评估的操作性。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-05 DOI: 10.1007/s10620-025-09357-5

Juncong Hu, Xiaosi Zhang, Wenjing Pei

引用次数: 0

Concerns Regarding Generalizability of IEL Cut-offs in Pediatric-Only Study for Celiac Disease Diagnosis. 对儿科乳糜泻诊断中IEL截止点的通用性的关注

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-05 DOI: 10.1007/s10620-025-09345-9

Aiman Ashfaq

引用次数: 0

Adult Patients with Celiac Disease Are Under-Vaccinated Against Pneumococcal Disease: A Quality Improvement Study. 成年乳糜泻患者接种肺炎球菌疫苗不足：一项质量改进研究

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-04 DOI: 10.1007/s10620-025-09350-y

Kaitlin Payne, Claire Jansson-Knodell, Emily Trommer, Andrew Ford, Kendra Weekley, David Gardinier, Alberto Rubio-Tapia

{"title":"Adult Patients with Celiac Disease Are Under-Vaccinated Against Pneumococcal Disease: A Quality Improvement Study.","authors":"Kaitlin Payne, Claire Jansson-Knodell, Emily Trommer, Andrew Ford, Kendra Weekley, David Gardinier, Alberto Rubio-Tapia","doi":"10.1007/s10620-025-09350-y","DOIUrl":"https://doi.org/10.1007/s10620-025-09350-y","url":null,"abstract":"Purpose: Patients with celiac disease (CeD) are at increased risk of pneumococcal infections, and guidelines recommend vaccination against pneumococcal disease as a safe and effective strategy at reducing the risk of infection. The rate of vaccination amongst patients with CeD is unknown. The aim of this study was to evaluate current underlying vaccination rates and to improve vaccination rates through a quality improvement initiative.Methods: Data regarding rates of pneumococcal vaccination amongst patients with biopsy-confirmed CeD were retrospectively collected. A prospective quality improvement initiative was then performed. An educational handout was provided to patients seen during in-person clinic visits, and the pneumococcal conjugate 20 vaccine (PCV20) was offered.Results: A total of 340 patients were initially reviewed. Only 78 patients (21%) were adequately vaccinated against pneumococcal infection. In the prospective portion, 93 CeD patients were seen in the office during the period of intervention, 33 of whom were already vaccinated (35%). The handout was given to 42/60 eligible patients, the majority of whom were vaccinated during the same clinic visit (62%). Of patients who did not receive the flier, 2/18 were vaccinated in the office. Patients were significantly more likely to get vaccinated after receiving the handout (odds ratio (OR) 13.0; 95% CI 2.6-64.2; p = 0.0016).Discussion: Patients with CeD are under-vaccinated against pneumococcal disease. Providing educational resources and administering PCV20 during in-person GI office visits appears to be an effective strategy to increase vaccination rates.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monomorphic Epitheliotropic Intestinal T-cell Lymphoma on Enteroscopy: Mucosal Surface Fine Fragmentation as a Key Diagnostic Clue. 小肠镜下单纯性上皮性肠t细胞淋巴瘤：粘膜表面细裂是诊断的关键线索。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-04 DOI: 10.1007/s10620-025-09359-3

Mark Pi-Chun Chuang, Yi-Chia Lee, Shan-Chi Yu, Chia-Hung Tu

引用次数: 0

Correction: Aflatoxin B1 Promotes M2-like Macrophage Polarization via IL-6 Expression in Hepatocellular Carcinoma. 更正：黄曲霉毒素B1通过IL-6表达促进肝细胞癌中m2样巨噬细胞极化。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-04 DOI: 10.1007/s10620-025-09376-2

Jingze Niu, Wenda Wu, Huayue Zhang, Zelin Li, Xiaojie Meng, Baocai Xu

引用次数: 0

Real World Performance of the Model for End-Stage Liver Disease Score Across Different Races and Ethnicities. 终末期肝病评分模型在不同种族和民族中的实际表现。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-03 DOI: 10.1007/s10620-025-09362-8

Maria Mironova, Zachary Zaiman, Mathew C Samuel, Judy Wawira Gichoya, Andre L Holder, Leo Anthony Celi, Daniel J Stein

{"title":"Real World Performance of the Model for End-Stage Liver Disease Score Across Different Races and Ethnicities.","authors":"Maria Mironova, Zachary Zaiman, Mathew C Samuel, Judy Wawira Gichoya, Andre L Holder, Leo Anthony Celi, Daniel J Stein","doi":"10.1007/s10620-025-09362-8","DOIUrl":"10.1007/s10620-025-09362-8","url":null,"abstract":"Background and aims: The MELD score assesses liver disease severity and guides liver allocation in the United States. This study aims to address the knowledge gap regarding potential disparities in the performance of MELD-Na and MELD 3.0 scores across races and ethnicities.Methods: A retrospective cohort study of Asian, White, African American, and Hispanic patients with cirrhosis from MIMIC-IV (Beth Israel Deaconess Medical Center) and Emory University databases. The performance of the MELD scores in predicting a composite outcome of death or liver transplant (LT) during the hospital stay or within 90 days was analyzed using AUROC for discrimination, and calibration curves for calibration.Results: A total of 4,306 patients with cirrhosis from MIMIC-IV and 5801 patients from Emory were included. Across both datasets, no significant differences were found in the discriminative ability of both scores to predict in-hospital death or LT across races and ethnicities (p > 0.05). A small group of Asian patients influenced score performance differences at 90 days in MIMIC-IV. Calibration plots showed both scores tend to overpredict outcomes at higher values, particularly MELD-Na in MIMIC-IV among African Americans.Conclusions: Both scores demonstrated consistent discriminative ability across major ethnic/racial groups. Both scores predicted outcomes better in Emory, a high-volume LT center, than in MIMIC-IV, suggesting site-specific differences and the Emory cohort's closer resemblance to populations used for MELD derivation. These findings suggest disparities in cirrhosis care may relate to socioeconomic factors rather than score performance.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Risk Stratification in HTG-AP and DKA: The Case for Broader Biomarker Inclusion. 优化HTG-AP和DKA的风险分层：更广泛的生物标志物纳入的案例。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-03 DOI: 10.1007/s10620-025-09367-3

Hira Khalid, Sakan Binte Imran

引用次数: 0

Methodological Considerations for Machine Learning-Based Identification of IBD Cohorts. 基于机器学习的IBD队列识别的方法学考虑。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-09-03 DOI: 10.1007/s10620-025-09378-0

Meerab Ali Khan, Muhammad Yousaf

引用次数: 0