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Malnutrition Is Common in Cyclic Vomiting Syndrome: A Prospective Study Using Validated Nutritional Assessment Tools. 营养不良在周期性呕吐综合征中很常见:一项使用有效营养评估工具的前瞻性研究。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-09 DOI: 10.1007/s10620-026-10088-4
Thangam Venkatesan, Praveen S Goday, Saranya Arumugam, Kebire Gofar, Mahima Vyas, Ana Petrova, Jimenez-Castillo Raul, Muhammad Ayyan, Sonali Srivastava, Kristen Heitman, Peter Madril, Kristin Goheen, Kristen M Roberts
{"title":"Malnutrition Is Common in Cyclic Vomiting Syndrome: A Prospective Study Using Validated Nutritional Assessment Tools.","authors":"Thangam Venkatesan, Praveen S Goday, Saranya Arumugam, Kebire Gofar, Mahima Vyas, Ana Petrova, Jimenez-Castillo Raul, Muhammad Ayyan, Sonali Srivastava, Kristen Heitman, Peter Madril, Kristin Goheen, Kristen M Roberts","doi":"10.1007/s10620-026-10088-4","DOIUrl":"10.1007/s10620-026-10088-4","url":null,"abstract":"<p><strong>Background: </strong>Cyclic vomiting syndrome (CVS) can impair nutritional status due to recurrent episodes of nausea and vomiting, yet systematic data are lacking. We aimed to evaluate nutritional status in adults with CVS using validated assessment tools.</p><p><strong>Methods: </strong>In a prospective study of adults diagnosed with CVS based on Rome IV criteria, nutritional status was evaluated using the Patient-Generated Subjective Global Assessment Short Form (PG-SGA-SF) completed by participants, the PG-SGA completed by a Registered Dietitian Nutritionist (RDN) and the Malnutrition Screening Tool (MST).</p><p><strong>Key results: </strong>Among 80 participants (mean age 39 ± 16 years) 77.5% (n = 62) were female, and 85% (n = 68) had moderate-to-severe CVS. Based on the PG-SGA-SF, 70% (n = 56) were at risk of malnutrition (42.5%, n = 34 severe; 27.5%, n = 22 moderate). More than half (41; 51%) were at risk for malnutrition (MST score ≥ 2). Despite this, 27% (n = 22) were obese, and 20% (n = 16) were overweight. Mean BMI did not differ between well-nourished and malnourished participants (28.4 ± 8.2 kg/m<sup>2</sup> vs. 29.1 ± 7.7; p = 0.7). Of the 64 participants with a completed PG-SGA, 62.5% were classified as malnourished (28%, n = 18 severe; 34%, n = 22 moderate). The PG-SGA-SF demonstrated high sensitivity (100%) and specificity (71%) for detecting malnutrition with a positive predictive value of 85% and a negative predictive value of 100%.</p><p><strong>Conclusions and inferences: </strong>Most adults with CVS met criteria for malnutrition, indicating a need for referral to an RDN. BMI should not be used as a screening tool for malnutrition, and mechanisms underlying obesity in CVS warrant further investigation.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5465-5472"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial. 一项针对炎症性肠病患者的护士自我管理方案的可行性、可接受性和初步效果:一项随机对照试验
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-18 DOI: 10.1007/s10620-026-10111-8
Kendra Kamp, Linda Yoo, Tanvi Kale, Xiaoyu Zhang, Caeli Malloy, Ihsan Kahveci, Rachael Cordova, Isabela Hernandez, Chi Shan Tsai, Tiffany D Pan, Kindra Clark-Snustad, Scott Lee, Rona L Levy, Laurie Keefer, Margaret Heitkemper
{"title":"Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial.","authors":"Kendra Kamp, Linda Yoo, Tanvi Kale, Xiaoyu Zhang, Caeli Malloy, Ihsan Kahveci, Rachael Cordova, Isabela Hernandez, Chi Shan Tsai, Tiffany D Pan, Kindra Clark-Snustad, Scott Lee, Rona L Levy, Laurie Keefer, Margaret Heitkemper","doi":"10.1007/s10620-026-10111-8","DOIUrl":"10.1007/s10620-026-10111-8","url":null,"abstract":"<p><strong>Purpose: </strong>Individuals with inflammatory bowel disease experience persistent symptoms and disease challenges which may not be solved with medical management. Self-management interventions may support patients, but their feasibility, acceptability, and preliminary effectiveness should be evaluated prior to large-scale testing.</p><p><strong>Methods: </strong>We conducted a pilot randomized controlled trial with 2:1 allocation of a nurse-delivered, self-management program to usual care. Adults with a healthcare provider diagnosis of ulcerative colitis or Crohn's disease, aged 18-75 years, currently reporting at least two symptoms were recruited. The self-management program included eight online modules plus weekly phone check-ins with a registered nurse. Feasibility and acceptability were measured using surveys and interviews. Secondary outcomes included patient activation, self-regulation, self-efficacy, functional impairment, quality of life, symptoms, and fecal calprotectin. Linear mixed models estimated the differences in change scores between groups from baseline to 3- and 6-month follow-up.</p><p><strong>Results: </strong>Fifty-five participants were randomized (n = 36 self-management, n = 19 usual care). Participants were on average 39.0 years old (range: 20-73), 76.4% women, and 80% Crohn's disease. The self-management program demonstrated high satisfaction (91.1/100), feasibility (4.34/5), and acceptability (4.28/5). Compared with usual care, the self-management program produced the largest improvement in functional impairment (mean change - 15.1 [95% CI - 23.3, - 6.8], with additional improvements in patient activation (10.3 [2.8, 17.9]), self-regulation (4.1 [1.1, 7.1]), and quality of life (4.6 [0.3, 8.9]). Symptom severity and fecal calprotectin were largely unchanged. Qualitative feedback emphasized the value of regular nurse check-ins, accountability, and applicability of the program beyond disease-specific concerns.</p><p><strong>Conclusions: </strong>A nurse-delivered self-management program was feasible, acceptable, and led to meaningful changes in key intervention targets for inflammatory bowel disease management. High engagement supports potential for future testing in a fully powered trial and eventual integration into routine care.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5592-5603"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes and Characteristics Across Age Groups of Patients with Positive MT-sDNA Stool Tests: Data from the New Hampshire Colonoscopy Registry. MT-sDNA粪便检测阳性患者的不同年龄组的结果和特征:来自新罕布什尔结肠镜登记的数据
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-08 DOI: 10.1007/s10620-026-10082-w
Joseph C Anderson, William M Hisey, Christina M Robinson, Paul J Limburg, Mallik Greene, Lynn F Butterly
{"title":"Outcomes and Characteristics Across Age Groups of Patients with Positive MT-sDNA Stool Tests: Data from the New Hampshire Colonoscopy Registry.","authors":"Joseph C Anderson, William M Hisey, Christina M Robinson, Paul J Limburg, Mallik Greene, Lynn F Butterly","doi":"10.1007/s10620-026-10082-w","DOIUrl":"10.1007/s10620-026-10082-w","url":null,"abstract":"<p><strong>Background and aims: </strong>Stool testing is a colorectal cancer (CRC) screening option for adults 45 years and older. Our aim was to examine characteristics and outcomes across age groups of patients who underwent colonoscopy following a positive multitarget stool DNA (mt-sDNA) test, compared to older age groups.</p><p><strong>Methods: </strong>We examined several outcomes reflecting both adenomatous and serrated pathways, including: any adenoma, clinically relevant serrated polyps (CRSPs, defined as sessile serrated polyps, traditional serrated adenomas, or hyperplastic polyps ≥ 1 cm) and advanced adenomas (AA, defined as any villous or tubulovillous adenomas, or tubular adenomas > 1 cm). Logistic regression models assessed the association between continuous age and each outcome, adjusting for patient sex and other relevant covariates.</p><p><strong>Results: </strong>The yield of advanced adenomas and CRSPs were equally high across all age groups, including the youngest group; we found no difference in the yield of AAs (OR = 0.99;95%CI:0.91-1.07) or CRSPs (OR = 0.95%CI:0.88-1.03) with increasing age. In contrast, the odds of any adenoma increased significantly with age (OR = 1.17;95%CI:1.09-1.26).</p><p><strong>Conclusions: </strong>The yield of clinically significant polyps at colonoscopy following a positive multitarget stool DNA (mt-sDNA) test was similarly high across age groups. These findings suggest that mt-sDNA screening provides comparable clinical benefit across all ages of screening-eligible populations. The consistently high detection of advanced polyps across age groups likely reflects the strong positive predictive value of mt-sDNA testing.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5428-5433"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors Associated with Recurrent Biliary Obstruction After Endoscopic Bilioduodenal Double Stenting. 内镜下胆十二指肠双支架置入术后复发性胆道梗阻的相关危险因素。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-08 DOI: 10.1007/s10620-026-10100-x
Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Hiroyuki Asama, Hiroshi Shimizu, Kentaro Sato, Kento Osawa, Rei Ohira, Jun Nakamura, Tsunetaka Kato, Takumi Yanagita, Mitsuru Otsuka, Takuto Hikichi, Hiromasa Ohira
{"title":"Risk Factors Associated with Recurrent Biliary Obstruction After Endoscopic Bilioduodenal Double Stenting.","authors":"Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Hiroyuki Asama, Hiroshi Shimizu, Kentaro Sato, Kento Osawa, Rei Ohira, Jun Nakamura, Tsunetaka Kato, Takumi Yanagita, Mitsuru Otsuka, Takuto Hikichi, Hiromasa Ohira","doi":"10.1007/s10620-026-10100-x","DOIUrl":"10.1007/s10620-026-10100-x","url":null,"abstract":"<p><strong>Objective: </strong>Endoscopic bilioduodenal double stenting is sometimes necessary for patients with malignant bilioduodenal obstruction (MBDO). The patency of biliary stents is important for preventing cholangitis and continuing treatment. However, the factors that influence recurrent biliary obstruction (RBO) in patients with MBDO are not well known. This study aimed to identify the factors associated with RBO in patients who underwent endoscopic bilioduodenal double stenting.</p><p><strong>Methods: </strong>Patient characteristics, device use, and endoscopic treatment procedures were evaluated as possible risk factors for RBO.</p><p><strong>Results: </strong>Overall, 55 patients with MBDO underwent endoscopic bilioduodenal double stenting (transpapillary drainage, n = 35; endoscopic ultrasound-guided biliary drainage, n = 20). Multivariate analysis using a Fine and Gray competing risk model revealed that biliary stenting on the oral side of the duodenal stricture (HR 2.98; 95% CI 1.16-7.68; p = 0.023) and chemotherapy (HR 3.74; 95% CI 1.25-11.22; p = 0.018) were significantly associated with RBO.</p><p><strong>Conclusion: </strong>Biliary stenting on the oral side of the duodenal stricture was associated with RBO during duodenal stenting in patients with MBDO. Although chemotherapy was also associated with RBO in the multivariable competing risk analysis, this finding should be interpreted cautiously. Careful treatment selection, including consideration of gastrojejunostomy in patients with oral-side biliary stenting, may help reduce the incidence of RBO.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5396-5404"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upward Mobility: How Mobile Endoscopy Revolutionized Endoscopic Practice in the Developing World. 向上流动:移动内窥镜如何革新发展中国家的内窥镜实践。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-06 DOI: 10.1007/s10620-026-10103-8
Jean-François Rey
{"title":"Upward Mobility: How Mobile Endoscopy Revolutionized Endoscopic Practice in the Developing World.","authors":"Jean-François Rey","doi":"10.1007/s10620-026-10103-8","DOIUrl":"10.1007/s10620-026-10103-8","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5979-5980"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hematologic and Inflammatory Biomarker-Based Prognostic Assessment in Acute Pancreatitis: The Role of CRP, Procalcitonin, and CRP/Albumin Ratio. 基于血液学和炎症生物标志物的急性胰腺炎预后评估:CRP、降钙素原和CRP/白蛋白比值的作用。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-06 DOI: 10.1007/s10620-026-10098-2
Beste Akıllı, Ali Can Kurtipek, Sevil Uygun İlikhan, Selma Karaahmetoğlu
{"title":"Hematologic and Inflammatory Biomarker-Based Prognostic Assessment in Acute Pancreatitis: The Role of CRP, Procalcitonin, and CRP/Albumin Ratio.","authors":"Beste Akıllı, Ali Can Kurtipek, Sevil Uygun İlikhan, Selma Karaahmetoğlu","doi":"10.1007/s10620-026-10098-2","DOIUrl":"10.1007/s10620-026-10098-2","url":null,"abstract":"<p><strong>Background/aims: </strong>Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality, characterized by the activation of pancreatic enzymes within the pancreas, leading to autolysis. The clinical spectrum of AP ranges from edematous pancreatitis to necrotizing pancreatitis and may result in local complications such as pancreatic necrosis, pseudocysts, and peripancreatic fluid collections. In this study, we aimed to evaluate the prognostic value of daily C-reactive protein (CRP), procalcitonin, and CRP/albumin levels in predicting local complications of pancreatitis.</p><p><strong>Materials and methods: </strong>The study included 350 patients with AP, who were hospitalised at Bilkent City Hospital, between 1 January 2020 and 31 December 2023. Demographic data, AP etiologies, and biochemical parameters were recorded. The daily trajectories of CRP, procalcitonin, and albumin levels were monitored over 14 days. All statistical analyses were performed using SPSS version 22.</p><p><strong>Results: </strong>To distinguish cases with and without peripancreatic fluid collection, the cutoff values for CRP on the first, second, and third days were determined as ≥ 30, ≥ 33, and ≥ 59 (AUC: 0.6574; 0.8343; 0.8897), respectively. The cutoff values for procalcitonin were ≥ 0.09, ≥ 0.07, and ≥ 0.12 (AUC: 0.6457; 0.7227; 0.7310), while for CRP/albumin, the cutoff values were ≥ 0.2609, ≥ 1.0476, and ≥ 1.7143 (AUC: 0.6586; 0.8314; 0.8856), respectively. For distinguishing acute peripancreatic fluid collection (APFC) from WON-pseudocyst, the cutoff values for CRP on the first, second, and third days were determined as ≥ 79, ≥ 124, and ≥ 131 (AUC: 0.7428; 0.8360; 0.9613), respectively. The cutoff values for procalcitonin were ≥ 0.18, ≥ 0.13, and ≥ 0.10 (AUC: 0.7403; 0.8493; 0.8967), while for the CRP/albumin ratio, the cutoff values were ≥ 2.000, ≥ 3.000, and ≥ 2.9556 (AUC: 0.7530; 0.8368; 0.9634), respectively. For distinguishing pseudocyst from walled-off necrosis (WON), the cutoff values for CRP on the first, second, and third days were determined as ≥ 234, ≥ 91, and ≥ 229 (AUC: 0.5750; 0.6285; 0.7148), respectively. The cutoff values for procalcitonin were ≥ 0.96, ≥ 0.39, and ≥ 0.69(AUC: 0.6083; 0.6813; 0.7319), while for the CRP/albumin ratio, the cutoff values were ≥ 6.50, ≥ 5.3684, and ≥ 7.3571 (AUC: 0.5603; 0.6357; 0.7456), respectively.</p><p><strong>Conclusion: </strong>Our study indicated that the daily variations in CRP, procalcitonin, and CRP/albumin ratio were significantly associated with AP complications.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5388-5395"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of Metachronous Gastric Cancer After Endoscopic Submucosal Dissection in Helicobacter pylori-uninfected Early Gastric Cancer. 未感染幽门螺杆菌的早期胃癌经内镜粘膜下剥离后异时性胃癌的发生率。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-16 DOI: 10.1007/s10620-026-10081-x
Yusuke Kawai, Junnosuke Hayasaka, Yorinari Ochiai, Junji Tanaka, Minoru Oda, Hiroshi Yamato, Yugo Suzuki, Yutaka Mitsunaga, Hiroyuki Odagiri, Akira Matsui, Shu Hoteya
{"title":"Incidence of Metachronous Gastric Cancer After Endoscopic Submucosal Dissection in Helicobacter pylori-uninfected Early Gastric Cancer.","authors":"Yusuke Kawai, Junnosuke Hayasaka, Yorinari Ochiai, Junji Tanaka, Minoru Oda, Hiroshi Yamato, Yugo Suzuki, Yutaka Mitsunaga, Hiroyuki Odagiri, Akira Matsui, Shu Hoteya","doi":"10.1007/s10620-026-10081-x","DOIUrl":"10.1007/s10620-026-10081-x","url":null,"abstract":"<p><strong>Purpose: </strong>Helicobacter pylori (H. pylori)-associated gastric cancer can progress to metachronous gastric cancer even after eradication; however, the incidence of metachronous gastric cancer in H. pylori-uninfected cases remains unclear. We aimed to investigate the incidence of metachronous gastric cancer after endoscopic submucosal dissection (ESD) in H. pylori-uninfected patients.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included 850 consecutive patients with gastric cancer (850 lesions) who underwent ESD between January 2010 and December 2021. The primary endpoint was the first metachronous gastric cancer detected more than 1 year after ESD. The secondary endpoint was synchronous gastric cancer detected within 1 year of ESD.</p><p><strong>Results: </strong>In total, 38 and 812 of the patients were H. pylori-uninfected and H. pylori-infected, respectively. Synchronous gastric cancer was less frequent in the H. pylori-uninfected group (0% vs. 7.0%), although the difference was not significant (p = 0.103). Metachronous gastric cancer was significantly less frequent in the H. pylori-uninfected group (0% vs. 16.9%, p = 0.002), and the cumulative incidence was significantly lower (p = 0.011). In exploratory multivariable Firth's penalized Cox regression analyses, H. pylori-uninfected status remained associated with a lower estimated risk of metachronous gastric cancer, although the association did not reach statistical significance.</p><p><strong>Conclusions: </strong>The incidence of metachronous gastric cancer after ESD for early gastric cancer is lower in H. pylori-uninfected patients than in H. pylori-infected patients. Although these findings should be interpreted as exploratory, they suggest that the optimal post-ESD surveillance strategy for H. pylori-uninfected patients warrants further investigation.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5546-5555"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discretionary Versus Routine Intravenous Fluids for Ambulatory Gastrointestinal Endoscopies: A Cohort Study Following Hurricane Helene. 在门诊胃肠内窥镜检查中酌情与常规静脉输液:飓风海伦后的一项队列研究。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-09 DOI: 10.1007/s10620-026-10090-w
Asha Dash, Alekya Menta, Anderson Huang, Kathryn Stiff, Ann Shum, Sonia Friedman, Sushrut Jangi, Christian Brice, Ariel Fischer, Saurav Kini, Michael Schoor, David Ongori, Xiaocen Zhang
{"title":"Discretionary Versus Routine Intravenous Fluids for Ambulatory Gastrointestinal Endoscopies: A Cohort Study Following Hurricane Helene.","authors":"Asha Dash, Alekya Menta, Anderson Huang, Kathryn Stiff, Ann Shum, Sonia Friedman, Sushrut Jangi, Christian Brice, Ariel Fischer, Saurav Kini, Michael Schoor, David Ongori, Xiaocen Zhang","doi":"10.1007/s10620-026-10090-w","DOIUrl":"10.1007/s10620-026-10090-w","url":null,"abstract":"<p><strong>Background and aims: </strong>Intravenous fluids (IVFs) are often routinely given to patients undergoing ambulatory gastrointestinal (GI) endoscopies, despite a lack of data to support this practice. A national IVF shortage occurred late 2024 after Hurricane Helene damaged a major manufacturing facility in the US. In response, our GI unit changed the IVF protocol from routine to discretionary administration to conserve fluid for those who needed it the most. This study examined the outcomes of this change.</p><p><strong>Methods: </strong>This is a cohort study conducted at a tertiary referral hospital in the USA. We compared procedure data from two periods, October-November 2024 (discretionary or \"as needed\" fluid) and October-November 2023 (routine fluid). The primary outcome was the percentage of patients receiving vasopressors. Secondary outcomes included perioperative vital sign change (hypotension, tachycardia, desaturation), medication use (fluid, sedative, and other anesthesia administered agents), and anesthesia and recovery times.</p><p><strong>Results: </strong>A total of 1827 consecutive ambulatory esophagogastroduodenoscopies and colonoscopies were performed under monitored anesthesia care during the study period (983 discretionary IVF and 844 routine IVF). A higher percentage of the patients in the discretionary IVF cohort received vasopressors (18.1% vs. 12.8%, p < 0.01). There was no significant difference in perioperative hypotension (26.5% vs. 29.6%, p = 0.14), tachycardia or desaturation, or anesthesia or recovery time.</p><p><strong>Conclusions: </strong>Discretionary vs. routine IVF administration for ambulatory GI endoscopies was associated with increased vasopressor use but not increased vital sign alteration or anesthesia or recovery time.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5449-5457"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal Pancreatic Parenchymal Atrophy and Delayed Enhancement in Early Pancreatic Ductal Adenocarcinoma: A Narrative Review of Pathologic Basis, Diagnostic Pitfalls, and Evidence Limitations. 早期胰腺导管腺癌的局灶性胰腺实质萎缩和延迟强化:病理基础、诊断缺陷和证据限制的叙述回顾。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-13 DOI: 10.1007/s10620-026-10065-x
Kenichiro Okumura, Kazuto Kozaka, Satoshi Kobayashi
{"title":"Focal Pancreatic Parenchymal Atrophy and Delayed Enhancement in Early Pancreatic Ductal Adenocarcinoma: A Narrative Review of Pathologic Basis, Diagnostic Pitfalls, and Evidence Limitations.","authors":"Kenichiro Okumura, Kazuto Kozaka, Satoshi Kobayashi","doi":"10.1007/s10620-026-10065-x","DOIUrl":"10.1007/s10620-026-10065-x","url":null,"abstract":"<p><p>Early pancreatic ductal adenocarcinoma (PDAC), including carcinoma in situ (CIS)/high-grade pancreatic intraepithelial neoplasia (PanIN) and very small invasive tumors, is increasingly recognized, but the significance of pancreatic parenchymal atrophy and delayed enhancement remains unsettled. This narrative review summarizes their pathological basis, technical determinants, observer variability, differential diagnoses, and evidence limitations across computed tomography (CT), magnetic resonance imaging (MRI)/magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasonography (EUS), and regionally variable pancreatic duct-oriented cytology pathways. Parenchymal atrophy should be distinguished from ductal abnormalities such as focal main pancreatic duct stenosis and perilesional branch-duct dilation, which depend heavily on technically optimized MRCP, including high-quality two-dimensional MRCP. Atrophy is a morphologic phenotype with heterogeneous substrates, whereas delayed enhancement more often reflects fibrosis-rich or inflammatory change and is not specific for PDAC, because focal autoimmune pancreatitis may show similar delayed enhancement. Reported prevalence and diagnostic value vary according to cohort spectrum, modality, phase definition, reader blinding, cytologic verification, and hindsight bias. Current evidence supports these signs as context-dependent clues, not diagnostic thresholds or management algorithms. Prospective pathology-linked studies with standardized protocols are needed.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"6020-6038"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Long Time Coming: How the Analysis of Gastric Slow-Wave Morphology May Improve the Diagnosis of Motility Disorders. 时间长了:胃慢波形态学分析如何提高运动障碍的诊断。
IF 2.8 4区 医学
Digestive Diseases and Sciences Pub Date : 2026-11-01 Epub Date: 2026-07-21 DOI: 10.1007/s10620-026-10129-y
Mohammad Bashashati
{"title":"A Long Time Coming: How the Analysis of Gastric Slow-Wave Morphology May Improve the Diagnosis of Motility Disorders.","authors":"Mohammad Bashashati","doi":"10.1007/s10620-026-10129-y","DOIUrl":"10.1007/s10620-026-10129-y","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5305-5306"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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