Digestive Diseases and Sciences最新文献

{"title":"Rectal Metastasis Mimicking Inflammatory Bowel Disease.","authors":"Mengqi Luo, Liansong Ye, Jingyi Ju, Zhaoyang Li, Zhonghui Wen, Yufang Wang","doi":"10.1007/s10620-025-09381-5","DOIUrl":"https://doi.org/10.1007/s10620-025-09381-5","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Resection of ESD Scar with Deficient MSH2 Protein Expression Using a Non-thermal Mechanical Endoscopic Resection Device in a Patient with Lynch Syndrome.","authors":"Wahid Aloweiwi, Achintya D Singh, Thomas P Plesec, Carol A Burke, Amit Bhatt","doi":"10.1007/s10620-025-09368-2","DOIUrl":"https://doi.org/10.1007/s10620-025-09368-2","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EphA3/EFNA3 Reverse Signalling Promotes Epithelial-to-Mesenchymal Transition via ERK Pathway to Facilitate Colorectal Cancer Metastasis.","authors":"Ying Tan, Xian Zhang, Jin Wang, Xue Xiao, Jin-Lin Yang","doi":"10.1007/s10620-025-09386-0","DOIUrl":"https://doi.org/10.1007/s10620-025-09386-0","url":null,"abstract":"<p><strong>Background and aims: </strong>Liver metastasis significantly contributes to poor survival in patients with colorectal cancer (CRC), posing therapeutic challenges due to limited understanding of its mechanisms. We aimed to identify a potential target critical for CRC liver metastasis.</p><p><strong>Methods: </strong>We analyzed the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) databases and identified EphrinA3 (EFNA3) as a potential clinically relevant target. The interacting proteins of EFNA3 were investigated by co-immunoprecipitation. The role of EphA3/EFNA3 axis were examined using EFNA3 knockdown and overexpressed CRC cells by transwell, wound healing, cell viability, colony formation and apoptosis assays, as well as subcutaneous and spleen injection tumour models in nude mice.</p><p><strong>Results: </strong>EFNA3 expression was significantly higher in CRC tissues than in para-carcinoma tissues, and elevated in metastatic tissues compared to primary CRC tissues. Higher EFNA3 was significantly correlated with advanced tumour stages and unfavourable clinical outcomes in CRC patients. Functional assays suggested that EFNA3 knockdown inhibited the migration, invasion and proliferation of CRC cells both in vitro and in vivo, while EFNA3 overexpression had opposite effects. Mechanistically, EphA3 was confirmed to bind to EFNA3, and EphA3/EFNA3 reverse signalling was found to promote epithelial-to-mesenchymal transition (EMT) by activating extracellular signal-regulated kinase (ERK) 1/2 signalling, thereby promoting metastasis.</p><p><strong>Conclusion: </strong>Our findings suggest that EFNA3 promotes CRC metastasis, and that EphA3/EFNA3 signalling may promote EMT by activating the ERK signalling. These results indicate that the EphA3/EFNA3 axis could be a potential target for metastatic CRC.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perforation that Occurred Right After Sigmoid Colon Cancer Stenting.","authors":"Hongtao Liu, Rixiong Zhang, Wenhao Wang, Wei Peng, Hua He","doi":"10.1007/s10620-025-09382-4","DOIUrl":"https://doi.org/10.1007/s10620-025-09382-4","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing Imperfect Tools to Decode AKI in Decompensated Cirrhosis.","authors":"Giuseppe Cullaro, Andrew S Allegretti, Kavish R Patidar, Elizabeth C Verna, Jennifer C Lai","doi":"10.1007/s10620-025-09379-z","DOIUrl":"10.1007/s10620-025-09379-z","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low FODMAP Diets in Populations with IBS: Modifying Western Concepts to Eastern Populations.","authors":"Valerie Yeap, Andrew Ming-Liang Ong","doi":"10.1007/s10620-025-09385-1","DOIUrl":"https://doi.org/10.1007/s10620-025-09385-1","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Diagnostic Performance of Repeated Endoscopic Ultrasound-Guided Tissue Acquisition Combined with Surrogate Repeated Endoscopic Retrograde Pancreatography for Small Pancreatic Cancer.","authors":"Yusuke Kurita, Shinichi Nihei, Kensuke Kubota, Shin Yagi, Yu Honda, Yuma Yamazaki, Takeshi Iizuka, Sho Hasegawa, Takamitsu Sato, Kunihiro Hosono, Jotaro Harada, Masato Yoneda, Noritoshi Kobayashi, Satoshi Fujii, Itaru Endo, Atsushi Nakajima","doi":"10.1007/s10620-025-09373-5","DOIUrl":"https://doi.org/10.1007/s10620-025-09373-5","url":null,"abstract":"<p><strong>Purpose: </strong>Diagnosing pancreatic tumors ≤ 10 mm is challenging due to limited visualization and low sampling sensitivity. This study aimed to evaluate the cumulative diagnostic performance of repeated endoscopic ultrasound-guided tissue acquisition (EUS-TA) and surrogate repeated endoscopic retrograde pancreatography (ERP).</p><p><strong>Methods: </strong>This study analyzed 40 patients with suspected pancreatic tumors ≤ 10 mm who underwent EUS-TA and/or ERP retrospectively. When a diagnosis could not be determined based on the initial EUS-TA or ERP procedure, EUS-TA or ERP was repeated as necessary. The cumulative diagnostic performance of EUS-TA and ERP for pancreatic tumors was evaluated.</p><p><strong>Results: </strong>EUS-TA was performed once for 35 cases, twice for seven cases, and three times for one case. ERP was performed for 15 cases, and the median number of ERP attempts was two (range, 1-8). The cumulative sensitivity of EUS-TA increased from 56.7% to 70.0% after three attempts, while ERP sensitivity increased from 54.5% to 72.7% after two attempts. The cumulative diagnostic performance of repeated EUS-TA and ERP combined by case included sensitivity and accuracy rates of 87.9% and 90.0%. When limited to pancreatic cancer, the sensitivity and accuracy rates were 95.8% and 96.8%, respectively. No severe adverse events occurred.</p><p><strong>Conclusion: </strong>Repeated EUS-TA and ERP showed good diagnostic sensitivity for small pancreatic cancers ≤ 10 mm. When malignancy is suspected but not confirmed by a single procedure, repeating both may be an option in selected cases. Performing EUS-TA and ERP at least twice may be reasonable when small pancreatic cancer is suspected.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Insights on \"Tolerability and Effectiveness of Glucagon‑Like Peptide‑1 Receptor Agonists in Patients with Inflammatory Bowel Disease\".","authors":"XiRui Yang, FengJie Xie","doi":"10.1007/s10620-025-09349-5","DOIUrl":"https://doi.org/10.1007/s10620-025-09349-5","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Factors Impact the Perception of Healthcare Experiences in Patients with Cirrhosis.","authors":"Nicole Ng, Subhanik Purkayastha, Xiaohan Ying, Arun Jesudian, Russell Rosenblatt","doi":"10.1007/s10620-025-09374-4","DOIUrl":"https://doi.org/10.1007/s10620-025-09374-4","url":null,"abstract":"<p><strong>Background: </strong>Suboptimal patient-provider relationship is a significant contributor to healthcare disparities. Minority populations report fewer favorable interactions, which may lead to poorer outcomes and engagement in care. Patients with chronic diseases are especially at risk.</p><p><strong>Aims: </strong>We aimed to study perceptions of healthcare providers and experience among those with cirrhosis.</p><p><strong>Methods: </strong>The nationally representative database, All of Us, was queried. The primary outcome was \"favorable healthcare experiences,\" defined as whether providers asked for opinions, demonstrated respect, and were easy to understand. The secondary outcome was \"unfavorable healthcare experiences,\" defined as whether patients felt they were treated with less courtesy, received poorer service, or not listened to. We compared the experience between income levels and other demographic variables. Multivariable logistic regression was adjusted for a priori covariates.</p><p><strong>Results: </strong>5753 patients with cirrhosis were included with a mean age of 58. The majority were male (51%), White (52%), and US-born (84%). On multivariable analysis, compared to those earning > $150 k annually, participants with $10-35 k and < $10 k reported significantly lower odds of finding providers easy to understand (OR 0.40 [0.17-0.96] and OR 0.37 [0.15-0.94], respectively) and higher odds of feeling they were treated with less courtesy (OR 3.10 [1.06-9.03] and OR 4.13 [1.30-13.1], respectively). After further controlling for education, participants with an annual income of $10-35 k and < $10 k still reported higher odds of feeling they received poorer service than others (OR 3.87 [1.09-13.71] and OR 5.01 [1.26-19.8], respectively). Compared to men, women felt that they were not listened to (OR 1.90 [1.37-2.63]).</p><p><strong>Conclusion: </strong>Patients with cirrhosis from various backgrounds report significantly different experiences with providers. Notably, those with lower income endorsed more unfavorable interactions. We identified areas for interventions to strengthen the patient-provider relationship among patients with chronic liver disease.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reappraising the Association Between Varicella Zoster Virus and Esophageal Motility Disorders: Methodological and Interpretive Concerns in Salivary DNA Analysis.","authors":"Muhammad Soban Jaffar, Ushna Nasir, Muhammad Ali Rana, Mohammad Hamza Abbas, Muneeb Khawar","doi":"10.1007/s10620-025-09380-6","DOIUrl":"https://doi.org/10.1007/s10620-025-09380-6","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}