Digestive Diseases and Sciences最新文献

Higher Inpatient Racial and Ethnic Diversity Is Associated with Better Outcomes in Hispanic and Native American Patients for Gastrointestinal Diseases. 较高的住院患者种族和民族多样性与西班牙裔和美洲原住民胃肠道疾病患者更好的预后相关

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-08 DOI: 10.1007/s10620-025-09004-z

Bishoy Lawendy, Tayyaba Bhatti, Ayooluwatomiwa D Adekunle, Muni Rubens, Oyedotun Babajide, Mary Sedarous, Tahniyat Tariq, Philip N Okafor

{"title":"Higher Inpatient Racial and Ethnic Diversity Is Associated with Better Outcomes in Hispanic and Native American Patients for Gastrointestinal Diseases.","authors":"Bishoy Lawendy, Tayyaba Bhatti, Ayooluwatomiwa D Adekunle, Muni Rubens, Oyedotun Babajide, Mary Sedarous, Tahniyat Tariq, Philip N Okafor","doi":"10.1007/s10620-025-09004-z","DOIUrl":"https://doi.org/10.1007/s10620-025-09004-z","url":null,"abstract":"Background: Evidence suggests that outcomes are poorer among patients from historically marginalized racial and ethnic backgrounds. The impact of patient racial and ethnic diversity on gastrointestinal outcomes is understudied.Aims: To investigate the impact of patient racial/ethnic diversity on gastrointestinal disease (GI) outcomes.Methods: Using the 2019 National Inpatient Sample (NIS), hospital inpatient racial/ethnic diversity was defined as the percentage of Hispanic or Native American discharges. We included gastrointestinal bleeding, inflammatory bowel diseases, gastrointestinal obstruction, cirrhosis, and alcohol-associated hepatitis. Logistic regression was used to predict outcomes [major complications (MCC), long length of stay, high total charges], controlling for age, gender, location, income quartile, hospital size, and region.Results: Our cohort included 537,830 hospitalizations. In the unadjusted analyses, MCC rates were higher among Hispanic (24.8%) and Native American patients (30.4%), compared to Whites (18.3%). In adjusted analyses, compared to Whites, Hispanic [adjusted odds ratio (OR) 1.21, 95% Confidence Interval (CI) 1.15-1.28] and Native American patients [OR 1.25, (95% CI) 1.09-1.43] had higher MCC rates. As hospital Hispanic diversity increased, MCC for Hispanics improved [OR 0.93, (95% CI) 0.87-1.14] and were even better among Native American patients as their diversity increased [OR 0.83, (95% CI) 0.73-0.94] (Table 1). A similar trend was observed in the 2018 validation cohort.Conclusion: Increasing hospital inpatient Hispanic and Native American diversity is associated with better outcomes for these groups. Further research is needed on the impact cultural competence and linguistic concordance on gastrointestinal outcomes.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Crosstalk Genes Between Primary Sjögren's Syndrome and Primary Biliary Cirrhosis by Transcriptome Analysis. 通过转录组分析鉴定原发性Sjögren综合征与原发性胆汁性肝硬化之间的串扰基因。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-08 DOI: 10.1007/s10620-025-08917-z

Tian Tao, Lizeyu Lv, Jun Chen, Yuchi He, Jialong Jia, Ling Wu, Bojun Xu, Liangbin Zhao

{"title":"Identification of Crosstalk Genes Between Primary Sjögren's Syndrome and Primary Biliary Cirrhosis by Transcriptome Analysis.","authors":"Tian Tao, Lizeyu Lv, Jun Chen, Yuchi He, Jialong Jia, Ling Wu, Bojun Xu, Liangbin Zhao","doi":"10.1007/s10620-025-08917-z","DOIUrl":"https://doi.org/10.1007/s10620-025-08917-z","url":null,"abstract":"Background: Growing evidence points a connection between Primary Sjögren's Syndrome (pSS) and Primary Biliary Cholangitis (PBC). This study seeks to identify the crosstalk genes between them.Method: Transcriptomic datasets for pSS (GSE66795) and PBC (GSE119600) were sourced from the Gene Expression Omnibus (GEO) database. Common genes between these two conditions were detected using Differential Expression Analysis and Weighted Gene Co-expression Network Analysis (WGCNA). Potential crosstalk genes were pinpointed through Least Absolute Shrinkage and Selection Operator (LASSO) regression. Validation of these genes were performed through single-sample gene set enrichment analysis (ssGSEA), multivariable logistic regression, and single-cell transcriptome analysis.Result: Differential expression analysis showed 339 commonly upregulated DEGs in both pSS and PBC. WGCNA analysis revealed 11 modules associated with pSS and 7 modules associated with PBC. Subsequently, 56 core genes were found to overlap between the genes identified by differential expression analysis and WGCNA. LASSO regression identified CX3CR1, ELF1, CUL1, PARP3, DDX60, SP140L, and MUC1 as pivotal crosstalk genes for both pSS and PBC. Moreover, ssGSEA analysis and multivariable logistic regression underscored the potential of these 7 genes as crosstalk genes. Single-cell analyses revealed higher proportions of NK cells, CD4+ T cells, and CD8+ T cells in pSS patients, with prominent expression of CX3CR1, ELF1, CUL1, PARP3, DDX60, SP140L, and MUC1 in these cells.Conclusion: Our study identified CX3CR1, ELF1, CUL1, PARP3, DDX60, SP140L and MUC1 as crosstalk genes between pSS and PBC, and highlighted the critical role of NK cells, CD4+ T cells and CD8+ T cells in disease mechanisms.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden Fecalith: Uncommon Presentation Within Inflammatory Polyp. 隐藏粪石：炎性息肉内罕见的表现。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-08 DOI: 10.1007/s10620-025-09037-4

Sebastian Stefanovic, Lea Gril Jevsek, Tatjana Bujas, Milan Stefanovic

引用次数: 0

Correction: Effects of Tegoprazan, Potassium‑Competitive Acid Blocker, on the Gastric Emptying and Postprandial Symptoms in Healthy Humans. 更正：替戈拉赞，钾竞争酸阻滞剂，对健康人胃排空和餐后症状的影响。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-07 DOI: 10.1007/s10620-025-09019-6

Hyung Seok Lim, Hai-Jeon Yoon, Hye-Kyung Jung, Ji Taek Hong, Min Young Yoo, Eui Sun Jeong

引用次数: 0

Evaluation of Acute Severe Ulcerative Colitis Predictors for Steroid Therapy Refractoriness. 急性重度溃疡性结肠炎类固醇治疗难治性预测因素的评估。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-05 DOI: 10.1007/s10620-025-08982-4

Alaa Abdelmeguid, Amany Ahmed El Banna, Wafaa Elsheikh, Ahmed Ismail Ellakany, Shaji Sebastian

{"title":"Evaluation of Acute Severe Ulcerative Colitis Predictors for Steroid Therapy Refractoriness.","authors":"Alaa Abdelmeguid, Amany Ahmed El Banna, Wafaa Elsheikh, Ahmed Ismail Ellakany, Shaji Sebastian","doi":"10.1007/s10620-025-08982-4","DOIUrl":"https://doi.org/10.1007/s10620-025-08982-4","url":null,"abstract":"Background: One-third of patients presenting with acute severe ulcerative colitis (ASUC) are steroid-refractory and require either colectomy or rescue therapy. Timely identification of risk factors predictive of steroid non-response in ASUC patients is crucial for initiating early rescue therapy.Aim: To identify factors predicting steroid failure or colectomy in ASUC.Methods: Records of ASUC admissions over a six-year period in a tertiary inflammatory bowel disease center were included. Clinical variables, laboratory markers, and endoscopic scores at admission were obtained. The primary outcome was non-response to intravenous (IV) steroids. Univariate and multivariate regression analyses were performed to identify factors associated with steroid non-response. Day-one and day-three composite indices were calculated. Their predictive value was assessed against the outcomes of steroid failure and requiring colectomy.Results: One hundred and three ASUC patients were included, of which 51 were steroid non-responders. Among non-responders, 48 received rescue therapy, and 6 underwent colectomy at index admission (3 after rescue therapy and 3 without). Day-one albumin (OR 0.906, P = 0.043) and being on oral steroids at entry (OR 3.009, P = 0.014) predicted non-response to steroids in both univariate and multivariate analyses. Admission hemoglobin level predicted steroid non-response only in univariate (OR 0.982, P = 0.047). Although an old score, Travis criteria predicted both steroid non-response (OR 8.4, P = 0.001) and requiring colectomy (OR 22.19, P = 0.006).Conclusion: Lower albumin levels and being on oral steroids at admission for ASUC can predict IV steroid failure, and we suggest the possibility of early initiation of advanced therapy in this subgroup.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical Impedance Spectroscopy in Endoscopic Procedures. 推进上消化道癌症检测：一项探索电阻抗谱在内镜手术中的潜力的单中心试点研究。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-05 DOI: 10.1007/s10620-025-08983-3

Hadi Mokhtari Dowlatabad, Reihane Mahdavi, Seyed Rouhollah Miri, Mohammad Reza Fattahi, Hossein Ataee, Narges Yousefpour, Navid Manoochehri, Reza Taslimi, Mohammad Abdolahad

{"title":"Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical Impedance Spectroscopy in Endoscopic Procedures.","authors":"Hadi Mokhtari Dowlatabad, Reihane Mahdavi, Seyed Rouhollah Miri, Mohammad Reza Fattahi, Hossein Ataee, Narges Yousefpour, Navid Manoochehri, Reza Taslimi, Mohammad Abdolahad","doi":"10.1007/s10620-025-08983-3","DOIUrl":"https://doi.org/10.1007/s10620-025-08983-3","url":null,"abstract":"Purpose: Early detection of GI cancer mass is of utmost importance due to the risks of misdiagnoses that occur through standard endoscopic evaluation.Methods: In this research, a real-time intra-endoscopic electrical diagnostic probe has been introduced to discriminate high-risk excision-required lesions utilizing a modified endoscopic biopsy forceps as a non-invasive method.Results: By testing on 52 patients who had undergone endoscopic biopsy with a total of 18 high-risk lesions, the invented device named Electrical Endoscopic Mass Characterizer (EEMC), showed %94.7 sensitivity, %93.9 specificity, and %94.2 accuracy (p < 0.01) based on histopathological evaluations of removed specimens as the gold standard.Conclusions: EEMC can be utilized as a precise complementary device during endoscopic evaluation for improving the accuracy of early-stage GI cancer detection with no interruptions in the routine procedure.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing Is Believing: Does Red Dichromatic Imaging (RDI) Predict Histological Remission and Clinical Outcomes in Ulcerative Colitis Patients? 眼见为实：红色二色成像（RDI）能否预测溃疡性结肠炎患者的组织学缓解和临床结果？

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-03 DOI: 10.1007/s10620-025-09027-6

Vedran Tomašić

引用次数: 0

Long-Term Outcomes of Carvedilol Plus Endoscopic Variceal Ligation in Secondary Prophylaxis of Variceal Bleeding. 卡维地洛加内窥镜下静脉曲张结扎二级预防静脉曲张出血的长期疗效。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-03 DOI: 10.1007/s10620-025-09000-3

Xiao Liu, Yifu Xia, Junyuan Zhu, Xiaochen Liu, Lixia Xin, Guangchuan Wang, Mingyan Zhang, Zhen Li, Guangjun Huang, Chunqing Zhang

{"title":"Long-Term Outcomes of Carvedilol Plus Endoscopic Variceal Ligation in Secondary Prophylaxis of Variceal Bleeding.","authors":"Xiao Liu, Yifu Xia, Junyuan Zhu, Xiaochen Liu, Lixia Xin, Guangchuan Wang, Mingyan Zhang, Zhen Li, Guangjun Huang, Chunqing Zhang","doi":"10.1007/s10620-025-09000-3","DOIUrl":"https://doi.org/10.1007/s10620-025-09000-3","url":null,"abstract":"Background: Carvedilol is key for primary prophylaxis of high-risk variceal bleeding but is less studied for secondary prophylaxis with EVL. This study compares the long-term outcomes of carvedilol plus EVL versus propranolol plus EVL in secondary prophylaxis.Methods: The long-term follow-up data regarding rebleeding, ascites recurrence, and survival of patients who were treated with EVL plus carvedilol (n = 147) or propranolol (n = 53) for secondary prophylaxis of variceal bleeding were compared.Results: Patients in the carvedilol group (n = 147) exhibited lower rebleeding rates (23.8% vs. 47.2%; hazard ratio(HR): 1.844; 95% confidence interval (CI) 1.099-3.096; p = 0.019) and ascites rates (7.5% vs. 30.2%; HR: 2.975; 95% CI 1.349-6.557; p = 0.003) compared to the propranolol group (n = 53). Cumulative mortality rates were similar between groups (12.2% vs. 30.2%; HR: 1.292; 95% CI 0.632-2.642; p = 0.48). In patients with viral cirrhosis, carvedilol resulted in lower rebleeding rates (HR: 2.236; 95% CI 1.188-4.208; p = 0.013) and improved ascites control (HR: 3.698; 95% CI 1.363-10.032; p = 0.010). Adjusted survival curves and 1:1 propensity score matching analyses confirmed these findings.Conclusions: Our findings suggest that carvedilol combined with EVL may reduce rebleeding and ascites recurrence compared to propranolol in patients with cirrhosis, particularly those with viral etiologies. However, the lack of mortality benefit and limited generalizability to non-viral cirrhosis necessitate further validation in prospective trials.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Will Rogers Paradox in Gastroenterology. Will Rogers肠胃病学悖论。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-03 DOI: 10.1007/s10620-025-09028-5

Amnon Sonnenberg, Anna M Buchner

引用次数: 0

Bone Broth Benefits: How Its Nutrients Fortify Gut Barrier in Health and Disease. 骨汤的好处：它的营养成分如何在健康和疾病中强化肠道屏障。

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-03 DOI: 10.1007/s10620-025-08997-x

Ayah Matar, Nada Abdelnaem, Michael Camilleri

{"title":"Bone Broth Benefits: How Its Nutrients Fortify Gut Barrier in Health and Disease.","authors":"Ayah Matar, Nada Abdelnaem, Michael Camilleri","doi":"10.1007/s10620-025-08997-x","DOIUrl":"https://doi.org/10.1007/s10620-025-08997-x","url":null,"abstract":"Bone broth is a traditional nutrient revered by different people from ancient times to the modern era as a remedy for various illnesses. This review investigates the nutritional components of bone broth, focusing primarily on the most abundant amino acids and minerals saturated in bone broth and their impact on health, particularly in the context of intestinal barrier integrity, intestinal permeability, inflammation, and their application in inflammatory bowel disease. Through comprehensive reviews of animal and human studies, this research highlights that bone broth includes amino acids (glutamine, glycine, proline, histidine, arginine), minerals (Ca, P, K, Mg, Zn) that are beneficial and not just a traditional remedy, resolving questions that have been posed for generations. The benefits documented for components in bone broth support the enhancement of gut health, alleviate inflammation in the intestinal barrier, improve intestinal barrier function in health and disease states, particularly in inflammatory bowel disease, as well as enhancing nutrient absorption. Bone broth offers a nutrient-dense option for enhancing overall health and may offer an alternative to dietary supplements with claims for enhanced gut health. We aim to foster interest in and provide evidence to substantiate claims for bone broth as a potential remedy, particularly for maintaining remission in conditions like IBD and possibly functional diarrhea and to encourage further research.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0