Digestive Diseases and Sciences最新文献

{"title":"Distinctive Endoscopic Ultrasound Features of Pancreatic Adenosquamous Carcinoma: A Propensity Score-Matched Analysis.","authors":"Chen Ke, Dang Yini, Zheng Qiang, He Ming, Liu Jianqiang","doi":"10.1007/s10620-026-10091-9","DOIUrl":"10.1007/s10620-026-10091-9","url":null,"abstract":"<p><strong>Purpose: </strong>Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive malignancy with poorer prognosis than pancreatic ductal adenocarcinoma (PDAC). This study aimed to identify distinctive endoscopic ultrasound (EUS) features for pre-operative differentiation between PASC and PDAC.</p><p><strong>Methods: </strong>Forty-six PASC patients and 683 PDAC patients were retrospectively enrolled. Propensity score matching (1:2) balanced age, sex, and tumor size. EUS characteristics were compared, and independent predictors were identified by multivariate logistic regression.</p><p><strong>Results: </strong>PASC tumors were significantly larger than PDAC tumors at baseline (p < 0.001). After matching, multivariate analysis identified five independent predictors of PASC: higher serum albumin (OR = 1.256), hyperechoic foci (OR = 7.733), non-infiltrative growth pattern (INF C: OR = 0.163), and absence of pancreatic duct dilation (positive: OR = 0.021; unknown: 0.008) (all p < 0.05). The model demonstrated good discrimination with an AUC of 0.931 (95% CI 0.888-0.974). PASC more frequently exhibited hyperechoic foci (69.6% vs. 34.8%) and expansive growth, while PDAC typically showed infiltrative growth and duct dilation.</p><p><strong>Conclusion: </strong>PASC demonstrates distinctive EUS features including hyperechoic foci, expansive growth pattern, and less frequent ductal obstruction compared with PDAC, which may facilitate pre-operative differentiation from PDAC.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5346-5355"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Intern to Fellow: A Bibliometric Analysis of Research Trends Among Matched Gastroenterology Fellows.","authors":"Henrik A Hahamyan, Cooper Bullough, Brice Walkowski, Landon Brown, Ahmed Hmidat","doi":"10.1007/s10620-026-10092-8","DOIUrl":"10.1007/s10620-026-10092-8","url":null,"abstract":"<p><strong>Purpose: </strong>Research is an important factor in matching into gastroenterology (GI) fellowship, yet limited data exist on the publication output of incoming fellows. The purpose of this study was to investigate the peer-reviewed publications of matched GI fellows by start of internal medicine (IM) residency and GI fellowship to characterize research trends in the GI fellowship match.</p><p><strong>Methods: </strong>A bibliometric analysis was performed on fellows entering GI programs in 2022-2024. Utilizing research databases, the quantity and quality of publications at the start of both IM residency and GI fellowship were extracted and analyzed temporally, by home-program match status, and degree type.</p><p><strong>Results: </strong>Across 192 programs, 1858 fellows had a median of 0 publications before IM residency, increasing to 3 publications by GI fellowship (mean: 1.32 vs. 5.08). At IM application, 50.9% had no publications, compared to 16.8% at GI application. By fellowship, matriculants averaged 36.1% first/last authored articles, 2.33 H-index, and 61.9% GI-related articles. Those remaining at their home program for fellowship had fewer publications than external matches. Non-US IMGs had more publications and higher H-indexes but published in lower-impact journals than allopathic graduates.</p><p><strong>Conclusion: </strong>Our findings suggest that research productivity increases between IM and GI applications, while providing background on current trends in other quality metrics in the match. Those who matched their home institutions had fewer mean publications than those who did not, suggesting that institutional familiarity may play a role. These findings can help applicants, advisors, and program directors set expectations and goals regarding research during the GI fellowship match.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5458-5464"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Recurrent Malignancy or Benign Overgrowth? Expanding Possibilities for Dysfunctional Esophageal Stents Placed for Malignant Obstruction.","authors":"Sanish Ancil","doi":"10.1007/s10620-026-10124-3","DOIUrl":"10.1007/s10620-026-10124-3","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5298-5301"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation Analysis of C-Reactive Protein-Triglyceride-Glucose Index with the Severity of Hyperlipidemic Acute Pancreatitis.","authors":"Youfei Wen, Wanwei Chen, Wei Zhang, Yan Huang, Yuxuan Zhang, Shanshan Xiong","doi":"10.1007/s10620-026-10121-6","DOIUrl":"10.1007/s10620-026-10121-6","url":null,"abstract":"<p><strong>Background: </strong>The novel serum C-reactive protein-triglyceride-glucose index (CTI) has been identified as an optimal biomarker integrating inflammation and insulin resistance (IR), which are the potential pathogenic mechanisms underlying hyperlipidemic acute pancreatitis (HLAP). This study aims to investigate the association between CTI and the severity of HLAP.</p><p><strong>Objective: </strong>To investigate the correlation between the serum CTI and the severity of HLAP.</p><p><strong>Methods: </strong>We conducted a retrospective study including 113 consecutive patients with HLAP admitted to the Guizhou Hospital of the First Affiliated Hospital of Sun Yat-sen University from July 2021 to November 2025. Patients were classified into severe and non-severe groups based on the Revised Atlanta Classification of Acute Pancreatitis. Logistic regression, subgroup analysis, restricted cubic spline (RCS) regression, and receiver operating characteristic (ROC) analysis were performed to explore the association between CTI and the severity of HLAP.</p><p><strong>Results: </strong>A total of 113 patients with HLAP were enrolled in this study, including 69 cases in the severe group and 44 cases in the non-severe group. The results demonstrated that the CTI was positively correlated with the severity of HLAP, regardless of covariate adjustment (odds ratio (OR) = 1.55, 95%CI 1.04-2.30, P = 0.03). The continuous variable CTI was further divided into four quartiles, followed by logistic regression analysis. Compared with the population in the lowest CTI quartile, the population in the highest CTI quartile showed a significantly higher risk of severe acute pancreatitis (SAP) after adjusting for confounding factors (OR = 6.0, 95%CI 1.37-26.21, P = 0.02). This finding was further verified by subgroup analysis. RCS analysis revealed a linear positive correlation between CTI and the risk of SAP. According to ROC curve analysis, CTI demonstrated a higher specificity and a larger AUC, suggesting superior overall discriminative performance compared with the Bedside Index for Severity in Acute Pancreatitis (BISAP) score. These findings suggested that the CTI has good predictive efficacy for the severity of HLAP.</p><p><strong>Conclusion: </strong>The CTI is positively correlated with the severity of HLAP, highlighting that the CTI is a potential clinical indicator for identifying and stratifying the severity of HLAP, which further guides clinical decision-making.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5636-5643"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of Laparoscopic Heller Myotomy in Achalasia Patients with Persistent or Recurrent Symptoms After Peroral Endoscopic Myotomy (POEM).","authors":"Elise M Wessels, Gwen M C Masclee, Marlies P Schijven, Albert J Bredenoord","doi":"10.1007/s10620-026-10123-4","DOIUrl":"10.1007/s10620-026-10123-4","url":null,"abstract":"<p><strong>Introduction: </strong>Peroral endoscopic myotomy (POEM) is an effective and safe treatment for achalasia. However, in some patients symptoms may persist or recur, requiring additional treatment. The aim of this study was to examine the efficacy and safety of performing laparoscopic Heller myotomy (LHM) in achalasia patients having persistent or recurrent symptoms after POEM.</p><p><strong>Methods: </strong>This retrospective study includes patients who underwent LHM after they failed on POEM, which was performed between August 2011 and March 2024. Follow-up data were extracted from hospital medical records, and patients completed questionnaires regarding achalasia symptoms and quality of life between March 2024 and August 2025. Primary outcome was treatment success after LHM, defined as Eckardt score ≤ 3 without subsequent retreatment.</p><p><strong>Results: </strong>In total, 22 patients were included (median age 43 years, 50.0% female) of which 21 completed questionnaires. Median follow-up time after LHM in patients who previously failed on POEM was 86 months. Treatment success was observed in three patients (13.6%, n = 3/22), with follow-up of 36, 74 and 110 months after LHM. A marked decline in success rate of LHM following POEM was observed over time: approximately 70% after one year and 30% after two years. For patients with treatment failure after LHM, 73.7% required retreatment (n = 14/19), predominantly with pneumatic dilation.</p><p><strong>Conclusion: </strong>LHM following POEM yields only minimal benefit with a rapid loss of success over time. These outcomes suggest limited clinical value of LHM following POEM failure and indicate that alternative strategies may be preferable.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5711-5719"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.","authors":"Tejas Easwar, Wasuwit Wanchaitanawong, Ashwin N Ananthakrishnan","doi":"10.1007/s10620-026-10145-y","DOIUrl":"10.1007/s10620-026-10145-y","url":null,"abstract":"<p><strong>Background and aims: </strong>Patients with inflammatory bowel disease (IBD) have a higher prevalence of various immune and non-immune comorbidities. Whether this reflects shared genetic susceptibility or is an effect of chronic inflammation remains unclear.</p><p><strong>Methods: </strong>We systematically assessed genetic risk underlying 20 IBD-comorbidity associations using polygenic risk scores (PRS) in 853 patients with IBD (542 Crohn's disease, 311 ulcerative colitis) and 4333 non-IBD controls from the Mass General Brigham Biobank. PRS were generated by clumping-and-thresholding approach in PLINK2.0 using largest available genome-wide association studies. Associations between PRS and IBD were tested with logistic regression adjusted for age, sex, and principal components. Bonferroni correction was applied for multiple testing.</p><p><strong>Results: </strong>Patients with IBD showed a significantly higher genetic risk for colorectal cancer (p = 4.1 × 10^-11), primary sclerosing cholangitis (p = 1.6 × 10^-5), and celiac disease (p = 0.0035), which may be consistent with partial shared polygenic architecture among these conditions. Conversely, patients showed significantly lower genetic risk for depression (p = 3.6 × 10^-7) and atopic dermatitis (p = 0.0016), suggesting co-occurrence may reflect factors other than shared inherited risk including shared environment or effect of chronic inflammation. Quartile analyses showed dose-response patterns for genetically mediated comorbidities. Patients with Crohn's disease had higher PRS for primary sclerosing cholangitis (p = 0.029) and type 1 diabetes (p = 0.038) compared to patients with ulcerative colitis.</p><p><strong>Conclusion: </strong>IBD comorbidities show selective, rather than uniform genetic overlap. These patterns are consistent with involvement of epithelial-immune related loci, although PRS data alone do not allow causal inference. Further work is needed to clarify relative contributions of inherited risk, inflammation, and environmental factors to comorbidity patterns in IBD. These findings support PRS-based precision medicine approaches for risk stratification and personalized screening.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5764-5776"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy, Technique, and Pancreatic Injury During Pancreatic Guidewire-Assisted Cannulation: A Video-Based Perspective.","authors":"Toru Kaneko, Mitsuhiro Kida, Chika Kusano","doi":"10.1007/s10620-026-10147-w","DOIUrl":"10.1007/s10620-026-10147-w","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5313-5314"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Practical Endoscopic Treatment Strategy for Appendiceal Orifice Lesions Using Forceps-Assisted Polypectomy (Strip Biopsy).","authors":"Toshifumi Iida, Jun Arimoto, Ai Hirohata, Akimichi Hayashi, Yu Ebisawa, Michiko Nakaoka, Tetsuo Nemoto, Hideyuki Chiba","doi":"10.1007/s10620-026-10140-3","DOIUrl":"10.1007/s10620-026-10140-3","url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic treatment of small lesions involving the appendiceal orifice remains technically challenging. Although endoscopic submucosal dissection (ESD) enables en bloc resection, it may represent overtreatment for such lesions. In contrast, forceps-assisted polypectomy; strip biopsy may serve as an effective therapeutic option. The aim of this study was to propose a practical, real-world treatment strategy and to evaluate the clinical usefulness of strip biopsy.</p><p><strong>Methods: </strong>This retrospective single-center study included patients who underwent endoscopic treatment for appendiceal orifice lesions between May 2017 and September 2025. Patients were classified into strip biopsy or ESD group. Procedural outcomes and adverse events were compared.</p><p><strong>Results: </strong>Twenty-two appendiceal orifice lesions were included, with 14 treated by strip biopsy and 8 by ESD. Baseline characteristics were comparable. Procedure time was significantly shorter in the strip biopsy group (6.6 ± 2.9 vs. 45.9 ± 31.3 min, p < 0.05). En bloc resection rates were 93 and 100%, respectively. No perforation occurred, and delayed bleeding was observed in one ESD case only. Positive or unclear horizontal margins were more frequent in the strip biopsy group than in the ESD group (50 vs. 13%, p = 0.16). Among patients who completed 1-year surveillance colonoscopy, no local recurrence was observed.</p><p><strong>Conclusion: </strong>Strip biopsy may be a feasible and rapid treatment option for carefully selected small appendiceal orifice lesions without endoscopic features suggestive of malignancy. However, because of the retrospective design, small sample size, and limited follow-up data, further prospective studies with larger cohorts and longer follow-up are warranted.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5986-5993"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saikosaponin D Improves Diarrhea-Predominant Irritable Bowel Syndrome by Regulating the Brain-Gut Axis: Based on Changes in the Gut HMGB1-TLR4/NF-κB Pathway and Hypothalamic HPA Axis.","authors":"Guilin Dong, Ao Li, Haizhou Zeng, Xinran Li, Yanli Xiong, Xiaoqing Xu, Jingjing Li, Yunxia Kuang, Chunli Lu, Guoqiang Qian","doi":"10.1007/s10620-026-10165-8","DOIUrl":"10.1007/s10620-026-10165-8","url":null,"abstract":"<p><strong>Background: </strong>Diarrhea-predominant irritable bowel syndrome (IBS-D) is characterized by diarrhea and is often accompanied by depression, abdominal symptoms, and emotional comorbidities. Preclinical and clinical studies have shown that dysfunction of the brain-gut axis is a key pathogenic factor in IBS-D, yet the specific mechanisms remain unclear. Saikosaponin D (SSD), a major bioactive component of Bupleurum chinense DC., exhibits anti-inflammatory, antidepressant, and antitumor activities, with multi-target and multi-pathway interactions.</p><p><strong>Methods: </strong>Acetic acid and restraint stress induced an IBS-D mouse model. SSD (purity ≥ 98%, Macklin Inc.) was administered orally at low, medium, and high doses (5, 10, 20 mg/kg). Visceral sensitivity, inflammatory status, intestinal barrier function, HPA axis activity, and gut microbiota composition were systematically evaluated using behavioral tests, Western blot, qRT-PCR, and 16S rRNA sequencing.</p><p><strong>Results: </strong>SSD significantly alleviated visceral hypersensitivity and depression-like behavior, inhibited the peripheral HMGB1-TLR4/NF-κB inflammatory pathway, and restored intestinal barrier integrity. SSD also downregulated hypothalamic Nesfatin-1/CRH/p-CREB expression, suppressed hyperactivation of the stress-related HPA neuroendocrine axis, and reshaped the gut microbial community structure (β-diversity). Network pharmacology analysis suggested that SSD targets were significantly enriched in brain-gut axis-related pathways.</p><p><strong>Conclusion: </strong>The present results indicate that SSD could ameliorate IBS-D by synergistically regulating peripheral inflammation, central stress, and intestinal microbes via the brain-gut-microbiota axis, providing experimental evidence for its potential application in TCM-based treatment.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5824-5840"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HKDC1 as a Prognostic and Tumor Microenvironment‑Associated Biomarker in Colorectal Cancer: An Integrated Multi‑omics and Spatial Transcriptomic Study.","authors":"Yuman Wu, Kairan Bian, Xueying Lu, Yinqiao Kong, Shang Lou, Jing Xie, Yu Huang, Limei Nong, Shengan Li, Qian Jiang, Jiale Mei, Chunyin Wei, Zhongnan Huang, Qi Zeng, Wenqi Luo","doi":"10.1007/s10620-026-10182-7","DOIUrl":"10.1007/s10620-026-10182-7","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a leading cause of cancer-related mortality, necessitating the discovery of novel metabolic biomarkers. Hexokinases (HKs) are pivotal in dysregulated glucose metabolism. However, the role of HKDC1, which is the fifth and most recently identified isoform, remains poorly understood in CRC.</p><p><strong>Methods: </strong>We employed an integrated multi-omics approach to characterize HKDC1. Candidate glycolysis-related genes were screened using WGCNA and differential expression analysis across TCGA, GEO, and GTEx datasets. Spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) were utilized to map the precise localization and cellular communication patterns of HKDC1. Findings were validated in a clinical cohort (n = 168) via Western blot and immunohistochemistry. Functional roles were assessed through HKDC1 knockdown in CRC cell lines using CCK-8, colony formation, Transwell, and wound healing assays. Finally, the relationship between HKDC1, immune infiltration, and drug sensitivity was explored.</p><p><strong>Results: </strong>HKDC1 was significantly upregulated in CRC across multiple cohorts and pan-cancer datasets. Spatial transcriptomics confirmed HKDC1 enrichment specifically within malignant regions compared to benign zones. High HKDC1 expression was identified as an independent prognostic factor correlated with poor overall survival. Functional assays demonstrated that HKDC1 knockdown significantly inhibited CRC cell proliferation, migration, invasion, and was associated with suppression of epithelial-mesenchymal transition (EMT) related features. Mechanistically, scRNA-seq analysis suggested that HKDC1+ epithelial cells may contribute to tumor progression and potentially interact with fibroblasts through ligand-receptor signaling, including the COL1A2-ITGA2 axis. Furthermore, HKDC1 expression was closely associated with immune cell infiltration and predicted drug sensitivity profiles.</p><p><strong>Conclusion: </strong>Our study identifies HKDC1 may act as a potential metabolic regulator associated with CRC progression, possibly involving EMT and tumor microenvironmental interactions. HKDC1 may serve as a potential prognostic biomarker and a candidate target for further therapeutic investigation.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"5948-5967"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}