Digestive Diseases and Sciences最新文献

{"title":"A Novel Endoscopic Technique for the Successful Closure of a Refractory Esophagotracheal Fistula.","authors":"Jia-Min Wang, Li Wang, Jia-Min Qin, Li-Ming Wen, Zhen Tang","doi":"10.1007/s10620-025-09415-y","DOIUrl":"https://doi.org/10.1007/s10620-025-09415-y","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Readmissions in Patients Undergoing Endoscopic Drainage for Peripancreatic Fluid Collections.","authors":"Timothy Tyler Daugherty, Renato Beas, Luis Hernandez, Mohamed Rajput, Juan Reyes Genere","doi":"10.1007/s10620-025-09407-y","DOIUrl":"https://doi.org/10.1007/s10620-025-09407-y","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic fluid collections (PFCs) are a frequent complication following acute pancreatitis and often necessitate endoscopic cystogastrostomy (EC) for drainage. Despite high technical and clinical success rates, unplanned readmissions remain common.</p><p><strong>Aims: </strong>This study aimed to evaluate readmission rates and identify associated risk factors in patients undergoing EC for PFCs.</p><p><strong>Methods: </strong>We conducted a retrospective review of 100 patients who underwent EC for symptomatic PFCs between June 2016 and August 2021. Demographic data, clinical characteristics, procedural details, and outcomes were analyzed. Univariate and multivariate logistic regression were used to identify factors associated with unplanned readmissions.</p><p><strong>Results: </strong>Clinical success was achieved in 95% of patients. However, 31% experienced unplanned readmissions, most commonly due to sepsis (47%), abdominal pain (28%), and gastrointestinal bleeding (14%). Univariate analysis identified intra-abdominal varices and paracolic gutter extension as significant risk factors. Multivariate analysis confirmed intra-abdominal varices as an independent predictor (OR 3.51, 95% CI 1.26-9.80, P = 0.016). Technical success was high (98%) with an overall adverse event rate of 14%.</p><p><strong>Conclusion: </strong>Unplanned readmissions are common after EC for PFCs, with intra-abdominal varices emerging as a key risk factor. Enhanced follow-up and risk stratification may improve patient outcomes and reduce healthcare burden.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cause of Hematochezia: Perianal Paget's Disease.","authors":"Hengchen Yan, Bo Gao","doi":"10.1007/s10620-025-09422-z","DOIUrl":"https://doi.org/10.1007/s10620-025-09422-z","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Response-\"Percutaneous Endoscopic Gastrostomy with Jejunal Extension Versus Direct Percutaneous Endoscopic Jejunostomy for Post-pyloric Feeding: A Dual-Center Retrospective Study\".","authors":"Soban Maan, Matthew R Krafft","doi":"10.1007/s10620-025-09393-1","DOIUrl":"https://doi.org/10.1007/s10620-025-09393-1","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EUS-Guided Radial Incision for Duodenal and Colonic Strictures: First Report Emphasizing Muscularis Propria Integrity as a Safety Predictor.","authors":"Zhang-Xiu Jiang, Song-Da Chen, Xiu-Xiu Yin, Fu-Jian Li","doi":"10.1007/s10620-025-09335-x","DOIUrl":"https://doi.org/10.1007/s10620-025-09335-x","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning from Yeast-How YEATS Domain Proteins Read Epigenetic Marks Driving Oncogenic Programs in Gastrointestinal Tumors.","authors":"Valeria Canu, Giovanni Blandino","doi":"10.1007/s10620-025-09401-4","DOIUrl":"https://doi.org/10.1007/s10620-025-09401-4","url":null,"abstract":"<p><p>YEATS domain-containing proteins (ENL, AF9, YEATS2, YEATS4) have emerged as key chromatin readers that recognize histone acylation marks to regulate transcription, chromatin accessibility, and DNA repair. In their recent review, Fu et al. delineate the diverse oncogenic functions of YEATS paralogs across digestive system malignancies, emphasizing their roles in integrating chromatin dynamics with signaling pathways such as PI3K/AKT, Wnt/β-catenin, HIF1α, and c-Myc. Although the structural features of YEATS domains pose challenges for pharmacological targeting, their consistent involvement in oncogenic transcriptional programs highlights them as promising epigenetic targets. This commentary critically appraises the review's contribution, highlighting its mechanistic breadth and the implications for targeting YEATS proteins in gastrointestinal tumors.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on Our Article, \"Outcomes of Acute Pancreatitis in Lean Versus Non-lean MASLD Patients: A Nationwide Analysis.","authors":"Prince A Ameyaw, Sarpong Boateng, Yussif Issaka, Erica S Ackah, Amita A Kasar, Yazan A Al-Ajlouni, Basile Njei","doi":"10.1007/s10620-025-09404-1","DOIUrl":"https://doi.org/10.1007/s10620-025-09404-1","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinical Features of Incidental Inflammatory Bowel Disease Identified During Screening and Surveillance Colonoscopy.","authors":"Sergio Bronze, Shabari Shenoy, Manasi Agrawal, Alexandros D Polydorides, Jean-Frédéric Colombel, Iago Rodríguez-Lago, Ryan C Ungaro","doi":"10.1007/s10620-025-09400-5","DOIUrl":"https://doi.org/10.1007/s10620-025-09400-5","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) can be detected in the absence of clinical symptoms.</p><p><strong>Aims: </strong>To determine the prevalence of incidental IBD in patients undergoing screening colonoscopy and to explore its clinical features and long-term outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study that included all asymptomatic adults who underwent colonoscopy for colorectal cancer screening or polyp surveillance between 2009 and 2023 in a large health system. Incidental IBD was defined as endoscopic and histologic findings consistent with the disease in the absence of symptoms. Clinical characteristics and outcomes were collected.</p><p><strong>Results: </strong>Among 40,573 patients who underwent colonoscopy, 60 were diagnosed with incidental IBD: 40 with Crohn's disease (CD), 10 with ulcerative colitis (UC), and 10 with IBD-unclassified (IBD-U). Mean age at diagnosis was 54.6 years for CD, 52.8 years for UC, and 55.7 years for IBD-U, with an overall female predominance (53%). Most CD patients had ileal involvement (98%) and inflammatory behavior (98%), and 60% of UC patients had extensive disease. After a mean follow-up period of 27.9 ± 34.7 months, 10 (16.7%) patients developed symptoms, and 5 (8.3%) initiated therapy, mostly after symptom onset. No hospitalizations or surgeries were reported.</p><p><strong>Conclusion: </strong>The prevalence of incidental IBD detected during colorectal cancer screening is low (0.15%), with 20% of CD and 20% of UC cases progressing to symptomatic disease. Incidental IBD has a mild disease course with a low likelihood of progression to complications.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Periampullary Diverticulum on ERCP Outcomes and Recurrence of Common Bile Duct Stones.","authors":"Xiaoxi Xie, Yanni Li, Yonghao Chen, Chong Geng, Yaoyu Guo, Xiao Li, Chunhui Wang","doi":"10.1007/s10620-025-09394-0","DOIUrl":"https://doi.org/10.1007/s10620-025-09394-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study was aimed to investigate the impact of periampullary diverticulum (PAD) on endoscopic retrograde cholangiopancreatography (ERCP) procedures and the recurrence of common bile duct stones (CBDS).</p><p><strong>Methods: </strong>830 CBDS cases with native papilla were finally enrolled in the study, including 239 cases with PAD (type I, type II, and type III). Procedures and complications of ERCP were compared between the two groups. The patients with successful stone removal were followed up every 6 months until December 31, 2023.</p><p><strong>Results: </strong>The successful cannulation rate in the PAD group (96.7%) and type I PAD group (76.9%) was lower than that in the non-PAD group (99.2%). PAD was associated with a wider bile duct diameter, larger stone size, and a higher rate of cannulation with double guidewires, endoscopic sphincterotomy combined with endoscopic papillary balloon dilation and mechanical lithotripsy during the ERCP procedure. The incidence of complications did not differ between the two groups. Multivariate analysis revealed that PAD (OR = 3.265, 95%CI: 1.854-5.751) was an independent risk factor for the recurrence of CBDS.</p><p><strong>Conclusion: </strong>PAD, especially type I PAD, may impact ERCP cannulation success rates. Additionally, PAD increases the complexity of stone extraction and is associated with CBDS recurrence.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Patient Experience with Point-of-Care Intestinal Ultrasound for Inflammatory Bowel Disease Monitoring: A Multicenter Study.","authors":"Emily Gore, Christopher Femino, Illya Aronskyy, Alexander Miller, Sara R Zelman, Michael W Winter, Michael T Dolinger","doi":"10.1007/s10620-025-09390-4","DOIUrl":"https://doi.org/10.1007/s10620-025-09390-4","url":null,"abstract":"<p><strong>Background: </strong>Intestinal ultrasound (IUS) is a non-invasive, accurate tool for monitoring inflammatory bowel disease (IBD), with growing adoption in the United States for real-time disease management within treat-to-target algorithms. While international studies highlight strong patient support for IUS, U.S.-based data on patient preferences and engagement are limited.</p><p><strong>Aims: </strong>This cross-sectional observational study, conducted at two academic IBD centers in the U.S., assessed patient experiences with IUS and preferences for disease monitoring.</p><p><strong>Methods: </strong>Adults with Crohn's disease (CD) and ulcerative colitis (UC) seen for a routine visit were selected to undergo IUS-driven care or non-IUS-driven care, at the discretion of their provider. Participants then completed a 20-item survey, which included Likert scales for comparing disease-monitoring modalities, as well as measures of patient engagement (Patient Activation Measure (PAM-13), Morisky Medication Adherence Scale (MMAS-4)), and disease activity. Electronic health records were reviewed for clinical data.</p><p><strong>Results: </strong>Of 326 patients (209 (64.1%) with CD; 117 (35.9%) with UC), 219 (67.2%) were IUS exposed (underwent IUS-driven care on the date of survey or previously) and 107 (32.8%) were IUS naïve. 133 (60.7%) IUS-exposed participants expressed a strong preference for IUS when comparing disease-monitoring modalities, with 153 (69.9%) reporting no discomfort. 225/326 (69.0%) expressed the strongest confidence in colonoscopy. 101 (46.1%) IUS-exposed participants expressed stronger confidence in IUS vs. blood work (96; 43.8%), stool studies (78; 35.6%), and other cross-sectional imaging (79; 36.1%).</p><p><strong>Conclusion: </strong>IUS is highly acceptable, well tolerated, and preferred by our U.S.</p><p><strong>Population: </strong>These findings support the implementation of IUS as a patient-centric monitoring tool.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}