Digestive Diseases and Sciences最新文献

{"title":"Simple Groove Pancreatitis: A Case Report of Diagnosis and Conservative Management.","authors":"Min Zhang, TianSong Fan, Bo Yin, PeiDong Wang","doi":"10.1007/s10620-025-09079-8","DOIUrl":"https://doi.org/10.1007/s10620-025-09079-8","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Per-oral Pancreatoscopy-Guided Lithotripsy Versus Extracorporeal Shock Wave Lithotripsy in Pancreatic Stone: A Meta-Analysis\".","authors":"Nirmal Noor, Rahat Khatoon","doi":"10.1007/s10620-025-09075-y","DOIUrl":"https://doi.org/10.1007/s10620-025-09075-y","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to 'Insights on Advanced Age as a Predictor of TIPS Outcomes in Elderly Patients'.","authors":"Gavisha Waidyaratne, Khalid Mumtaz","doi":"10.1007/s10620-025-09051-6","DOIUrl":"https://doi.org/10.1007/s10620-025-09051-6","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound-Assisted Endoscopic Submucosal Dissection for the Removal of a Toothpick.","authors":"Zhang-Xiu Jiang, Fu-Jian Li, Xiu-Xiu Yin","doi":"10.1007/s10620-025-09005-y","DOIUrl":"https://doi.org/10.1007/s10620-025-09005-y","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple, Interpretable Machine Learning Model Based on Clinical Factors Accurately Predicts Incident Dysplasia or Malignancy in Barrett's Esophagus.","authors":"Ashwin Rao, Jasmine Haydel, Samuel Ma, Aaron P Thrift, Theresa Nguyen-Wenker, Hashem B El-Serag","doi":"10.1007/s10620-025-09069-w","DOIUrl":"https://doi.org/10.1007/s10620-025-09069-w","url":null,"abstract":"<p><strong>Purpose: </strong>Identifying patients likely to develop dysplasia or malignancy is critical for effective surveillance in patients with Barrett's Esophagus (BE). However, current predictive models are limited. We evaluated the performance of machine learning (ML) models in predicting incident dysplasia or malignancy in a cohort of veteran patients with BE.</p><p><strong>Methods: </strong>We analyzed data from 598 patients newly diagnosed with non-dysplastic BE (NDBE), BE indefinite for dysplasia (BE-IND), and BE with non-persistent low-grade dysplasia (LGD) at the Michael DeBakey Veterans Affairs Medical Center from November 1990 to January 2019 with follow-up through January 2024. Progressors were patients who developed persistent LGD, HGD, or EAC within 5 years of index endoscopy. Six models were evaluated, encompassing regression and ensemble-based ML methods.</p><p><strong>Results: </strong>Of 598 qualifying patients, 61 (10.2%) progressed. Longer segments and indefinite/non-persistent LGD pathology were associated with higher risk of progression in unadjusted analyses. BE segment length remained significant on multivariate analysis (OR 1.26; 95% CI 1.17-1.36 per 1 cm increase). A decision tree (DT) model, using only segment length, achieved the highest discrimination (AUROC = 0.79) and excellent sensitivity (93.3%). The DT model also identified segment length thresholds for risk stratification: < 0.95 cm (minimal risk), 0.95-2.44 cm (low), 2.44-9.45 cm (moderate),  > 9.45 cm (high).</p><p><strong>Conclusions: </strong>A simple, interpretable DT model with segment length as the sole predictor outperformed regression and complex ML-based models in predicting BE progressors. Findings align with European Society of Gastrointestinal Endoscopy (ESGE) guidelines suggesting tailored surveillance based on segment length and provide actionable thresholds. These results offer a practical ML tool for BE surveillance.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium Channel Blocker and Hepatocellular Carcinoma Risk.","authors":"Shih-Wei Lai","doi":"10.1007/s10620-025-09080-1","DOIUrl":"https://doi.org/10.1007/s10620-025-09080-1","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mixed-Methods Approach to Assessing Barriers and Facilitators to Cancer Genetics Care in Black and Latino/a Individuals Impacted by Pancreatic Cancer: The Racial/ethnic Equity in GENetic Education, Risk Assessment, and TEsting (REGENERATE) Study.","authors":"Nicolette Juliana Rodriguez, Tara B Coffin, Andrew J Ward, Juan Felipe Rodriguez, Chinedu Ukaegbu, Allison Rosenzweig, Alyson Caruso, Anna Revette, Barbara Kenner, Scott H Nelson, Michael Goggins, Anirban Maitra, Sapna Syngal","doi":"10.1007/s10620-025-09018-7","DOIUrl":"https://doi.org/10.1007/s10620-025-09018-7","url":null,"abstract":"<p><strong>Purpose: </strong>Pancreatic ductal adenocarcinoma (PDAC) disproportionately impacts Black and Latino/a communities, who are less likely to receive genetic counseling/testing referrals, hindering early cancer detection/prevention access. This study aims to determine the barriers/facilitators to PDAC genetics care/surveillance among Black and Latino/a populations.</p><p><strong>Methods: </strong>This is a concurrent mixed-methods study that utilized electronic surveys and semi-structured focus groups/in-depth interviews (02/14/2022-12/21/2022). This was a volunteer sample of Black or Latino/a general participants with a personal or family history of PDAC and community leaders serving these groups. Participants discussed barriers/facilitators to PDAC cancer genetics care/surveillance. Health literacy, cancer worry, medical trust, and inherited cancer risk were assessed using electronic surveys. Discussions were recorded, transcribed, and analyzed using a content analysis approach. Chi-square tests, two-sample t-tests, and one-way analysis of variance were used to evaluate survey data using R v4.3.2.</p><p><strong>Results: </strong>55 participants (n = 27 general participants, 28 leaders) completed surveys. 27 (49%) self-identified as Black and 23 (42%) as Latino/a. Leaders (74%) reported higher levels of perceived medical mistrust among their communities than general participants (Trust in Physician Scale mean/SD 29.9/4.2 vs. 38.4/5.2, p < 0.001; Medical Mistrust Index = 18.8/4.2 vs. 24.4/3.6; p < 0.001, respectively). General participants self-reported higher digital health seeking capabilities than leaders' perception of that skillset (p < 0.001). 24 of these participants completed a focus group/in-depth interview, emphasizing informed discussions with a trusted/established provider.</p><p><strong>Conclusions: </strong>Individuals impacted by PDAC are open to genetics care and desire resources to promote PDAC surveillance. It is also crucial that leaders and providers be engaged to facilitate access to this care.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Capsule Removal from the Left Main Bronchus with a Gastroscope.","authors":"Adonis A Protopapas, Eleni Trypaki, Vaia Kyritsi, Athanasios Filippidis, Alexandra Tsankof, Christos Savopoulos, Andreas N Protopapas","doi":"10.1007/s10620-025-09078-9","DOIUrl":"https://doi.org/10.1007/s10620-025-09078-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Exposure to Air Pollution and Pediatric Biliary Atresia: A Nationwide Population-Based Cohort Study.","authors":"Chieh-Chung Lin, Shu-Yen Chan, Wei-Szu Lin, Meng-Che Wu, Natchaya Polpichai, Chien-Heng Lin, James Cheng-Chung Wei","doi":"10.1007/s10620-025-08957-5","DOIUrl":"https://doi.org/10.1007/s10620-025-08957-5","url":null,"abstract":"<p><strong>Introduction: </strong>Biliary atresia (BA) is a serious pediatric liver disease and the leading cause of liver transplants in children. Although its cause is unknown, prior research suggests air pollution may influence childhood diseases. This study examines the potential association between prenatal air pollution exposure and BA incidence.</p><p><strong>Methods: </strong>This nationwide, longitudinal matched case-control study used data from the National Health Insurance Research Database in Taiwan. BA cases were identified using ICD codes in children who underwent the Kasai procedure or liver transplantation. Controls, matched by age, index month, and gender, were selected at a 1:10 ratio. Multivariable logistic regression models, adjusted for potential confounders (age, gender, maternal age, delivery mode, and preterm birth), were utilized to assess the association between individual air pollutants (PSI, SO₂, CO, O₃, PM_2.5, PM₁₀, NO, NO₂, and NO_x) and BA. Quartiles of cumulative air pollutant amounts were analyzed for dose-dependent effects.</p><p><strong>Results: </strong>A total of 1,663,737 first-time pregnancies were identified from 2004 to 2016. After excluding 8,523 newborns due to congenital neonatal defects, 1,655,214 individuals remained. Among them, a cohort of 253 BA patients was identified. After adjusting for multiple confounders, no significant associations were found between prenatal exposure to air pollutants and BA risk. Quartile analysis of cumulative air pollutant exposure also indicated no dose-response relationship with BA risk for each air pollutant.</p><p><strong>Conclusion: </strong>This population-based study found no statistically significant association between prenatal air pollution exposure and the risk of BA in newborns in Taiwan.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Therapy for Anastomotic Bleeding in Inflammatory Bowel Disease.","authors":"Weiwei Zheng, Ravi P Kiran, Bo Shen","doi":"10.1007/s10620-025-09029-4","DOIUrl":"https://doi.org/10.1007/s10620-025-09029-4","url":null,"abstract":"<p><p>Lower gastrointestinal (GI) anastomotic bleeding in patients with inflammatory bowel disease (IBD) is rare but can be detrimental. Time and effective management is critical to prevent morbidity. Endoscopy has emerged as a minimally invasive and highly effective treatment modality for the management of this complication. However, endoscopic treatment for anastomotic bleeding faces challenges such as recurrent bleeding, complication of the procedure, and need for interdisciplinary collaboration. In this study, we focus on the techniques, efficacy, and safety of endoscopic interventions for the treatment of lower GI anastomotic bleeding in patients with IBD.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}