Digestive Diseases and Sciences最新文献

{"title":"Scoping to Minuet in G.","authors":"Navin L Kumar","doi":"10.1007/s10620-025-09428-7","DOIUrl":"https://doi.org/10.1007/s10620-025-09428-7","url":null,"abstract":"<p><p>Dr. Shinichi Suzuki believed that all children had the ability to become skilled musicians when nurtured in a supportive environment with a dedicated teacher. His Suzuki method, which emphasizes learning strategies such as listening, imitation, and review, offers a framework that translates well to the endoscopy suite. In this paper, I describe the central components of the Suzuki method and propose the endoscopy teaching correlates-such as observation, modeling, and stepwise instruction-that can improve the way we teach endoscopy to our trainees.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish Bone in the Gastric Wall: A Diagnostic Pitfall in Endoscopic Ultrasound.","authors":"Jia-Min Wang, Li-Ming Wen, Li Wang, Jia-Min Qin, Zhen Tang","doi":"10.1007/s10620-025-09426-9","DOIUrl":"https://doi.org/10.1007/s10620-025-09426-9","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NCAPD2 Modulates MHC-I Antigen Presentation via the PI3K/AKT Axis to Drive Metastatic Progression in Gastric Cancer.","authors":"Qiong Luo, Sheng Yang, Qian Xu","doi":"10.1007/s10620-025-09402-3","DOIUrl":"https://doi.org/10.1007/s10620-025-09402-3","url":null,"abstract":"<p><strong>Background: </strong>Impaired major histocompatibility complex class I (MHC-I) antigen presentation constitutes a fundamental mechanism of tumor immune evasion, yet the upstream molecular drivers in gastric cancer (GC) remain enigmatic. Although non-structural maintenance of chromosomes condensin I complex subunit D2 (NCAPD2) demonstrates oncogenic potential across malignancies, its functional crosstalk with immune surveillance mechanisms remains unexplored.</p><p><strong>Methods: </strong>We conducted transcriptome sequencing on NCAPD2-silenced GC cell lines to identify differentially expressed genes (DEGs), followed by GO and KEGG pathway analyses. Leveraging the TCGA cohort, we analyzed NCAPD2 expression patterns and evaluated its clinical relevance in GC through survival analysis. Orthogonal validation was performed via qRT-PCR and Western blot to quantify mRNA and protein levels of NCAPD2 and MHC-I. To functionally characterize the oncogenic phenotype, we employed CCK-8, wound healing, Transwell, and flow cytometry, providing a multi-parametric assessment of malignant progression mechanisms.</p><p><strong>Results: </strong>NCAPD2 was overexpressed in GC tissues and associated with poorer patient survival. Functional characterization in GC cell lines revealed that NCAPD2 knockdown significantly inhibited malignant phenotypes, including slowed proliferation, weakened migration, reduced invasion, and enhanced apoptosis. Mechanistically, NCAPD2 downregulated MHC-I surface expression, a critical immune evasion mechanism, and this suppression was partially rescued by treatment with the PI3K inhibitor LY294002, suggesting the involvement of the PI3K/Akt signaling pathway in NCAPD2-mediated immune escape.</p><p><strong>Conclusion: </strong>In GC, elevated NCAPD2 expression is a negative prognostic marker associated with advanced tumor stage and poorer survival. Functionally, NCAPD2 promotes malignant phenotypes and downregulates MHC-I antigen presentation via the PI3K/AKT pathway, thereby facilitating immune evasion. These findings suggest NCAPD2 as a potential therapeutic target in GC.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blocked Veins, Damaged Gut: Unraveling the Link Between Celiac Disease and Budd-Chiari Syndrome.","authors":"Ahlam Boutaleb, Zouaoui Mehdi, Youssef Hnach, Mbarek Azouaoui, Nourdin Aqodad","doi":"10.1007/s10620-025-09420-1","DOIUrl":"https://doi.org/10.1007/s10620-025-09420-1","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Efficacy of Histology Combined with Single Cytology for Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Solid Pancreatic Lesions: A Retrospective Single-Center Study.","authors":"Fu-Qiang Liu, Li-Na Ren, Qin Lu, Ling Xiao, Xue-Qin Li, Wei-Hui Liu","doi":"10.1007/s10620-025-09409-w","DOIUrl":"https://doi.org/10.1007/s10620-025-09409-w","url":null,"abstract":"<p><strong>Background and aims: </strong>Studies comparing the diagnostic efficacy of histology combined with smear cytology (SC) and liquid-based cytology (LBC) in endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of solid pancreatic lesions are limited, mainly due to the ongoing debate about the need for simultaneous use of SC and LBC as adjuncts to histology. We aimed to evaluate the diagnostic efficacy of combining histology with single cytology in EUS-FNA of solid pancreatic lesions.</p><p><strong>Methods: </strong>We retrospectively searched hospital database from January 2021 to December 2023 to identify patients who underwent EUS-FNA with concomitant histology, SC and LBC. The diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under curve (AUC) of the above methods were compared. The primary endpoint was the diagnostic efficacy of each method, with the final diagnosis confirmed by surgical pathology, or clinical follow-up.</p><p><strong>Results: </strong>Of the 293 patients included, 236 were malignant and 57 were benign. Histology alone demonstrated a higher diagnostic performance than either SC or LBC. Combining histology with either SC or LBC improved sensitivity, but reduced specificity. No significant increase in diagnostic efficacy was observed when combining histology with both cytological methods. Additionally, SC with more than 8 smears showed higher sensitivity and accuracy than LBC.</p><p><strong>Conclusions: </strong>EUS-FNA histology only requires combination with one cytological method (either SC or LBC), rather than both methods, to improve diagnostic accuracy for solid pancreatic lesions, meet clinical diagnostic requirements, and achieve high cost-effectiveness.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not Quite Achalasia: Getting to the GIST of it.","authors":"Pedro Mesquita, Edgar Afecto, Maria Luísa Proença, João Correia, Teresa Freitas","doi":"10.1007/s10620-025-09424-x","DOIUrl":"https://doi.org/10.1007/s10620-025-09424-x","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Another commentary on Our Article, \"Outcomes of Acute Pancreatitis in Lean Versus Non-lean MASLD Patients: A Nationwide Analysis\".","authors":"Prince A Ameyaw, Sarpong Boateng, Yussif Issaka, Erica S Ackah, Amita A Kasar, Yazan A Al-Ajlouni, Basile Njei","doi":"10.1007/s10620-025-09406-z","DOIUrl":"https://doi.org/10.1007/s10620-025-09406-z","url":null,"abstract":"","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Choledochoduodenostomy Versus Gallbladder Drainage for Malignant Biliary Obstruction: A Propensity Score Matched Study.","authors":"Noppachai Siranart, Christopher C Thompson, Marvin Ryou, Steven N Steinway","doi":"10.1007/s10620-025-09417-w","DOIUrl":"https://doi.org/10.1007/s10620-025-09417-w","url":null,"abstract":"<p><strong>Introduction: </strong>Endoscopic ultrasound-guided gallbladder drainage (EUS-GB) is an emerging alternative to choledochoduodenostomy (EUS-CBD) for malignant distal biliary obstruction (MDBO), particularly when conventional access is not feasible.</p><p><strong>Methods: </strong>We conducted a multicenter, retrospective study of patients undergoing EUS-GB or EUS-CBD for MDBO between January 2015 and October 2024. Primary outcomes were technical and clinical success. Secondary outcomes included procedural time, 6-month reintervention, adverse events (AEs), and all-cause mortality. Propensity score matching (PSM) was used to adjust for baseline differences.</p><p><strong>Results: </strong>Eighty-two patients were included (22 EUS-GB, 60 EUS-CBD). Technical success was comparable between groups (95.5% vs. 96.7%). EUS-GB was used as salvage in 50% of cases when EUS-CBD was not feasible, with a 90.9% technical success rate. PSM yielded 21 matched pairs. After propensity score matching, clinical success was similar (95.2% EUS-GB vs. 85.7% EUS-CBD, p = 0.61). EUS-GB had significantly lower 6-month reintervention (4.8% vs. 23.8%, p = 0.004) and stent-related complications (0% vs. 18.9%). Adverse event rates and all-cause mortality were similar. Median follow-up was 116 days (IQR: 51-300). In the EUS-GB group, pre-procedural cystic duct patency predicted clinical success (94.1%).</p><p><strong>Conclusion: </strong>EUS-GB is a technically effective and clinically comparable alternative to EUS-CDS for MDBO, with significantly fewer reinterventions and stent-related complications. When cystic duct patency is confirmed on imaging, EUS-GB may be considered as a primary approach or salvage strategy for biliary drainage in MDBO.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopy Unit Implementation of a Sealed In-Room Air Purifier with Ultraviolet Irradiation Reduces Bacterial and Airborne Particle Levels.","authors":"Monique T Barakat, Linda D Lee, Natalie Conti, Timothy Angelotti","doi":"10.1007/s10620-025-09388-y","DOIUrl":"https://doi.org/10.1007/s10620-025-09388-y","url":null,"abstract":"<p><strong>Purpose: </strong>There is a need for enhanced air quality in healthcare settings, particularly in areas with high levels of airborne particles and complex room layouts. This study evaluated the impact of germicidal ultraviolet air purification devices (GUVAPD) on bacterial contamination and airborne particle levels in endoscopic procedural rooms.</p><p><strong>Methods: </strong>We compared two endoscopy rooms and assessed whether GUVAPDs would further improve air quality above standard cleaning protocols. We compared an experimental room equipped with four germicidal ultraviolet chambers (Clean Air Unit, UV Angel) and a control room; both rooms performed similar endoscopic procedures. Microbial air and settled surface samples were collected, and airborne particle counts (0.3 and 2.5 um) were performed before and after the installation of GUVAPD, using standard techniques.</p><p><strong>Results: </strong>A significant 79% reduction of airborne bacterial colony-forming units (CFUs) from 130.8 to 27.2 CFUs (p < 0.0001) and a 68% reduction in settled surface bacterial CFUs from 10.2 to 5.7 CFUs (p = 0.016) were observed following installation of GUVPADs. Additionally, particulate matter measurements indicated a particle reduction of 47% and 75% (0.3 and 2.5 micron, respectively) after installation of GUVAPDs.</p><p><strong>Conclusions: </strong>These findings demonstrate that supplemental UV air treatment administered via GUVAPD effectively reduced both microbial and particulate contaminants in a complex room environment. Integrating GUVAPDs into current infection control strategies holds promising potential for improving patient and staff safety. Future research should explore the long-term effects and applicability of these systems in diverse clinical settings to further establish their efficacy in mitigating infections.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disorders Among Patients Diagnosed with Chronic Pancreatitis: A Systematic Review.","authors":"Ansuman Panigrahi, Jewel Ipsita Sahani, Swati Sambita Mohanty, Sanghamitra Pati","doi":"10.1007/s10620-025-09410-3","DOIUrl":"https://doi.org/10.1007/s10620-025-09410-3","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic pancreatitis is associated with various sleep disorders, impacting patients' quality of life. This systematic review aimed to synthesize existing evidence on the prevalence, associated risk factors, and health-related quality of life impacts of sleep disorders among patients diagnosed with chronic pancreatitis.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, Embase, Scopus, Web of Science, ScienceDirect, ProQuest, EBSCO, Google Scholar, and Shodhganga for studies published between January 1, 1990 and May 31, 2024, using predefined keywords and MeSH terms related to chronic pancreatitis, sleep disorders, and sleep quality, following our PROSPERO-registered protocol. The review exclusively focused on English-published studies because of limited resources, potentially introducing language bias. Gray literature was explored via Shodhganga and Google Scholar. The review was registered with PROSPERO (CRD42024547787). Eligible studies included those that investigated sleep disorders or sleep quality among patients diagnosed with chronic pancreatitis. The methodological quality of all included studies was appraised using the Joanna Briggs Institute critical appraisal checklist. Study selection and data extraction were performed independently by three reviewers, with discrepancies resolved by consensus or adjudication to reduce selection bias.</p><p><strong>Results: </strong>Out of 995 records, 9 studies were included after screening. These comprised six cross-sectional studies, one prospective cohort, and two retrospective cohort studies. Studies reported sleep disorder prevalence ranging from 33 to 81.6%. The Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Insomnia Severity Index served as the primary assessment tools across the studies. Most studies demonstrated high methodological quality, with eight scoring ≥ 7 on the JBI checklist.</p><p><strong>Conclusion: </strong>This systematic review revealed a high prevalence of sleep disorders in patients with chronic pancreatitis, underscoring the poor sleep quality in this population. These disturbances adversely affect the overall quality of life, emphasizing the need to integrate sleep management into comprehensive care.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}