Digestive Diseases and Sciences最新文献_第3页

Gastroenterology Fellow Knowledge of Esophageal Motility and Manometry: Assessment and Improvement Initiative at an Academic Center.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1007/s10620-025-08899-y

Ala A Abdel Jalil, Thai Hau Koo, John B Marshall, Ronnie Fass

{"title":"Gastroenterology Fellow Knowledge of Esophageal Motility and Manometry: Assessment and Improvement Initiative at an Academic Center.","authors":"Ala A Abdel Jalil, Thai Hau Koo, John B Marshall, Ronnie Fass","doi":"10.1007/s10620-025-08899-y","DOIUrl":"10.1007/s10620-025-08899-y","url":null,"abstract":"Background: There is scarce information on the state of general gastrointestinal (GI) fellow knowledge of esophageal motility and the interpretation skills of esophageal high-resolution manometry (HRM).Aim: This study aimed to assess GI fellow knowledge of esophageal motility and manometry interpretation.Methods: A 6-month educational program consisting of eight didactic sessions in the form of a weekly educational email, three didactic conferences, and handouts pertaining to the Chicago Classification (v3.0) of esophageal HRM was conducted. Both pre- and post-intervention surveys were collected using SurveyMonkey®. Five questions assessed fellows' knowledge of esophageal motility and manometry, and two questions examined their self-assessment of knowledge and confidence in managing esophageal motility disorders (EMDs). Descriptive statistics and Student's t test were used for the analysis.Results: Ten GI fellows (four first-year, five second-year, and one third-year) from a single academic institution participated in the intervention. Fellows showed a trend for better knowledge of the clinical aspects of esophageal motility over HRM interpretation (P value 0.09). On a scale of 1-5, with 5 being the highest, fellows' self-assessment of esophageal motility knowledge pre-intervention averaged 1.8 (SD 0.78) and post-intervention 2.9 (SD 0.99); P value 0.007. Fellows' confidence in managing EMDs pre-intervention averaged 1.7 (SD 0.66) and post-intervention 2.8 (SD 0.91); P value 0.04. Subgroup analyses, including fellows' self-assessment of knowledge, and fellows' confidence in managing EMDs, maintained statistically significance for level of training.Conclusion: GI fellow knowledge of esophageal motility and manometry interpretation, as well as confidence in managing EMDs, improved significantly after a 6-month formal educational program.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1342-1349"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PPIs Have It: Does Tegoprazan Affect Gastric Emptying and Produce Dyspeptic Symptoms?

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1007/s10620-025-08857-8

José María Remes-Troche

引用次数: 0

Digging Deeper: How Looking Under the Surface May Help Understand the Mechanism of Duodenal Mucosal Resurfacing.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1007/s10620-025-08887-2

Bhavna A Guduguntla, Ahmad Najdat Bazarbashi

引用次数: 0

Transanal Opening of the Intersphincteric Space (TROPIS) for Managing High Complex Perianal Fistula in a Crohn's Disease Case with Anorectal Stenosis.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1007/s10620-025-08859-6

Yanting Sun, Yang Liu, Pengfei Zhou, Meifeng Yang, Jiawen Wang

引用次数: 0

Barrett's Oesophagus with High Grade Dysplasia in Systemic Sclerosis with Advanced Microstomia: Diagnosis and Treatment Challenges.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1007/s10620-025-08895-2

Amelia Bowman, Sujata Biswas, Barbara Braden

引用次数: 0

Correction to: Homocysteine Promotes Intestinal Inflammation in Colitis Mice Through the PGE2/STAT3 Signaling Pathway.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 DOI: 10.1007/s10620-025-08903-5

Akang Shao, Qiu Zhao, Min Chen

引用次数: 0

Correction to: Chromosome 12 Open Reading Frame 49 Promotes Tumor Growth and Predicts Poor Prognosis in Colorectal Cancer.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 DOI: 10.1007/s10620-025-08901-7

Yiming Tao, Jia Luo, Hongyi Zhu, Yi Chu, Lei Pei

引用次数: 0

Switching to Subcutaneous Infliximab Maintenance Therapy Is Effective in Patients with Inflammatory Bowel Disease.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-13 DOI: 10.1007/s10620-025-08876-5

Jaakko Rautakorpi, Sara Kolehmainen, Eliisa Löyttyniemi, Clas-Göran Af Björkesten, Perttu Arkkila, Taina Sipponen, Kimmo Salminen

{"title":"Switching to Subcutaneous Infliximab Maintenance Therapy Is Effective in Patients with Inflammatory Bowel Disease.","authors":"Jaakko Rautakorpi, Sara Kolehmainen, Eliisa Löyttyniemi, Clas-Göran Af Björkesten, Perttu Arkkila, Taina Sipponen, Kimmo Salminen","doi":"10.1007/s10620-025-08876-5","DOIUrl":"10.1007/s10620-025-08876-5","url":null,"abstract":"Background: Recent studies suggest that subcutaneous infliximab is effective and safe for treating patients with inflammatory bowel disease. Real-world studies with larger cohorts are needed to confirm the efficacy of subcutaneous treatment.Aims: The aim was to assess real-world treatment persistence, clinical outcomes, infliximab concentrations, and treatment safety after switching from intravenous to subcutaneous infliximab treatment with patients with inflammatory bowel disease.Methods: This retrospective register-based study included patients with inflammatory bowel disease who were in clinical remission and switched from intravenous infliximab maintenance therapy to subcutaneous infliximab in two tertiary centers.Results: A total of 274 patients (104 Crohn's disease and 170 ulcerative colitis) were included. After the switch, the treatment persistence at 12 months was 94.8% in patients with Crohn's disease and 88.8% in patients with ulcerative colitis. Only 11.3% (n = 31) of the patients discontinued the treatment during 79-week median follow-up. Compared to the baseline, no change occurred in clinical disease activity at the time points of 3, 6, and 12 months, based on the Harvey-Bradshaw Index or partial Mayo Score (p = 0.792 and p = 0.426, respectively). Infliximab median concentrations were higher (p < 0.0001) during subcutaneous treatment (16.75 µg/ml) compared to the intravenous treatment median trough levels before the switch (6.71 µg/ml). In total, 15.0% (n = 41) of the patients reported adverse events.Conclusion: Switching to subcutaneous infliximab maintenance therapy was associated with high treatment persistence, a stable disease course, increased infliximab concentrations, and an acceptable safety profile.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1457-1466"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal Gastric Emptying Scintigraphy Values for Limited Meal Ingestion.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1007/s10620-025-08883-6

Henry P Parkman, Reena Anand, Alexandra C Barrett, Rona Cooper, Simindokht Dadparvar, Alan H Maurer

{"title":"Normal Gastric Emptying Scintigraphy Values for Limited Meal Ingestion.","authors":"Henry P Parkman, Reena Anand, Alexandra C Barrett, Rona Cooper, Simindokht Dadparvar, Alan H Maurer","doi":"10.1007/s10620-025-08883-6","DOIUrl":"10.1007/s10620-025-08883-6","url":null,"abstract":"Introduction: Patients with symptoms of gastroparesis are assessed with gastric emptying scintigraphy (GES). However, patients may not eat the entire meal due to their symptoms. The aim of this study was to quantify in normal subjects the effect of different ingested meal sizes and how these results could affect interpretation of patients' GES.Methods: Normal subjects underwent three GES tests ingesting the currently established Tc-99 m radiolabeled liquid egg white sandwich served as a full (100%), half (50%), or quarter (25%) meal. Percent gastric retention was calculated for each imaging time (0, 0.5, 1, 2, 3, 4 h). T1/2 for GE was calculated using power exponential curve fit.Results: 24 normal subjects completed three GES tests. Percent gastric retention at 0.5, 1, 2, 3 h postprandially were significantly less for half and quarter meal compared to the full meal. Mean + 2SD gastric retention values at 2 h for 50% meal and 25% meal were 41.6% and 59.5%. Compared to T1/2 for the full-size meal (94 ± 21 (SD) min), T1/2 for half meal (67 ± 19 min; p < 0.01) and quarter meal (69 ± 28 min; p < 0.01) were significantly shorter. Mean + 2SD T1/2 emptying values for 50% and 25% meal ingestion were 105.2 and 125.8 min.Conclusion: Gastric emptying is affected by amount of the meal ingested. T1/2 was shorter, and percent retention at 0.5, 1, 2, 3 h postprandially were less for half- and quarter-size meals compared to the full meal. Based on our results, if a patient ingests 50% of the standard GES meal, > 41.6% retention at 2 h or T1/2 is > 105.2 min is consistent with delayed GE.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"1435-1440"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Cause of Large Bowel Obstruction.

IF 2.5 4区医学

Digestive Diseases and Sciences Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1007/s10620-025-08888-1

Courtenay Ryan-Fisher, Murali Dharan

引用次数: 0