Doklady Biological Sciences最新文献

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Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington's Disease into Striatal Neurons to Create Models of Pathology. 将亨廷顿氏病患者的体表皮肤细胞直接重编程为纹状体神经元,以创建病理模型。
Doklady Biological Sciences Pub Date : 2024-04-01 Epub Date: 2024-01-08 DOI: 10.1134/S0012496623700849
N A Kraskovskaya, M G Khotin, A N Tomilin, N A Mikhailova
{"title":"Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington's Disease into Striatal Neurons to Create Models of Pathology.","authors":"N A Kraskovskaya, M G Khotin, A N Tomilin, N A Mikhailova","doi":"10.1134/S0012496623700849","DOIUrl":"10.1134/S0012496623700849","url":null,"abstract":"<p><p>A new in vitro model of Huntington's disease (HD) was developed via a direct reprogramming of dermal fibroblasts from HD patients into striatal neurons. A reprogramming into induced pluripotent stem (iPS) cells is obviated in the case of direct reprogramming, which thus yields neurons that preserve the epigenetic information inherent in cells of a particular donor and, consequently, the age-associated disease phenotype. A main histopathological feature of HD was reproduced in the new model; i.e., aggregates of mutant huntingtin accumulated in striatal neurons derived from a patient's fibroblasts. Experiments with cultured neurons obtained via direct reprogramming make it possible to individually assess the progression of neuropathology and to implement a personalized approach to choosing the treatment strategy and drugs for therapy. The in vitro model of HD can be used in preclinical drug studies.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nemertodermatida-Endosymbionts of Deep-Sea Acorn Worms (Hemichordata, Torquaratoridae). Nemertodermatida-Endosymbionts of Deep-Sea Acorn Worms (Hemichordata, Torquaratoridae).
Doklady Biological Sciences Pub Date : 2024-04-01 Epub Date: 2024-03-12 DOI: 10.1134/S001249662360015X
O V Ezhova, A I Lukinykh, V V Malakhov
{"title":"Nemertodermatida-Endosymbionts of Deep-Sea Acorn Worms (Hemichordata, Torquaratoridae).","authors":"O V Ezhova, A I Lukinykh, V V Malakhov","doi":"10.1134/S001249662360015X","DOIUrl":"10.1134/S001249662360015X","url":null,"abstract":"<p><p>Worm-like endosymbionts were found in the hepatic region of the digestive tract of the deep-sea acorn worm Quatuoralisia malakhovi Ezhova et Lukinykh, 2022 (family Torquaratoridae) from the Bering Sea. The symbionts were assigned to the taxon Nemertodermatida on the basis of histological examination. Torquaratoridae are similar in feeding type to holothuroids, which have also been found to have Xenacoelomorpha endosymbionts.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digestive System Anatomy and Feeding Mechanism of Quatuoralisia malakhovi (Hemichordata, Torquaratoridae). Quatuoralisia malakhovi(半知菌纲,食蚁兽科)的消化系统解剖和进食机制。
Doklady Biological Sciences Pub Date : 2024-02-01 Epub Date: 2023-12-19 DOI: 10.1134/S0012496623600100
V V Malakhov, A I Lukinykh, O V Ezhova
{"title":"Digestive System Anatomy and Feeding Mechanism of Quatuoralisia malakhovi (Hemichordata, Torquaratoridae).","authors":"V V Malakhov, A I Lukinykh, O V Ezhova","doi":"10.1134/S0012496623600100","DOIUrl":"10.1134/S0012496623600100","url":null,"abstract":"<p><p>The digestive system was anatomically studied in the deep-sea enteropneust Quatuoralisia mala-khovi. It was shown that lateral collar lips are twisted in such a way that they form a ciliary groove that leads to an internal channel, through which collected detritus particles are transferred to peripheral pharyngeal channels. The size of the selected particles ranges from 1-6 to 100-200 μm, which corresponds to feeding on the remains of planktonic diatoms. A fecal cord was observed to act as an anchor that holds the heavily watered jelly-like body of Torquaratoridae at the sea floor during feeding.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Gland Type Discovered in Cestodes: Neurosecretory Neurons Release a Secret into the Fish Host. 在绦虫中发现新的腺体类型:神经分泌神经元向鱼类宿主释放秘密
Doklady Biological Sciences Pub Date : 2024-02-01 Epub Date: 2023-12-19 DOI: 10.1134/S0012496623700801
N M Biserova, I A Kutyrev, V V Malakhov
{"title":"New Gland Type Discovered in Cestodes: Neurosecretory Neurons Release a Secret into the Fish Host.","authors":"N M Biserova, I A Kutyrev, V V Malakhov","doi":"10.1134/S0012496623700801","DOIUrl":"10.1134/S0012496623700801","url":null,"abstract":"<p><p>Free endings of peripheral neurosecretory neurons (NNs) were found in the tegument of plerocercoids of five species of parasitic cestodes of fish in an ultrastructural study. The free terminals secreted vesicles on the tegument surface and into the host body. Secretion was experimentally shown to increase in response to the host fish blood serum. In the cestode body, NNs form paracrine-type contacts near the cell membranes of the frontal glands, the tegument, and muscles, functioning as endocrine glands. Simultaneously, NNs function as exocrine glands and secrete the so-called manipulative factors, which influence the physiology of the host.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Tegument Ultrastructure and Morphology of the Capsule Surrounding the Tetrathyridia of the Genus Mesocestoides Vaillant, 1863 in the Liver of the Root Vole 勘误:根田鼠肝脏中介壳虫属(Mesocestoides Vaillant, 1863)包囊的表皮超微结构和形态学
Doklady Biological Sciences Pub Date : 2024-01-25 DOI: 10.1134/s001249662305006x
N. A. Pospekhova, K. V. Kusenko
{"title":"Erratum to: Tegument Ultrastructure and Morphology of the Capsule Surrounding the Tetrathyridia of the Genus Mesocestoides Vaillant, 1863 in the Liver of the Root Vole","authors":"N. A. Pospekhova, K. V. Kusenko","doi":"10.1134/s001249662305006x","DOIUrl":"https://doi.org/10.1134/s001249662305006x","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S001249662305006X</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"198 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Infection with Trematodes in Littorina obtusata Snails (Gastropoda: Littorinidae) with Different Shell Color Genotypes 勘误:不同壳色基因型的 Littorina obtusata 蜗牛(腹足纲:Littorinidae)感染吸虫的情况
Doklady Biological Sciences Pub Date : 2024-01-25 DOI: 10.1134/s0012496623050046
E. V. Kozminsky
{"title":"Erratum to: Infection with Trematodes in Littorina obtusata Snails (Gastropoda: Littorinidae) with Different Shell Color Genotypes","authors":"E. V. Kozminsky","doi":"10.1134/s0012496623050046","DOIUrl":"https://doi.org/10.1134/s0012496623050046","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050046</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: A New Species of Hapalodectes (Hapalodectidae, Mesonychia) from the Paleocene of Mongolia 勘误:来自蒙古古新世的一个 Hapalodectes (Hapalodectidae, Mesonychia)新种
Doklady Biological Sciences Pub Date : 2024-01-25 DOI: 10.1134/s0012496623050101
A. V. Lopatin
{"title":"Erratum to: A New Species of Hapalodectes (Hapalodectidae, Mesonychia) from the Paleocene of Mongolia","authors":"A. V. Lopatin","doi":"10.1134/s0012496623050101","DOIUrl":"https://doi.org/10.1134/s0012496623050101","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050101</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"214 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Finding of an Unusually Colored Sporocyst of the Genus Leucochloridium in a Succinea putris Snail 勘误:在琥珀蜗牛体内发现颜色异常的褐藻属孢子囊
Doklady Biological Sciences Pub Date : 2024-01-25 DOI: 10.1134/s0012496623050083
R. R. Usmanova, E. E. Prokhorova
{"title":"Erratum to: Finding of an Unusually Colored Sporocyst of the Genus Leucochloridium in a Succinea putris Snail","authors":"R. R. Usmanova, E. E. Prokhorova","doi":"10.1134/s0012496623050083","DOIUrl":"https://doi.org/10.1134/s0012496623050083","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050083</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Fatty Acid Composition of Total Lipids in Atlantic Salmon Salmo salar L. Parr and Smolts Reared in Aquaculture at Various Lighting Regimes 勘误:不同光照条件下水产养殖大西洋鲑(Salmo salar L.)稚鱼和幼鱼总脂的脂肪酸组成
Doklady Biological Sciences Pub Date : 2024-01-25 DOI: 10.1134/s0012496623050113
D. S. Provotorov, S. A. Murzina, V. P. Voronin, A.E. Kuritsyn, N. N. Nemova
{"title":"Erratum to: Fatty Acid Composition of Total Lipids in Atlantic Salmon Salmo salar L. Parr and Smolts Reared in Aquaculture at Various Lighting Regimes","authors":"D. S. Provotorov, S. A. Murzina, V. P. Voronin, A.E. Kuritsyn, N. N. Nemova","doi":"10.1134/s0012496623050113","DOIUrl":"https://doi.org/10.1134/s0012496623050113","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050113</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Content of 13 С and 15 N Isotopes in Bone Collagen of Geographical, Age, and Sex Groups of the Ural Cave Bear (Mammalia, Carnivora, Ursidae, Ursus (Spelaearctos) kanivetz Verestchagin, 1973) 勘误:乌拉尔洞熊(哺乳纲,食肉目,熊科,Ursus (Spelaearctos) kanivetz Verestchagin, 1973)地理、年龄和性别组骨骼胶原中 13 С 和 15 N 同位素的含量
Doklady Biological Sciences Pub Date : 2024-01-25 DOI: 10.1134/s0012496623050095
P. A. Kosintsev, K. Yu. Konovalova, G. V. Simonova
{"title":"Erratum to: Content of 13 С and 15 N Isotopes in Bone Collagen of Geographical, Age, and Sex Groups of the Ural Cave Bear (Mammalia, Carnivora, Ursidae, Ursus (Spelaearctos) kanivetz Verestchagin, 1973)","authors":"P. A. Kosintsev, K. Yu. Konovalova, G. V. Simonova","doi":"10.1134/s0012496623050095","DOIUrl":"https://doi.org/10.1134/s0012496623050095","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050095</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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