N A Kraskovskaya, M G Khotin, A N Tomilin, N A Mikhailova
{"title":"Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington's Disease into Striatal Neurons to Create Models of Pathology.","authors":"N A Kraskovskaya, M G Khotin, A N Tomilin, N A Mikhailova","doi":"10.1134/S0012496623700849","DOIUrl":"10.1134/S0012496623700849","url":null,"abstract":"<p><p>A new in vitro model of Huntington's disease (HD) was developed via a direct reprogramming of dermal fibroblasts from HD patients into striatal neurons. A reprogramming into induced pluripotent stem (iPS) cells is obviated in the case of direct reprogramming, which thus yields neurons that preserve the epigenetic information inherent in cells of a particular donor and, consequently, the age-associated disease phenotype. A main histopathological feature of HD was reproduced in the new model; i.e., aggregates of mutant huntingtin accumulated in striatal neurons derived from a patient's fibroblasts. Experiments with cultured neurons obtained via direct reprogramming make it possible to individually assess the progression of neuropathology and to implement a personalized approach to choosing the treatment strategy and drugs for therapy. The in vitro model of HD can be used in preclinical drug studies.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nemertodermatida-Endosymbionts of Deep-Sea Acorn Worms (Hemichordata, Torquaratoridae).","authors":"O V Ezhova, A I Lukinykh, V V Malakhov","doi":"10.1134/S001249662360015X","DOIUrl":"10.1134/S001249662360015X","url":null,"abstract":"<p><p>Worm-like endosymbionts were found in the hepatic region of the digestive tract of the deep-sea acorn worm Quatuoralisia malakhovi Ezhova et Lukinykh, 2022 (family Torquaratoridae) from the Bering Sea. The symbionts were assigned to the taxon Nemertodermatida on the basis of histological examination. Torquaratoridae are similar in feeding type to holothuroids, which have also been found to have Xenacoelomorpha endosymbionts.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Digestive System Anatomy and Feeding Mechanism of Quatuoralisia malakhovi (Hemichordata, Torquaratoridae).","authors":"V V Malakhov, A I Lukinykh, O V Ezhova","doi":"10.1134/S0012496623600100","DOIUrl":"10.1134/S0012496623600100","url":null,"abstract":"<p><p>The digestive system was anatomically studied in the deep-sea enteropneust Quatuoralisia mala-khovi. It was shown that lateral collar lips are twisted in such a way that they form a ciliary groove that leads to an internal channel, through which collected detritus particles are transferred to peripheral pharyngeal channels. The size of the selected particles ranges from 1-6 to 100-200 μm, which corresponds to feeding on the remains of planktonic diatoms. A fecal cord was observed to act as an anchor that holds the heavily watered jelly-like body of Torquaratoridae at the sea floor during feeding.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Gland Type Discovered in Cestodes: Neurosecretory Neurons Release a Secret into the Fish Host.","authors":"N M Biserova, I A Kutyrev, V V Malakhov","doi":"10.1134/S0012496623700801","DOIUrl":"10.1134/S0012496623700801","url":null,"abstract":"<p><p>Free endings of peripheral neurosecretory neurons (NNs) were found in the tegument of plerocercoids of five species of parasitic cestodes of fish in an ultrastructural study. The free terminals secreted vesicles on the tegument surface and into the host body. Secretion was experimentally shown to increase in response to the host fish blood serum. In the cestode body, NNs form paracrine-type contacts near the cell membranes of the frontal glands, the tegument, and muscles, functioning as endocrine glands. Simultaneously, NNs function as exocrine glands and secrete the so-called manipulative factors, which influence the physiology of the host.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: Tegument Ultrastructure and Morphology of the Capsule Surrounding the Tetrathyridia of the Genus Mesocestoides Vaillant, 1863 in the Liver of the Root Vole","authors":"N. A. Pospekhova, K. V. Kusenko","doi":"10.1134/s001249662305006x","DOIUrl":"https://doi.org/10.1134/s001249662305006x","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S001249662305006X</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"198 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: Infection with Trematodes in Littorina obtusata Snails (Gastropoda: Littorinidae) with Different Shell Color Genotypes","authors":"E. V. Kozminsky","doi":"10.1134/s0012496623050046","DOIUrl":"https://doi.org/10.1134/s0012496623050046","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050046</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: A New Species of Hapalodectes (Hapalodectidae, Mesonychia) from the Paleocene of Mongolia","authors":"A. V. Lopatin","doi":"10.1134/s0012496623050101","DOIUrl":"https://doi.org/10.1134/s0012496623050101","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050101</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"214 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: Finding of an Unusually Colored Sporocyst of the Genus Leucochloridium in a Succinea putris Snail","authors":"R. R. Usmanova, E. E. Prokhorova","doi":"10.1134/s0012496623050083","DOIUrl":"https://doi.org/10.1134/s0012496623050083","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050083</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. S. Provotorov, S. A. Murzina, V. P. Voronin, A.E. Kuritsyn, N. N. Nemova
{"title":"Erratum to: Fatty Acid Composition of Total Lipids in Atlantic Salmon Salmo salar L. Parr and Smolts Reared in Aquaculture at Various Lighting Regimes","authors":"D. S. Provotorov, S. A. Murzina, V. P. Voronin, A.E. Kuritsyn, N. N. Nemova","doi":"10.1134/s0012496623050113","DOIUrl":"https://doi.org/10.1134/s0012496623050113","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050113</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. A. Kosintsev, K. Yu. Konovalova, G. V. Simonova
{"title":"Erratum to: Content of 13 С and 15 N Isotopes in Bone Collagen of Geographical, Age, and Sex Groups of the Ural Cave Bear (Mammalia, Carnivora, Ursidae, Ursus (Spelaearctos) kanivetz Verestchagin, 1973)","authors":"P. A. Kosintsev, K. Yu. Konovalova, G. V. Simonova","doi":"10.1134/s0012496623050095","DOIUrl":"https://doi.org/10.1134/s0012496623050095","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050095</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}