Doklady Biological Sciences最新文献

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Fructose-Containing Plant Carbohydrates: Biological Activities and Medical Applications 含果糖的植物碳水化合物:生物活性和医学应用
Doklady Biological Sciences Pub Date : 2023-12-12 DOI: 10.1134/s0012496623700655
E. S. Vasfilova
{"title":"Fructose-Containing Plant Carbohydrates: Biological Activities and Medical Applications","authors":"E. S. Vasfilova","doi":"10.1134/s0012496623700655","DOIUrl":"https://doi.org/10.1134/s0012496623700655","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The review considers the chemical structure specifics and distribution in plants for fructose-containing carbohydrates (fructans). Various biological activities were observed in fructans and associated with their physicochemical features. Fructans affect many physiological and biochemical processes in the human body, improving health and reducing the risk of various disorders. Prebiotic activity is the most important physiological function of fructans. Fructans improve the microflora composition in the colon and intestinal mucosa by increasing the content of useful bacteria and decreasing the content of potentially harmful microorganisms, stimulate the physiological functions of the microflora, and provide for a better state of the intestine and a better health status. By modifying the intestinal microbiota and utilizing certain additional mechanisms, fructans can favorably affect the immune function, decrease the risk of various inflammatory processes, and to reduce the likelihood of tumorigenesis due to exposure to carcinogens. Fructans improve carbohydrate and lipid metabolism by reducing the blood levels of glucose, total cholesterol, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) and increasing the blood content of high-density lipoprotein (HLD). Fructans are low in calories, and their use in foods reduces the risk of obesity. Fructans facilitate higher calcium absorption and increase the bone density, thus reducing the risk of osteoporosis. Fructants protect the body from oxidative stress, intestinal infections, and parasitic invasions.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138629560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep with Open Eyes in Two Species of Deer, the Indian Sambar (Rusa unicolor) and Sika Deer (Cervus nippon) 两种鹿--印度桑巴鹿(Rusa unicolor)和梅花鹿(Cervus nippon)--睁眼睡觉的情况
Doklady Biological Sciences Pub Date : 2023-12-12 DOI: 10.1134/s0012496623700679
O. I. Lyamin, J. M. Siegel, E. A. Nazarenko, Manh Vu, V. V. Rozhnov
{"title":"Sleep with Open Eyes in Two Species of Deer, the Indian Sambar (Rusa unicolor) and Sika Deer (Cervus nippon)","authors":"O. I. Lyamin, J. M. Siegel, E. A. Nazarenko, Manh Vu, V. V. Rozhnov","doi":"10.1134/s0012496623700679","DOIUrl":"https://doi.org/10.1134/s0012496623700679","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The relationship between postures, sleep stages and eye state was established in two species of deer, the Indian sambar (<i>Rusa unicolor</i>) and sika deer (<i>Cervus nippon</i>), based on video recording. In both species, the state of rest or behavioral sleep was recorded in the sternal position, holding the head above the ground, and in the lateral position, with the head resting on the croup or on the ground. Rest accounted for at least 80% of the time in these positions. Based on behavior criteria a substantial portion of rest represented slow-wave sleep. Episodes of rapid eye movements (REM sleep) were recorded in the lateral position. They did not exceed 2 min. When the deer were in the sternal posture, they kept their eyes open most of the time: in average 96% of the time in sambars and 82% in sika deer. Episodes of the open eye in this posture lasted up to 8.4 min in sambars and up to 3.3 min in sika deer. In the lateral position, such episodes were 4 and 1.5 times shorter. Sleeping with open eyes in ungulates may be an important mechanism of maintaining vigilance.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138629855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus 先兆子痫和妊娠糖尿病患者胎盘和外周血的形态功能和分子变化
Doklady Biological Sciences Pub Date : 2023-12-08 DOI: 10.1134/s0012496623700722
K. A. Artemieva, Yu. V. Stepanova, I. I. Stepanova, M. V. Shamarakova, N. B. Tikhonova, N. V. Nizyaeva, S. G. Tsakhilova, L. M. Mikhaleva
{"title":"Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus","authors":"K. A. Artemieva, Yu. V. Stepanova, I. I. Stepanova, M. V. Shamarakova, N. B. Tikhonova, N. V. Nizyaeva, S. G. Tsakhilova, L. M. Mikhaleva","doi":"10.1134/s0012496623700722","DOIUrl":"https://doi.org/10.1134/s0012496623700722","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association is unclear. The objective of this work was to study the morphofunctional and molecular changes in the placenta and peripheral blood in PE and GDM. Local and systemic changes in the production of several placental proteins were assessed along with markers of inflammation and metabolic disorders. Expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase 3 in villi was found to change in complicated pregnancy groups. Similarity of underlying pathogenic mechanisms was demonstrated for PE and GDM.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138561817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogels Based on Recombinant Spidroin Stimulate Proliferation and Migration of Human Corneal Cells. 基于重组雪松素的水凝胶可刺激人类角膜细胞增殖和迁移
Doklady Biological Sciences Pub Date : 2023-12-01 Epub Date: 2024-03-12 DOI: 10.1134/S0012496623600173
O I Agapova, D S Ostrovsky, M Kh Khubetsova, T Z Kerimov, S A Borzenok, V G Bogush, L I Davydova, S E Cheperegin, A E Efimov, I I Agapov, V G Debabov
{"title":"Hydrogels Based on Recombinant Spidroin Stimulate Proliferation and Migration of Human Corneal Cells.","authors":"O I Agapova, D S Ostrovsky, M Kh Khubetsova, T Z Kerimov, S A Borzenok, V G Bogush, L I Davydova, S E Cheperegin, A E Efimov, I I Agapov, V G Debabov","doi":"10.1134/S0012496623600173","DOIUrl":"10.1134/S0012496623600173","url":null,"abstract":"<p><p>The effect of recombinant spidroin (RS) hydrogel (HG) on anterior epithelial cells and keratocytes of the human cornea was studied in vitro. Corneal injuries are highly prevalent in developing countries according to the World Health Organization. Various technologies have recently been proposed to restore the damaged surface of the cornea. Use of biodegradable silk-based materials, including recombinant analogs of the spider silk protein spidroin, is an important avenue of research in the field of wound healing and corneal regeneration. Spidroins are well known for their optimal balance of strength and elasticity. Given their biological compatibility, lack of immunogenicity, and biodegradability, spidroins provide a biomaterial for tissue engineering and regenerative medicine. HGs based on RS rS2/12-RGDS were therefore tested for cytotoxicity toward isolated corneal epithelial cells and keratocytes with regard to possible changes in cell phenotype and migratory activity. A promising outlook and therapeutic potential were demonstrated for RS-based HGs.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"S41-S44"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Ultrastructural Details of the Astrocyte Process System in Nervous Tissue of the Brain Using Correlative Scanning Probe and Transmission Electron Microscopy. 利用相关扫描探针和透射电子显微镜鉴定脑神经组织中星形胶质细胞过程系统的超微结构细节。
Doklady Biological Sciences Pub Date : 2023-12-01 Epub Date: 2024-03-02 DOI: 10.1134/S0012496623600185
O I Agapova, A E Efimov, E A Obraztsova, K E Mochalov, D O Solovyeva, V A Oleinikov, I I Agapov, S V Gautier
{"title":"Identification of Ultrastructural Details of the Astrocyte Process System in Nervous Tissue of the Brain Using Correlative Scanning Probe and Transmission Electron Microscopy.","authors":"O I Agapova, A E Efimov, E A Obraztsova, K E Mochalov, D O Solovyeva, V A Oleinikov, I I Agapov, S V Gautier","doi":"10.1134/S0012496623600185","DOIUrl":"10.1134/S0012496623600185","url":null,"abstract":"<p><p>Nanoscale morphological features of branched processes of glial cells may be of decisive importance for neuron-astrocyte interactions in health and disease. The paper presents the results of a correlation analysis of images of thin processes of astrocytes in nervous tissue of the mouse brain, which were obtained by scanning probe microscopy (SPM) and transmission electron microscopy (TEM) with high spatial resolution. Samples were prepared and imaged using a unique hardware combination of ultramicrotomy and SPM. Astrocyte details with a thickness of several tens of nanometers were identifiable in the images, making it possible to reconstruct the three-dimensional structure of astrocytic processes by integrating a series of sequential images of ultrathin sections of nervous tissue in the future.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"S51-S54"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty Acid Composition of Total Lipids in Atlantic Salmon Salmo salar L. Parr and Smolts Reared in Aquaculture at Various Lighting Regimes. 不同光照条件下大西洋大马哈鱼和小鲑鱼总脂肪脂肪酸组成的研究
Doklady Biological Sciences Pub Date : 2023-12-01 Epub Date: 2023-11-11 DOI: 10.1134/S0012496623700734
D S Provotorov, S A Murzina, V P Voronin, A E Kuritsyn, N N Nemova
{"title":"Fatty Acid Composition of Total Lipids in Atlantic Salmon Salmo salar L. Parr and Smolts Reared in Aquaculture at Various Lighting Regimes.","authors":"D S Provotorov, S A Murzina, V P Voronin, A E Kuritsyn, N N Nemova","doi":"10.1134/S0012496623700734","DOIUrl":"10.1134/S0012496623700734","url":null,"abstract":"<p><p>Continuous artificial lighting (24LD) was introduced experimentally in the standard technology to grow salmon juveniles in a southern region (Republic of North Ossetia-Alania) and its effect on fatty acid (FA) composition of total lipids in muscles and the liver was assessed in parr and smolts of the Atlantic salmon Salmo salar L. Changes in the key FA were observed in the FA spectrum of fish, indicating that smoltification was complete and that smolts were ready for new habitat conditions. Thus the content of polyunsaturated FAs (PUFAs) significantly increased as a result of an increase in (n-3) PUFAs, and, in particular, marine-type 22:6(n-3), and high values were observed for (n-3)/(n-6) and 22:6(n-3)/18:3(n-3) PUFA ratios. The most significant changes were detected in muscles. In all experimental groups, a decrease in saturated FAs (SFAs) and an increase in total lipid unsaturation was attributed primarily to PUFAs, while monounsaturated FAs (MUFAs) decreased along with SFAs. The experimental data on the lipid and FA composition in salmon juveniles and a higher proportion of smolts in the test groups indicated that smoltification was the most successful in groups with continuous lighting and 24-h feeding and a natural regime of lighting and feeding.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"382-386"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Salinity on Reproduction and Fatty Acid Profile of the Microalga Nitzschia сf. thermaloides. 盐度对微藻 Nitzschia сf. thermaloides 繁殖和脂肪酸谱的影响
Doklady Biological Sciences Pub Date : 2023-12-01 Epub Date: 2023-12-19 DOI: 10.1134/S0012496623700795
N S Repkina, V P Voronin, O I Davidovich, N A Davidovich, S A Murzina
{"title":"Effect of Salinity on Reproduction and Fatty Acid Profile of the Microalga Nitzschia сf. thermaloides.","authors":"N S Repkina, V P Voronin, O I Davidovich, N A Davidovich, S A Murzina","doi":"10.1134/S0012496623700795","DOIUrl":"10.1134/S0012496623700795","url":null,"abstract":"<p><p>The microalga Nitzschia cf. thermaloides was found in reservoirs of mud volcanoes in eastern Crimea. The species was observed to have a wide range of halotolerance and, in particular, to be capable of vegetative reproduction within a substrate salinity range of 0-110‰. The effect of salinity on the fatty acid (FA) profile was for the first time studied in N. cf. thermaloides. The quantitative and qualitative FA composition remained unchanged regardless of salinity, suggesting maintenance of a stable compacted membrane structure, which probably contributes to the species adaptation to salinity. Saturated FAs accounted for a major portion of total FAs, and the species was therefore assumed to provide a potentially valuable source of saturated FAs for biotechnology and an alternative raw material for biofuel.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"S10-S13"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Endobiotic Ciliates from the Rumen of the European Bison Bison Bonasus (Linnaeus, 1758) from the Vologda Oblast of Russia 勘误:俄罗斯沃洛格达州欧洲野牛瘤胃中的内生纤毛虫
Doklady Biological Sciences Pub Date : 2023-12-01 DOI: 10.1134/s0012496623050034
{"title":"Erratum to: Endobiotic Ciliates from the Rumen of the European Bison Bison Bonasus (Linnaeus, 1758) from the Vologda Oblast of Russia","authors":"","doi":"10.1134/s0012496623050034","DOIUrl":"https://doi.org/10.1134/s0012496623050034","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050034</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Highly Aggressive Invasive Race Group PstS2 in Russian Populations of the Wheat Yellow Rust Pathogen 勘误:俄罗斯小麦黄锈病病原体种群中的高侵略性入侵种族群 PstS2
Doklady Biological Sciences Pub Date : 2023-12-01 DOI: 10.1134/s0012496623050071
{"title":"Erratum to: Highly Aggressive Invasive Race Group PstS2 in Russian Populations of the Wheat Yellow Rust Pathogen","authors":"","doi":"10.1134/s0012496623050071","DOIUrl":"https://doi.org/10.1134/s0012496623050071","url":null,"abstract":"<p>An Erratum to this paper has been published: https://doi.org/10.1134/S0012496623050071</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139551621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Data on the Ecology of the Fossil Don Hare Lepus tanaiticus Gureev, 1964. 唐兔化石生态学的新数据 Lepus tanaiticus Gureev,1964 年。
Doklady Biological Sciences Pub Date : 2023-12-01 Epub Date: 2024-03-02 DOI: 10.1134/S0012496624700923
M R Pavlova, G G Boeskorov, M Yu Cheprasov, G P Novgorodov
{"title":"New Data on the Ecology of the Fossil Don Hare Lepus tanaiticus Gureev, 1964.","authors":"M R Pavlova, G G Boeskorov, M Yu Cheprasov, G P Novgorodov","doi":"10.1134/S0012496624700923","DOIUrl":"10.1134/S0012496624700923","url":null,"abstract":"<p><p>A spore and pollen research was performed for the first time to study the contents of the gastrointestinal tracts (GITs) and sediments containing frozen mummies of the fossil Don hare from the Upper Pleistocene ice complex of the Verkhoyansk district of Yakutia. Radiocarbon dating (C<sup>14</sup>) revealed that the hares lived during the Karginian Interstadial of the Late Pleistocene, 32.5 thousand years ago (calibrated date). The results expanded the understanding of the ecology of extinct Lepus tanaiticus. The species was assumed to live in cold steppes dominated by xerophytic communities, as well as in grass-forb and sedge-forb meadows. Herbaceous plants mostly constituted the winter diet of Don hare in contrast to the modern mountain hare L. timidus, which feeds mainly on branches and bark of trees and shrubs in winter.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"S72-S76"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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