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Architecture of the Medulla in Mammalian Vibrissae: Polymorphism and Nomenclature. 哺乳动物触须科髓质结构：多态性和命名。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496625600010
O F Chernova, Yu F Ivlev, E G Potapova, O V Zherebtsova, E M Shchelkanov
{"title":"Architecture of the Medulla in Mammalian Vibrissae: Polymorphism and Nomenclature.","authors":"O F Chernova, Yu F Ivlev, E G Potapova, O V Zherebtsova, E M Shchelkanov","doi":"10.1134/S0012496625600010","DOIUrl":"https://doi.org/10.1134/S0012496625600010","url":null,"abstract":"<p><p>For the first time, scanning electron microscopy was used to identify, study, and systematize the architecture of the vibrissa medulla in 101 species from 80 genera belonging to eight orders of Mammalia, using an original nomenclature. A wide architectural variation is due to the diversity of sizes and relationships of vibrissal internal compartments (air cavities and partitions). Several types of the medulla were determined: membranous, pyramidal, blocky cylindrical, blocky polyhedral, chaotic, small-alveolar, large-alveolar, star-shaped, uniserial, and hollow. Different medulla types may be combined in one vibrissa. Vibrissae of a number of subterranean (moles and mole rats), semi-aquatic (desman), or aquatic (bowhead whale) species have no medulla.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"81-94"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ontogeny of the Epileptic System in the Krushinsky-Molodkina Rat Strain with Genetically Determined Audiogenic Epilepsy. 克鲁辛斯基-莫洛奇纳大鼠遗传性听原性癫痫的癫痫系统个体发育。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600489
S A Litvinova, A A Yakovleva, T A Voronina, N A Gladysheva, V V Radontseva, N M Surina, I I Poletaeva, I B Fedotova, A D Durnev
{"title":"Ontogeny of the Epileptic System in the Krushinsky-Molodkina Rat Strain with Genetically Determined Audiogenic Epilepsy.","authors":"S A Litvinova, A A Yakovleva, T A Voronina, N A Gladysheva, V V Radontseva, N M Surina, I I Poletaeva, I B Fedotova, A D Durnev","doi":"10.1134/S0012496624600489","DOIUrl":"https://doi.org/10.1134/S0012496624600489","url":null,"abstract":"<p><p>Susceptibility to audiogenic epilepsy (AE) seizures and phenotypic manifestations of epileptic activity in rats of the Krushinsky-Molodkina (KM) strain were shown to develop in parallel with the appearance of seizure EEG patterns from 2 to 7 months of age. The seizure latency decreased with age, while the intensity of convulsive seizures increased. Two types of epileptiform discharges (EDs) were identified in background EEGs (no exposure to sound) of KM rats. One type had a form of high-amplitude generalized packs of waves with the animal shuddering. The other type had a form of generalized non-seizure absence-like spike-and-wave discharges with the animal freezing. The total and mean durations of single absence-like discharges increased with age. Parallel age-related increases in the severity of AE seizures and the number of generalized absence-like discharges in the forebrain EEG suggests the development of the epileptic system in KM rats.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"95-101"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted Therapy in Combination with an Agent That Enhances Terminal Differentiation of Cancer Cells. 靶向治疗联合一种促进癌细胞终末分化的药物。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600702
E I Shramova, G M Proshkina, I N Zavestovskaya, S M Deyev
{"title":"Targeted Therapy in Combination with an Agent That Enhances Terminal Differentiation of Cancer Cells.","authors":"E I Shramova, G M Proshkina, I N Zavestovskaya, S M Deyev","doi":"10.1134/S0012496624600702","DOIUrl":"https://doi.org/10.1134/S0012496624600702","url":null,"abstract":"<p><p>Currently, in addition to standard methods, an approach is being developed for the treatment of oncological diseases in which terminal differentiation of cancer cells is induced by pharmacological drugs, which increases the response to traditional treatment methods. According to literature data, dimethyl sulfoxide (DMSO) is a safe adjuvant that stimulates the differentiation of various types of the cancer cells. A method proposed in the article was designed to eliminate SKOV3.ip1 human ovarian cancer cell adenocarcinomas by combining targeted therapy based on the HER2-specific toxin DARPin-LoPE and treatment with DMSO as an enhancing agent for terminal differentiation of cancer cells.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"152-155"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual Pattern of Cerebral Electrical Activity in the Mongolian Hamster (Allocricetulus curtatus) During Heterothermia. 异温状态下蒙古仓鼠脑电活动的异常模式。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496625600022
V M Kovalzon, A D Komarova, M Yu Smagina, N Yu Feoktistova, A V Surov
{"title":"Unusual Pattern of Cerebral Electrical Activity in the Mongolian Hamster (Allocricetulus curtatus) During Heterothermia.","authors":"V M Kovalzon, A D Komarova, M Yu Smagina, N Yu Feoktistova, A V Surov","doi":"10.1134/S0012496625600022","DOIUrl":"https://doi.org/10.1134/S0012496625600022","url":null,"abstract":"<p><p>Electroencephalogram (EEG), brain and abdominal temperature, and motor activity were recorded for the first time in 18 adult males of facultative hibernator, the Mongolian hamster, during hibernation under controlled laboratory conditions in winter. At room temperature, clear synchronous circadian rhythms of motor activity and body temperature were observed. In most animals, a gradual decrease in external temperature (from 24 to 4°C) led to a significant increase in motor activity, combined with an increase in the amplitude of circadian oscillations of body temperature. Six hamsters demonstrated torpor bouts and hibernation with radical changes in the EEG up to reaching the isoelectric line, as well as the disappearance of oscillations of brain temperature. It has been found that Mongolian hamsters can easily enter and exit both a state of torpor and a fairly deep hibernation with a decrease in body temperature down to 10°C during normal sleep periods.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"138-145"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and Verification of Hybrid Betula nana L. Plants in the Urals. 乌拉尔地区桦树杂交植物的检测与验证。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600696
S O Medvedeva, O E Cherepanova, I V Petrova, A Yu Teptina
{"title":"Detection and Verification of Hybrid Betula nana L. Plants in the Urals.","authors":"S O Medvedeva, O E Cherepanova, I V Petrova, A Yu Teptina","doi":"10.1134/S0012496624600696","DOIUrl":"https://doi.org/10.1134/S0012496624600696","url":null,"abstract":"<p><p>Hybrid plants were verified in Betula nana populations of the Urals by flow cytometry and were especially numerous in the northern part of the region. ITS1 nucleotide sequences were obtained by Sanger sequencing. Based on their analysis, low differentiation was observed for B. nana and B. pubescens and associated with current and ancestral hybridization processes. Intragenomic polymorphism of ITS1 sequences was assessed using the Illumina technology and detected both B. nana and B. pubescens rDNAs in the genomes of first-generation interspecific hybrids.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"107-110"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycobiota of Acorn Worm Saccoglossus mereschkowskii (Hemichordata, Enteropneusta) and Its Habitats. 橡实虫的真菌区系及其生境。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600568
O V Ezhova, O A Grum-Grzhimaylo, Ju A Kokurkina, I A Ekimova, M M Gantsevich, V V Malakhov
{"title":"Mycobiota of Acorn Worm Saccoglossus mereschkowskii (Hemichordata, Enteropneusta) and Its Habitats.","authors":"O V Ezhova, O A Grum-Grzhimaylo, Ju A Kokurkina, I A Ekimova, M M Gantsevich, V V Malakhov","doi":"10.1134/S0012496624600568","DOIUrl":"https://doi.org/10.1134/S0012496624600568","url":null,"abstract":"<p><p>Tissues and mucus of acorn worms are known to contain phenolic compounds, which inhibit activity of aerobic bacteria. Mycobiota of tissues, the body surface, and burrows were studied for the acorn worm Saccoglossus mereschkowskii (Wagner, 1885). Three fungal species were found in the plating of intestine samples. Seven fungi were isolated from samples washed out from the S. mereschkowskii body surface. Five species were found in burrow samples; and 15, in sediment samples from the S. mereschkowskii habitat. Cultures of intact specimens, gill bars, and axial organ did not reveal the growth of mycelial fungi. A potential fungistatic effect was consequently assumed for acorn worm tissues.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"146-151"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hair Microstructure in a Mummy of a Juvenile Saber-Toothed Cat Homotherium latidens (Felidae, Carnivora). 剑齿猫幼崽木乃伊毛发微结构研究（猫科动物科，食肉目）。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600660
O F Chernova, A I Klimovsky, A V Protopopov
{"title":"Hair Microstructure in a Mummy of a Juvenile Saber-Toothed Cat Homotherium latidens (Felidae, Carnivora).","authors":"O F Chernova, A I Klimovsky, A V Protopopov","doi":"10.1134/S0012496624600660","DOIUrl":"https://doi.org/10.1134/S0012496624600660","url":null,"abstract":"<p><p>The microstructure of hairs from several parts of the body of a three-week-old cub of Pleistocene Homotherium latidens was for the first time studied using light microscopy and scanning electron microscopy (SEM). The frozen H. latidens mummy dated to 31 808-37 019 years ago was found in Yakutia and first described by Russian paleontologists. The H. latidens mummy was shown to have poorly differentiated short uniform tangled dark-brown hair. Hairs had rather poor heat-protective properties because of the weak development of the hair medulla, while their mechanical strength was excellent. The hair microstructure varied depending on the hair location on the body. The findings were compared with data on the hair of cave and African lion cubs. Similarities and differences in microstructure were observed for the species and were explained from the functional viewpoint.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"117-122"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 24-Epibrassinolide and Its Conjugate with Succinic Acid on the Resistance of Rapeseed Plants to Chloride Salinization. 24-表油菜素内酯及其与琥珀酸缀合物对油菜耐氯盐渍化的影响。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600726
L V Kolomeichuk, R P Litvinovskaya, V A Khripach, V V Kuznetsov, M V Efimova
{"title":"Effects of 24-Epibrassinolide and Its Conjugate with Succinic Acid on the Resistance of Rapeseed Plants to Chloride Salinization.","authors":"L V Kolomeichuk, R P Litvinovskaya, V A Khripach, V V Kuznetsov, M V Efimova","doi":"10.1134/S0012496624600726","DOIUrl":"https://doi.org/10.1134/S0012496624600726","url":null,"abstract":"<p><p>Exogenous 24-epibrassinolide (EBL) and a synthetic EBL-based conjugate (2,3,22,23-tetraester of EBL and succinic acid) used at 10 nM were for the first time shown to almost equally mitigate the negative effects of salt stress (150 mM NaCl) on rapeseed plants, sustaining their photosynthetic activity and growth parameters. Specificity was observed in the action of the compounds in regulating the NaCl resistance of rapeseed plants. EBL increased the content of carotenoids and superoxide dismutase and peroxidase activities in plants exposed to chloride salinization, while the EBL conjugate increased peroxidase activity only. Pretreatment of plants for 4 h before stress exposure was more efficient than treatment applied simultaneously with stress.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"111-116"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regenerative Potential of Platelet-Rich Plasma in Diabetes Mellitus. 糖尿病患者富血小板血浆的再生潜能。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600556
T I Vlasova, E P Brodovskaya, K S Madonov, V P Ageev, A P Abelova, S I Pinyaev, A P Vlasov
{"title":"Regenerative Potential of Platelet-Rich Plasma in Diabetes Mellitus.","authors":"T I Vlasova, E P Brodovskaya, K S Madonov, V P Ageev, A P Abelova, S I Pinyaev, A P Vlasov","doi":"10.1134/S0012496624600556","DOIUrl":"https://doi.org/10.1134/S0012496624600556","url":null,"abstract":"<p><p>The regenerative potential of platelet-rich plasma (PRP) samples from patients with type 1 diabetes mellitus (DM) was studied in vitro. In a series of experiments, PRP was added to the culture medium of human dermal fibroblasts. The cells were tested for metabolic (including reactive oxygen species production), migration, and proliferative activities at several time points; growth factors and exosome levels were assessed in PRP and the medium. A lower proliferative effect, pro-oxidant properties, and toxicity were observed for PRPs from diabetic patients. Namely, treated fibroblasts showed lower metabolic activity, a lower cell viability, and a greater percentage of necrosis in culture, while their migration properties were not impaired. PRPs from diabetic patients exerted a lower stimulatory effect on growth factor secretion by dermal fibroblasts. PRPs from elderly diabetics had the greatest effects.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"123-133"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure of the Shell Wall in Raskiniella plana (Subclass Spirillinana). 标题螺旋藻亚纲扁螺壳壁结构。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496625700012
V I Mikhalevich
{"title":"Structure of the Shell Wall in Raskiniella plana (Subclass Spirillinana).","authors":"V I Mikhalevich","doi":"10.1134/S0012496625700012","DOIUrl":"https://doi.org/10.1134/S0012496625700012","url":null,"abstract":"<p><p>The shell wall ultrastructure is known for three of the four classes of multicameral Foraminifera with a secretive calcareous shell wall: Rotaliata Mikhalevich, 1980; Miliolata Saidova, 1981; and Nodosariata Mikhalevich, 1992. It was believed that one or few large crystals form the wall in Spirillinata Mikhalevich, 1992. The study showed that the entire shell is formed of amorphous, rather than crystalline, CaCO<sub>3</sub> in Raskiniella plana (previously classified as Spirillina plana Wiesner, 1931), which is a typical representative of this class. Amorphous calcareous skeletons are known in certain unicellular algae and multicellular eukaryotes, a skeleton of the entire adult shell completely build of amorphous CaCO<sub>3</sub> was observed for the first time in Foraminifera.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"134-137"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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