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Comparative Genetic Diversity of Landlocked Seals. 内陆海豹的比较遗传多样性。
Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI: 10.1134/S0012496624600477
S I Meschersky, I G Meschersky, M A Solovyeva, N V Kryukova, M-R D Magomedov, F V Klimov, V V Rozhnov
{"title":"Comparative Genetic Diversity of Landlocked Seals.","authors":"S I Meschersky, I G Meschersky, M A Solovyeva, N V Kryukova, M-R D Magomedov, F V Klimov, V V Rozhnov","doi":"10.1134/S0012496624600477","DOIUrl":"https://doi.org/10.1134/S0012496624600477","url":null,"abstract":"<p><p>Genetic diversity of neutral markers (15 microsatellite loci) was assessed for the first time in two landlocked seal species, the Baikal seal Pusa sibirica and Caspian seal P. caspica, and compared with that in the oceanic species ringed seal P. hispida of the same genus. Lower genetic diversity was observed in both of the landlocked seal species, the Baikal seal having the lowest level. A high probability of a historical bottleneck effect was shown for both Baikal and Caspian seals, while signs of a sharp decline in the past were not observed in the ringed seal population. A data analysis with the VarEff package suggested different times to the most recent common ancestor (TMRCA) for each of the three populations. The time established for the Baikal seal was significantly shorter than that of the Caspian seal.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"521 1","pages":"102-106"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vivo UV-Induced Fluorescence Spectroscopy of Skin in Parkinson's Disease. 帕金森病患者体内紫外线诱导的皮肤荧光光谱研究。
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1134/S0012496624600398
V V Salmin, V B Loschenov, A B Ochirova, N P Bainaev-Mangilev, M N Andreev, E Yu Fedotova, A B Salmina, S N Illarioshkin
{"title":"In Vivo UV-Induced Fluorescence Spectroscopy of Skin in Parkinson's Disease.","authors":"V V Salmin, V B Loschenov, A B Ochirova, N P Bainaev-Mangilev, M N Andreev, E Yu Fedotova, A B Salmina, S N Illarioshkin","doi":"10.1134/S0012496624600398","DOIUrl":"10.1134/S0012496624600398","url":null,"abstract":"<p><p>Characteristic patterns of UV-induced skin autofluorescence were determined for patients with Parkinson's disease (PD) and associated with dysmetabolic alterations, such as nonenzymatic protein glycation, an increase in extracellular matrix stiffness, impaired metabolism of tissue fluorophores, mitochondrial dysfunction, and accumulation of aberrant proteins. Key differences in skin autofluorescence spectra were for the first time observed in PD, making it possible to discriminate between PD patients and healthy persons or individuals without signs of chronic neurodegeneration. Namely, skin fluorescence related to the reflected signal upon excitation with UV light at 375 nm was lower in PD patients.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico Identification of Antimicrobial Sequences of Rainbow Trout Brain Proteins in the Context of Aquaculture Waste Recycling. 水产养殖废弃物循环利用中虹鳟鱼脑蛋白抗菌序列的计算机鉴定
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1134/S001249662460057X
A A Kochneva, A E Kuritsin, S A Murzina
{"title":"In Silico Identification of Antimicrobial Sequences of Rainbow Trout Brain Proteins in the Context of Aquaculture Waste Recycling.","authors":"A A Kochneva, A E Kuritsin, S A Murzina","doi":"10.1134/S001249662460057X","DOIUrl":"10.1134/S001249662460057X","url":null,"abstract":"<p><p>Aquaculture is one of the main sources of fish products and ensures their sustainable growth on the global scale, exceeding industrial fishing. At the same time, integrated processing of aquaculture by-products is an important environmental and industrial problem. Valuable biological components might be found in fish processing wastes left after manufacturing the target products (fillet, offal, etc.). In particular, antimicrobial peptides that exhibit broad-spectrum antimicrobial activity are expressed in fish. A first exploratory analysis of rainbow trout Oncorhynchus mykiss brain proteins was performed to identify the theoretical antimicrobial patterns. More than half of the identified proteins were predicted to have antimicrobial regions. The proteins included histones, vitellogenin, collagen, etc. The results may be of interest for designing drugs based on peptides active against various pathogens. The field is of importance in view of the increasing antibiotic resistance of pathogenic microorganisms.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of MST1/2 Kinases of the Hippo Signaling Pathway Enhances Antitumor Chemotherapy in Hematological Cancers. 抑制希波信号通路的 MST1/2 激酶可增强血液肿瘤的抗肿瘤化疗效果
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1134/S0012496624600635
A G Stepchenko, Yu V Ilyin, S G Georgieva, E V Pankratova
{"title":"Inhibition of MST1/2 Kinases of the Hippo Signaling Pathway Enhances Antitumor Chemotherapy in Hematological Cancers.","authors":"A G Stepchenko, Yu V Ilyin, S G Georgieva, E V Pankratova","doi":"10.1134/S0012496624600635","DOIUrl":"10.1134/S0012496624600635","url":null,"abstract":"<p><p>Primary drug resistance of tumor cells or resistance acquired during treatment is among the main factors that significantly limit the efficacy of antitumor chemotherapy, along with severe side effects depending on the drug dose. To increase the efficacy, chemotherapeutics can be used in combination with substances that modulate the functions of cell signaling pathways. In this work, the substance XMU-MP-1, an inhibitor of key MST1/2 kinases of the Hippo signaling pathway, was shown to enhance the antitumor activity of two genotoxic chemotherapeutics, etoposide and cisplatin, against Namalwa Burkitt's B-cell lymphoma cells. XMU-MP-1 increased the cytotoxicity of the agents and significantly reduced their CTD<sub>50</sub>. The drug efficacy is therefore possible to increase significantly, and a therapeutic effect might be achieved at a lower drug concentration to reduce the likelihood of life-threatening side effects.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oocyte Size Suggests the Presence of Larvae in Deep-Sea Acorn Worms Torquaratoridae (Hemichordata, Enteropneusta). 卵母细胞大小表明深海橡子虫Torquaratoridae（半趾纲，Enteropneusta）中存在幼虫。
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1134/S001249662460043X
O V Ezhova, A I Lukinykh, V V Malakhov
{"title":"Oocyte Size Suggests the Presence of Larvae in Deep-Sea Acorn Worms Torquaratoridae (Hemichordata, Enteropneusta).","authors":"O V Ezhova, A I Lukinykh, V V Malakhov","doi":"10.1134/S001249662460043X","DOIUrl":"10.1134/S001249662460043X","url":null,"abstract":"<p><p>The type of development is known to correlate with the egg size in marine invertebrates. Data on the maximum oocyte size were considered for deep-sea acorn worms of the family Torquaratoridae. The family was assumed to include species with direct development, species with lecithotrophic larvae, and species with planktotrophic larvae. Mysterious giant larvae of Planctosphaera pelagica may be planktotrophic larvae of Torquaratoridae.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"5-7"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of HOX Cluster Genes in Early Larval Development of Sea Urchin Strongylocentrotus intermedius (Echinodermata, Echinoidea). HOX簇基因在海胆早期幼体发育中的表达
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1134/S0012496624600416
N V Ageenko, O V Ezhova, K V Kiselev, A I Lukinykh, V V Malakhov
{"title":"Expression of HOX Cluster Genes in Early Larval Development of Sea Urchin Strongylocentrotus intermedius (Echinodermata, Echinoidea).","authors":"N V Ageenko, O V Ezhova, K V Kiselev, A I Lukinykh, V V Malakhov","doi":"10.1134/S0012496624600416","DOIUrl":"10.1134/S0012496624600416","url":null,"abstract":"<p><p>Expression of 11 genes of the Hox cluster (SiHox1, 2, 3, 5, 6, 7, 8, 9/10, 11/13a, 11/13b, and 11/13c) was assessed in the sea urchin Strongylocentrotus intermedius at early developmental stages, including the blastula (13 h post fertilization (hpf)), gastrula (35 hpf), prism (46 hpf), and pluteus (4 and 9 days post fertilization (dpf)) stages. Expression of SiHox7, 11/13b, and 11/13c was observed at the blastula stage; early activation of 11/13c was detected for the first time in regular sea urchins. The expression level was very low at the gastrula and prism stages. The pluteus stage showed a significant increase in expression of all Hox cluster genes. Deviations from temporal collinearity of Hox gene expression in echinoderms are discussed.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac Regenerative Potential of Spiny Mice (Acomys cahirinus) Manifests Itself in Expansion of Pacemaker Myocardium and Predominance of Noncanonical, IK, ACH-Independent Pathway of Cholinergic Regulation in Cardiac Pacemaking. 刺鼠（Acomys cahirinus）心脏再生潜能表现为心脏起搏器心肌的扩张和非规范、IK、ach独立的胆碱能调节途径在心脏起搏中的优势。
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1134/S0012496624600623
V S Kuzmin, Yu V Egorov, A M Karhov, M A Boldyreva, E V Parfyonova
{"title":"Cardiac Regenerative Potential of Spiny Mice (Acomys cahirinus) Manifests Itself in Expansion of Pacemaker Myocardium and Predominance of Noncanonical, I<sub>K, ACH</sub>-Independent Pathway of Cholinergic Regulation in Cardiac Pacemaking.","authors":"V S Kuzmin, Yu V Egorov, A M Karhov, M A Boldyreva, E V Parfyonova","doi":"10.1134/S0012496624600623","DOIUrl":"10.1134/S0012496624600623","url":null,"abstract":"<p><p>Spiny mice (Acomys cahirinus) exhibit the ability to regenerate the damaged myocardium and functional indices of the heart. demonstrated in various models of cardiac pathologies. Cardioregenerative potential of Acomys is associated with partial preservation of the neonatal phenotype of cardiac tissue in adult animals. The electrophysiology and mechanisms regulating the heart rhythm in Acomys are extremely poorly understood. The EEG was recorded in vivo and bioelectrical activity of the supraventricular myocardium was evaluated and mapped in spiny mice. Pacemaker-type action potentials were detected in a significant part of the right atrium, and primary activation involved approximately 41% of the atrium surface in Acomys. Cholinergic stimulation caused pronounced suppression of automaticity and changed the activation pattern of the pacemaker myocardium. IKAch-independent mechanisms mediated the cholinergic inhibition of automaticity in Acomys. Thus, the cardioregenerative potential of spiny mice manifests itself in delocalization and nonclassical regulation of the cardiac pacemaker.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth and Adaptive Significance of Various Forms of Energy Processes in Marine Fishes of Arctic. 北极海洋鱼类各种形式能量过程的生长和适应意义。
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1134/S0012496624600647
L I Karamushko, O V Karamushko
{"title":"Growth and Adaptive Significance of Various Forms of Energy Processes in Marine Fishes of Arctic.","authors":"L I Karamushko, O V Karamushko","doi":"10.1134/S0012496624600647","DOIUrl":"10.1134/S0012496624600647","url":null,"abstract":"<p><p>Based on expeditions and experimental studies, energy characteristics underlying the interaction of energy exchange processes were assessed quantitatively in fishes of the Arctic. The linear and weight growth was studied for the first time in the nonmigratory species Arctic flounder Liopsetta glacialis (Pallas, 1776) of the Kara Sea. It was found that deceleration of biosynthetic processes leads to a relative decrease in the proportion of entropy generated by metabolic processes in cold-water marine fish species, while the growth becomes more efficient at low temperatures.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological Comparison of Lipofilling and Hyaluronic Acid Filler Injection 30 Days after Simulation in Rats. 大鼠模拟后30天脂质填充和透明质酸填充剂注射的组织学比较。
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1134/S0012496624600465
E A Lavrenteva, M V Khlystalov, S E Moroz, O S Hodorovich, A G Korolev, S S Ibadullaeva, I V Kastyro, A F Kartasheva, I B Ganshin, M I Barannik, P V Sarygin, A N Inozemtsev
{"title":"Histological Comparison of Lipofilling and Hyaluronic Acid Filler Injection 30 Days after Simulation in Rats.","authors":"E A Lavrenteva, M V Khlystalov, S E Moroz, O S Hodorovich, A G Korolev, S S Ibadullaeva, I V Kastyro, A F Kartasheva, I B Ganshin, M I Barannik, P V Sarygin, A N Inozemtsev","doi":"10.1134/S0012496624600465","DOIUrl":"10.1134/S0012496624600465","url":null,"abstract":"<p><p>A histological comparison of lipofilling and hyaluronic acid filler injection was performed in rats. Studies at the histological level showed that, compared with hyaluronic acid filler injection, autologous fat grafting led to a more uniform distribution of adipose tissue at 30 days after treatment and a decrease in the area of sebaceous glands. Compared with lipofilling, the hyaluronic acid filler facilitated an increase in epidermis thickness because the granular layer and dermis grew thicker in addition to the filler injected into the subcutaneous space.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nudibranch Coryphella trophina (Bergh, 1890) (Gastropoda, Nudibranchia) Uses Twice Stolen Nematocysts for Its Defense. 裸鳃科（Bergh, 1890）（腹足目，裸鳃目）利用两次偷来的线虫囊进行防御。
Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1134/S0012496624600295
N R Krupitskaya, I A Ekimova, V V Malakhov
{"title":"Nudibranch Coryphella trophina (Bergh, 1890) (Gastropoda, Nudibranchia) Uses Twice Stolen Nematocysts for Its Defense.","authors":"N R Krupitskaya, I A Ekimova, V V Malakhov","doi":"10.1134/S0012496624600295","DOIUrl":"10.1134/S0012496624600295","url":null,"abstract":"<p><p>Most nudibranchs feed on hydroids and anemones and utilize kleptocnidae, which are stinging capsules stolen from eaten victims, for their own defense. The nudibranch Coryphella trophina (Bergh, 1890) was found to eat other nudibranchs. Stinging capsules that the predator uses for its defense have been stolen twice: first by mollusks feeding on cnidarians and then by C. trophina eating the mollusks.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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