Doklady Biological Sciences最新文献_第2页

Thioridazine Induces Increase in Expression of the Pyruvate Transporter MPC1 Associated with Immune Infiltration in Malignant Tumors. 硫利达嗪诱导丙酮酸转运体 MPC1 的表达增加与恶性肿瘤的免疫渗透有关

Doklady Biological Sciences Pub Date : 2025-01-31 DOI: 10.1134/S001249662460060X

E A Bogomolova, M M Murashko, E M Stasevich, A N Uvarova, E A Zheremyan, K V Korneev, D V Kuprash, D E Demin

{"title":"Thioridazine Induces Increase in Expression of the Pyruvate Transporter MPC1 Associated with Immune Infiltration in Malignant Tumors.","authors":"E A Bogomolova, M M Murashko, E M Stasevich, A N Uvarova, E A Zheremyan, K V Korneev, D V Kuprash, D E Demin","doi":"10.1134/S001249662460060X","DOIUrl":"https://doi.org/10.1134/S001249662460060X","url":null,"abstract":"The MPC1 gene is involved in the transport of pyruvate into mitochondria, playing an important role in metabolic processes. Recently, it has been reported that higher MPC1 expression correlates with an increased number of immune cells in human cervical and lung cancers, indicating an enhanced antitumor immune response. Reduced MPC1 levels in gastric tumors are associated with a more severe disease course. Correlational analysis of the MPC1 gene in human lung, hippocampus and frontal cortex tissue samples based on data from the GTEx database revealed associations of this gene with schizophrenia, non-small cell lung cancer, and immune diseases. Our experiments showed that the mRNA level of the MPC1 gene in the non-small cell lung cancer cell line A549 increases 5-fold under the influence of the schizophrenia neuroleptic thioridazine. The observed elevation of MPC1 level may cause tumor infiltration by immune cells, complementing the previously reported data indicating the ability of thioridazine to slow cell growth, induce apoptosis and reduce the ability of cells to migrate.","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo UV-Induced Fluorescence Spectroscopy of Skin in Parkinson's Disease.

Doklady Biological Sciences Pub Date : 2025-01-22 DOI: 10.1134/S0012496624600398

V V Salmin, V B Loschenov, A B Ochirova, N P Bainaev-Mangilev, M N Andreev, E Yu Fedotova, A B Salmina, S N Illarioshkin

引用次数: 0

Expression of HOX Cluster Genes in Early Larval Development of Sea Urchin Strongylocentrotus intermedius (Echinodermata, Echinoidea).

Doklady Biological Sciences Pub Date : 2025-01-22 DOI: 10.1134/S0012496624600416

N V Ageenko, O V Ezhova, K V Kiselev, A I Lukinykh, V V Malakhov

引用次数: 0

Nudibranch Coryphella trophina (Bergh, 1890) (Gastropoda, Nudibranchia) Uses Twice Stolen Nematocysts for Its Defense.

Doklady Biological Sciences Pub Date : 2025-01-22 DOI: 10.1134/S0012496624600295

N R Krupitskaya, I A Ekimova, V V Malakhov

引用次数: 0

Efficacy of Poloxamer 188 in Carboplatin-Induced Aplastic Anemia Model in CBA Mice.

Doklady Biological Sciences Pub Date : 2025-01-22 DOI: 10.1134/S0012496624600428

A V Bervinova, V A Palikov, N A Borozdina, I N Kravchenko, I A Pakhomova, R A Dalevich, S Z Hajiguliyeva, E V Arshintseva, S Yu Pushkin, I A Dyachenko, A N Murashev

引用次数: 0

Fatty Acid Content and Lipid Nutritional Indexes in the Antarctic Krill Euphausia superba Collected from Three Regions of the Atlantic Sector of Antarctica. 从南极洲大西洋部分三个地区采集的南极磷虾中的脂肪酸含量和脂质营养指数。

Doklady Biological Sciences Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1134/S0012496624600386

S A Murzina, V P Voronin, D G Bityutskii, N N Nemova

引用次数: 0

Comparative Component Composition of Flowers in Several Syringa Species (Oleaceae). 几种丁香树（油茶科）花的成分比较。

Doklady Biological Sciences Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI: 10.1134/S0012496624701205

K A Pupykina, N V Polyakova, N V Kudashkina, E V Krasyuk

{"title":"Comparative Component Composition of Flowers in Several Syringa Species (Oleaceae).","authors":"K A Pupykina, N V Polyakova, N V Kudashkina, E V Krasyuk","doi":"10.1134/S0012496624701205","DOIUrl":"10.1134/S0012496624701205","url":null,"abstract":"Because insufficient relevant data are available, the component composition of flowers was studied comparatively in six lilac species of the genus Syringa L. (Oleaceae): S. emodi Wall., S. josikaea Jacg., S. komarowii Schneid., S. reticulata (Blume) H. Hara ssp. amurensis (Rupr.) P. S. Green et M. C. Chang, S. sweginzowii Koehne et Lingelsh, and S. vulgaris L. Plants were from the collection of the South Ural Botanical Garden-Institute. Contents were established for major groups of biologically active substances (BASs): flavonoids, hydroxycinnamic acids, tannins, and organic acids. The highest contents of all BAS groups were observed in S. komarowii flowers: flavonoids, 4.25 ± 0.21%; hydroxycinnamic acids, 6.13 ± 0.29%; tannins, 9.3 ± 0.5%; ascorbic acid, 0.468 ± 0.022%; and organic acids, 10.7 ± 0.5%. The contents were somewhat lower in S. emodi and S. sweginzowii and minimum in S. josikaea. Comparisons of the qualitative and quantitative BAS profiles showed that certain Syringa species cultivated in the Republic of Bashkortostan are promising to further study in terms of their possible use in scientific medicine and the development of herbal remedies.","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"325-331"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Data on Fungal Species Composition in Spruce Trunk Canker. 云杉树干腐烂病真菌物种组成的新数据。

Doklady Biological Sciences Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI: 10.1134/S0012496624701229

D A Shabunin, E Yu Varentsova, B G Popovichev, A V Selikhovkin

{"title":"New Data on Fungal Species Composition in Spruce Trunk Canker.","authors":"D A Shabunin, E Yu Varentsova, B G Popovichev, A V Selikhovkin","doi":"10.1134/S0012496624701229","DOIUrl":"10.1134/S0012496624701229","url":null,"abstract":"The composition of canker mycobiota on spruce trunks was studied in the Lisinsky forestry (Leningrad Oblast). Small cankers or canker parts were placed in a humid chamber. Fungi were identified by morphological features. Sorocybe resinae (Fr.) Fr. and Penicillium glaucoalbidum (Desm.) Houbraken & Samson were the most common. The S. resinae occurrence was 75.9 ± 7.9%. The fungus developed in the surface layers of dried resin, but was not detected in the absence of resin production. The fungus S. resinae was therefore assumed to be a nearly ubiquitous component of the mycobiota of resinous cankers on spruce trunks in Leningrad Oblast. The fungus P. glaucoalbidum has only been observed as a saprotroph in Russia earlier. Weak pathogenic properties were detected in the species in experiments; i.e., P. glaucoalbidum grew on live bark tissues in a humid chamber. Based on its high occurrence (41.4 ± 9.1%), P. glaucoalbidum was identified as a regular component of the microbiota in spruce necrotic canker. Pure cultures of P. glaucoalbidum and Oidiodendron sp. were obtained. To test the respective species as possible causative agents of trunk canker, trunks of 20 spruce trees were inoculated with the fungal cultures in a forest stand. The cultures stimulated resin secretion without causing necrosis to spread beyond the inflicted wound. To better understand the phenomenon, a more detailed study of the biota in necrotic cankers is necessary to perform with a special focus on their nonpathogenic part, which has not received proper attention as of yet.","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"350-355"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Holocene Taymyr Mammoth Petya: Mineralogical, Isotope, and Geochemical Properties of Bones, Soft Tissues, Skin, and Hair and Paleoecological Reconstructions. 前全新世泰米尔猛犸象 Petya：骨骼、软组织、皮肤和毛发的矿物学、同位素和地球化学特性以及古生态重建。

Doklady Biological Sciences Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI: 10.1134/S0012496624701217

V I Silaev, A S Shuyskiy, I V Smoleva, S N Shanina, E A Vasiliev, D V Kiseleva, A F Khazov, B A Makeev, A E Sukharev, A K Fokina

引用次数: 0

The Systematics and Phylogeny of Myxomycetes: Yesterday, Today, and Tomorrow. 粘菌纲的系统学和系统发育：昨天、今天和明天

Doklady Biological Sciences Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1134/S0012496624701242

E L Moroz, V I Gmoshinskiy, O N Shchepin, Yu K Novozhilov

{"title":"The Systematics and Phylogeny of Myxomycetes: Yesterday, Today, and Tomorrow.","authors":"E L Moroz, V I Gmoshinskiy, O N Shchepin, Yu K Novozhilov","doi":"10.1134/S0012496624701242","DOIUrl":"10.1134/S0012496624701242","url":null,"abstract":"Myxomycetes are amoeboid fungus-like organisms (Amoebozoa) with a unique life cycle characterized by a great morphological diversity of fruiting bodies. Due to the similarity of these structures to the fruiting bodies of some representatives of Ascomycota and Basidiomycota, myxomycetes have been classified as fungi since the first known scientific description in 1654. Only in the 19th century, when their life cycle was studied, did the difference of this group from fungi become clear. During the same period, microscopic structures of fruiting bodies, as well as ornamentation of the spore surface, began to be considered as diagnostic features. Due to this, in the period from the end of the 19th to the middle of the 20th century, a rather stable system was formed. However, as further studies have shown, both macro- and micromorphological characters are often quite variable, depend on environmental conditions, and often result from convergent evolution, which causes difficulties in defining species and taxonomic units of higher ranks. Since the first decade of the 21st century, due to the development of molecular genetic methods and the accumulation of data on nucleotide sequences of marker genes together with the improvement of microscopic studies, it has been possible to obtain data on the evolutionary relationships of different groups of myxomycetes. A milestone in this process was the publication of the first phylogenetic system of myxomycetes in 2019. This work was the starting point for a number of studies on the relationships between different groups of myxomycetes at a lower taxonomic level. Thus, there has been a surge in the number of studies that bring us closer to constructing a natural system.","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"356-369"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0