帕金森病患者体内紫外线诱导的皮肤荧光光谱研究。

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI:10.1134/S0012496624600398

V V Salmin, V B Loschenov, A B Ochirova, N P Bainaev-Mangilev, M N Andreev, E Yu Fedotova, A B Salmina, S N Illarioshkin

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引用次数: 0

摘要

研究人员对帕金森病（PD）患者紫外线诱导皮肤自身荧光的特征模式进行了测定，这些患者与代谢异常改变相关，如非酶蛋白糖基化、细胞外基质硬度增加、组织荧光团代谢受损、线粒体功能障碍和异常蛋白积累。皮肤自身荧光光谱的关键差异首次在PD中观察到，这使得区分PD患者和健康人或没有慢性神经变性迹象的个体成为可能。即，PD患者在375 nm紫外光激发下，与反射信号相关的皮肤荧光较低。

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In Vivo UV-Induced Fluorescence Spectroscopy of Skin in Parkinson's Disease.

Characteristic patterns of UV-induced skin autofluorescence were determined for patients with Parkinson's disease (PD) and associated with dysmetabolic alterations, such as nonenzymatic protein glycation, an increase in extracellular matrix stiffness, impaired metabolism of tissue fluorophores, mitochondrial dysfunction, and accumulation of aberrant proteins. Key differences in skin autofluorescence spectra were for the first time observed in PD, making it possible to discriminate between PD patients and healthy persons or individuals without signs of chronic neurodegeneration. Namely, skin fluorescence related to the reflected signal upon excitation with UV light at 375 nm was lower in PD patients.

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来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.