Diagnostic Cytopathology最新文献

{"title":"Metastatic Head and Neck Squamous Cell Carcinoma: Cytomorphological Spectrum on Fine Needle Aspiration Biopsy Cytology and Its Relevance.","authors":"Dipanwita Biswas, Aadya Kerkar, Nuli Muni Kiran, Sushmita Ghoshal, Suvradeep Mitra, Nalini Gupta, Amanjit Bal, Radhika Srinivasan","doi":"10.1002/dc.70019","DOIUrl":"https://doi.org/10.1002/dc.70019","url":null,"abstract":"<p><strong>Background: </strong>Head and neck squamous cell carcinoma (HNSCC) frequently metastasizes to the cervical lymph nodes and is subjected to fine needle aspiration biopsy cytology (FNABC). The aim of this study was to describe the cytomorphological spectrum and explore the association with the primary site of origin and the short-term outcome following radiation therapy.</p><p><strong>Methods: </strong>A retrospective cytomorphological evaluation was performed on 338 cases of metastatic squamous cell carcinoma to cervical lymph nodes from HNSCC primaries. The clinical details including the age, sex, primary site of origin confirmed on histopathology, composite stage, and outcome at 1-year follow-up (86) were obtained from the records. An exploratory analysis was performed to derive any association of the cytomorphological features with the primary site of origin and short-term outcome.</p><p><strong>Results: </strong>The patients' age ranged from 28 to 89 years (mean, 56.6 years) with marked male preponderance, and the majority in Stage IV. The primary site was the oral cavity (45.2%) followed by the oropharynx (37%), hypopharynx (8.5%), nasopharynx (6.2%) and larynx (3.1%). Cytomorphology revealed keratinization of any degree in 86% of cases. The background was necroinflammatory, fluidy, or reactive lymphocytic with granulomatous reaction in 5% of cases. The chromatin pattern (vesicular, coarse or dense hyperchromatic), presence of nucleoli, and reactive lymphocytic background showed site-specific differences. However, no cytomorphological parameter showed any association with short-term outcome.</p><p><strong>Conclusion: </strong>Metastatic HNSCC to the cervical lymph nodes presents a broad cytomorphological spectrum with no specific association with outcome.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Biopsy in CRC Management: Early Detection, Minimal Residual Disease, and Therapy Optimization—Clinical Evidence and Challenges","authors":"Qi Liu,&nbsp;Xiaoyong Li,&nbsp;Tiejun Jin,&nbsp;Sibo Huo,&nbsp;Shuai Su,&nbsp;Nan Liu","doi":"10.1002/dc.70009","DOIUrl":"10.1002/dc.70009","url":null,"abstract":"<div>\u0000 \u0000 <p>Colorectal cancer (CRC) is a major global health burden, ranking among the leading causes of cancer-related deaths. Despite improvements in screening and treatment, challenges such as late-stage diagnosis, high recurrence rates, and therapy resistance continue to impede optimal outcomes. Liquid biopsy, a minimally invasive technique that analyzes tumor-derived components in bodily fluids—including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs)—is emerging as a powerful tool to transform CRC management across the disease continuum. This review provides a comprehensive overview of liquid biopsy's current and emerging applications in CRC. We examine its role in early detection, where sensitive ctDNA-based assays and epigenetic biomarkers have demonstrated the ability to identify CRC at asymptomatic or early stages, potentially improving screening uptake and compliance. Furthermore, we explore how liquid biopsy enables dynamic monitoring of treatment response and clonal evolution, facilitating the timely identification of resistance mutations and supporting personalized therapy adjustments. Innovations in multi-omics integration, artificial intelligence, and ultra-sensitive sequencing technologies are also discussed as pivotal advancements that enhance the clinical utility of liquid biopsy. Despite significant progress, the widespread adoption of liquid biopsy faces several hurdles, including assay standardization, sensitivity for low-shedding tumors, regulatory approval, and cost-effectiveness. Continued research, validation in large prospective trials, and harmonization of testing protocols are essential to overcome these challenges. Ultimately, liquid biopsy holds the potential to become a cornerstone of precision oncology in CRC, enabling earlier intervention, more tailored treatment strategies, and improved patient outcomes.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"580-591"},"PeriodicalIF":1.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Cytopathological Diagnosis of Extracranial Anaplastic Meningioma Using Fine-Needle Aspiration.","authors":"Burcu Özcan","doi":"10.1002/dc.70017","DOIUrl":"https://doi.org/10.1002/dc.70017","url":null,"abstract":"<p><p>This case report presents the cytological characteristics of an extracranial anaplastic meningioma-an exceptionally rare entity rarely sampled via fine-needle aspiration. We aim to highlight specific cytomorphological features that may aid in the preoperative identification of the anaplastic subtype.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytology Screening Using Z-Stack Digital Slides: A Validation Study","authors":"Kei Tanaka,&nbsp;Kris Lami,&nbsp;Takuma Odate,&nbsp;Takashi Hori,&nbsp;Tsubasa Sato,&nbsp;Ethan N. Okoshi,&nbsp;Junya Fukuoka","doi":"10.1002/dc.70015","DOIUrl":"10.1002/dc.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>For applications of digital pathology in cytology, challenges such as focal precision and data volume remain. The goals of this validation study are to compare diagnostic accuracy, screening time, annotation counts, and inter- and intra-observer agreement between digital slides using Z-stack scanning (z-WSI) and conventional glass slides in liquid-based cervical cytology (LBC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected 91 LBC samples, with an equal number of NILM, LSIL, HSIL, and SCC cases. Four cytotechnologists evaluated cases using glass slides and z-WSI separately. They classified cases under two separate schemas: (1) “Screening-2-Category”: NILM (normal) vs. other lesions (ASC-US and above); and (2) “Morpho-3-Category”: NILM vs. LSIL (mild dysplasia) vs. ASC-H and higher (moderate dysplasia to squamous cell carcinoma) to reflect lesion severity and treatment implications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For Screening-2-Category classifications, inter-observer agreement was 0.685 for glass slides and 0.637 for z-WSI, with intra-observer agreement ranging from 82.4% to 95.6%. For Morpho-3-Category classifications, inter-observer agreement was 0.700 for glass slides and 0.598 for z-WSI, indicating reduced agreement with z-WSI. Accuracy was 91.2% (glass slides) and 87.1% (z-WSI) for Screening-2-Category, and 86.5% and 81.0% for Morpho-3-Category, with no significant differences. In both modalities, cytotechnologists tended to apply more annotations in true positive cases but fewer in false negative cases. Screening time for z-WSI was 2–5 min longer on average for all cytotechnologists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>z-WSI is not completely equivalent to glass slides, but it has the potential to be used as a tool for cytology screening. Training specifically designed for WSI is expected to enhance diagnostic accuracy and improve workflow efficiency.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"568-575"},"PeriodicalIF":1.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surprise Diagnosis of a Lumbar Mass: Cytological Diagnosis of Retroperitoneal Ganglioneuroma in a Rare Presentation.","authors":"Shruti Gupta, Pankaj Kumar, Shruti Dabas, Harshit Bajpai, Arvind Kumar, Niraj Kumari","doi":"10.1002/dc.70016","DOIUrl":"https://doi.org/10.1002/dc.70016","url":null,"abstract":"<p><p>Ganglioneuromas (GNs) are the rare benign tumors belonging to the spectrum of the neuroblastic tumors and can be found anywhere across the distribution of the sympathetic nervous system, including the retroperitoneum. The majority of retroperitoneal GNs are asymptomatic and are diagnosed incidentally. We present a case of a retroperitoneal GN presenting as a palpable lumbar swelling, scoliosis, and inability to walk in a 6-year-old child, diagnosed on fine needle aspiration cytology (FNAC) and confirmed on histopathology. This case report discusses the rare presentation and challenges in FNAC diagnosis of these lesions.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fruiting Bodies of Aspergillus in a Cavitary Lung Mass: A Rare Finding on Fine Needle Aspiration","authors":"Maria Luisa C. Policarpio-Nicolas,&nbsp;Jacob Rattin,&nbsp;Sanjay Mukhopadhyay","doi":"10.1002/dc.70014","DOIUrl":"10.1002/dc.70014","url":null,"abstract":"<p>Endobronchial ultrasound (EBUS) guided fine needle aspiration is a modality for diagnosing lung nodules as well as fungal organisms. One of the most frequently isolated fungal organisms from immunocompromised patients or immunocompetent patients with severe COPD is <i>Aspergillus</i> spp.<i>,</i> which is characterized by septate hyphae with progressive dichotomous branching. However, this finding is not entirely specific to <i>Aspergillus</i> spp. since it can be seen in non-Aspergillus fungi. Nonetheless, the presence of fruiting bodies, background inflammation, and in correlation with the clinical and radiologic findings are supportive of <i>Aspergillus</i> infection. This case report describes a 73-year-old male smoker with severe COPD who presented with multiple lung nodules and hilar lymphadenopathy. An EBUS guided fine needle aspiration of the largest left lung cavitary nodule showed the presence of uniformly sized, septate hyphae with progressive dichotomous branching. There were randomly distributed fruiting bodies composed of a smooth stalk, a swollen vesicle at the terminal end of the stalk, and a single row of phialides occupying the upper two-thirds of the vesicle. The background showed marked acute inflammation and singly dispersed conidia (spores). The GMS stain highlighted the presence of fruiting bodies, dichotomous branching septate hyphae, and singly dispersed conidia. The Fungal PCR result confirmed the presence of <i>Aspergillus fumigatus</i>. Hence, the presence of fruiting bodies is extremely helpful in the identification of the <i>Aspergillus</i> spp. over the other non-Aspergillus fungi. While species identification is often performed in culture, the cytomorphology of the fruiting body could favor <i>Aspergillus</i> spp., which could facilitate prompt medical management.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"576-579"},"PeriodicalIF":1.0,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Cytological Diagnosis of Intrathyroidal Thymic Carcinoma: A Case Report With Review of the Literature","authors":"Makoto Yamada,&nbsp;Shota Sezaki,&nbsp;Tomonari Ikeya,&nbsp;Masatoshi Furuta,&nbsp;Shogo Mizuno,&nbsp;Yoshiro Otsuki","doi":"10.1002/dc.70011","DOIUrl":"10.1002/dc.70011","url":null,"abstract":"<div>\u0000 \u0000 <p>Intrathyroidal thymic carcinoma (ITTC) is a rare malignant thyroid tumor that is similar to thymus epithelium-related tumors. Herein, we report a case of ITTC diagnosed by fine-needle aspiration cytology (FNA). A 55-year-old male presented with a slowly increasing cervical mass. Cervical ultrasonography revealed an irregular mass measuring 3.7 × 2.5 × 2.1 cm. FNA was performed. Cytological findings showed that the tumor was highly cellular and tumor cells were arranged in islet-like clusters accompanied by lymphocytes. The tumor cells had a high nuclear-to-cytoplasmic ratio. The nuclei were round to ovoid or spindle-shaped. The fusiform tumor cells exhibited a regular streaming arrangement, similar to squamous cell carcinoma. Immunocytochemically, the tumor cells were positive for CD5 and c-KIT. Pathological examination of the resected thyroid specimen revealed confluent cell nests of epithelioid and spindle cells with significant lymphocyte and plasma cell infiltration throughout the tumor. Immunohistochemically, the tumor cells were positive for cytokeratin, CD5, c-KIT, and p63, and negative for TTF-1 and thyroglobulin. Therefore, the tumor was diagnosed as ITTC. Although ITTC is rare, it should be considered in the differential diagnosis of a mass in the lower pole of the thyroid gland that exhibits large cohesive islet-like clusters with numerous lymphocytes and features resembling those of squamous cell carcinoma.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"E221-E226"},"PeriodicalIF":1.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant Hematolymphoid Plasmacytic Effusions: A Cytopathologic Study of Six Cases","authors":"Badr AbdullGaffar","doi":"10.1002/dc.70013","DOIUrl":"10.1002/dc.70013","url":null,"abstract":"<div>\u0000 \u0000 <p>Compared to myelomatous effusions, there is a lack of studies that specifically address hematolymphoid plasmacytic effusions (HPEs). We conducted a retrospective review study over 15 years to investigate the prevalence, cytologic patterns, potential interpretation pitfalls, and clinical associations of HPEs. Serous effusion fluids in which plasmacytoid and plasma cells represented more than 10% of effusion cells were classified as HPEs. We extracted relevant clinical, laboratory, and follow-up data for each patient. We found six patients [age range: 60–88, average age: 73, male to female ratio 1:1] with HPEs that constituted 0.2% of serous effusions. Relevant clinical history prompted us to consider HPEs and include plasma cell immunomarkers in cellblock sections. Light chain-restricted plasmacytic cellular infiltrates confirmed the cytologic diagnosis in the absence of fluid flow cytometry. We have recognized three cytomorphologic patterns: pure plasmacytic infiltrates, lymphoplasmacytic infiltrates, and plasma cells intermixed with other cellular constituents. Four patients had multiple myeloma (two patients with pure high-grade large pleomorphic myeloma cells, two patients with mature plasma cells intermixed with inflammatory cells), one patient had marginal zone lymphoma, and another patient had lymphoplasmacytic lymphoma. The patients had similar clinical features with even kappa (3 cases) and lambda (3 cases) light chain distribution. HPEs are uncommon malignant effusions that occur in elderly patients with multiple myeloma and low-grade B-cell lymphomas. High-grade myeloma cells can be confused with hematolymphoid and non-hematolymphoid malignancies, whereas mature plasma cells in multiple myeloma and low-grade lymphomas can be misinterpreted as reactive plasmacytosis. Cellblock immunocytochemistry is a valuable diagnostic tool.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"555-567"},"PeriodicalIF":1.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Biopsy in the Diagnosis of Pancreatic Neuroendocrine Neoplasms: A Series of 72 Cases","authors":"John Findley,&nbsp;Hamideh Doozandeh,&nbsp;Lucas Yan,&nbsp;Lin Cheng,&nbsp;Lei Yan","doi":"10.1002/dc.70012","DOIUrl":"10.1002/dc.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) are widely used for the diagnosis of pancreatic tumors. The aim of our study was to compare the diagnostic performance of EUS-FNA and EUS-FNB for the diagnosis of pancreatic neuroendocrine (NE) neoplasms and to review tumors' cytopathology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent EUS-FNA and EUS-FNB for pancreatic NE neoplasms were reviewed retrospectively. Sample adequacy, diagnostic yield (defined as percentage of definitive diagnosis) and sensitivity were compared between FNA and FNB. The common cytologic features of pancreatic NE neoplasms were reviewed and quantified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 72 patients were diagnosed with pancreatic NE neoplasms at our institution by EUS-FNA and EUS-FNB. The mean age at diagnosis was 57.5 years. The proportions of adequate samples were 68/68 (100%) for EUS-FNA and 57/58 (98.3%) for EUS-FNB. EUS-FNB demonstrated a higher diagnostic yield than FNA, 57/58 (98.3%) for EUS-FNB and 61/68 (89.7%) for EUS-FNA. When concurrent EUS-FNBs were performed, the diagnostic yield increased to 97.1% with an incremental increase of 5/68 (7.4%) relative to EUS-FNA alone. When sensitivity was defined as the ability to identify cytological atypia and above categories, the sensitivity for EUS-FNA and EUS-FNB was 98.5% and 91.4%, respectively. The grading of well-differentiated neuroendocrine tumors was 32/51 Grade 1 tumors (62.7%) and 19/51 Grade 2 tumors (37.3%). Four patients were found to have poorly differentiated neuroendocrine carcinomas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EUS-FNA and EUS-FNB were comparable in sample adequacy for diagnosing pancreatic NE neoplasms. EUS-FNA appeared to have higher sensitivity but lower diagnostic yield than EUS-FNB in our study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"546-554"},"PeriodicalIF":1.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meningeal Solitary Fibrous Tumor: A Cytological Report With Emphasis on the Usefulness of Immunocytochemical Analysis for STAT6","authors":"Hiroyuki Okanishi,&nbsp;Mitsuaki Ishida,&nbsp;Naoto Kohno,&nbsp;Isako Kataoka,&nbsp;Mari Tomiuka,&nbsp;Mayumi Uragami,&nbsp;Shizuka Ono,&nbsp;Chihiro Deguchi,&nbsp;Reika Takeda,&nbsp;Yoshitaka Kurisu,&nbsp;Yoshinobu Hirose","doi":"10.1002/dc.70007","DOIUrl":"10.1002/dc.70007","url":null,"abstract":"<p>Solitary fibrous tumors (SFTs) are rare neoplasms characterized by spindle neoplastic cell proliferation within collagenous stroma and prominent dilated vasculature. They present a wide histopathological spectrum, ranging from hypocellular lesions with a rich collagenous stroma to hypercellular lesions with scant stroma. Meningeal SFTs are usually hypercellular, and their cytological features remain poorly characterized. This brief report presents a cytological description of a meningeal SFT with immunocytochemical analysis for signal transducer and activator of transcription 6 (STAT6). A 55-year-old Japanese male, with a history of surgical resection of SFT 11 years earlier, was discovered to have a recurrent tumor in the left cerebellar tentorium. An intraoperative touch smear of the tumor revealed loosely aggregated hypercellular clusters and scattered round-to-oval spindle cells in a clear background, with large nuclei and hyperchromasia. Although minimal stromal components were observed, no dilated vascular structures were identified. Immunocytochemistry showed diffuse positive immunoreactivity for STAT6, confirming the diagnosis of meningeal SFT. Histopathological and immunohistochemical analyses confirmed recurrent meningeal SFT. The cytological features of meningeal SFT differ from those of pleural SFT in terms of minimal collagenous stroma and the presence of nuclear atypia. STAT6 is a specific marker for SFT, and immunocytochemical staining is useful for its diagnosis.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"E210-E214"},"PeriodicalIF":1.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}