{"title":"脑膜孤立性纤维性肿瘤:细胞学报告,强调免疫细胞化学分析对STAT6的有用性。","authors":"Hiroyuki Okanishi, Mitsuaki Ishida, Naoto Kohno, Isako Kataoka, Mari Tomiuka, Mayumi Uragami, Shizuka Ono, Chihiro Deguchi, Reika Takeda, Yoshitaka Kurisu, Yoshinobu Hirose","doi":"10.1002/dc.70007","DOIUrl":null,"url":null,"abstract":"<p>Solitary fibrous tumors (SFTs) are rare neoplasms characterized by spindle neoplastic cell proliferation within collagenous stroma and prominent dilated vasculature. They present a wide histopathological spectrum, ranging from hypocellular lesions with a rich collagenous stroma to hypercellular lesions with scant stroma. Meningeal SFTs are usually hypercellular, and their cytological features remain poorly characterized. This brief report presents a cytological description of a meningeal SFT with immunocytochemical analysis for signal transducer and activator of transcription 6 (STAT6). A 55-year-old Japanese male, with a history of surgical resection of SFT 11 years earlier, was discovered to have a recurrent tumor in the left cerebellar tentorium. An intraoperative touch smear of the tumor revealed loosely aggregated hypercellular clusters and scattered round-to-oval spindle cells in a clear background, with large nuclei and hyperchromasia. Although minimal stromal components were observed, no dilated vascular structures were identified. Immunocytochemistry showed diffuse positive immunoreactivity for STAT6, confirming the diagnosis of meningeal SFT. Histopathological and immunohistochemical analyses confirmed recurrent meningeal SFT. The cytological features of meningeal SFT differ from those of pleural SFT in terms of minimal collagenous stroma and the presence of nuclear atypia. STAT6 is a specific marker for SFT, and immunocytochemical staining is useful for its diagnosis.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 11","pages":"E210-E214"},"PeriodicalIF":1.0000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.70007","citationCount":"0","resultStr":"{\"title\":\"Meningeal Solitary Fibrous Tumor: A Cytological Report With Emphasis on the Usefulness of Immunocytochemical Analysis for STAT6\",\"authors\":\"Hiroyuki Okanishi, Mitsuaki Ishida, Naoto Kohno, Isako Kataoka, Mari Tomiuka, Mayumi Uragami, Shizuka Ono, Chihiro Deguchi, Reika Takeda, Yoshitaka Kurisu, Yoshinobu Hirose\",\"doi\":\"10.1002/dc.70007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Solitary fibrous tumors (SFTs) are rare neoplasms characterized by spindle neoplastic cell proliferation within collagenous stroma and prominent dilated vasculature. They present a wide histopathological spectrum, ranging from hypocellular lesions with a rich collagenous stroma to hypercellular lesions with scant stroma. Meningeal SFTs are usually hypercellular, and their cytological features remain poorly characterized. This brief report presents a cytological description of a meningeal SFT with immunocytochemical analysis for signal transducer and activator of transcription 6 (STAT6). A 55-year-old Japanese male, with a history of surgical resection of SFT 11 years earlier, was discovered to have a recurrent tumor in the left cerebellar tentorium. An intraoperative touch smear of the tumor revealed loosely aggregated hypercellular clusters and scattered round-to-oval spindle cells in a clear background, with large nuclei and hyperchromasia. Although minimal stromal components were observed, no dilated vascular structures were identified. Immunocytochemistry showed diffuse positive immunoreactivity for STAT6, confirming the diagnosis of meningeal SFT. Histopathological and immunohistochemical analyses confirmed recurrent meningeal SFT. The cytological features of meningeal SFT differ from those of pleural SFT in terms of minimal collagenous stroma and the presence of nuclear atypia. STAT6 is a specific marker for SFT, and immunocytochemical staining is useful for its diagnosis.</p>\",\"PeriodicalId\":11349,\"journal\":{\"name\":\"Diagnostic Cytopathology\",\"volume\":\"53 11\",\"pages\":\"E210-E214\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.70007\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic Cytopathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/dc.70007\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Cytopathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dc.70007","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Meningeal Solitary Fibrous Tumor: A Cytological Report With Emphasis on the Usefulness of Immunocytochemical Analysis for STAT6
Solitary fibrous tumors (SFTs) are rare neoplasms characterized by spindle neoplastic cell proliferation within collagenous stroma and prominent dilated vasculature. They present a wide histopathological spectrum, ranging from hypocellular lesions with a rich collagenous stroma to hypercellular lesions with scant stroma. Meningeal SFTs are usually hypercellular, and their cytological features remain poorly characterized. This brief report presents a cytological description of a meningeal SFT with immunocytochemical analysis for signal transducer and activator of transcription 6 (STAT6). A 55-year-old Japanese male, with a history of surgical resection of SFT 11 years earlier, was discovered to have a recurrent tumor in the left cerebellar tentorium. An intraoperative touch smear of the tumor revealed loosely aggregated hypercellular clusters and scattered round-to-oval spindle cells in a clear background, with large nuclei and hyperchromasia. Although minimal stromal components were observed, no dilated vascular structures were identified. Immunocytochemistry showed diffuse positive immunoreactivity for STAT6, confirming the diagnosis of meningeal SFT. Histopathological and immunohistochemical analyses confirmed recurrent meningeal SFT. The cytological features of meningeal SFT differ from those of pleural SFT in terms of minimal collagenous stroma and the presence of nuclear atypia. STAT6 is a specific marker for SFT, and immunocytochemical staining is useful for its diagnosis.
期刊介绍:
Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.