Diagnostic Cytopathology最新文献

{"title":"Cytological Assessment of Metastatic Gastrointestinal Stromal Tumor in Ascitic Fluid.","authors":"Hadi Sultan, Zohre Sadeghian, Elvia Goez-Gutierrez, M Julia Diacovo, Esther Yoon","doi":"10.1002/dc.25499","DOIUrl":"https://doi.org/10.1002/dc.25499","url":null,"abstract":"<p><p>Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms typically arising in the stomach and small intestine and rarely involving extra-gastrointestinal organs. While fine-needle aspiration (FNA) offers reliable diagnosis, exfoliation of GIST cells into body fluids is exceedingly rare and diagnostically challenging. We report a case of a 69-year-old male with metastatic GIST in ascitic fluid. The cells revealed atypical epithelioid morphology with high nuclear-to-cytoplasmic ratio and nuclear irregularities. Immunohistochemistry (IHC) demonstrated positivity for CD117 and DOG1. Diagnosis requires integration of clinical history, cytomorphology, and a broad IHC panel. Awareness of its cytologic features, application of mesenchymal markers, and molecular testing are critical for accurate diagnosis and effective clinical management.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAP1 Loss on Immunocytochemistry and Its Association With Monosomy 3 in Uveal Melanoma Fine-Needle Aspirations.","authors":"Precious Ann Fortes, Michelle Nguyen, Po Chu Fung, Erika F Rodriguez, Teresa H Kim, Kosuke Kawai, Neda A Moatamed","doi":"10.1002/dc.25496","DOIUrl":"https://doi.org/10.1002/dc.25496","url":null,"abstract":"<p><strong>Background: </strong>Loss of nuclear BRCA1-associated protein 1 (nBAP1) expression is strongly linked to monosomy 3 in uveal melanoma. While fine-needle aspiration (FNA) aids diagnosis, the prognostic value of nBAP1 immunocytochemistry (ICC) is still being investigated. This study examines the correlation between nBAP1 loss on ICC and fluorescence in situ hybridization (FISH) findings, as well as its clinical impact.</p><p><strong>Methods: </strong>Intraocular FNA cytology specimens with clinical concern for uveal melanoma from April 2015 to March 2023 with available nBAP1 ICC, FISH results, and clinical follow-up were examined. Two independent reviewers, blinded to the cytogenetic results, interpreted the nBAP1 ICC as either loss or retained. Statistical analysis using Fisher's exact test was utilized to evaluate the relationship between nBAP1 loss on ICC and FISH findings. Kaplan-Meier survival plots were constructed to examine the metastasis-free survival.</p><p><strong>Results: </strong>Among the 79 cases included in the study, 86.1% (68/79) showed nBAP1 loss. Approximately 63.2% of patients with nBAP1 loss had monosomy 3, whereas none with nBAP1 retained had monosomy 3 (p < 0.001). Of the nBAP1 loss cases, 41.2% (28/68) had monosomy 3 alone, while 22.1% (15/68) had both monosomy 3 and 6p gain. Patients with nBAP1 loss had a significantly higher risk of metastasis (p ≤ 0.04), with a 5-year metastasis-free survival of 57.1% versus 100% in nBAP1 retained cases.</p><p><strong>Conclusion: </strong>BAP1 ICC is a cost-effective prognostic tool in uveal melanoma FNAs, strongly correlating with monosomy 3 and poor outcomes. Integrating BAP1 ICC with FISH enhances risk stratification, enabling earlier identification of high-risk patients and guiding treatment decisions.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Polyoma Virus and Polyoma Virus-Like Changes in Urine Cytology: When Should an Atypical Diagnosis Be Considered.","authors":"Yaogong Li, Yonca Kanber, Derin Caglar, Wassim Kassouf, Manon Auger, Fadi Brimo","doi":"10.1002/dc.25494","DOIUrl":"https://doi.org/10.1002/dc.25494","url":null,"abstract":"<p><strong>Background: </strong>While the Paris system for reporting urinary cytology states that cells with well-recognized and typical changes of polyoma virus (PV) infection should not lead to a diagnosis of 'atypia, the prognostic significance of PV-like features is unknown.</p><p><strong>Methods: </strong>Included were 284 urine cytology cases with PV or PV-like changes. Four cell types were identified. Cell A was typical of PV infection, cell B had a spider-web chromatin pattern, and cells C and D were degenerated cells with clumpy chromatin or homogeneous severely hyperchromatic nuclei, respectively. Events were correlated with a subsequent histological diagnosis of high-grade urothelial carcinoma (HGUC).</p><p><strong>Results: </strong>47% of cases had more than one cell type. The most common cell was D (64%) and the least common was A (27%). The most common cell to be present in isolation was D (n = 109, 60%). 92% of cases with cell A had other cell types. Overall, the presence of cell A was associated with a benign follow-up (1.2% association with HGUC). There was a gradual increase in the association with a HGUC diagnosis in cases with cells B (PPV = 8%), C (PPV = 15.5%), and D (PPV = 44%). The presence of only cells B, C, or D was predictive of HGUC in 22.4%, 33.3%, and 61.5%, respectively.</p><p><strong>Conclusions: </strong>Cases with cell type A can be confidently diagnosed as 'negative for HGUC', even in the presence of associated cells with PV-like changes. Cases with cells displaying PV-like features (cell type B, C, or D) in the absence of type A features may represent degenerated HGUC cells.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Analysis of 1151 Chinese Women With Atypical Glandular Cells: Impact of High-Risk Human Papilloma Virus Status and Age on Cervical and Endometrial Neoplasia Risk.","authors":"Ruhang Fan, Shuang Song, Haiyan Shi, Xiaofei Zhang, Bingjian Lu","doi":"10.1002/dc.25495","DOIUrl":"https://doi.org/10.1002/dc.25495","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical significance of high-risk human papillomavirus (hrHPV) testing and age in women with atypical glandular cells (AGC) on Pap tests.</p><p><strong>Methods: </strong>We retrospectively analyzed the relationship between hrHPV and cytology co-testing, follow-up histopathology within 6 months, age, and other demographic features in a large cohort of AGC patients from a single Chinese academic institution.</p><p><strong>Results: </strong>Among1510 AGC patients, 1151, 1260, and 866 patients had histopathologic results, hrHPV co-testing, and both, respectively. High-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS) and worse lesions (HSIL/AIS+) and endometrial atypical hyperplasia (EAH)/endometrial carcinoma (EC) (EAH/EC+) were present in 27.8% (281/1009) and 25.1% (113/450) patients, respectively. hrHPV was positive in 34.5% (435/1260) patients. Among hrHPV+ patients with genotyping by the Aptima assay, 48.8% (125/256) had HPV16 and/or 18/45. Compared to hrHPV- patients, hrHPV+ women had a significantly increased risk of HSIL/AIS+ (OR: 10.958, 95% CI: 7.657-15.682), particularly with HPV16 and/or18/45 (OR: 3.556, 95% CI: 2.122-5.959; both p < 0.001). Among hrHPV- patients, those aged ≥ 40 years had higher risks of HSIL/AIS+ (including 18 HPV-independent and 11 metastatic adenocarcinomas; OR: 5.882, 95% CI: 2.702-12.806) and EAH/EC+ (OR: 7.622, 95% CI: 3.188-18.225) compared to younger patients (both p < 0.001).</p><p><strong>Conclusions: </strong>Combining hrHPV testing and age effectively stratifies risks in AGC patients: hrHPV positivity predicts high-grade cervical lesions, while older hrHPV-negative women are more likely to have endometrial or extra-uterine malignancies. These findings may optimize management of AGC patients with cumulative supportive data.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Cytology and Histology of Breast Phyllodes Tumor: Atypical Spindle Cells and Multinucleated Cells.","authors":"Takahiko Sakuma, Mina Yamashita, Masanori Ando, Koji Matsuo","doi":"10.1002/dc.25492","DOIUrl":"https://doi.org/10.1002/dc.25492","url":null,"abstract":"<p><p>A case of clinically malignant phyllodes tumor (PT) of the breast is reported. A 55-year-old woman with a lump in her left breast, which had been diagnosed as a fibroadenoma by fine needle aspiration (FNA) cytology five year before, noticed abruptly accelerated growth of the tumor. Repeated FNA cytology revealed atypical spindle and multinucleated cells, but the origin of these atypical cells could not be specifically determined. The rapid growth of the tumor resulted in an open skin ulcer and an emergent mastectomy was performed to control the intractable bleeding from the ulcer. The histological diagnosis was PT. The cytological and histological findings were compared, and there was favorable correlation. Although the tumour was clearly malignant clinically, it did not fulfill the WHO criteria for malignant PT completely. The desirable modification of the diagnostic criteria for malignant PT is discussed.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FNAC of Crystallizing Galactocele: Case Series of a Rare Entity With Review of Literature.","authors":"Kamali, Jyotsna Naresh Bharti, Jyoti Verma, Arumulla Mithilesh","doi":"10.1002/dc.25485","DOIUrl":"https://doi.org/10.1002/dc.25485","url":null,"abstract":"<p><p>Galactoceles are one of the most common non-neoplastic breast lesions occurring predominantly in pregnant and lactating women. Long-standing cases of galactocele can crystallize and form a rare entity called crystallizing galactocele. We report two cases of crystallizing galactocele. The first case is a 21-year-old female who presented with bilateral breast lumps for 1 year, which was diagnosed as left breast crystallizing galactocele and right breast as inflamed galactocele. This is the first reported case with synchronous presentation of crystallizing galactocele and inflamed galactocele in the same patient. The second case is a 19-year-old female who presented with a painless right breast lump for 2 weeks, for which FNAC turned out to be crystallizing galactocele. To the best of our knowledge, to date, there are only 21 cases of crystallizing galactoceles published in the English literature.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is a Significant Nuclear Groove in Thyroid Fine Needle Aspiration Cytology?","authors":"Imad A El Hag, Sadeem Al-Subaie, Shuaa M Asiri, Fadel Z Alotaibi, Somya M Alabashi, Abdulmalik Alsheikh, Abrar G Alghamdi","doi":"10.1002/dc.25491","DOIUrl":"https://doi.org/10.1002/dc.25491","url":null,"abstract":"<p><strong>Background: </strong>Nuclear grooves are an important diagnostic feature in thyroid fine needle aspiration (FNA). However, their exact role remains undefined.</p><p><strong>Materials and methods: </strong>This study includes both retrospective and prospective analyses of the significance of identifying and counting deep grooves under low-power magnification (20×) in Pap-stained cytology smears for the classification of thyroid FNA results and, consequently, patient management.</p><p><strong>Result: </strong>Two cut-off points have been identified to stratify thyroid smears into three categories: benign with no grooves identified, 1-9 grooves in indeterminate cases, and ≥ 10 grooves in papillary thyroid carcinoma (PTC). Deep groove identification and counting under 20× magnification are highly reproducible between observers (K = 0.61). Using groove-based criteria instead of the archival Bethesda System for Reporting Thyroid Cytology (BSRTC) leads to a significantly higher diagnosis of follicular adenomas as benign (p < 0.0001), with fewer noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) categorized as benign (p = 0.002). The follicular variant of papillary carcinomas (FV-PTC), previously considered indeterminate, showed a significant decline (p < 0.001), and false-negative diagnoses of PTC and FV-PTC were eliminated. A significant difference favoring the groove-based approach was noted regarding specificity and positive (PLR) and negative (NLR) likelihood ratios (p = 0.0014). Finally, a substantial reduction in the false-negative rate was observed prospectively (p = 0.0014). The number of unnecessary surgeries among benign cases has decreased.</p><p><strong>Conclusion: </strong>Incorporating the presence and frequency of deep nuclear grooves seen at 20× magnification improves the outcome of thyroid FNA classification and overall patient management.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series: Can a Cytological Smear Indicate the Histological Type of Thymoma and Distinguish Thymoma From Thymic Carcinoma?","authors":"Nikola Gardić, Sonja Tomić, Dejan Miljković, Aleksandra Lovrenski","doi":"10.1002/dc.25493","DOIUrl":"https://doi.org/10.1002/dc.25493","url":null,"abstract":"<p><strong>Introduction: </strong>The cytological characteristics of thymoma are not extensively documented in the literature, primarily due to the tumor's rarity. To our knowledge, there are no standardized criteria for the cytological classification of thymomas.</p><p><strong>Case reports: </strong>We report three cases of female patients with cytological smears of thymic epithelial neoplasms, correlating them with the corresponding surgical specimens. In all three smears, the cytological features of the cells were similar and consisted of epithelial and lymphocytic components. Epithelial cells were approximately twice the size of lymphocytes, although some were five times larger, displaying prominent nucleoli and marked nuclear atypia. In many areas of the smears, prominent crush artifacts with chromatin streaking were observed in thymoma cases. The thymic carcinoma case had an inconspicuous crush artifact. The number of lymphocytes varied on the smears. In the smears of thymoma, we had a high number of lymphocytes intermixed with epithelial cells, while in thymic carcinoma, we have just a few scattered lymphocytes. In one case of thymoma, a higher number of mast cells were observed.</p><p><strong>Conclusion: </strong>Preoperative diagnosis of mediastinal masses is essential for the future clinical management of these patients. As such, cytological diagnosis sometimes plays an important role, although the distinct cytological features of thymic epithelial lesions can be challenging. Our cases suggest specific cytological features that may help differentiate thymoma from thymic carcinoma.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Cytologic and Histologic Grading of Malignant Salivary Gland Tumors and Salivary Gland Neoplasms of Uncertain Malignant Potential: A 6-Year Review at a Single Institution.","authors":"Agnes I Udoh, Cecilia G Clement","doi":"10.1002/dc.25490","DOIUrl":"https://doi.org/10.1002/dc.25490","url":null,"abstract":"<p><strong>Background: </strong>The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) developed and published in 2018 recommends grading salivary gland neoplasms into high-grade (HG) or low-grade (LG), given its impact on clinical management. Although this cytologic grading can be done, in certain cases it can be challenging. Herein we assess the accuracy of cytologic grading of salivary gland neoplasms at our institution.</p><p><strong>Method: </strong>A retrospective review of medical records identified 365 patients who underwent salivary gland FNA between 2017 and 2022. Cases categorized as malignant, suspicious for malignancy, and salivary gland neoplasms of uncertain malignant potential (SUMP) by the Milan system and with available follow-up histology were selected. FNA cases were reviewed and blindly assigned a cytologic grade. No ancillary testing or cell blocks associated with study cases were examined. The cytologic grade was correlated with the final surgical diagnosis and grade. The diagnostic performance of cytologic tumor grading was determined using histologic grading as the gold standard. One case with intermediate (INT) histologic grade was excluded from this analysis.</p><p><strong>Results: </strong>Out of 40 cases included in the study, 70% (n = 28) were SUMPs, 5% (n = 2) were suspicious of malignancy, and 25% (n = 10) were malignant. Among the 39 cases analyzed (12 histologic HG, 27 histologic LG), cytologic grading correctly identified 7 of the 12 HG cases, yielding a sensitivity of 58.3% (95% CI: 30.4%-82.5%). Twenty-six of 27 LG cases were accurately categorized as LG on cytology, resulting in a specificity of 96.3% (95% CI: 81.7%-99.8%). The positive predictive value for cytologically diagnosed HG cases was 87.5% (7 of 8; 95% CI: 52.9%-97.8%), and the negative predictive value (LG accuracy) was 83.9%. Overall, cytologic grading demonstrated an accuracy of 84.6% (33 of 39; 95% CI: 69.5%-93.0%). The most common diagnosis among the LG cases accurately graded was acinic cell carcinoma. HG-mucoepidermoid carcinoma (MEC) was the most common diagnosis among HG cases accurately graded. There were seven cases (17.5%) with cytology-histology discordances, four of which involved SUMP tumors that were HG malignancies by histology. Three of the discrepancies involved a histologic diagnosis of adenoid cystic carcinoma.</p><p><strong>Conclusion: </strong>The study showed an overall high accuracy for cytologic grading of salivary gland neoplasms. Discordance in cytologic grading was more frequent in the SUMP category and involved a histologic diagnosis of HG adenoid cystic carcinoma. Communication with the clinical team should be in place, especially when grading cannot be provided with confidence, and in that situation, suggesting intraoperative consultation for management decisions seems appropriate.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Combined With FNA-Tg Predicts the Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.","authors":"Yan Liu, Ling Xiang, Yi Wang, Noorazrul Azmie Yahya, Jing-Kun Yin, Wei Li, Hamzaini Bin Abdul Hamid, Jia-Ning Chai, Hanani Abdul Manan","doi":"10.1002/dc.25489","DOIUrl":"https://doi.org/10.1002/dc.25489","url":null,"abstract":"<p><strong>Objective: </strong>The present study analyzed typical ultrasound manifestations and fine-needle aspiration thyroglobulin (FNA-Tg) levels to investigate their association with cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC).</p><p><strong>Methods: </strong>The data of 139 PTC patients with ultrasonically suspected cervical lymph node metastasis treated in our hospital from December 2022 to November 2023 were retrospectively analyzed. All included patients underwent ultrasound examination of cervical lymph nodes, fine needle aspiration cytology (FNA-C) examination, and ultrasound-guided lymph node aspiration eluent thyroglobulin (FNA-Tg). Typical ultrasound signs for diagnosing cervical lymph node metastasis (US-M) and ultrasound-guided FNA-Tg for diagnosing cervical lymph node metastasis were compared and analyzed.</p><p><strong>Results: </strong>Results indicate that 71 patients were diagnosed with cervical lymph node metastasis through surgery and subsequently included in the metastatic group; the remaining 68 patients were included in the nonmetastatic group. The FNA-Tg value in the metastatic group was higher than that in the nonmetastatic group; the difference was significant (p < 0.001). The AUC values for diagnosing cervical lymph node metastasis in PTC patients using US-M, FNA-Tg, and US-M+FNA-Tg were 0.854, 0.927, and 0.952. When the cut-off value of FNA-Tg was 229.1 ng/mL, the sensitivity and specificity for diagnosing cervical lymph node metastasis in PTC patients were 84.5% and 89.5%.</p><p><strong>Conclusions: </strong>Ultrasound-guided FNA-Tg level is closely related to cervical lymph node metastasis in patients with PTC. The combination of ultrasound examination and FNA-Tg testing significantly enhances the accuracy of predicting lateral cervical lymph node metastasis in patients with PTC.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}