Diagnostic Cytopathology最新文献

{"title":"Diagnostic Utility of Clusterin in Fine Needle Aspiration Biopsy and Core Biopsies of Hepatocellular Carcinoma.","authors":"Bhawana Dhiman, Reetu Kundu, Radhika Srinivasan, Suvradeep Mitra, Naveen Kalra, Madhumita Premkumar, Ajay Kumar Duseja","doi":"10.1002/dc.25473","DOIUrl":"https://doi.org/10.1002/dc.25473","url":null,"abstract":"<p><strong>Background: </strong>Several immunohistochemical markers are available for demonstrating hepatocytic differentiation, thereby confirming the diagnosis of hepatocellular carcinoma (HCC). Clusterin is a new marker of malignant hepatocytes, not evaluated in fine needle aspiration biopsy (FNAB) samples. Hence, we evaluated its diagnostic utility in FNAB cell blocks (CB) and core biopsy samples.</p><p><strong>Methods: </strong>A total of 47 cases of HCC diagnosed on FNAB with CB (41)/core biopsy (6) were retrieved. For comparison, CB from metastatic adenocarcinoma (15) and cases with incidental benign hepatocytes (12) were included. Immunohistochemistry (IHC) for clusterin was performed and the 3 groups were compared to derive its sensitivity and specificity. Canalicular expression was considered positive for hepatocytic differentiation.</p><p><strong>Results: </strong>The cohort comprised 47 cases of HCC, with 43 (91.5%) male and 4 (8.5%) female patients with an age range of 20-78 years. On clusterin IHC, benign hepatocytes showed a track-like canalicular pattern whereas in HCC, typical enhanced canalicular positivity (3+ intensity) was seen in 32/47 (68%) cases, 17 of which additionally showed cytoplasmic positivity. Only cytoplasmic positivity was noted in 7 HCC cases and was considered negative. All cases of well differentiated (6/6), 67.6% (25/37) of moderately differentiated, and 25% (1/4) of poorly differentiated HCC showed enhanced canalicular positivity, whereas metastatic adenocarcinoma showed cytoplasmic (2/15) or nucleocytoplasmic (1/15) positivity only.</p><p><strong>Conclusion: </strong>IHC for clusterin with enhanced canalicular pattern of expression revealed 68% sensitivity and 100% specificity for HCC, aiding its distinction from metastatic adenocarcinoma and benign hepatocytes in FNAB samples, thereby confirming its diagnostic utility.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Testing Using ThyGeNEXT/ThyraMIR in Thyroid Nodules With Indeterminate Cytology: A Single Medical Institute Experience.","authors":"Zhongbo Yang, Komal Ijaz, Magda Esebua","doi":"10.1002/dc.25474","DOIUrl":"https://doi.org/10.1002/dc.25474","url":null,"abstract":"<p><strong>Background: </strong>Up to 30% of thyroid nodules, by fine needle aspiration (FNA), have indeterminate cytology, including Bethesda III (atypia of undetermined significance [AUS]), IV (follicular neoplasm/suspicious for follicular neoplasm [FN/SFN]), and V (suspicious for malignancy). Molecular testing is utilized for further risk stratification of these indeterminate thyroid nodules. A multiplatform test (MPTX), one of the commercially offered molecular tests, combines next-generation sequencing panel (ThyGeNEXT) with microRNA expression classifier (ThyraMIR) to help with risk stratification. This study aimed to evaluate the performance of MPTX in cytologically indeterminate thyroid nodules in real-world experience.</p><p><strong>Methods: </strong>All cases with indeterminate thyroid FNA results and corresponding MPTX test results in a period of 5 years were searched and retrieved. Subsequent clinical or surgical follow-up information was obtained. Molecular test results were compared to the histologic diagnoses. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated accordingly.</p><p><strong>Results: </strong>A total of 106 cases were identified in the search, including 89 Bethesda III and 17 Bethesda IV. Overall MPTX results were negative in 59 cases, positive in 36 cases, and nondiagnostic in 11 cases. Only 17% of cases with negative molecular results had surgery, whereas 86% of those with positive molecular results had surgical follow-up. The false negative rate and false positive rate based on cytologic-histologic correlation (CHC) alone were 70% and 29%, respectively. In addition, based on both surgical and clinical follow-up data, the MPTX tests had an overall sensitivity of 76%, specificity of 75%, NPV of 83%, and PPV of 67%.</p><p><strong>Conclusions: </strong>This study showed that more than half (56%) of the thyroid nodules with indeterminate cytology had benign molecular results by MPTX testing. The MPTX test showed moderate to high NPV and moderate PPV, suggesting that the MPTX test can be useful as an ancillary study to further risk-stratify cytologically indeterminate thyroid nodules. It is critical, however, to know the limitations of this assay, and the molecular results should be considered in correlation with clinical and radiologic findings.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleural Metastasis of Merkel Cell Carcinoma","authors":"Sina Maghsoudlou,&nbsp;Marc Pusztaszeri,&nbsp;Mauro Saieg","doi":"10.1002/dc.25472","DOIUrl":"10.1002/dc.25472","url":null,"abstract":"<p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often challenging to diagnose due to its morphological resemblance to other malignancies. Diagnosis is typically confirmed by immunohistochemistry (IHC), with most cases being positive for both neuroendocrine and epithelial markers, particularly the characteristic dot-like cytoplasmic pattern seen with Cytokeratin 20 (CK20). This case report describes a 68-year-old male with MCC originating in the left elbow, who developed pleural metastasis 10 months after initial diagnosis and 4 months following a pathologic complete response. IHC analysis confirmed MCC in the pleural fluid with positive markers including: CK20, chromogranin, synaptophysin, MCC polyomavirus, and SATB2, the latter emerging as a valuable adjunct in distinguishing MCC from other neuroendocrine tumors.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"308-311"},"PeriodicalIF":1.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.25472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Malignancy in Patients With a Repeated Diagnosis of Bethesda Category in Thyroid Nodules Who Underwent Surgery.","authors":"Veli Vural, Hasan Calis, Burhan Mayir, Ilhan Tasdoven, Bulent Comcali, Osman Cem Yilmaz, Tolga Dinc, Ozgur Dandin, Guldeniz Karadeniz Cakmak, Ali Ugur Emre, Nusret Yilmaz, Cumhur Arici","doi":"10.1002/dc.25463","DOIUrl":"https://doi.org/10.1002/dc.25463","url":null,"abstract":"<p><p>Fine Needle Aspiration Biopsy (FNAB) is a diagnostic modality commonly utilized in thyroid nodules, and the incorporation of the Bethesda System further enhances its diagnostic performance. However, category III nodules according to the Bethesda System are challenging due to their suspicious cytology, which renders an indeterminate risk of malignancy and requires repeated FNAB. Previous studies emphasize the possible advantage of repeated FNAB and some clinical and radiological markers in stratification of malignancy risk, though the exact predictive factors for malignancy among Bethesda III cases remain inadequately known. The aim of this study is to focus on the analysis of clinical and radiological predictors influencing malignancy risk in patients with repeated Bethesda III diagnoses. In this retrospective study, the authors reviewed three hospitals from 2015 to 2022 and retrospectively identified 120 patients with a repeat FNAB diagnosis of Bethesda III who underwent thyroid surgery. Demographic, clinical, and ultrasound data were collected, and logistic regression was performed to identify independent predictors of malignancy. The rate of malignancy was 39.2%, which was much higher than in previous reports. There were strong associations with gender, male gender, and increased risk of malignancy, with a cumulative odds ratio of 3.67. These findings suggest that repeat FNAB in association with patient-specific factors and nodule-specific factors, such as gender and ultrasound findings, may improve the prediction of the risk of malignancy in Bethesda III thyroid nodules. This could translate into better clinical decision-making, avoiding unnecessary surgery, and improved outcomes for the patient overall.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series and Literature Review of Angiosarcoma With Malignant Effusion-A Challenging Cytologic Diagnosis With Dire Prognostic Implications.","authors":"Jamie C Y Lam, Iris Y H Liu, Joanna K M Ng, Joshua J X Li","doi":"10.1002/dc.25471","DOIUrl":"https://doi.org/10.1002/dc.25471","url":null,"abstract":"<p><p>Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course. Key clinical hints, useful cytological features, and immunocytochemical markers in the diagnostic approach of this entity are presented.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FNAC Diagnosis of Rare Port-Site Metastasis in Gallbladder Cancer Post-Cholecystectomy","authors":"Arushi Gupta,&nbsp;Durre Aden,&nbsp;Sabina Khan,&nbsp;Nehal Ahmad","doi":"10.1002/dc.25469","DOIUrl":"10.1002/dc.25469","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Port-site metastasis (PSM) following laparoscopic cholecystectomy (LC) for unsuspected gallbladder carcinoma (GBC) is a rare occurrence. Fine Needle Aspiration Cytology is a simple and time-saving technique, thus it has proven useful in diagnosing such metastases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>We present a case of a 45-year-old female who developed painful, multinodular epigastric swellings 2 years post-LC, initially performed for presumed benign cholelithiasis. FNAC of the port-site swelling revealed hypercellular smears with malignant epithelial cells, leading to a diagnosis of poorly differentiated malignancy. Follow-up imaging and histopathology confirmed incidental primary gallbladder carcinoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Port site metastasis in gallbladder carcinoma has a poor prognosis; thus, early detection and intervention are essential. Advanced imaging and FNAC under guidance serve as critical tools for early diagnosis, especially in cases lacking prior histological examination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the critical role of vigilant post-surgical monitoring and comprehensive histopathological analysis following cholecystectomy, especially in areas with a higher incidence of gallbladder carcinoma. FNAC also plays a valuable diagnostic modality for early detection and management of Port site metastasis in unsuspected gallbladder carcinoma cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"E115-E118"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tzanck Smear: Old Handy Tool in Modern Dermatology.","authors":"Sachin Chaudhari, Nisha Meshram, Milind Bhatkule, Ankita Srivastava, Rasika Gadkari","doi":"10.1002/dc.25470","DOIUrl":"https://doi.org/10.1002/dc.25470","url":null,"abstract":"<p><p>Tzanck smears, first introduced by Arnault Tzanck, are widely used in dermatology for the cytodiagnosis of cutaneous lesions. In the current era of evidence-based medicine with the availability of more confirmatory sophisticated tests, the use of this bedside tool is limited. In this article, the authors tried to assess the utility of Tzanck smear in various dermatological disorders. Findings in the Pemphigus group of disorders were studied in detail with complete and incomplete changes. Results were compared with histopathology, anti-desmoglein antibody status, and in combination. Further subtle features of the acantholytic cells were studied in detail. The sensitivity and specificity with histopathology and anti-desmoglein antibodies were 80.70%, 68.18% and 82.75%,100%. When patients were having either follow-up of histopathology or anti-desmoglein antibodies, each sensitivity was 81.01% and specificity was 87.50%. Complete acantholytic cells were predominant in 39.18%, and incomplete cells were predominant in 60.32% of cases. Rounding was the most consistent feature followed by nuclear enlargement. Streptocytes, dyskeratosis, and tadpole cells were also seen in a few cases. Other diagnoses of viral infections, like molluscum contagiosum (4 cases) and Herpes virus cytopathic effects (25 cases), were also observed in the study. Finally, Tzanck smear is still useful in dermatology, which can aid in rapid diagnosis and starting early treatment. Incomplete acantholytic cells, when seen in smear, help to pick up Pemphigus disorders even if all the classical features are not seen.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Prevalence and Genotype Distribution of High-Risk Human Papillomavirus in Varamin (Iran).","authors":"Mahboubeh Jamshidi, Shohreh Zare Karizi, Hoda Baghizadeh, Vahid Ezzatizadeh, Fatemeh Shasti Karimi, Ghasem Khazaee, Zahra Salehi, Amir Javadi, Amitis Ramezani, Mona Sadat Larijani, Amir Houshang Nejadeh","doi":"10.1002/dc.25465","DOIUrl":"https://doi.org/10.1002/dc.25465","url":null,"abstract":"<p><p>Cervical cancer is the fourth most common type of female malignancy worldwide. Although appropriate algorithms are available for precise HPV testing in order to manage women with abnormal Papanicolaou smears, region-to-region adoption is really critical. The present study aimed at cervical cell cytology assessment as well as HPV genotyping in cervical specimens. A total of 1047 samples of the women who attended for the routine referral indications were examined in four laboratories in Varamin City (Tehran Province) from April 2021 to May 2022. Genetic analysis of cervical cells was performed by PCR and reverse dot blotting. A total of 994 samples were also investigated with Pap staining, and analysis was performed based on the Bethesda 2014 system. Among the total participants with a mean age of 34.2 years, HPV prevalence was detected in 40.12%. The highest HPV infection was determined inthe 31-40-year-old population. Furthermore, 22.15% of the detected HPVs belonged to high-risk genotypes. The most frequent high-risk HPV genotype was HPV-16, accounting for 6.78%. In addition, 951 (95.67%) women had normal NILM cytology test results, whereas 43 (4.32%) demonstrated ASC-US lesions. HPV-16 was the most prevalent type in ASC-US lesions. Furthermore, there was a significant association between the high-risk HPVs and changes in the Pap smear results (p < 0.001). Considering the high prevalence of high-risk HPV genotypes in the studied population, the genotyping technique is recommended as a priority to determine potential HPV infection, rather than liquid Pap smear analysis as a complementary approach to liquid Pap smear analysis to enhance cervical cancer screening strategies. The findings of this study can contribute to policymaking by providing updated local data on HPV prevalence, which may support vaccination strategies and screening programs in Iran.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus Prevalence and Genotype Distribution Among Women With Cervical Cytological Abnormalities in Urumqi, Xinjiang, China.","authors":"Jing Ma, Min Yang, Guohong Huang","doi":"10.1002/dc.25467","DOIUrl":"https://doi.org/10.1002/dc.25467","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China.</p><p><strong>Methods: </strong>The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction.</p><p><strong>Result: </strong>The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25-34 year-olds, but in the 35-44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions.</p><p><strong>Conclusion: </strong>Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of SOX17 Immunohistochemical Stain in Serous Fluid Cytology Cell Block Specimens","authors":"Neharika Shrestha,&nbsp;Xulang Zhang,&nbsp;Syed M. Gilani","doi":"10.1002/dc.25468","DOIUrl":"10.1002/dc.25468","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The identification of metastatic tumors in serous fluid cytology specimens (SFCS) has always been a challenge. In this study, we explored SOX17 as an immunohistochemical (IHC) marker for the diagnosis of metastatic gynecologic tumors in body fluid specimens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We selected 97 tumor cases, including 85 SFCS with adequate cell block material (from gynecologic primary, <i>n</i> = 30 and others, <i>n</i> = 55) and 12 histology specimens (thymic and thyroid tumors). SOX17 IHC was performed on all selected cases, and results were interpreted as positive or negative. Positive results were further characterized by intensity (nuclear staining) as weak (1+), moderate (2+), and strong (3+) and percentage of positive cells as focal (&lt; 10%), patchy (10%–50%) and diffuse (&gt; 50%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In SFCS of gynecologic primary tumors, SOX17 exhibited strong nuclear staining in 28 out of 30 tumors, with two cases showing moderate staining. All non-gynecologic metastatic tumors in effusion cytology specimens were SOX17-negative except for one case of renal cell carcinoma, which displayed a moderate patchy staining pattern. All histology cases consisting of thymic and thyroid tumors were negative for SOX17.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this study, all tumors of gynecologic tract origin in effusion SFCS were SOX17 positive, while all other non-gynecologic tumors were negative for SOX17 except for one case. This finding suggests that SOX17 IHC is an excellent addition to the IHC panel while working up tumors at metastatic sites, specifically when gynecologic primary tumors are in the differential diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"304-307"},"PeriodicalIF":1.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}