Hadi Sultan, Zohre Sadeghian, Elvia Goez-Gutierrez, M Julia Diacovo, Esther Yoon
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引用次数: 0
Abstract
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms typically arising in the stomach and small intestine and rarely involving extra-gastrointestinal organs. While fine-needle aspiration (FNA) offers reliable diagnosis, exfoliation of GIST cells into body fluids is exceedingly rare and diagnostically challenging. We report a case of a 69-year-old male with metastatic GIST in ascitic fluid. The cells revealed atypical epithelioid morphology with high nuclear-to-cytoplasmic ratio and nuclear irregularities. Immunohistochemistry (IHC) demonstrated positivity for CD117 and DOG1. Diagnosis requires integration of clinical history, cytomorphology, and a broad IHC panel. Awareness of its cytologic features, application of mesenchymal markers, and molecular testing are critical for accurate diagnosis and effective clinical management.
期刊介绍：
Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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