Metastatic Head and Neck Squamous Cell Carcinoma: Cytomorphological Spectrum on Fine Needle Aspiration Biopsy Cytology and Its Relevance.

IF 1 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Dipanwita Biswas, Aadya Kerkar, Nuli Muni Kiran, Sushmita Ghoshal, Suvradeep Mitra, Nalini Gupta, Amanjit Bal, Radhika Srinivasan
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Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) frequently metastasizes to the cervical lymph nodes and is subjected to fine needle aspiration biopsy cytology (FNABC). The aim of this study was to describe the cytomorphological spectrum and explore the association with the primary site of origin and the short-term outcome following radiation therapy.

Methods: A retrospective cytomorphological evaluation was performed on 338 cases of metastatic squamous cell carcinoma to cervical lymph nodes from HNSCC primaries. The clinical details including the age, sex, primary site of origin confirmed on histopathology, composite stage, and outcome at 1-year follow-up (86) were obtained from the records. An exploratory analysis was performed to derive any association of the cytomorphological features with the primary site of origin and short-term outcome.

Results: The patients' age ranged from 28 to 89 years (mean, 56.6 years) with marked male preponderance, and the majority in Stage IV. The primary site was the oral cavity (45.2%) followed by the oropharynx (37%), hypopharynx (8.5%), nasopharynx (6.2%) and larynx (3.1%). Cytomorphology revealed keratinization of any degree in 86% of cases. The background was necroinflammatory, fluidy, or reactive lymphocytic with granulomatous reaction in 5% of cases. The chromatin pattern (vesicular, coarse or dense hyperchromatic), presence of nucleoli, and reactive lymphocytic background showed site-specific differences. However, no cytomorphological parameter showed any association with short-term outcome.

Conclusion: Metastatic HNSCC to the cervical lymph nodes presents a broad cytomorphological spectrum with no specific association with outcome.

转移性头颈部鳞状细胞癌:细针穿刺活检细胞学的细胞形态学谱及其相关性。
背景:头颈部鳞状细胞癌(HNSCC)经常转移到颈部淋巴结,需要进行细针穿刺活检细胞学检查(FNABC)。本研究的目的是描述细胞形态学谱,并探讨与原发部位和放射治疗后短期结果的关系。方法:对338例HNSCC原发颈部淋巴结转移性鳞状细胞癌进行回顾性细胞形态学分析。临床细节包括年龄、性别、组织病理学证实的原发部位、复合分期和1年随访结果(86例)。进行探索性分析,以得出细胞形态学特征与原发部位和短期预后之间的任何关联。结果:本组患者年龄28 ~ 89岁,平均56.6岁,男性居多,以IV期居多,以口腔为主(45.2%),其次为口咽(37%)、下咽(8.5%)、鼻咽(6.2%)、喉(3.1%)。细胞形态学显示86%的病例有不同程度的角化。背景为坏死性炎症、流质或反应性淋巴细胞伴肉芽肿反应(5%)。染色质模式(水泡状、粗大或致密的深染)、核仁的存在和反应性淋巴细胞背景显示出位点特异性差异。然而,没有细胞形态学参数显示与短期预后有任何关联。结论:转移到颈部淋巴结的HNSCC表现出广泛的细胞形态学谱,与预后无特异性关联。
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来源期刊
Diagnostic Cytopathology
Diagnostic Cytopathology 医学-病理学
CiteScore
2.60
自引率
7.70%
发文量
163
审稿时长
3-6 weeks
期刊介绍: Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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