Diagnostic and interventional radiology最新文献

{"title":"Computed tomography for the diagnosis of gastroesophageal varices and risk assessment in patients with cirrhosis: a systematic review and meta-analysis","authors":"Jinkui Li, Yuanhui Zhu, Jinrong Ni, Lili Wang, Junqiang Lei","doi":"10.4274/dir.2024.242723","DOIUrl":"10.4274/dir.2024.242723","url":null,"abstract":"<p><strong>Purpose: </strong>This meta-analysis aimed to evaluate the diagnostic accuracy of computed tomography (CT) for detecting gastroesophageal varices (GEVs) and identify high-risk GEVs in patients with cirrhosis.</p><p><strong>Methods: </strong>A comprehensive search of databases identified 28 studies reporting on CT-based diagnosis for GEVs confirmed via endoscopy. Meta-analyses were conducted to calculate pooled sensitivity (SEN) and pooled specificity (SPE), positive likelihood ratio (PLR) and negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC).</p><p><strong>Results: </strong>Based on the number of patients (or varices), the pooled SEN, SPE, PLR, NLR, DOR, and AUC of CT-based diagnosis were estimated at 0.91 (0.92), 0.81 (0.45), 4.82 (1.67), 0.11 (0.17), 42.47 (10.26), and 0.93 (0.94), respectively, for any GEV and at 0.89 (0.89), 0.90 (0.79), 8.86 (4.28), 0.12 (0.14), 75.71 (30.19), and 0.95 (0.85), respectively, for high-risk GEVs. Subgroup analyses indicated that CT had a higher diagnostic accuracy for esophageal varices compared with gastric varices (AUC: 0.93 vs. 0.89, <i>P</i> < 0.05), and the 64-slice CT yielded superior SEN compared with 16-slice and <16-slice CT (AUC: 0.97 vs. 0.92 and 0.82, respectively, <i>P</i> < 0.05). Prospective studies demonstrated higher diagnostic accuracy than retrospective studies (AUC: 0.95 vs. 0.90, <i>P</i> < 0.05). Regarding variceal size, a cut-off of 3 mm and 5 mm discriminated between low- and high-risk individuals, respectively, with high diagnostic accuracy (AUC: 0.992 vs. 0.997, <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>CT demonstrates promising diagnostic accuracy for identifying gastroesophageal varices and distinguishing high-risk GEVs in patients with cirrhosis. Further research to validate optimal variceal size cut-offs is warranted to enhance clinical utility.</p><p><strong>Clinical significance: </strong>Such a high diagnostic accuracy of CT scans for predicting varices is clinically meaningful for patients with cirrhosis accompanied by portal hypertension. If high-risk varices are identified at CT scans, early intervention would be helpful to reduce the risk of variceal bleeding.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring radiomics research quality scoring tools: a comparative analysis of METRICS and RQS","authors":"Burak Koçak, Tugba Akinci D'Antonoli, Renato Cuocolo","doi":"10.4274/dir.2024.242793","DOIUrl":"10.4274/dir.2024.242793","url":null,"abstract":"","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography-guided cryoablation in treating adrenal metastases: a retrospective single-center study.","authors":"Claudio Pusceddu, Eliodoro Faiella, Claudio Cau, Pierluigi Rinaldi, Luca Melis, Salvatore Marsico","doi":"10.4274/dir.2024.242956","DOIUrl":"https://doi.org/10.4274/dir.2024.242956","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effectiveness and safety of computed tomography (CT)-guided cryoablation for treating adrenal metastases (AMs).</p><p><strong>Methods: </strong>This study included 12 patients treated with 13 CT-guided cryoablation procedures for AMs between 2016 and 2020. Patients were selected based on specific criteria, including tumor size ≤5 cm and suitability for surgery. Procedures were performed by expert radiologists, with comprehensive monitoring for complications and regular post-treatment evaluations.</p><p><strong>Results: </strong>The primary technical success rate was 91.7%, with a secondary success rate of 100% following repeat procedures. Over an 8-24-month follow-up period, local tumor recurrence was observed in 16.7% of patients, and systemic progression occurred in five (41.6%) patients. The average overall survival duration was 26.4 ± 5.6 months.</p><p><strong>Conclusion: </strong>CT-guided cryoablation is a feasible and effective treatment option for AMs, demonstrating high technical success rates and manageable complications.</p><p><strong>Clinical significance: </strong>This study highlights CT-guided cryoablation as a promising treatment for AMs, offering a minimally invasive alternative to surgery with good local control and safety profile. Further research, including multi-center studies, is needed to confirm these findings.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of flow diverter stents in the treatment of bifurcation cerebral aneurysms: single-center experience.","authors":"Yerbol Makhambetov, Aiman Maidan, Chingiz Nurimanov, Assylbek Kaliyev, Baurzhan Kunakbayev, Nurtay Nurakay, Serik Dyussembayev, Nursultan Makhambetov","doi":"10.4274/dir.2024.242903","DOIUrl":"https://doi.org/10.4274/dir.2024.242903","url":null,"abstract":"<p><strong>Purpose: </strong>The use of flow diverter (FD) stents is continually expanding. Aneurysms on arterial bifurcation typically have an undesirable anatomical form, are frequently wide-necked, and include one or more side-branch arteries. In recent years, the off-label use of flow diversion in treating intracranial aneurysms beyond the internal carotid artery has become increasingly popular. This study reports our center's initial experience treating bifurcation aneurysms with FD devices, documenting occlusion outcomes using the O'Kelly-Marotta and modified Cekirge-Saatci scales, as well as the safety of FD usage in bifurcation locations.</p><p><strong>Methods: </strong>This retrospective, single-center study analyzed a prospectively maintained database of patients with cerebral aneurysms treated endovascularly. The study identified bifurcation aneurysms that were treated between January 2019 and May 2022 by placing an FD device covering the neck of the aneurysm.</p><p><strong>Results: </strong>Our short series suggests that flow diversion is a viable therapeutic option for bifurcation aneurysms with favorable angiographic outcomes.</p><p><strong>Conclusion: </strong>In highly selective cases, flow diversion may be considered for treating bifurcation aneurysms in patients who will undergo follow-up examinations in the future.</p><p><strong>Clinical significance: </strong>Flow diversion has emerged as a valuable technique in the management of bifurcation aneurysms, offering the potential for satisfactory occlusion and long-term outcomes.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility and interpretability in radiomics: a critical assessment.","authors":"Aydın Demircioğlu","doi":"10.4274/dir.2024.242719","DOIUrl":"https://doi.org/10.4274/dir.2024.242719","url":null,"abstract":"<p><p>Radiomics aims to improve clinical decision making through the use of radiological imaging. However, the field is challenged by reproducibility issues due to variability in imaging and subsequent statistical analysis, which particularly affects the interpretability of the model. In fact, radiomics extracts many highly correlated features that, combined with the small sample sizes often found in radiomics studies, result in high-dimensional datasets. These datasets, which are characterized by containing more features than samples, have different statistical properties than other datasets, thereby complicating their training by machine learning and deep learning methods. This review critically examines the challenges of both reproducibility issues and interpretability, beginning with an overview of the radiomics pipeline, followed by a discussion of the imaging and statistical reproducibility issues. It further highlights how limited model interpretability hinders clinical translation. The discussion concludes that these challenges could be mitigated by following best practices and by creating large, representative, and publicly available datasets.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consolidation in the right middle lobe in pediatric bronchial-pulmonary artery shunt: radiology's Aunt Minnie?","authors":"Chi Wang, Rongchang Wu, Zihan Wang, Shuai Ma, Xinyu Yuan, Yuchun Yan, Yun Peng","doi":"10.4274/dir.2024.242908","DOIUrl":"https://doi.org/10.4274/dir.2024.242908","url":null,"abstract":"<p><strong>Purpose: </strong>By retrospectively studying the chest computed tomography (CT) data of children with bronchial artery (BA)-pulmonary artery fistula, this study summarizes the characteristic imaging features of the disease and provides imaging support for the diagnosis and clinical treatment of these children.</p><p><strong>Methods: </strong>Digital subtraction angiography and CT angiography data were collected from 74 children with pulmonary hemorrhage following BA embolization. Bronchial-pulmonary shunt was present in 30 cases.</p><p><strong>Results: </strong>Of the 74 children with pulmonary hemorrhage in this study, seven exhibited signs of consolidation in the middle lobe of the right lung, and bronchial-pulmonary shunt existed in all of them. A total of 30 children with BA-pulmonary artery shunt (PAS) had BA tortuosity and thickening. Regarding primary BA-PAS, the middle lobe and lower lobe of the right lung were involved in 94.1% (16) of the children. Those with a fistula located in the middle lobe of the right lung accounted for 58.8% (10 cases), of which 40.0% (four cases) presented consolidation. In this study, 41.2% (seven) of the children with primary BA-PAS exhibited no abnormal changes on chest CT, and 58.8% (10 cases) exhibited abnormal changes in the unilateral lung.</p><p><strong>Conclusion: </strong>For children with pulmonary hemorrhage who have consolidation in the right middle lobe, the formation of BA-PAS should be anticipated. The possibility of primary BA-PAS should not be disregarded in children with pulmonary hemorrhage with tortuosity and dilation of BAs, despite no apparent abnormalities on lung CT, or ground-glass density or consolidation on only one side.</p><p><strong>Clinical significance: </strong>The chest CT of patients with pulmonary hemorrhage showed consolidation of the right middle lobe of the lung, which was highly likely to indicate BA-PAS.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating small coronary stents with dual-source photon-counting computed tomography: effect of different scan modes on image quality and performance in a phantom.","authors":"Thomas Stein, Constantin von Zur Muhlen, Niklas Verloh, Till Schürmann, Tobias Krauss, Martin Soschynski, Dirk Westermann, Jana Taron, Elif Can, Christopher L Schlett, Fabian Bamberg, Christopher Schuppert, Muhammad Taha Hagar","doi":"10.4274/dir.2024.242893","DOIUrl":"10.4274/dir.2024.242893","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to assess the feasibility and image quality of dual-source photon-counting detector computed tomography (PCD-CT) in evaluating small-sized coronary artery stents with respect to different acquisition modes in a phantom model.</p><p><strong>Methods: </strong>Utilizing a phantom setup mimicking the average patient's water-equivalent diameter, we examined six distinct coronary stents inflated in a silicon tube, with stent sizes ranging from 2.0 to 3.5 mm, applying four different CT acquisition modes of a dual-source PCD-CT scanner: \"high-pitch,\" \"sequential,\" \"spiral\" (each with collimation of 144 × 0.4 mm and full spectral information), and \"ultra-high-resolution (UHR)\" (collimation of 120 × 0.2 mm and no spectral information). Image quality and diagnostic confidence were assessed using subjective measures, including a 4-point visual grading scale (4 = excellent; 1 = non-diagnostic) utilized by two independent radiologists, and objective measures, including the full width at half maximum (FWHM).</p><p><strong>Results: </strong>A total of 24 scans were acquired, and all were included in the analysis. Among all CT acquisition modes, the highest image quality was obtained for the UHR mode [median score: 4 (interquartile range (IQR): 3.67-4.00)] (<i>P</i> = 0.0015, with 37.5% rated as \"excellent\"), followed by the sequential mode [median score: 3.5 (IQR: 2.84-4.00)], <i>P</i> = 0.0326 and the spiral mode [median score: 3.0 (IQR: 2.53-3.47), <i>P</i> > 0.05]. The lowest image quality was observed for the high-pitch mode [median score: 2 (IQR: 1- 3), <i>P</i> = 0.028]. Similarly, diagnostic confidence for evaluating stent patency was highest for UHR and lowest for high-pitch (<i>P</i> < 0.001, respectively). Measurement of stent dimensions was accurate for all acquisition modes, with the UHR mode showing highest robustness (FWHM for sequential: 0.926 ± 0.061 vs. high-pitch: 0.990 ± 0.083 vs. spiral: 0.962 ± 0.085 vs. UHR: 0.941 ± 0.036, <i>P</i> = non-significant, respectively).</p><p><strong>Conclusion: </strong>Assessing small-sized coronary stents using PCD-CT technology is feasible. The UHR mode offers superior image quality and diagnostic confidence, while all modes show consistent and accurate measurements.</p><p><strong>Clinical significance: </strong>These findings highlight the potential of PCD-CT technology, particularly the UHR mode, to enhance non-invasive coronary stent evaluation. Confirmatory research is necessary to influence the guidelines, which recommend cardiac CT only for stents of 3 mm or larger.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor re: evaluating Microsoft Bing with ChatGPT-4 for the assessment of abdominal computed tomography and magnetic resonance imaging.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4274/dir.2024.242994","DOIUrl":"https://doi.org/10.4274/dir.2024.242994","url":null,"abstract":"","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximum standardized uptake value-to-tumor size ratio in fluorodeoxyglucose F18 positron emission tomography/computed tomography: a simple prognostic parameter for non-small cell lung cancer.","authors":"Soo Jeong Kim, Koeun Lee, Hyun Joo Lee, Du-Young Kang, Young Hwan Kim","doi":"10.4274/dir.2024.242837","DOIUrl":"https://doi.org/10.4274/dir.2024.242837","url":null,"abstract":"<p><strong>Purpose: </strong>By correcting the effect of tumor size on metabolic activity, the maximum standardized uptake value-to-tumor size (SUV_max:tumor size) ratio on fluorodeoxyglucose F18 positron emission tomography (¹⁸F-FDG PET)/computed tomography (CT) scans can be a prognostic parameter of non-small cell lung cancer (NSCLC). The current study evaluates the prognostic value of SUV_max:tumor size ratio on pretreatment ¹⁸F-FDG PET/CT scans in patients with NSCLC. Furthermore, the SUV_max:tumor size ratio is compared with other established PET parameters.</p><p><strong>Methods: </strong>This study included 108 patients with NSCLC who underwent pretreatment ¹⁸F-FDG PET/CT scans and curative lung surgery. The associations between the SUV_max:tumor size ratio and other conventional PET parameters were investigated. The recurrence-free survival according to the SUV_max:tumor size ratio was also analyzed. In addition, the SUV_max:tumor size ratio was compared according to postoperative pathologic findings.</p><p><strong>Results: </strong>In total, 72 (66.7%) of the 108 participants presented with adenocarcinoma (ADC). Nineteen (17.6%) patients experienced recurrence during a median follow-up period of 32.3 months. The median SUV max:tumor size ratio was 2.37 (1.23 for ADCs and 3.90 for other histologic types). The SUV_max:tumor size ratio was associated with SUV_max and mean SUV, as well as metabolic tumor volume and total lesion glycolysis. Patients with an SUV_max:tumor size ratio higher than the median had a worse recurrence outcome than those with an SUV_max:tumor size ratio lower than the median. Participants with ADC who presented with lymphovascular invasion had a higher SUV_max:tumor size ratio than those without. The presence of lymph node metastasis and advanced histologic grade were associated with a high SUV_max:tumor size ratio in patients with ADC.</p><p><strong>Conclusion: </strong>The SUV_max:tumor size ratio on pretreatment ¹⁸F-FDG PET/CT scans was associated with aggressive tumor behavior and poor outcome in NSCLCs, particularly ADC.</p><p><strong>Clinical significance: </strong>The SUV_max:tumor size ratio on pretreatment ¹⁸F-FDG PET/CT scans has a prognostic value in patients with NSCLCs, especially ADC.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of catheter-directed sclerotherapy for ovarian endometrioma.","authors":"Jae Hwan Lee, Jihyung Yoon, Chong-Ho Lee, Kun Yung Kim, Chang Jin Yoon, Minuk Kim, Seul Ki Kim","doi":"10.4274/dir.2024.242874","DOIUrl":"https://doi.org/10.4274/dir.2024.242874","url":null,"abstract":"<p><strong>Purpose: </strong>Although favorable results have been reported on catheter-directed sclerotherapy (CDS) for ovarian endometrioma, a thorough evaluation of its long-term efficacy is lacking. This study evaluates the long-term efficacy and safety of CDS with 99% ethanol for treatment of ovarian endometrioma.</p><p><strong>Methods: </strong>Between January 2020 and February 2022, data from 33 consecutive patients with symptomatic ovarian endometriomas who underwent CDS were retrospectively evaluated. All patients underwent pre-procedural and 6- and 12-month post-procedural ultrasonography. To assess the effect on ovarian reserve, serum anti-Müllerian hormone (AMH) levels were measured before and after the procedure. Procedure-related complications were also assessed.</p><p><strong>Results: </strong>The mean volume of endometriomas decreased from 80.22 ± 66.43 to 0.73 ± 1.10 mL (<i>P</i> < 0.001), and the mean percentage of volume reduction was 98.99% ± 1.53%. No recurrences were observed during the follow-up period. In patients whose serum AMH levels were monitored for 1 year, no significant change in AMH level before and after CDS was observed (3.07 ± 1.81 vs. 2.72 ± 2.02 ng/mL, <i>P</i> = 0.190). One patient complained of moderate abdominal pain after CDS, which was conservatively managed.</p><p><strong>Conclusion: </strong>CDS remained safe and effective in treating ovarian endometrioma at the 1-year follow-up. Ovarian function after CDS was well preserved.</p><p><strong>Clinical significance: </strong>CDS is a safe and effective treatment option for patients with ovarian endometrioma without compromising ovarian function.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}