Diagnostic and interventional radiology最新文献

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Reply: Solitary plasmacytoma: a rare and unusual tumor of the liver. 回答:孤立性浆细胞瘤:一种罕见的肝脏肿瘤。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-08-19 DOI: 10.4274/dir.2025.253566
Nir Stanietzky, Khaled M Elsayes
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引用次数: 0
Evaluation of the congenital absence of the vas deferens with magnetic resonance imaging: preliminary findings. 磁共振成像对先天性输精管缺失的评价:初步结果。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-11-19 DOI: 10.4274/dir.2025.253612
Hakan İmamoğlu, Erdem Sarı, Özgür Karabıyık, Emre Can Akınsal, Gökmen Zararsız, Oğuz Ekmekçioğlu
{"title":"Evaluation of the congenital absence of the vas deferens with magnetic resonance imaging: preliminary findings.","authors":"Hakan İmamoğlu, Erdem Sarı, Özgür Karabıyık, Emre Can Akınsal, Gökmen Zararsız, Oğuz Ekmekçioğlu","doi":"10.4274/dir.2025.253612","DOIUrl":"10.4274/dir.2025.253612","url":null,"abstract":"<p><strong>Purpose: </strong>To date, no study provides definitive evidence for the pathogenesis of congenital absence of the vas deferens (CAVD). This study aims to evaluate the vas deferens (VD), particularly the intra-abdominal part and accompanying seminal vesicle (SV) pathologies, in search of an explanation for the pathogenesis of the disease using magnetic resonance imaging (MRI) in patients clinically diagnosed with CAVD.</p><p><strong>Methods: </strong>MRI scans of patients admitted to our center with clinically diagnosed unilateral CAVD (CUAVD) or bilateral CAVD (CBAVD) in the infertility clinic were retrospectively evaluated. SV hypoplasia, SV agenesis, the distal part of the VD close to the ampulla, and the intra-abdominal part of the VD were investigated. Additionally, the association of CAVD and SV pathologies was assessed.</p><p><strong>Results: </strong>Clinically and confirmed with scrotal sonography by evaluating the proximal part of the VD, 32 patients (62.7%) had CBAVD, and 19 patients (37.3) had CUAVD. In MRI, the intra-abdominal part of the VD was visible in 52.9% of all patients. The association between the intra-abdominal part of the VD and CAVD was statistically significant in the CBAVD patient group compared with the CUAVD group (Bonferroni-adjusted <i>P</i> value = 0.006). The intra-abdominal part of the VD dilatation is a new finding in CAVD and was not found in patients with CUAVD. Only 2 out of 51 patients (3.9%) had a standard SV.</p><p><strong>Conclusion: </strong>In the assessment of CAVD and accompanying SV pathologies, detailed findings are obtained by MRI even in the evaluation of the intra-abdominal part of the VD. Preliminary findings in this study are consistent with the theory of acquired vasal agenesis in CBAVD.</p><p><strong>Clinical significance: </strong>The detailed findings of an MRI may contribute to a better understanding of the disease.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"249-254"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of changes in dynamic contrast-enhanced magnetic resonance imaging and flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters from baseline to post-neoadjuvant therapy in predicting pathological response in breast cancer. 动态增强磁共振成像和氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描参数从基线到新辅助治疗后预测乳腺癌病理反应的变化比较
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-08-18 DOI: 10.4274/dir.2025.253391
Hüseyin Akkaya, Aygül Polat Kelle, Tuba Dalgalar Akkaya, Selim Özdemir, Kübra Karaaslan Erişen, Bozkurt Gülek
{"title":"Comparison of changes in dynamic contrast-enhanced magnetic resonance imaging and flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters from baseline to post-neoadjuvant therapy in predicting pathological response in breast cancer.","authors":"Hüseyin Akkaya, Aygül Polat Kelle, Tuba Dalgalar Akkaya, Selim Özdemir, Kübra Karaaslan Erişen, Bozkurt Gülek","doi":"10.4274/dir.2025.253391","DOIUrl":"10.4274/dir.2025.253391","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the value of differences (Δ) in parameters obtained via both dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) between baseline and post-neoadjuvant therapy in predicting the pathological response to neoadjuvant therapy in breast cancer.</p><p><strong>Methods: </strong>A total of 109 patients who underwent both baseline and post-neoadjuvant therapy DCE-MRI and <sup>18</sup>F-FDG PET/CT examinations were retrospectively analyzed. The DCE-MRI parameters and <sup>18</sup>F-FDG PET/CT parameters [metabolic tumor volume (MTV), standardized uptake value (SUV)<sub>max</sub>, SUV<sub>mean</sub>, and total lesion glycolysis] were recorded at both time points. Additionally, the Δs between these parameters were calculated. Postsurgical pathology reports were documented, and the patients were subsequently categorized into two groups: those exhibiting pathologic complete response (pCR) and those exhibiting partial response. Parameters from DCE-MRI and <sup>18</sup>F-FDG PET/CT were compared to determine which predicted pathological response to neoadjuvant therapy more effectively.</p><p><strong>Results: </strong>Patients with partial response demonstrated a higher rate of histologic grade 3 than those with pCR (<i>P</i> = 0.030). The only DCE-MRI parameter to indicate a significant difference between the two groups (<i>P</i> = 0.024) was the Δ(%)wash-out rate. Among the baseline parameters, only MTV successfully predicted pathological response (<i>P</i> = 0.033). The only post-neoadjuvant therapy parameter to be predictive of pathological response (<i>P</i> = 0.003) was SUV<sub>mean</sub>. In receiver operating characteristic analysis, ΔSUV<sub>mean</sub> emerged as the most significant parameter for predicting pathological response, followed by post-neoadjuvant SUV<sub>mean</sub> [area under the curve: 0.724 (95% confidence interval: 0.630-0.805) and 0.673 (0.577-0.760), respectively].</p><p><strong>Conclusion: </strong>The Δ<sup>18</sup>F-FDG PET/CT parameters are better than ΔDCE-MRI in predicting pathologic response to neoadjuvant therapy. Among these parameters, ΔSUV<sub>mean</sub> is the most successful.</p><p><strong>Clinical significance: </strong>Neoadjuvant chemotherapy (NAC) response is one of the most important criteria in breast cancer prognosis. The two most important imaging modalities in breast cancer diagnosis and follow-up protocols are MRI and <sup>18</sup>F-FDG PET/CT. However, it is not clear which of these two modalities is more successful in predicting the difference in treatment response between baseline and post-NAC.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"279-286"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solitary plasmacytoma: a rare and unusual tumor of the liver. 孤立性浆细胞瘤:一种罕见的肝脏肿瘤。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-08-18 DOI: 10.4274/dir.2025.253396
Ayşe Erden, Koray Ceyhan
{"title":"Solitary plasmacytoma: a rare and unusual tumor of the liver.","authors":"Ayşe Erden, Koray Ceyhan","doi":"10.4274/dir.2025.253396","DOIUrl":"10.4274/dir.2025.253396","url":null,"abstract":"","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"255-257"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When AI reviews your work: author-centered reflections on LLMs in peer review. 当人工智能审查你的工作时:在同行评审中对法学硕士的以作者为中心的反思。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-06-02 DOI: 10.4274/dir.2025.253449
Burak Koçak, Mehmet Ruhi Onur
{"title":"When AI reviews your work: author-centered reflections on LLMs in peer review.","authors":"Burak Koçak, Mehmet Ruhi Onur","doi":"10.4274/dir.2025.253449","DOIUrl":"10.4274/dir.2025.253449","url":null,"abstract":"","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"276-278"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Diagnostic value of the flare sign in predicting extracapsular extension in metastatic axillary lymph nodes and nodal status on breast magnetic resonance imaging. 回复:胸磁振征象对预测转移性腋窝淋巴结囊外延伸及淋巴结状态的诊断价值。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-09-29 DOI: 10.4274/dir.2025.253598
Cihan Özgür, Baran Serdar Sunal, Savaş Hereklioğlu, Meltem Öznur
{"title":"Reply: Diagnostic value of the flare sign in predicting extracapsular extension in metastatic axillary lymph nodes and nodal status on breast magnetic resonance imaging.","authors":"Cihan Özgür, Baran Serdar Sunal, Savaş Hereklioğlu, Meltem Öznur","doi":"10.4274/dir.2025.253598","DOIUrl":"10.4274/dir.2025.253598","url":null,"abstract":"","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"289-290"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated calculation of slice-specific volume computed tomography dose index, water-equivalent diameter, and size-specific dose estimation for computed tomography scans. 切片特异性体积计算机断层扫描剂量指数的自动计算,水当量直径,以及计算机断层扫描的尺寸特异性剂量估计。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-11-03 DOI: 10.4274/dir.2025.253555
Supawitoo Sookpeng, Rosario Lopez-Gonzalez, Suwapim Chanlaor, Boriphat Kadman
{"title":"Automated calculation of slice-specific volume computed tomography dose index, water-equivalent diameter, and size-specific dose estimation for computed tomography scans.","authors":"Supawitoo Sookpeng, Rosario Lopez-Gonzalez, Suwapim Chanlaor, Boriphat Kadman","doi":"10.4274/dir.2025.253555","DOIUrl":"10.4274/dir.2025.253555","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To develop and validate an automated computational tool for calculating a slice-specific volume computed tomography (CT) dose index (CTDI&lt;sub&gt;vol&lt;/sub&gt;), a water-equivalent diameter (D&lt;sub&gt;w&lt;/sub&gt;), and size-specific dose estimates (SSDEs) from CT images, addressing limitations of conventional console-displayed values that provide only averaged values across scan regions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A custom ImageJ macro was developed based on methodologies proposed in American Association of Physicists in Medicine reports 220 and 293. The tool employs threshold-based body contour segmentation [-140 Hounsfield unit (HU)] to extract patient cross-sectional areas and calculates slice-specific D&lt;sub&gt;w&lt;/sub&gt; using mean CT numbers. Slice-specific CTDI&lt;sub&gt;vol&lt;/sub&gt; values are estimated by normalizing scanner-displayed CTDI&lt;sub&gt;vol&lt;/sub&gt; to individual slice exposure values from Digital Imaging and Communications in Medicine metadata. An SSDE was computed using appropriate correction factors for head and body examinations. Validation was performed using water phantoms, anthropomorphic phantoms, and clinical datasets from ≥30 patients. Two Siemens CT scanners were evaluated: SOMATOM go.Top&lt;sup&gt;®&lt;/sup&gt;, with console-displayed values, and SOMATOM Force&lt;sup&gt;®&lt;/sup&gt;, with Radimetrics software. Agreement was assessed using intraclass correlation coefficients (ICCs) and Bland-Altman analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Water phantom validation demonstrated excellent accuracy, with differences of &lt;2.3% for both D&lt;sub&gt;w&lt;/sub&gt; and SSDEs. The macro required approximately 30 seconds per examination to complete the analysis. Bland-Altman plots confirmed clinically acceptable mean differences. Importantly, the slice-specific approach revealed substantial intra-scan dose variations not captured by console-reported averages, particularly in the chest phantom, where SSDEs ranged from 5.77 to 23.68 mGy despite identical average values. For the clinical dataset, ICC (3,1) values for Scanner A indicated good to excellent agreement across both head and chest/abdomen examinations (head CT-CTDI vol: 0.974, D&lt;sub&gt;w&lt;/sub&gt;: 0.893, SSDE: 0.965; chest/abdomen CT-CTDI&lt;sub&gt;vol&lt;/sub&gt;: 1.000, D&lt;sub&gt;w&lt;/sub&gt;: 0.994, SSDE: 0.989). By contrast, Scanner B demonstrated near-perfect agreement for head CT in CTDI&lt;sub&gt;vol&lt;/sub&gt; (0.996) and SSDE (0.967) but poor agreement for D&lt;sub&gt;w&lt;/sub&gt; (0.267). For chest/abdomen CT, however, Scanner B showed consistently high agreement, with ICC values ranging from 0.884 to 1.000.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The developed ImageJ macro provides accurate, transparent, and low-cost open-source solution slice-specific CT dose estimation that correlates well with commercial systems while offering superior spatial resolution. This automated method overcomes the limitations of traditional dose reporting by providing detailed slice-by-slice dose variations, which are often overlooked in average summary values, allowing f","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"342-350"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The AI Act: responsibilities and obligations for healthcare professionals and organizations. 人工智能法案:医疗保健专业人员和组织的责任和义务。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-05-29 DOI: 10.4274/dir.2025.252851
Kicky Gerhilde van Leeuwen, Leon Doorn, Erik Gelderblom
{"title":"The AI Act: responsibilities and obligations for healthcare professionals and organizations.","authors":"Kicky Gerhilde van Leeuwen, Leon Doorn, Erik Gelderblom","doi":"10.4274/dir.2025.252851","DOIUrl":"10.4274/dir.2025.252851","url":null,"abstract":"","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"273-275"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally invasive management of a post-cholecystectomy bile leak using a microvascular plug. 微血管塞微创治疗胆囊切除术后胆漏。
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-11-19 DOI: 10.4274/dir.2025.253601
Mohammed Misbahuddin-Leis, Andreas R R Weiß, Yazan Amin, Robert Grützmann, Axel Schmid
{"title":"Minimally invasive management of a post-cholecystectomy bile leak using a microvascular plug.","authors":"Mohammed Misbahuddin-Leis, Andreas R R Weiß, Yazan Amin, Robert Grützmann, Axel Schmid","doi":"10.4274/dir.2025.253601","DOIUrl":"10.4274/dir.2025.253601","url":null,"abstract":"<p><p>Bouveret syndrome is a rare form of gallstone ileus in which a gallstone causes gastric outlet obstruction via a cholecystoenteric fistula. We present the case of an elderly patient who underwent emergency surgery due to clinical signs of gastric outlet obstruction. Intraoperatively, a large gallstone was identified and removed from the duodenum. A subtotal cholecystectomy was performed, during which the identification of the course of the cystic duct was limited due to considerable inflammatory changes. In the early postoperative period, bile-stained output from the surgical drain raised suspicion of a leak from the cystic duct stump. Given the patient's clinical status and the complexity of the local anatomy with severely inflamed and fibrotic tissues in the hepatoduodenal ligament, the decision was made to proceed with percutaneous treatment. A percutaneous transhepatic biliary drainage was established, and contrast extravasation from the cystic duct remnant was confirmed via fluoroscopic cholangiography. Through the same access, a microvascular plug was successfully deployed into the cystic duct, achieving immediate cessation of bile leakage. The patient's clinical condition improved markedly, and no further intervention was required. This case demonstrates the successful off-label use of polytetrafluoroethylene-covered vascular occlusion devices in managing biliary complications.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"338-341"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic performance of magnetic resonance imaging-targeted biopsy for PI-RADS ≥3 peripheral zone lesions in multiparametric prostate magnetic resonance imaging: correlation with clinically significant prostate cancer. 多参数前列腺磁共振成像PI-RADS≥3外周带病变的磁共振成像靶向活检诊断价值:与临床显著性前列腺癌的相关性
IF 2.7 4区 医学
Diagnostic and interventional radiology Pub Date : 2026-05-04 Epub Date: 2025-11-03 DOI: 10.4274/dir.2025.253590
Serdar Aslan, Emrah Sülün, Ertuğrul Çakır, Ural Oğuz, Tümay Bekçi
{"title":"Diagnostic performance of magnetic resonance imaging-targeted biopsy for PI-RADS ≥3 peripheral zone lesions in multiparametric prostate magnetic resonance imaging: correlation with clinically significant prostate cancer.","authors":"Serdar Aslan, Emrah Sülün, Ertuğrul Çakır, Ural Oğuz, Tümay Bekçi","doi":"10.4274/dir.2025.253590","DOIUrl":"10.4274/dir.2025.253590","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate magnetic resonance imaging (MRI)-targeted biopsy (MRI-TB) performance in detecting clinically significant prostate cancer (csPCa) with a Prostate Imaging Reporting and Data System (PI-RADS) score of ≥3 peripheral zone (PZ) lesions using multiparametric MRI (mpMRI)-histopathology correlation.</p><p><strong>Methods: </strong>This retrospective study included 141 patients with 187 PZ lesions who underwent mpMRI followed by both MRI-TB and transrectal ultrasound-guided systematic biopsy (SB) between December 2021 and December 2024. All mpMRI scans were evaluated by a board-certified experienced radiologist in accordance with the PI-RADS version 2.1 criteria. The csPCa detection rates of SB, MRI-TB, and combined biopsy (CB) were compared. Statistical analyses included McNemar's test, Fisher's exact test, and the Mann-Whitney U test. A P value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among the 141 patients (187 PI-RADS ≥3 PZ lesions), patients with csPCa exhibited significantly higher prostate-specific antigen (PSA) levels (15.3 vs. 8.2 ng/mL; <i>P</i> = 0.02), lower prostate volume (52.4 vs. 78.6 mL; <i>P</i> < 0.001), and three-fold higher PSA density (PSAD) (0.30 vs. 0.10 ng/mL/mL; <i>P</i> < 0.001) than non-csPCa cases. Notably, PSAD > 0.15 ng/mL/mL occurred in 78% of patients with csPCa vs. 18% in non-csPCa cases (<i>P</i> < 0.001). Moreover, MRI-TB detected significantly more csPCa than SB (17.7% vs. 10.7% of lesions; <i>P</i> < 0.001), with maximal advantage in PI-RADS 4 lesions (20.7% vs. 10.9%; <i>P</i> = 0.004). By contrast, CB did not significantly increase csPCa detection over MRI-TB alone (19.8% vs. 17.7%; <i>P</i> = 0.125). Chronic prostatitis (CP) (34.0% of benign cases) confounded PI-RADS specificity.</p><p><strong>Conclusion: </strong>For csPCa detection in PI-RADS ≥3 PZ lesions, particularly PI-RADS 4, MRI-TB outperforms SB. For PI-RADS 5, SB and MRI-TB showed equivalent efficacy. However, MRI-TB alone suffices for PI-RADS ≥4 lesions or PSAD >0.15 ng/mL/mL, whereas CB remains preferable for PI-RADS 3. The high CP prevalence underscores the need for adjunctive biomarkers to improve specificity.</p><p><strong>Clinical significance: </strong>MRI-TB optimizes csPCa detection for PI-RADS ≥4 PZ lesions, reducing reliance on SBs. A PSAD threshold >0.15 ng/mL/mL effectively stratifies biopsy necessity, and high CP prevalence (34% of benign cases) underscores the need for adjunct biomarkers to improve specificity in PI-RADS 3-4 lesions.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"328-337"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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