{"title":"基于双能计算机断层扫描的体积甲状腺碘定量:与甲状腺激素状态、病理诊断和幻象验证的相关性。","authors":"Younghen Lee","doi":"10.4274/dir.2025.243132","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between intrathyroidal iodine concentration (IC) (mg I/mL) and thyroid hormonal status or pathologic diagnosis with the use of dual-energy computed tomography (DECT).</p><p><strong>Methods: </strong>We retrospectively included patients who underwent neck CT examination between September 2016 and August 2021 using a dual-layer DECT scanner (120 kilovolt peak) for preoperative thyroid imaging. We performed volumetric IC measurements at the thyroid parenchyma on the additional iodine map generated from non-contrast images. We then compared the mean IC of thyroid parenchyma based on thyroid hormonal status (hypothyroid, euthyroid, and hyperthyroid) and diffuse thyroid disease (DTD). Additionally, we determined the accuracy of iodine quantification with our site-specific DECT acquisition protocol using a Gammex<sup>TM</sup> phantom containing seven iodine inserts with different ICs ranging from 2 to 20 mgI/mL.</p><p><strong>Results: </strong>Among the 578 patients (M:F: 87:491, age: 48.6 ± 11.7 years) who were finally selected, the mean thyroid parenchymal ICs was the lowest in the hyperthyroid group, followed by the hypothyroid group, and then the euthyroid group (0.68 ± 0.37, n = 44 vs. 1.13 ± 0.42, n = 61 vs. 1.32 ± 0.43, n = 473, <i>P</i> < 0.01, respectively). In the patients with euthyroidism, the mean parenchymal IC was already lower in the patients with pathologically proven DTD than in those without DTD (1.22 ± 0.44 mgI/mL vs. 1.45 ± 0.37 mgI/mL, <i>P</i> < 0.01). Based on the phantom study, the median percentage deviations from the expected values were 5.1% for ICs of 2-20 mgI/mL.</p><p><strong>Conclusion: </strong>DECT-based IC quantification could be a potentially useful method for identifying patients with thyroid hormone dysfunction or DTD without the use of contrast media.</p><p><strong>Clinical significance: </strong>Without the need for intravenous administration, DECT-based intrathyroidal IC quantification provides potentially valuable information from the non-contrast CT image of the thyroid parenchyma.</p>","PeriodicalId":11341,"journal":{"name":"Diagnostic and interventional radiology","volume":" ","pages":"226-233"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057531/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dual-energy computed tomography-based volumetric thyroid iodine quantification: correlation with thyroid hormonal status, pathologic diagnosis, and phantom validation.\",\"authors\":\"Younghen Lee\",\"doi\":\"10.4274/dir.2025.243132\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate the relationship between intrathyroidal iodine concentration (IC) (mg I/mL) and thyroid hormonal status or pathologic diagnosis with the use of dual-energy computed tomography (DECT).</p><p><strong>Methods: </strong>We retrospectively included patients who underwent neck CT examination between September 2016 and August 2021 using a dual-layer DECT scanner (120 kilovolt peak) for preoperative thyroid imaging. We performed volumetric IC measurements at the thyroid parenchyma on the additional iodine map generated from non-contrast images. We then compared the mean IC of thyroid parenchyma based on thyroid hormonal status (hypothyroid, euthyroid, and hyperthyroid) and diffuse thyroid disease (DTD). Additionally, we determined the accuracy of iodine quantification with our site-specific DECT acquisition protocol using a Gammex<sup>TM</sup> phantom containing seven iodine inserts with different ICs ranging from 2 to 20 mgI/mL.</p><p><strong>Results: </strong>Among the 578 patients (M:F: 87:491, age: 48.6 ± 11.7 years) who were finally selected, the mean thyroid parenchymal ICs was the lowest in the hyperthyroid group, followed by the hypothyroid group, and then the euthyroid group (0.68 ± 0.37, n = 44 vs. 1.13 ± 0.42, n = 61 vs. 1.32 ± 0.43, n = 473, <i>P</i> < 0.01, respectively). In the patients with euthyroidism, the mean parenchymal IC was already lower in the patients with pathologically proven DTD than in those without DTD (1.22 ± 0.44 mgI/mL vs. 1.45 ± 0.37 mgI/mL, <i>P</i> < 0.01). Based on the phantom study, the median percentage deviations from the expected values were 5.1% for ICs of 2-20 mgI/mL.</p><p><strong>Conclusion: </strong>DECT-based IC quantification could be a potentially useful method for identifying patients with thyroid hormone dysfunction or DTD without the use of contrast media.</p><p><strong>Clinical significance: </strong>Without the need for intravenous administration, DECT-based intrathyroidal IC quantification provides potentially valuable information from the non-contrast CT image of the thyroid parenchyma.</p>\",\"PeriodicalId\":11341,\"journal\":{\"name\":\"Diagnostic and interventional radiology\",\"volume\":\" \",\"pages\":\"226-233\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057531/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic and interventional radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4274/dir.2025.243132\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic and interventional radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4274/dir.2025.243132","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/18 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的:应用双能计算机断层扫描(DECT)探讨甲状腺内碘浓度(IC) (mg I/mL)与甲状腺激素状态及病理诊断的关系。方法:我们回顾性纳入了2016年9月至2021年8月期间使用双层DECT扫描仪(峰值120千伏)进行术前甲状腺成像的颈部CT检查的患者。我们在非对比图像生成的附加碘图上对甲状腺实质进行了体积IC测量。然后,我们比较了基于甲状腺激素状态(甲状腺功能减退、甲状腺功能正常和甲状腺功能亢进)和弥漫性甲状腺疾病(DTD)的甲状腺实质的平均IC。此外,我们使用GammexTM模型确定了碘定量的准确性,该模型含有7个碘插入物,不同的ic范围为2至20 mgI/mL。结果:最终入选578例患者(男:女:87:491,年龄:48.6±11.7岁),甲状腺功能亢组甲状腺实质ic均值最低,甲状腺功能减退组次之(0.68±0.37,n = 44比1.13±0.42,n = 61比1.32±0.43,n = 473, P < 0.01)。在甲状腺功能减退患者中,病理证实有DTD的患者的平均实质IC已低于无DTD的患者(1.22±0.44 mgI/mL vs. 1.45±0.37 mgI/mL, P < 0.01)。根据幻影研究,ic为2-20 mgI/mL时,与期望值的中位数偏差百分比为5.1%。结论:在不使用造影剂的情况下,基于ect的IC定量可能是一种潜在的有效方法来识别甲状腺激素功能障碍或DTD患者。临床意义:在不需要静脉给药的情况下,基于ect的甲状腺内IC定量从甲状腺实质的非对比CT图像中提供了潜在的有价值的信息。
Dual-energy computed tomography-based volumetric thyroid iodine quantification: correlation with thyroid hormonal status, pathologic diagnosis, and phantom validation.
Purpose: To investigate the relationship between intrathyroidal iodine concentration (IC) (mg I/mL) and thyroid hormonal status or pathologic diagnosis with the use of dual-energy computed tomography (DECT).
Methods: We retrospectively included patients who underwent neck CT examination between September 2016 and August 2021 using a dual-layer DECT scanner (120 kilovolt peak) for preoperative thyroid imaging. We performed volumetric IC measurements at the thyroid parenchyma on the additional iodine map generated from non-contrast images. We then compared the mean IC of thyroid parenchyma based on thyroid hormonal status (hypothyroid, euthyroid, and hyperthyroid) and diffuse thyroid disease (DTD). Additionally, we determined the accuracy of iodine quantification with our site-specific DECT acquisition protocol using a GammexTM phantom containing seven iodine inserts with different ICs ranging from 2 to 20 mgI/mL.
Results: Among the 578 patients (M:F: 87:491, age: 48.6 ± 11.7 years) who were finally selected, the mean thyroid parenchymal ICs was the lowest in the hyperthyroid group, followed by the hypothyroid group, and then the euthyroid group (0.68 ± 0.37, n = 44 vs. 1.13 ± 0.42, n = 61 vs. 1.32 ± 0.43, n = 473, P < 0.01, respectively). In the patients with euthyroidism, the mean parenchymal IC was already lower in the patients with pathologically proven DTD than in those without DTD (1.22 ± 0.44 mgI/mL vs. 1.45 ± 0.37 mgI/mL, P < 0.01). Based on the phantom study, the median percentage deviations from the expected values were 5.1% for ICs of 2-20 mgI/mL.
Conclusion: DECT-based IC quantification could be a potentially useful method for identifying patients with thyroid hormone dysfunction or DTD without the use of contrast media.
Clinical significance: Without the need for intravenous administration, DECT-based intrathyroidal IC quantification provides potentially valuable information from the non-contrast CT image of the thyroid parenchyma.
期刊介绍:
Diagnostic and Interventional Radiology (Diagn Interv Radiol) is the open access, online-only official publication of Turkish Society of Radiology. It is published bimonthly and the journal’s publication language is English.
The journal is a medium for original articles, reviews, pictorial essays, technical notes related to all fields of diagnostic and interventional radiology.