{"title":"Evaluation of non-conformities in the drafting of bulletins for urine cytobacteriological examinations at Sikasso Hospital (Mali).","authors":"Luka Diarra, Moussa Mariko, Salif Traore, Safi Bazi Dicko, Aboudou Dolo, Moussa Coulibaly, Daouda Sidibé, Moumouni Daou, Hachimi Poma, Madou Traore, Ibrahim Guindo","doi":"10.33393/dti.2024.2670","DOIUrl":"10.33393/dti.2024.2670","url":null,"abstract":"<p><strong>Background: </strong>Non-compliance in the drafting of examination bulletins makes it difficult to perform them and interpret the results. With the aim of continuously improving laboratory services and guaranteeing the quality of urine cytobacteriological examination (ECBU) results, we initiated this study to evaluate non-compliance in the drafting of ECBU reports.</p><p><strong>Materials and methods: </strong>This was a retrospective descriptive cross-sectional study which focused on non-compliance in the drafting of ECBU reports analysed in the laboratory from January to December 2022.</p><p><strong>Results: </strong>During the study period, we collected 383 non-compliant ECBU reports out of 672, with a frequency of 56.99%. Non-compliances were related to age (2.68%), profession (24.40%), clinical information (6.70%) and residence (52.08%). The majority of non-compliant reports came from the medicine (35.51%) and urology (25.85%) departments.</p><p><strong>Conclusion: </strong>The high frequency of non-compliance is a cause for concern and is of concern to all prescribers in this hospital.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"18 ","pages":"1-3"},"PeriodicalIF":2.7,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug Target InsightsPub Date : 2023-12-20eCollection Date: 2023-01-01DOI: 10.33393/dti.2023.2660
Ria Pothoven
{"title":"Management of urinary tract infections in the era of antimicrobial resistance.","authors":"Ria Pothoven","doi":"10.33393/dti.2023.2660","DOIUrl":"https://doi.org/10.33393/dti.2023.2660","url":null,"abstract":"<p><p>Urinary tract infections (UTIs) are among the most common infections globally, imposing a substantial personal and economic burden on individuals and health resources. Despite international health concerns and sustained public awareness campaigns about the emergence of resistant microorganisms through the inappropriate therapeutic use of antimicrobial agents, the problem of antimicrobial resistance (AMR) is worsening, and AMR in UTIs represents a critical global healthcare issue. This narrative review summarizes evidence-based scientific material, recommendations from the current medical literature, and the latest clinical guidelines on antibiotic and antibiotic-sparing strategies for managing urological infections, including practical approaches to improve the management of patients with acute and recurrent UTIs (rUTIs) in routine clinical practice. Novel emerging therapies and prophylaxis options are described as potential alternatives to overcome the abuse and overuse of antibiotics and the practical application of the guideline recommendations and issues relating to best practice in managing UTIs.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 ","pages":"126-137"},"PeriodicalIF":2.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10731245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mortality rate and factors associated with mortality of carbapenem-resistant Enterobacteriaceae infection","authors":"Apichart So-ngern, Naphol Osaithai, Atibordee Meesing, Worawat Chumpangern","doi":"10.33393/dti.2023.2622","DOIUrl":"https://doi.org/10.33393/dti.2023.2622","url":null,"abstract":"Background: Carbapenem-resistant Enterobacteriaceae (CRE) is a serious pathogen with high mortality. Recognition of factors associated with mortality and treating these modifiable factors are crucial to reducing mortality.Objective: To determine the 30-day mortality and factors associated with a 30-day mortality of CRE infection.Methods: A retrospective cohort study was conducted between January 1, 2015, and December 31, 2019. All patients diagnosed with CRE infection aged ≥18 years were included. Multivariate logistic regression was used for evaluating the factors associated with 30-day mortality and presented as adjusted odds ratio (aOR) with 95% confidence interval (CI).Result: One hundred and ninety-four patients were enrolled. The 30-day mortality occurred in 75 patients (38.7%). The common antibiotic regimen was monotherapy and combination of carbapenem, colistin, amikacin, tigecycline, and fosfomycin. CRE isolates were susceptible to tigecycline (93.8%), colistin (91.8%), fosfomycin (89.2%), and amikacin (89.2%). The independent factors associated with 30-day mortality were an increasing simplified acute physiology (SAP) II score (aOR 1.11, 95% CI 1.05-1.16, p < 0.001), sepsis at time of CRE infection diagnosis (aOR 7.93, 95% CI 2.21-28.51, p = 0.002), pneumonia (aOR 4.48, 95% CI 1.61-12.44, p = 0.004), monotherapy (aOR 4.69, 95% CI 1.71-12.85, p = 0.003), and improper empiric antibiotic (aOR 5.13, 95% CI 1.83-14.40, p = 0.002).Conclusion: The overall 30-day mortality of CRE infection was high. The factors associated with mortality were an increasing SAP II score, sepsis at time of CRE infection diagnosis, pneumonia, monotherapy, and improper empiric antibiotic. The study suggested that proper empiric antibiotic and combination antibiotics might reduce mortality from CRE infection.","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"431 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug Target InsightsPub Date : 2023-10-09eCollection Date: 2023-01-01DOI: 10.33393/dti.2023.2614
Ebtehaj Saud Almughais, Fatmah Fahad Alreshidi, Hussain Gadelkarim Ahmed
{"title":"Prevalence of antibiotic misuse in cases of pneumonia and diarrhea in Saudi Arabia.","authors":"Ebtehaj Saud Almughais, Fatmah Fahad Alreshidi, Hussain Gadelkarim Ahmed","doi":"10.33393/dti.2023.2614","DOIUrl":"10.33393/dti.2023.2614","url":null,"abstract":"<p><strong>Background: </strong>Antibiotic misuse is a major public health issue with long-term repercussions.</p><p><strong>Objective: </strong>The purpose of this investigation was to evaluate the effects of pneumonia and diarrhea, with an emphasis on antibiotic misuse.</p><p><strong>Methodology: </strong>This study included 410 participants (217 fathers and 193 mothers), of whom 239 purchased antibiotics for their children without a prescription, whereas 171 had a prescription or were unsure if one was required.</p><p><strong>Results: </strong>Antibiotics were used incorrectly by 58.1% of respondents. About 51.2% of participants said they were taking two antibiotics at the same time. Around 30% of people admitted to using antibiotics inefficiently. The most prevalent reason for use was \"viral and bacterial,\" followed by \"viral,\" and then \"bacterial,\" with 35%, 21%, and 20%, respectively. In addition, 22.4% of patients have used antibiotics for an unknown reason.</p><p><strong>Conclusion: </strong>Saudi parents of children with pneumonia and diarrhea abuse antibiotics. Saudi legislation banning medications without a prescription has helped reduce antibiotic abuse, but more community-based education and awareness are needed.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 ","pages":"114-119"},"PeriodicalIF":2.7,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/1a/dti-17-114.PMC10563503.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug Target InsightsPub Date : 2023-10-06eCollection Date: 2023-01-01DOI: 10.33393/dti.2023.2626
Alessandro Inno, Giuseppe Bogina, Giulio Settanni, Matteo Salgarello, Giovanni Foti, Carlo Pomari, Vincenzo Picece, Stefania Gori
{"title":"First-line tepotinib for a very elderly patient with metastatic NSCLC harboring <i>MET</i> exon 14 skipping mutation and high PD-L1 expression.","authors":"Alessandro Inno, Giuseppe Bogina, Giulio Settanni, Matteo Salgarello, Giovanni Foti, Carlo Pomari, Vincenzo Picece, Stefania Gori","doi":"10.33393/dti.2023.2626","DOIUrl":"10.33393/dti.2023.2626","url":null,"abstract":"<p><p>Optimal treatment for metastatic non-small cell lung cancer (NSCLC) with mesenchymal epithelial transition gene (<i>MET</i>) exon 14 skipping mutation has not been established yet. MET inhibitors were demonstrated to be effective and tolerated in patients with this condition, while evidence on safety and efficacy of immunotherapy and/or chemotherapy in this population is limited. Here we report the case of an 86-year-old male with metastatic NSCLC harboring <i>MET</i> exon 14 skipping mutation and with high programmed cell death ligand 1 (PD-L1) expression (tumor proportion score ≥50%). The patient received the MET inhibitor tepotinib as first-line treatment, achieving a partial response, with G2 peripheral edema as adverse event that was successfully managed with temporary discontinuation, dose reduction, diuretics and physical therapy. After 31 months, the patient is still receiving tepotinib, with an ongoing response. Tepotinib is a valuable therapeutic option for first-line treatment of older patients with NSCLC harboring <i>MET</i> exon 14 skipping mutation, even in the presence of high PD-L1 expression.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 ","pages":"110-113"},"PeriodicalIF":2.7,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/1e/dti-17-110.PMC10568218.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of anti-pathogenic activity among <i>in silico</i> predicted small-molecule inhibitors of <i>Pseudomonas aeruginosa</i> LasR or nitric oxide reductase (NOR).","authors":"Gemini Gajera, Niel Henriksen, Bryan Cox, Vijay Kothari","doi":"10.33393/dti.2023.2638","DOIUrl":"10.33393/dti.2023.2638","url":null,"abstract":"<p><strong>Introduction: </strong>Antibiotic-resistant <i>Pseudomonas aeruginosa</i> strains cause considerable morbidity and mortality globally. Identification of novel targets in this notorious pathogen is urgently warranted to facilitate discovery of new anti-pathogenic agents against it. This study attempted to identify small-molecule inhibitors of two important proteins LasR and nitric oxide reductase (NOR) in <i>P. aeruginosa</i>. 'Las' system can be said to be the 'master' regulator of quorum sensing in <i>P. aeruginosa</i>, whose receptor protein is LasR. Similarly, NOR is crucial to detoxification of reactive nitrogen species.</p><p><strong>Methods: </strong><i>In silico</i> identification of potential LasR or NOR inhibitors was attempted through a virtual screening platform AtomNet® to obtain a final subset of <100 top scoring compounds. These compounds were evaluated for their <i>in vivo</i> anti-pathogenic activity by challenging the model host <i>Caenorhabditis elegans</i> with <i>P. aeruginosa</i> in the presence or absence of test compounds. Survival of the worm population in 24-well assay plates was monitored over a period of 5 days microscopically.</p><p><strong>Results: </strong>Of the 96 predicted LasR inhibitors, 11 exhibited anti-<i>Pseudomonas</i> activity (23%-96% inhibition of bacterial virulence as per third-day end-point) at 25-50 µg/mL. Of the 85 predicted NOR inhibitors, 8 exhibited anti-<i>Pseudomonas</i> activity (40%-85% inhibition of bacterial virulence as per second-day end-point) at 25-50 µg/mL.</p><p><strong>Conclusion: </strong>Further investigation on molecular mode of action of compounds found active in this study is warranted. Virtual screening can be said to be a useful tool in narrowing down the list of compounds requiring actual wet-lab screening, saving considerable time and efforts for drug discovery.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 ","pages":"101-109"},"PeriodicalIF":2.7,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/04/dti-17-101.PMC10551673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ESBL and carbapenemase-producing Enterobacteriaceae in infectious pleural effusions: current epidemiology at Hôpital du Mali.","authors":"Aimé Césaire Kalambry, Tchamou Malraux Fleury Potindji, Ibrehima Guindo, Ambara Kassogue, Boubacar Sidiki Ibrahim Drame, Seydou Togo, Sadio Yena, Seydou Doumbia, Mahamadou Diakite","doi":"10.33393/dti.2023.2613","DOIUrl":"10.33393/dti.2023.2613","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) is a global health concern, with extended-spectrum β-lactamases (ESBLs) and carbapenemases being major contributors. Pleural infection (PI) is a severe condition in West Africa, complicated by AMR. This study aimed to investigate the prevalence and molecular characteristics of ESBL and carbapenemase-producing enterobacteria in pleural effusions in Mali.</p><p><strong>Materials and methods: </strong>Pleural fluid samples from 526 patients with pleuritis were analyzed. Enterobacterial species were isolated and identified, and the prevalence of resistance genes (<i>bla<sub>OXA-48</sub>, bla<sub>NDM-1</sub>, bla<sub>KPC</sub>, bla<sub>TEM</sub>, bla<sub>SHV</sub></i>) and virulence factors was determined.</p><p><strong>Results: </strong>Among the patients, 110 were diagnosed with enterobacterial pleuritis. <i>Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis</i> were the main pathogens identified. Resistance to β-lactams and cephalosporins was high, while carbapenems showed good activity. ESBL production was detected in 33.6% of isolates, with <i>bla</i><i><sub>TEM</sub></i> being the most common gene. Carbapenemase gene (<i>bla<sub>NDM-1</sub></i>) was found in three isolates.</p><p><strong>Conclusion: </strong>The study highlights the high prevalence of multidrug-resistant bacteria and the need for appropriate antibiotic selection based on local resistance patterns. Understanding the molecular characteristics of resistance is crucial for optimizing patient care and developing effective therapeutic strategies. Further research is needed to monitor and control AMR in PIs in Mali.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 ","pages":"92-100"},"PeriodicalIF":2.7,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/3b/dti-17-92.PMC10466504.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR)","authors":"G. Gajera, N. Henriksen, Bryan Cox, V. Kothari","doi":"10.1101/2023.07.17.549273","DOIUrl":"https://doi.org/10.1101/2023.07.17.549273","url":null,"abstract":"Antibiotic resistant Pseudomonas aeruginosa strains cause considerable morbidity and mortality. Identification of novel targets in this notorious pathogen is urgently warranted to facilitate discovery of new anti-pathogenic agents acting against it. Attacking non-essential targets is believed to be a potential anti-virulence strategy. This study attempted to identify small molecule inhibitors of two important proteins LasR and nitric oxide reductase (NOR) in P. aeruginosa. This bacterial pathogen possesses multiple quorum sensing (QS) systems to regulate expression of many of its genes including those associated with virulence. Among these QS systems, ‘Las’ system can be said to be the ‘master’ regulator, whose receptor protein is LasR. Similarly, NOR plays crucial role in detoxification of reactive nitrogen species. This study attempted in silico identification of potential LasR or NOR inhibitors through a virtual screen employing AtomNet®, a proprietary deep learning neural network. Following virtual screening of a large number of compounds for their affinity to LasR or NOR, a final subset of <100 compounds was created by clustering and filtering the top scoring compounds. These compounds were evaluated for their in vivo anti-pathogenic activity by challenging the model host Caenorhabditis elegans with P. aeruginosa in presence or absence of test compounds. Survival of the worm population in 24-well assay plates was monitored over a period of 5 days microscopically. Of the 96 predicted LasR inhibitors, 11 exhibited anti-Pseudomonas activity (23-96% inhibition of bacterial virulence as per third-day end point) at 25-50 µg/ml. Of the 85 predicted NOR inhibitors, 8 exhibited anti-Pseudomonas activity (40-85% inhibition of bacterial virulence as per second-day end point) at 25-50 µg/ml. Further investigation on molecular mode of action of active compounds is warranted.","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 1","pages":"101 - 109"},"PeriodicalIF":2.7,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45888013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug Target InsightsPub Date : 2023-06-05eCollection Date: 2023-01-01DOI: 10.33393/dti.2023.2583
Safiya Fatima Khan, Bhavya Shetty, Ibrahim Fazal, Asim Mustafa Khan, Faheem Muzaffar Mir, Muhamood Moothedath, V J Reshma, Muhaseena Muhamood
{"title":"Licorice as a herbal extract in periodontal therapy.","authors":"Safiya Fatima Khan, Bhavya Shetty, Ibrahim Fazal, Asim Mustafa Khan, Faheem Muzaffar Mir, Muhamood Moothedath, V J Reshma, Muhaseena Muhamood","doi":"10.33393/dti.2023.2583","DOIUrl":"10.33393/dti.2023.2583","url":null,"abstract":"<p><p>Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (<i>Glycyrrhiza glabra</i>) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of <i>Glycyrrhiza uralensis</i> and <i>G. glabra</i>. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"17 ","pages":"70-77"},"PeriodicalIF":2.7,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/86/dti-17-70.PMC10243202.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9597793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Safiya Fatima Khan, Bhavya Shetty, Ibrahim Fazal, Asim Mustafa Khan, Faheem Muzaffar Mir, Muhamood Moothedath, Reshma VJ, Muhaseena Muhamood
{"title":"Licorice as a herbal extract in periodontal therapy","authors":"Safiya Fatima Khan, Bhavya Shetty, Ibrahim Fazal, Asim Mustafa Khan, Faheem Muzaffar Mir, Muhamood Moothedath, Reshma VJ, Muhaseena Muhamood","doi":"10.33393/dti.2023.2583","DOIUrl":"https://doi.org/10.33393/dti.2023.2583","url":null,"abstract":"Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (Glycyrrhiza glabra) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of Glycyrrhiza uralensis and G. glabra. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135658074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}