药物再利用的阴暗面。从临床试验挑战到抗菌药耐药性:基于三大领域的分析。

IF 2 Q3 PHARMACOLOGY & PHARMACY
Drug Target Insights Pub Date : 2024-05-10 eCollection Date: 2024-01-01 DOI:10.33393/dti.2024.3019
Iyad Y Natsheh, Majd M Alsaleh, Ahmad K Alkhawaldeh, Duaa K Albadawi, Maisa' M Darwish, Mohammed Jamal A Shammout
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引用次数: 0

摘要

药物再利用是一项战略性工作,需要为市场上已有的药品确定新的治疗用途。尽管实施这一特殊战略的优势在于其成本效益和缩短药物发现过程所需时间的效率,但必须牢记的是,有各种因素必须得到慎重考虑和考虑。到目前为止,明显缺乏对药物再利用局限性的全面分析。本综述的主要目的是从心血管、癌症和糖尿病这三大领域的临床角度出发,全面阐述在考虑药物再利用时所面临的各种挑战,并进一步强调在使用再利用抗生素治疗非传染性和传染性疾病时与抗菌素耐药性(AMR)的出现相关的潜在风险。在开发再利用药物的过程中,由于每个具体病例的证据可能不同,因此在设计开发计划时必须发挥创造力和创新精神。为了有效地重新利用药物,必须考虑到这一过程中可能产生的临床影响和潜在弊端。通过全面分析这些挑战,我们可以更深入地理解药物再利用所涉及的复杂问题,最终开发出更有效、更安全的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The dark side of drug repurposing. From clinical trial challenges to antimicrobial resistance: analysis based on three major fields.

Drug repurposing is a strategic endeavor that entails the identification of novel therapeutic applications for pharmaceuticals that are already available in the market. Despite the advantageous nature of implementing this particular strategy owing to its cost-effectiveness and efficiency in reducing the time required for the drug discovery process, it is essential to bear in mind that there are various factors that must be meticulously considered and taken into account. Up to this point, there has been a noticeable absence of comprehensive analyses that shed light on the limitations of repurposing drugs. The primary aim of this review is to conduct a thorough illustration of the various challenges that arise when contemplating drug repurposing from a clinical perspective in three major fields-cardiovascular, cancer, and diabetes-and to further underscore the potential risks associated with the emergence of antimicrobial resistance (AMR) when employing repurposed antibiotics for the treatment of noninfectious and infectious diseases. The process of developing repurposed medications necessitates the application of creativity and innovation in designing the development program, as the body of evidence may differ for each specific case. In order to effectively repurpose drugs, it is crucial to consider the clinical implications and potential drawbacks that may arise during this process. By comprehensively analyzing these challenges, we can attain a deeper comprehension of the intricacies involved in drug repurposing, which will ultimately lead to the development of more efficacious and safe therapeutic approaches.

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来源期刊
Drug Target Insights
Drug Target Insights PHARMACOLOGY & PHARMACY-
CiteScore
2.70
自引率
0.00%
发文量
5
审稿时长
8 weeks
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