Diseases of the Colon & Rectum最新文献

{"title":"Surgical Outcomes in Metastatic Mismatch Repair-Deficient/Microsatellite Instability-High Colorectal Cancer Following Disease Control with Immune Checkpoint Inhibition: A Retrospective Observational Study.","authors":"Qiaoqi Sui, Leen Liao, Jie-Hai Yu, Linjie Zhang, Bin-Yi Xiao, Wu Jiang, Zhi-Zhong Pan, Pei-Rong Ding","doi":"10.1097/DCR.0000000000003845","DOIUrl":"https://doi.org/10.1097/DCR.0000000000003845","url":null,"abstract":"<p><strong>Background: </strong>Surgical intervention following systemic therapy improves prognosis in metastatic colorectal cancer. However, surgical outcomes after immune checkpoint inhibition remain controversial in patients with mismatch repair-deficient/microsatellite instability-high disease.</p><p><strong>Objective: </strong>This study aimed to demonstrate the outcomes of metastatic mismatch repair-deficient/microsatellite instability-high colorectal cancer patients who underwent curative surgery after achieving disease control with immune checkpoint inhibition.</p><p><strong>Design: </strong>This is a single-center retrospective observational study.</p><p><strong>Setting: </strong>This study was conducted in a tertiary referral center in China.</p><p><strong>Patients: </strong>The data of patients diagnosed with metastatic mismatch repair-deficient/microsatellite instability-high colorectal cancers between 2017 and 2023 were reviewed. Patients who achieved disease control after immune checkpoint inhibition and underwent curative surgeries were enrolled.</p><p><strong>Main outcome measures: </strong>Pathological responses and survival outcomes were assessed.</p><p><strong>Results: </strong>A total of 39 patients were enrolled. The median age was 41 years (range, 16-74). Pathological residuals were diagnosed in 38.5% (15/39) of the patients, whereas 61.5% (24/39) achieved a pathological complete response. Mucinous adenocarcinoma (33.3% vs. 4.2%, difference: 29.1%, 95% CI: 3.9%-53.3%, p = 0.02) was associated with pathological residual, while extensive disease (residual lesions in ≥2 organs or ≥2 residual lesions in a single organ) (93.3% vs. 62.5%, difference: 30.8%, 95% CI: 7.7%-53.9%, p = 0.06) and liver/peritoneum residuals (93.3% vs. 62.5%, difference: 30.8%, 95% CI: 7.7%-53.9%, p = 0.06) suggested possible associations with pathological residual. Pathological complete response (HR: 0.059, 95% CI: 0.007-0.500, p = 0.01), mucinous adenocarcinoma (HR: 7.170, 95% CI: 1.438-35.759, p = 0.02), and a surgical interval >1 year (HR: 4.673, 95% CI: 1.003-21.779, p = 0.02) were observed to be associated with relapse-free survival.</p><p><strong>Limitations: </strong>Limitations include potential selection bias and a small sample size.</p><p><strong>Conclusions: </strong>Pathological residuals are relatively common and pose a threat for patients with metastatic mismatch repair-deficient/microsatellite instability-high colorectal cancers controlled via immune checkpoint inhibitions. Patients with mucinous adenocarcinoma, extensive disease, or liver/peritoneal involvement may benefit from surgical resection. See Video Abstract.</p>","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Irritant Contact Dermatitis and Review of Peristomal Skin Complications.","authors":"Andres Doval Rojas, Kurt S Schultz, Jennifer L Giannettino, Lisa Cioffi, Ira L Leeds","doi":"10.1097/DCR.0000000000003740","DOIUrl":"https://doi.org/10.1097/DCR.0000000000003740","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anal Sphincteroplasty for Fecal Incontinence.","authors":"Amanda Pereira Lima, Rodrigo Âmbar Pinto, Isaac José Felippe Corrêa Neto","doi":"10.1097/DCR.0000000000003758","DOIUrl":"10.1097/DCR.0000000000003758","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Low Anterior Resection With En-Bloc Pelvic Peritonectomy, Omentectomy and Hyperthermic Intraperitoneal Chemotherapy.","authors":"Christine Li, Thomas G Barnes, Satish Warrier","doi":"10.1097/DCR.0000000000003742","DOIUrl":"10.1097/DCR.0000000000003742","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency Laparoscopic Right Hemicolectomy With Intracorporeal Anastomosis.","authors":"Chloe McDonald, Zi Qin Ng","doi":"10.1097/DCR.0000000000003650","DOIUrl":"10.1097/DCR.0000000000003650","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Left Lateral Pelvic Lymph Node Dissection in Female.","authors":"Subhathira Manohkaran, Akash Mor, Avanish Saklani","doi":"10.1097/DCR.0000000000003745","DOIUrl":"10.1097/DCR.0000000000003745","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Dissection of the Left Retrocolic Fascial Plane.","authors":"José Azevedo, Elisa Paoluzzi Tomada, Amjad Parvaiz","doi":"10.1097/DCR.0000000000003674","DOIUrl":"10.1097/DCR.0000000000003674","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transanal Endoscopic Submucosal Dissection for Large Rectal Lesions.","authors":"Matheus Meyer, Peterson M Neves, Henrique A Lima","doi":"10.1097/DCR.0000000000003682","DOIUrl":"10.1097/DCR.0000000000003682","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Commentary on Tumor Deposits in Colon Cancer.","authors":"Sandy H Fang","doi":"10.1097/DCR.0000000000003865","DOIUrl":"https://doi.org/10.1097/DCR.0000000000003865","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Deposits in Colon Cancer.","authors":"Richard Sassun, Nicholas P McKenna","doi":"10.1097/DCR.0000000000003864","DOIUrl":"https://doi.org/10.1097/DCR.0000000000003864","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}