Diseases of the Colon & Rectum最新文献

{"title":"Rethinking Intestinal Stem Cells: Why Fgfbp1 + Progenitors Might Be More Critical Than the Lgr5+ Population.","authors":"Amy L Lightner","doi":"10.1097/DCR.0000000000004112","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004112","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymph Node Sparing Radiation in Rectal Cancer - the Key to Unlocking the Potential of Immunotherapy?","authors":"Richard Garfinkle, Te Vuong, Dean A Fergusson","doi":"10.1097/DCR.0000000000004208","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004208","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Timing: Reevaluating the Complexity of Surgical Decision-Making After Total Neoadjuvant Therapy for Rectal Cancer.","authors":"Min Zou, Feng Gao, Zengqiang Yang","doi":"10.1097/DCR.0000000000004083","DOIUrl":"10.1097/DCR.0000000000004083","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"471"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Port Laparoscopic Hartmann Reversal Through Colostomy Site.","authors":"Elisa Paoluzzi Tomada, Michele Maria Carvello, Antonino Spinelli","doi":"10.1097/DCR.0000000000003906","DOIUrl":"10.1097/DCR.0000000000003906","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"464"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Competence Through Holistic Ostomy Care.","authors":"Gifty Kwakye","doi":"10.1097/DCR.0000000000004086","DOIUrl":"10.1097/DCR.0000000000004086","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"313-315"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"March 2026 Translations.","authors":"","doi":"10.1097/DCR.0000000000004167","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004167","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":"69 3","pages":"473-537"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Management of Recurrent Peritoneal Colon Cancer.","authors":"Tetsuo Ishizaki, Yuichi Nagakawa, Kei Yokozuka, Toshimichi Kobayashi, Yuji Kikuchi, Satoshi Tabuchi, Naokazu Chiba, Munehide Nakatsugawa, Shigeyuki Kawachi","doi":"10.1097/DCR.0000000000004025","DOIUrl":"10.1097/DCR.0000000000004025","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"457"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145603112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectal Cancer in the Elderly: To Operate or Not to Operate? A Nationwide Retrospective Study of the Italian Society of Surgical Oncology-Colorectal Cancer Network Collaborative Group.","authors":"Rossella Reddavid, Ugo Elmore, Danila Azzolina, Jacopo Moro, Simona Ceraolo, Paola De Nardi, Alberto Biondi, Roberto Persiani, Leonardo Solaini, Donato P Pafundi, Desiree Cianflocca, Diego Sasia, Marco Milone, Giulia Turri, Michela Mineccia, Francesca Pecchini, Gaetano Gallo, Daniela Rega, Simona Gili, Fabio Maiello, Andrea Barberis, Federico Costanzo, Monica Ortenzi, Andrea Divizia, Caterina Foppa, Gabriele Anania, Antonino Spinelli, Giuseppe S Sica, Mario Guerrieri, Roberto Polastri, Francesco Bianco, Paolo Delrio, Micaela Piccoli, Alessandro Ferrero, Corrado Pedrazzani, Giovanni D De Palma, Felice Borghi, Claudio Coco, Davide Cavaliere, Domenico D'Ugo, Riccardo Rosati, Maurizio Degiuli","doi":"10.1097/DCR.0000000000003961","DOIUrl":"10.1097/DCR.0000000000003961","url":null,"abstract":"<p><strong>Background: </strong>Patients older than 70 years account for 44% of all rectal cancer cases. Although surgery is the criterion standard treatment, elderly patients can also be offered other treatments, such as total neoadjuvant therapy with watch and wait.</p><p><strong>Objective: </strong>This study aimed to investigate whether postoperative 90-day mortality is higher in elderly patients than in younger patients.</p><p><strong>Design: </strong>This nationwide retrospective study included all consecutive resections of rectal cancer performed between 2005 and 2016 using data from the RALAR study. Patients were divided into 2 groups based on age: nonelderly (younger than 70 years) and elderly (70 years or older).</p><p><strong>Setting: </strong>Data were obtained from 19 Italian referral centers for colorectal surgery.</p><p><strong>Patients: </strong>A total of 3573 patients underwent rectal surgery: 2071 (57.9%) nonelderly and 1502 (42%) elderly.</p><p><strong>Main outcome measures: </strong>The primary end point was 90-day postoperative mortality. Secondary end points included intensive care unit stay, hospitalization, surgical and general postoperative complications, overall survival, disease-specific survival, and recurrence rate.</p><p><strong>Results: </strong>Ninety-day postoperative mortality was comparable between groups (0.41% nonelderly vs 1.05% elderly, p = 0.087). Elderly patients were monitored more frequently in intensive care units and developed more postoperative general complications, whereas no differences were found between the groups in terms of postoperative surgical complications. Hospitalization was longer in elderly patients (median [interquartile range]: 12.3 [9.7] vs 11.1 [14.6] days). Five-year overall survival was higher in the nonelderly group (77.3%) than in the elderly group (45.8%; adjusted OR 1.70; 95% CI, 0.57-5.65), whereas the disease-specific survival was similar between groups.</p><p><strong>Limitations: </strong>There are limitations inherent in this retrospective study, including the long accrual period and the unknown proportion of patients who did not undergo surgery.</p><p><strong>Conclusions: </strong>Although elderly patients experience a higher rate of postoperative general complications without an increase in postoperative mortality, rectal surgery yields similar surgical and oncological outcomes compared with younger patients. This study suggests that age alone should not exclude a patient from surgery. See Video Abstract .</p><p><strong>Cncer rectal en personas mayores operar o no operar estudio retrospectivo a nivel nacional del grupo colaborativo de la red de cncer colorrectal de la sociedad italiana de oncologa quirrgica: </strong>ANTECEDENTES:Los pacientes mayores de 70 años representan el 44 % de todos los casos de cáncer rectal. Aunque la cirugía es el tratamiento de referencia, a los pacientes de edad avanzada también se les pueden ofrecer otros tratamientos, como la terapia neoa","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"392-401"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Open, Laparoscopic, and Robotic Approaches for Hartmann's Reversal: The Mayo Clinic Experience.","authors":"Davide Ferrari, Thomas Peponis, Tommaso Violante, Amy E Glasgow, William R G Perry, David W Larson, Kevin T Behm","doi":"10.1097/DCR.0000000000004066","DOIUrl":"10.1097/DCR.0000000000004066","url":null,"abstract":"<p><strong>Background: </strong>End colostomy reversal with colorectal anastomosis (Hartmann's reversal) is a technically challenging procedure associated with significant morbidity due to adhesions and distorted anatomy after the index surgery.</p><p><strong>Objective: </strong>To compare perioperative outcomes of open, laparoscopic, and robotic approaches for Hartmann's reversal.</p><p><strong>Design: </strong>Retrospective analysis of prospectively maintained data.</p><p><strong>Settings: </strong>High-volume tertiary referral center with specialized colorectal surgery expertise.</p><p><strong>Patients: </strong>A total of 218 patients who underwent Hartmann's reversal between May 2018 and April 2023.</p><p><strong>Main outcome measures: </strong>Primary outcomes included hospital length of stay and rate of conversion. Secondary outcomes included overall complication rates and time to return of bowel function.</p><p><strong>Results: </strong>Of 218 patients, 139 (63.8%) underwent open surgery, 48 (22.0%) underwent laparoscopic surgery, and 31 (14.2%) underwent robotic surgery. Robotic surgery had the lowest estimated blood loss (median 77.5 vs 100 mL laparoscopic and 150 mL open, p < 0.0001). Conversion to open surgery occurred in 16.1% of robotic cases compared with 35.4% of laparoscopic cases ( p = 0.0618). Minimally invasive approaches were associated with shorter hospital length of stay (median 3.0 vs 4.0 days, p < 0.0001) and faster return of bowel function (median 2.0 vs 3.0 days, p = 0.0095) compared to open surgery. Overall 30-day morbidity was 23.4%, with no significant difference among approaches ( p = 0.30). The temporal trend showed increasing adoption of robotic techniques, from 0% in 2018 to 53.8% in 2023, and a decrease in the proportion of cases approached by open surgery, from 76.9% in 2018 to 23.1% in 2023.</p><p><strong>Limitations: </strong>Retrospective design and single-institution experience with limited follow-up duration.</p><p><strong>Conclusions: </strong>Minimally invasive approaches to Hartmann's reversal are associated with improved short-term outcomes compared to open surgery. The robotic approach shows promise in reducing conversion rates, potentially extending the benefits of minimally invasive surgery to more patients undergoing this challenging procedure. See Video Abstract .</p><p><strong>Comparacin de los enfoques abierto, laparoscpico y robtico para la reversin de hartmann la experiencia de la clnica mayo: </strong>ANTECEDENTES:La reversión de la colostomía terminal con anastomosis colorrectal (reversión de Hartmann) es un procedimiento técnicamente complejo asociado a una morbilidad significativa debido a las adherencias y la distorsión anatómica tras la cirugía inicial.OBJETIVO:Comparar los resultados perioperatorios de los abordajes abiertos, laparoscópicos y robóticos para la reversión de Hartmann.DISEÑO:Análisis retrospectivo de datos mantenidos prospectivamente.ENTORNO:Centro terciario de referencia ","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"432-441"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Salih Karahan, Metincan Erkaya, Emre Gorgun","doi":"10.1097/DCR.0000000000004084","DOIUrl":"10.1097/DCR.0000000000004084","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":"472"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}