Diseases of the Colon & Rectum最新文献

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Oncologic Outcomes and Adjuvant Chemotherapy Use in Early- Versus Late-Onset Colon Cancer: A Propensity Score-Matched Analysis. 早发性结肠癌与晚发性结肠癌的肿瘤预后和辅助化疗:倾向评分匹配分析。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-16 DOI: 10.1097/DCR.0000000000004491
Soo Young Oh, In Ja Park, Young Il Kim, Eun Jung Park, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim
{"title":"Oncologic Outcomes and Adjuvant Chemotherapy Use in Early- Versus Late-Onset Colon Cancer: A Propensity Score-Matched Analysis.","authors":"Soo Young Oh, In Ja Park, Young Il Kim, Eun Jung Park, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim","doi":"10.1097/DCR.0000000000004491","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004491","url":null,"abstract":"<p><strong>Background: </strong>The incidence of early-onset colon cancer is increasing, and younger patients are often treated more intensively on the assumption of worse prognosis.</p><p><strong>Objective: </strong>To determine whether early-onset presentation is independently associated with prognosis, and to compare adjuvant chemotherapy use and effect between age groups.</p><p><strong>Design: </strong>Retrospective cohort study with 1:3 propensity score matching and exact matching on stage.</p><p><strong>Settings: </strong>A single tertiary referral center.</p><p><strong>Patients: </strong>Patients who underwent curative resection for stage I to III colon cancer between 2012 and 2020. Early onset was defined as diagnosis before age 50.</p><p><strong>Interventions: </strong>Curative resection with or without adjuvant chemotherapy.</p><p><strong>Main outcome measures: </strong>Recurrence-free survival was the primary outcome; overall survival and adjuvant chemotherapy use and effect were secondary.</p><p><strong>Results: </strong>Of 5,032 patients, 749 (14.9%) had early-onset disease; 656 were matched to 1,968 late-onset patients. Five-year recurrence-free survival did not differ between the groups (88.0 vs 86.1%; p = 0.09), and early onset was not independently associated with recurrence or death after adjustment for tumor factors and adjuvant chemotherapy, both in the matched (adjusted hazard ratio 0.85; 95% confidence interval 0.66-1.10) and entire cohort (0.79; 0.62-1.00). Among early-onset patients, recurrence-free survival was independently associated with T4 classification, nodal category, and poor differentiation. Nonetheless, early-onset patients received adjuvant chemotherapy more often (60.2 vs 53.5%; p = 0.003), including in low-risk Stage II disease (37.7 vs 14.3%; p < 0.001).</p><p><strong>Limitations: </strong>Retrospective single-center design with potential residual confounding; few early-onset patients did not receive chemotherapy.</p><p><strong>Conclusions: </strong>Early-onset presentation was not significantly associated with recurrence-free survival after multivariable adjustment in the matched cohort. Early-onset patients nonetheless received adjuvant chemotherapy more frequently and more intensively, including in low-risk Stage II disease. The observational design and the small number of untreated early-onset patients limit conclusions regarding age-specific chemotherapy benefit. See Video Abstract.</p>","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Quantitative Endoscopic Tumor Regression Grading System for Predicting Pathological Response Following Neoadjuvant Therapy in Rectal Cancer. 一种预测直肠癌新辅助治疗后病理反应的新型定量内镜肿瘤回归分级系统。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-15 DOI: 10.1097/DCR.0000000000004501
Metincan Erkaya, Josh Sommovilla, Mustafa Oruc, Joseph A Trunzo, David R Rosen, Salih Karahan, Hermann Kessler, Michael Valente, Scott R Steele, David Liska, Emre Gorgun
{"title":"A Novel Quantitative Endoscopic Tumor Regression Grading System for Predicting Pathological Response Following Neoadjuvant Therapy in Rectal Cancer.","authors":"Metincan Erkaya, Josh Sommovilla, Mustafa Oruc, Joseph A Trunzo, David R Rosen, Salih Karahan, Hermann Kessler, Michael Valente, Scott R Steele, David Liska, Emre Gorgun","doi":"10.1097/DCR.0000000000004501","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004501","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;While pathological and magnetic resonance imaging-based tumor regression grading systems are widely utilized following neoadjuvant therapy for rectal cancer, existing endoscopic approaches rely on qualitative assessment without quantitative weighting of individual features. Although individual endoscopic features associated with response have been described, no weighted scoring system exists to integrate these features into an objective assessment tool. This lack of a statistically weighted grading framework leads to subjective clinical impressions and significant interobserver variability in documentation and interpretation, limiting standardized patient selection for organ preservation strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To develop a quantitative, point-based endoscopic tumor Regression Grading system to standardize post-neoadjuvant therapy endoscopic assessment and predict pathological complete response.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;Retrospective cohort study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Single tertiary care center.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients: &lt;/strong&gt;Patients with locally advanced rectal cancer treated with total neoadjuvant therapy and surgical resection between 2018 and 2025 who had complete pre- and post-total neoadjuvant therapy endoscopic documentation were included.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Interventions: &lt;/strong&gt;Two experienced colorectal surgeons independently evaluated endoscopic images in blinded fashion, scoring predefined endoscopic features. A statistically weighted, point-based scoring algorithm was developed, with quantitative point values assigned proportional to the strength of association with American Joint Committee on Cancer pathological response. The system incorporated mucosal healing features (whitening, telangiectasia, scarring, erythema), adverse features (ulceration, necrosis), mass regression levels, and stricture characteristics, classifying patients into 3 tiers: Endoscopic Tumor Regression Grading 1 (complete), Endoscopic Tumor Regression Grading 2 (near complete), or Endoscopic Tumor Regression Grading 3 (partial/incomplete).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measures: &lt;/strong&gt;Predictive performance of the Endoscopic Tumor Regression Grading system for pathological complete response, 3-tier risk stratification, and interobserver reliability, evaluated using diagnostic performance metrics and receiver operating characteristic analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Seventy-six patients (mean age 58 ± 12 years; 58% male) were eligible. The 2 endoscopists demonstrated excellent interobserver agreement for the overall response assessment (weighted κ = 0.9) with 88.2% exact agreement. Univariate analysis identified whitening of the mucosa as the strongest predictor of complete response (odds ratio 47), followed by telangiectasia (odds ratio 23), scarring (odds ratio 16), and erythema (odds ratio 16). Ulceration and necrosis were powerful negative predictors (odds ratio 0.03 each). Each","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The New Face of an Old Disease: A Survey of Young People regarding Early-Onset Colorectal Cancer. 一种老病的新面貌:一项关于早发性结直肠癌的年轻人调查。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-14 DOI: 10.1097/DCR.0000000000004497
Sean J Langenfeld, Sophia Zigouras, J Joshua Smith, Zoe Garoufalia, Heather Dahlen, Carly Raasch, Mika Kadono, Memi Miscally, Kirsten B Wilkins
{"title":"The New Face of an Old Disease: A Survey of Young People regarding Early-Onset Colorectal Cancer.","authors":"Sean J Langenfeld, Sophia Zigouras, J Joshua Smith, Zoe Garoufalia, Heather Dahlen, Carly Raasch, Mika Kadono, Memi Miscally, Kirsten B Wilkins","doi":"10.1097/DCR.0000000000004497","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004497","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Colorectal cancer is now the leading cause of cancer-related deaths for people under the age of 50.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;As an initial step of the Early-Onset Colorectal Cancer Awareness Campaign, the purpose of this study was to survey a large sample of members of the public age 20 to 44 to determine their baseline levels of early-onset colorectal cancer understanding as well as their comfort discussing early-onset colorectal cancer and the associated symptoms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;This was an online survey conducted in December 2025, before the launch of the Early-Onset Colorectal Cancer Awareness Campaign, to establish baseline measures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measures: &lt;/strong&gt;Baseline demographics were collected, including age, gender, race/ethnicity, region, and survey language. Survey measures were developed based on the Health Belief Model, focus group findings, and subject matter expert review.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants: &lt;/strong&gt;Participants aged 20 to 44 were recruited from a respondent panel maintained by a market-research vendor, and recruitment was stopped after meeting a quota of 1,000 respondents. Healthcare providers were excluded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 1,000 respondents were included with even distribution of age and sex. The survey was taken in Spanish by 27%. Overall awareness of colorectal cancer (CRC) and early-onset colorectal cancer was low (41 and 24%, respectively). Knowledge of family history was low for colorectal cancer (22%) as well as colorectal polyps (17%). Twenty-nine percent of respondents had not heard of any symptoms of colorectal cancer while 36% identified rectal bleeding and 29% identified changes in stool habits as symptoms of colorectal cancer. Only 22% of respondents had looked for information on colorectal cancer within the last year. Female respondents felt less comfortable than their male counterparts discussing early-onset colorectal cancer with a healthcare provider (55 vs 67%, p = 0.017) or with their friends and family (56% vs 67%, p = 0.025). When asked about potential reasons to avoid or postpone a colonoscopy, respondents reported concerns about cost (69%), risk of complications (68%), fear of a cancer diagnosis (68%), and mistrust of the health care system (57%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;The limitations of the study include the use of an opt-in survey, as this requires a self-selected group of respondents with potential differences in health literacy, digital engagement, and survey-taking behavior from the public.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Currently, people under the age of 45 have a low overall understanding of early-onset colorectal cancer, and most are unaware of their own family history of colorectal cancer and colon polyps. Several important roadblocks to gaining information and/or seeking care for early-onset colorectal cancer were also identified. These findings will be used to inform ","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Evaluation of Intrarectal Botulinum Toxin Injection Sessions for Treating Urge and Mixed Fecal Incontinence: Results from a Monocentric Historical Cohort. 直肠内注射肉毒杆菌毒素治疗急尿和混合性大便失禁的长期评价:来自单中心历史队列的结果。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-13 DOI: 10.1097/DCR.0000000000004499
Charlotte Desprez, Camille Imparato, Chloé Melchior, Guillaume Gourcerol, Virginie Vernon, Valérie Bridoux, Anne-Marie Leroi
{"title":"Long-term Evaluation of Intrarectal Botulinum Toxin Injection Sessions for Treating Urge and Mixed Fecal Incontinence: Results from a Monocentric Historical Cohort.","authors":"Charlotte Desprez, Camille Imparato, Chloé Melchior, Guillaume Gourcerol, Virginie Vernon, Valérie Bridoux, Anne-Marie Leroi","doi":"10.1097/DCR.0000000000004499","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004499","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of long-term data on the outcomes of intrarectal botulinum toxin injections as a new option therapy for urge fecal incontinence, particularly following reinjection sessions, reasons for treatment dropout, and safety data.</p><p><strong>Objective: </strong>The objective of this study was to detail the outcomes of intrarectal botulinum toxin injections in our monocentric historical cohort with the longest known follow-up to date.</p><p><strong>Design: </strong>This retrospective study included patients who underwent at least one intrarectal injection session of botulinum toxin administered during sigmoidoscopy.</p><p><strong>Patients: </strong>We included patients who were being treated at our center for urge fecal incontinence with failure of first-line or second-line therapy.</p><p><strong>Main outcome measures: </strong>Treatment success after the injection sessions required patient satisfaction, with none to moderate symptoms and the absence of additional treatments (excluding medication).</p><p><strong>Results: </strong>Seventy-nine patients were included (median age: 62.0 (51.0-69.0); 77/79 female gender) with a median follow-up of 37.0 (10.0 to 72.0) months. A total of 238 injection sessions were performed (median number of 1.0 (0.5-1.8) injection session by patient year of follow-up) with 76% efficacy after the first injection session. The median delay between reinjection sessions was 12.5 months (9.8 to 20.3). Twenty-nine patients experienced treatment failure (36.7%) during follow-up, mainly because symptoms did not improve significantly. A decrease from 11 (9.0 to 15.0) to 9.0 (5.0 to 12.0) was observed for the median Cleveland score. Eighty-eight nonserious adverse events, mainly constipation, were observed in 47 patients (59.5%).</p><p><strong>Limitations: </strong>As the present study was monocentric, the number of patients included was limited, albeit the patient cohort was larger than in most other published series.</p><p><strong>Conclusions: </strong>Intrarectal botulinum toxin injections for urge fecal incontinence seem to be efficacious in the long term. Further studies need to focus on injection methods and standardize follow-up and reinjection criteria. (See Video Abstract).</p>","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectal Foreign-Body Extraction and Fecal Disimpaction: Coding, Documentation, and Financial Implications. 直肠异物提取和粪便去除:编码、文件和财务意义。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-13 DOI: 10.1097/DCR.0000000000004498
Razmik Ghukasyan
{"title":"Rectal Foreign-Body Extraction and Fecal Disimpaction: Coding, Documentation, and Financial Implications.","authors":"Razmik Ghukasyan","doi":"10.1097/DCR.0000000000004498","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004498","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognition, Evaluation, and Diagnosis of Early-Onset Colorectal Cancer. 早发性结直肠癌的识别、评估和诊断。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-12 DOI: 10.1097/DCR.0000000000004489
Colleen Donahue, Yasmin Zerhouni, Michael Kelly, George Theodoropoulos, Ramy Behman, Beatrice Dionigi, Mark Hanna, Miquell Miller, T Cristina Sardinha, Samantha Hendren, J Joshua Smith, Marina Chilov, Robin O'Hanlon, Jennifer Ayscue, Kelly Finan
{"title":"Recognition, Evaluation, and Diagnosis of Early-Onset Colorectal Cancer.","authors":"Colleen Donahue, Yasmin Zerhouni, Michael Kelly, George Theodoropoulos, Ramy Behman, Beatrice Dionigi, Mark Hanna, Miquell Miller, T Cristina Sardinha, Samantha Hendren, J Joshua Smith, Marina Chilov, Robin O'Hanlon, Jennifer Ayscue, Kelly Finan","doi":"10.1097/DCR.0000000000004489","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004489","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Provider Knowledge, Risk Perceptions, and Communication Readiness Drive Discussions about Early-Onset Colorectal Cancer: A National Survey of US Healthcare Providers. 提供者知识,风险认知和沟通准备推动讨论早发性结直肠癌:美国医疗保健提供者的全国调查。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-12 DOI: 10.1097/DCR.0000000000004490
Jeffrey Butcher, Steven A Fassler, Jade Bedell, Benjamin Denison, Heather Dahlen, Mika Kadono, Memi Miscally, Sonia Ramamoorthy, Elizabeth C Wick, Kirsten B Wilkins
{"title":"Provider Knowledge, Risk Perceptions, and Communication Readiness Drive Discussions about Early-Onset Colorectal Cancer: A National Survey of US Healthcare Providers.","authors":"Jeffrey Butcher, Steven A Fassler, Jade Bedell, Benjamin Denison, Heather Dahlen, Mika Kadono, Memi Miscally, Sonia Ramamoorthy, Elizabeth C Wick, Kirsten B Wilkins","doi":"10.1097/DCR.0000000000004490","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004490","url":null,"abstract":"<p><strong>Background: </strong>The incidence of early-onset colorectal cancer continues to increase among adults younger than 50 years, yet delays in diagnosis remain common.</p><p><strong>Objective: </strong>As an initial step of the Early-Onset Colorectal Cancer Awareness campaign, we evaluated U.S. healthcare providers' knowledge, attitudes, diagnostic practices, and perceived barriers related to the timely recognition and evaluation of early-onset colorectal cancer.</p><p><strong>Design: </strong>This survey established baseline measures for a national early-onset colorectal cancer awareness campaign.</p><p><strong>Setting: </strong>We conducted a national cross-sectional survey of physicians, nurse practitioners, and physician assistants practicing family medicine, internal medicine, emergency medicine/urgent care, and obstetrics and gynecology.</p><p><strong>Main outcome measures: </strong>The survey assessed early-onset colorectal cancer awareness, screening recommendations, evaluation of symptomatic younger adults, perceived barriers to diagnosis, and educational needs. Descriptive statistics summarized responses, and multivariable regression identified factors associated with guideline-concordant screening and diagnostic evaluation.</p><p><strong>Results: </strong>A total of 277 providers completed the survey. Although 87% were concerned or very concerned about early-onset colorectal cancer and 82% reported increased concern over the preceding five years, providers identified substantial barriers to timely diagnosis. Approximately one-half reported that younger adults commonly experienced symptoms for four months or longer before seeking care. The most frequently cited barriers included patients expecting symptoms to resolve (84%), insurance and financial barriers (79%), reluctance to undergo colonoscopy (77%), and failure to recognize symptoms as serious (65%). Most providers (79%) identified additional guidance on early-onset colorectal cancer symptoms, risk factors, and diagnostic evaluation as the educational resource most likely to improve care.</p><p><strong>Conclusions: </strong>Despite widespread awareness of the increasing incidence of early-onset colorectal cancer, patient- and system-level barriers continue to delay diagnosis in younger adults. These findings identify opportunities for targeted education, clinical decision support, and health system interventions to promote timely evaluation of symptomatic patients and improve early detection of early-onset colorectal cancer. See Video Abstract.</p>","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert Commentary on Diagnosis and Management of HIV-Associated Colitis. hiv相关结肠炎的诊断和治疗专家评论。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-12 DOI: 10.1097/DCR.0000000000004496
Jehan Budak
{"title":"Expert Commentary on Diagnosis and Management of HIV-Associated Colitis.","authors":"Jehan Budak","doi":"10.1097/DCR.0000000000004496","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004496","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and Management of HIV-Associated Colitis. hiv相关结肠炎的诊断和治疗。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-12 DOI: 10.1097/DCR.0000000000004495
Carlos Fairen Oro, Olga Beresneva
{"title":"Diagnosis and Management of HIV-Associated Colitis.","authors":"Carlos Fairen Oro, Olga Beresneva","doi":"10.1097/DCR.0000000000004495","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004495","url":null,"abstract":"<p><p>A 63-year-old male with a history of untreated HIV presented to the emergency room with acute on chronic watery diarrhea, weight loss, fatigue, fever and chills. His vital signs were within normal limits and his abdomen was soft, nondistended and tender to palpation in 4 quadrants without peritonitis. He did not have leukocytosis on presentation. CD4 count was 310. CT scan showed inflammatory changes in the rectum and sigmoid colon. Comprehensive infectious workup was negative for any pathogens including cytomegalovirus (CMV), cryptosporidium, chlamydia, gonorrhea, C. difficile, cryptococcus, tuberculosis (TB) and herpes simplex virus (HSV). Colonoscopy was performed and showed a continuous area of nonbleeding ulcerated mucosa in the rectum, sigmoid, descending and transverse colon (Fig. 1). Pancolonic biopsies revealed active colitis with focal areas of basal plasmacytosis and crypt branching in left colon, suggestive of acute on chronic colitis and possible ulcerative colitis (UC). Gastroenterology and infectious disease were consulted and patient was started on IV methylprednisolone for presumed UC flare. Over the next few weeks, the patient proceeded to develop melena as well as increased lower abdominal and pelvic pain with intermittent fevers despite IV steroid treatment. The patient was trialed on IV infliximab also without significant improvement. After several weeks of steroid and biologic treatment, he developed increased abdominal pain with tachycardia and hemodynamic instability. His examination was significant for peritonitis with abdominal distension concerning for fulminant colitis. Colorectal surgery was consulted and proceeded to do an emergent total abdominal colectomy and end ileostomy. Intraoperatively he was found to have a small anterior distal rectal perforation. The decision was made to drain this area widely with rectal drain and fecal diversion and start him on IV antibiotic therapy. His final pathology from the index operation showed ulceration and acute colitis. There was no chronic crypt architectural distortion such as crypt dropout, disarray, crypt branching or basal plasmacytosis that are often seen in inflammatory bowel disease (IBD). There was also increased apoptotic bodies and mitoses that were not consistent with IBD. After reviewing the clinical presentation, his disease progression, and final pathology, the treating team diagnosed the patient with HIV-associated colitis.</p>","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic Intracorporeal Single-Stapled Anastomosis as a Rescue Strategy After Multiple Linear Stapler Firings During Rectal Transection. 机器人体内单吻合器作为直肠横断术中多次线性吻合器发射后的抢救策略。
IF 3.1 2区 医学
Diseases of the Colon & Rectum Pub Date : 2026-10-12 DOI: 10.1097/DCR.0000000000004430
Paulo Roberto Stevanato Filho, Julia Nicioli, Tiago Santoro Bezerra, Tomas Mansur Duarte de Miranda Marques, Renata Mayumi Takahashi, Rebeca Hara Nahime, Ademar Lopes, Samuel Aguiar Junior
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