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Drug Metabolism and Pharmacokinetics最新文献

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Preclinical DDI risk assessment in drug discovery and development 药物发现和开发中的临床前DDI风险评估
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101080
Niresh Hariparsad
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引用次数: 0
Drug-induced gastrointestinal toxicity due to disruption of the interinfluence between serotonin and gut microbiota 5 -羟色胺与肠道微生物群之间相互影响的破坏引起的药物诱导胃肠道毒性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101121
Suguru Asaji , Yuta Funai , Yuta Seki , Kotone Banba , Jun Hida , Ikumi Tamai , Yoshiyuki Shirasaka
{"title":"Drug-induced gastrointestinal toxicity due to disruption of the interinfluence between serotonin and gut microbiota","authors":"Suguru Asaji , Yuta Funai , Yuta Seki , Kotone Banba , Jun Hida , Ikumi Tamai , Yoshiyuki Shirasaka","doi":"10.1016/j.dmpk.2025.101121","DOIUrl":"10.1016/j.dmpk.2025.101121","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101121"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex drug-drug interactions: Study design and clinical interpretation 复杂的药物-药物相互作用：研究设计和临床解释
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101081
Manoli Vourvahis
{"title":"Complex drug-drug interactions: Study design and clinical interpretation","authors":"Manoli Vourvahis","doi":"10.1016/j.dmpk.2025.101081","DOIUrl":"10.1016/j.dmpk.2025.101081","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101081"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range 蛋白表达作为评估CYP2B6诱导的终点：应用免疫亲和捕获方法可以提高动态反应范围
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101156
Julius Enoru, Anand Joshi, Paramasivam Natarajan, Mira Jones, Hetal Sarvaiya, Steve Keller
{"title":"Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range","authors":"Julius Enoru, Anand Joshi, Paramasivam Natarajan, Mira Jones, Hetal Sarvaiya, Steve Keller","doi":"10.1016/j.dmpk.2025.101156","DOIUrl":"10.1016/j.dmpk.2025.101156","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101156"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of QPCR method to detect human cells in mouse and rat tissues 小鼠和大鼠组织中检测人细胞的QPCR方法的验证
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101143
Kuniyoshi Abe, Haruka Inoue, Yuka Torikai, Naoki Kaname, Seulgi Lee, Akiko Suzuki, Yukiko Arimura, Yurie Okawa, Tetsuya Yoshikawa
{"title":"Validation of QPCR method to detect human cells in mouse and rat tissues","authors":"Kuniyoshi Abe, Haruka Inoue, Yuka Torikai, Naoki Kaname, Seulgi Lee, Akiko Suzuki, Yukiko Arimura, Yurie Okawa, Tetsuya Yoshikawa","doi":"10.1016/j.dmpk.2025.101143","DOIUrl":"10.1016/j.dmpk.2025.101143","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101143"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why and when do i use PBPK modeling 为什么以及何时使用PBPK建模
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101060
Kunal Taskar
{"title":"Why and when do i use PBPK modeling","authors":"Kunal Taskar","doi":"10.1016/j.dmpk.2025.101060","DOIUrl":"10.1016/j.dmpk.2025.101060","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101060"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oligonucleotide target engagement 寡核苷酸目标交战
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101076
Michael McCoy
{"title":"Oligonucleotide target engagement","authors":"Michael McCoy","doi":"10.1016/j.dmpk.2025.101076","DOIUrl":"10.1016/j.dmpk.2025.101076","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101076"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alteration of blood brain-barrier proteome in various conditions 不同条件下血脑屏障蛋白质组的改变
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101113
Sumio Ohtsuki
{"title":"Alteration of blood brain-barrier proteome in various conditions","authors":"Sumio Ohtsuki","doi":"10.1016/j.dmpk.2025.101113","DOIUrl":"10.1016/j.dmpk.2025.101113","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101113"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The blood brain barrier demonstrates capability to influence heterogenous tenofovir and emtricitabine metabolism and transport in the brain 血脑屏障显示有能力影响异质替诺福韦和恩曲他滨在大脑中的代谢和运输
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101119
Hannah Wilkins , Ben Orsburn , Dionna Williams
{"title":"The blood brain barrier demonstrates capability to influence heterogenous tenofovir and emtricitabine metabolism and transport in the brain","authors":"Hannah Wilkins , Ben Orsburn , Dionna Williams","doi":"10.1016/j.dmpk.2025.101119","DOIUrl":"10.1016/j.dmpk.2025.101119","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101119"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Species specificity and selection of animal models for drug oxygenations differently contributed by polymorphic human enzymes 多态酶对药物氧合作用的物种特异性和动物模型的选择
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101105
Hiroshi Yamazaki
{"title":"Species specificity and selection of animal models for drug oxygenations differently contributed by polymorphic human enzymes","authors":"Hiroshi Yamazaki","doi":"10.1016/j.dmpk.2025.101105","DOIUrl":"10.1016/j.dmpk.2025.101105","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101105"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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