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Drug Metabolism and Pharmacokinetics最新文献

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Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models 全氟辛酸和全氟己烷磺酸在各种大鼠模型中的药代动力学
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100959
Kyungsun Moon, Sung-Hoon Ahn
{"title":"Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models","authors":"Kyungsun Moon, Sung-Hoon Ahn","doi":"10.1016/j.dmpk.2023.100959","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100959","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"129 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocyte CEBPA restricts the progression of liver fibrosis 肝细胞 CEBPA 限制肝纤维化的进展
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100898
Tingting Yan, Nana Yan, Yangliu Xia, Haiping Hao, Frank J. Gonzalez
{"title":"Hepatocyte CEBPA restricts the progression of liver fibrosis","authors":"Tingting Yan, Nana Yan, Yangliu Xia, Haiping Hao, Frank J. Gonzalez","doi":"10.1016/j.dmpk.2023.100898","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100898","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"189 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of cyp and non-cyp hepatic abundance changes in PBPK modelling of renal impairment (RI) populations 在肾功能损伤（RI）人群的 PBPK 建模中整合细胞色素和非细胞色素肝丰度变化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100971
Oliver Hatley, Trevor Johnson, Iain Gardner, Karen Rowland Yeo
{"title":"Integration of cyp and non-cyp hepatic abundance changes in PBPK modelling of renal impairment (RI) populations","authors":"Oliver Hatley, Trevor Johnson, Iain Gardner, Karen Rowland Yeo","doi":"10.1016/j.dmpk.2023.100971","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100971","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"193 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rifampin- and silymarin-mediated pharmcokinetic interactions of pitavastatin, pravastatin, coproporphyrin I, and coproporphyrin III in a transgenic OATP1B mouse model 利福平和水飞蓟素介导的匹伐他汀、普伐他汀、共卟啉 I 和共卟啉 III 在转基因 OATP1B 小鼠模型中的药物动力学相互作用
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100980
Baron Bechtold, Katherine Lynch, Victoria Oyanna, Michael Ridge Call, John Clarke
{"title":"Rifampin- and silymarin-mediated pharmcokinetic interactions of pitavastatin, pravastatin, coproporphyrin I, and coproporphyrin III in a transgenic OATP1B mouse model","authors":"Baron Bechtold, Katherine Lynch, Victoria Oyanna, Michael Ridge Call, John Clarke","doi":"10.1016/j.dmpk.2023.100980","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100980","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"48 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs. Encequidar 是一种肠道限制 P-GP 特异性抑制剂，可提高口服生物利用度，抑制大鼠和狗的肠道分泌。
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100989
Murali Subramanian, Aaliyah Shodeinde, Gregg Schwarzwalder, Ana Gonzalez, Josh Yu, Guangyu Zhao, Jia Hao, Xiaomin Liang, Yurong Lai, Raju Subramanian
{"title":"Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs.","authors":"Murali Subramanian, Aaliyah Shodeinde, Gregg Schwarzwalder, Ana Gonzalez, Josh Yu, Guangyu Zhao, Jia Hao, Xiaomin Liang, Yurong Lai, Raju Subramanian","doi":"10.1016/j.dmpk.2023.100989","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100989","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional characterization of ENT2/SLC29A2 as a uric acid transporter ENT2/SLC29A2作为尿酸转运体的功能特征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100984
Isamu Matake, Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa
{"title":"Functional characterization of ENT2/SLC29A2 as a uric acid transporter","authors":"Isamu Matake, Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa","doi":"10.1016/j.dmpk.2023.100984","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100984","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"66 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De-risking idiosyncratic adverse drug reactions and toxicities in drug discovery utilizing a qualitative in-vitro high-throughput reactive metabolite trapping method 利用定性体外高通量反应性代谢物捕获法降低药物发现过程中的特异性药物不良反应和毒性风险
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100940
Shantanu Roychowdhury, Kevin Thomas, Allison Liverar, Michell Martineau, Libby Bell, Lucus Albrecht
{"title":"De-risking idiosyncratic adverse drug reactions and toxicities in drug discovery utilizing a qualitative in-vitro high-throughput reactive metabolite trapping method","authors":"Shantanu Roychowdhury, Kevin Thomas, Allison Liverar, Michell Martineau, Libby Bell, Lucus Albrecht","doi":"10.1016/j.dmpk.2023.100940","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100940","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"4 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo and in vitro biotransformation of molnupiravir (MOV), An oral prodrug of the antiviral ribonucleoside analog Β-D-N4-hydroxycytidine (NHC) 抗病毒核糖核苷类似物Β-D-N4-羟基胞苷（NHC）口服原药莫仑吡韦（MOV）的体内和体外生物转化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100933
Ping Lu, Randy Miller, Jianmei Pang, Sheri Smith, Jason Hoar, Mark Concilla
{"title":"In vivo and in vitro biotransformation of molnupiravir (MOV), An oral prodrug of the antiviral ribonucleoside analog Β-D-N4-hydroxycytidine (NHC)","authors":"Ping Lu, Randy Miller, Jianmei Pang, Sheri Smith, Jason Hoar, Mark Concilla","doi":"10.1016/j.dmpk.2023.100933","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100933","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"67 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of substrate concentration on reactive metabolite assessment in drug discovery research 底物浓度对药物发现研究中活性代谢物评估的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100937
Makoto Ozawa, Hideyuki Shiozawa, Masaya Shimada, Chie Makino, Hideo Takakusa, Kengo Watanabe, Kyosuke Suzuki
{"title":"Effect of substrate concentration on reactive metabolite assessment in drug discovery research","authors":"Makoto Ozawa, Hideyuki Shiozawa, Masaya Shimada, Chie Makino, Hideo Takakusa, Kengo Watanabe, Kyosuke Suzuki","doi":"10.1016/j.dmpk.2023.100937","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100937","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"2018 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The practical impact of the FDA draft guidance on human mass balance studies – a year of client discussions 美国食品药物管理局人体质量平衡研究指南草案的实际影响--一年来客户的讨论情况
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100943
Iain Shaw, Adam Robinson-Miller, Phil Evans, Stuart Mair
{"title":"The practical impact of the FDA draft guidance on human mass balance studies – a year of client discussions","authors":"Iain Shaw, Adam Robinson-Miller, Phil Evans, Stuart Mair","doi":"10.1016/j.dmpk.2023.100943","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100943","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"32 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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