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Drug Metabolism and Pharmacokinetics最新文献

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Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human 人参皂甙的药代动力学以及乳酸菌对小鼠和人参皂甙药代动力学的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100965
Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Min-Koo Choi, Im-Sook Song
{"title":"Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human","authors":"Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Min-Koo Choi, Im-Sook Song","doi":"10.1016/j.dmpk.2023.100965","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100965","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and characterisation of a novel amino acid conjugate; ergothioneine conjugate of raloxifene through in vitro and in vivo studies 通过体外和体内研究鉴定和描述一种新型氨基酸共轭物；雷洛昔芬的麦角硫因共轭物
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100946
Prakash R. Vachaspati, Abhijth P. Rao, Sivaprasad Putluru, Prasanth Eapen, Hemantha Kumar, Raviraj Landage, Srikanth Sridhar, Silvi Chacko, Khemraj Bairwa, Micheal Sinz, T. Thanga Mariappan
{"title":"Identification and characterisation of a novel amino acid conjugate; ergothioneine conjugate of raloxifene through in vitro and in vivo studies","authors":"Prakash R. Vachaspati, Abhijth P. Rao, Sivaprasad Putluru, Prasanth Eapen, Hemantha Kumar, Raviraj Landage, Srikanth Sridhar, Silvi Chacko, Khemraj Bairwa, Micheal Sinz, T. Thanga Mariappan","doi":"10.1016/j.dmpk.2023.100946","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100946","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel approaches and troubleshooting for developing a high-throughput oligonucleotide LC-MS method beyond the current stage 超越现阶段开发高通量寡核苷酸 LC-MS 方法的新方法和故障排除方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100954
Changhong Yun, Hyun Chong Woo, Ditte Lovatt, Craig A. Parish, Daniel S. Spellman, Honglue Shen
{"title":"Novel approaches and troubleshooting for developing a high-throughput oligonucleotide LC-MS method beyond the current stage","authors":"Changhong Yun, Hyun Chong Woo, Ditte Lovatt, Craig A. Parish, Daniel S. Spellman, Honglue Shen","doi":"10.1016/j.dmpk.2023.100954","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100954","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-GP limits rodent oral absoprtion of protacs P-GP 限制啮齿动物口服吸收原酸
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100978
Stefanus Steyn, Mark Niosi, Emi Kimoto, Emi Yamaguchi
{"title":"P-GP limits rodent oral absoprtion of protacs","authors":"Stefanus Steyn, Mark Niosi, Emi Kimoto, Emi Yamaguchi","doi":"10.1016/j.dmpk.2023.100978","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100978","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches 通过实验和计算方法确定 UGT2B17 在药物和类固醇代谢中的杂交性和定量贡献
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100955
Deepak Ahire, Charles Mariasoosai, Siavosh Naji-Talakar, Senthil Natesan, Bhagwat Prasad
{"title":"Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches","authors":"Deepak Ahire, Charles Mariasoosai, Siavosh Naji-Talakar, Senthil Natesan, Bhagwat Prasad","doi":"10.1016/j.dmpk.2023.100955","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100955","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions of sutezolid and its active metabolite with human transporters 沙替佐利及其活性代谢物与人体转运体的相互作用
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100979
Upendra Argikar, Nathalie Rioux, Monicah Otieno
{"title":"Interactions of sutezolid and its active metabolite with human transporters","authors":"Upendra Argikar, Nathalie Rioux, Monicah Otieno","doi":"10.1016/j.dmpk.2023.100979","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100979","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to de-risk structural alerts in compound progression 在化合物进展过程中降低结构警报风险的方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100939
Charles Rotter, Heather Estrella, Takai Takafumi, Sean Zhu
{"title":"Approach to de-risk structural alerts in compound progression","authors":"Charles Rotter, Heather Estrella, Takai Takafumi, Sean Zhu","doi":"10.1016/j.dmpk.2023.100939","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100939","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elacridar leads to a much more pronounced boost in dog absorption than expected based on available non-clinical and clinical observations 根据现有的非临床和临床观察结果，Elacridar 对狗吸收的促进作用比预期的要明显得多
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100987
Diane Ramsden, Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad
{"title":"Elacridar leads to a much more pronounced boost in dog absorption than expected based on available non-clinical and clinical observations","authors":"Diane Ramsden, Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad","doi":"10.1016/j.dmpk.2023.100987","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100987","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics 犬 CYP2D15 基因多态性对塞来昔布体外肝脏代谢和体内药代动力学的影响，以及准确预测人体药代动力学的策略
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100967
Miyuu Yanai, Kazutaka Sekiguchi, Yasuto Kido
{"title":"Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics","authors":"Miyuu Yanai, Kazutaka Sekiguchi, Yasuto Kido","doi":"10.1016/j.dmpk.2023.100967","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100967","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of the relay method for low-turnover compounds in hepatocyte 建立肝细胞中低周转化合物的中继方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100947
Xiangling Wang, Haijuan Liu, Zhengu Xu, Yi Tao, Liang Shen, Genfu Chen
{"title":"Establishment of the relay method for low-turnover compounds in hepatocyte","authors":"Xiangling Wang, Haijuan Liu, Zhengu Xu, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100947","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100947","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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