发布求助
文献互助 智能选刊 最新文献

Drug Metabolism and Pharmacokinetics最新文献

筛选
英文 中文
SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue sds稳定的udp -葡萄糖醛基转移酶2B7的同型低聚物：通过特定的半胱氨酸残基参与二硫键的形成
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101152
Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii
{"title":"SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue","authors":"Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii","doi":"10.1016/j.dmpk.2025.101152","DOIUrl":"10.1016/j.dmpk.2025.101152","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101152"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI platform to accelerate drug discovery 人工智能平台加速药物发现
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101077
Yasushi Okuno
{"title":"AI platform to accelerate drug discovery","authors":"Yasushi Okuno","doi":"10.1016/j.dmpk.2025.101077","DOIUrl":"10.1016/j.dmpk.2025.101077","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101077"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems 巴马猪皮肤不同组织处理方法作为局部给药系统动物模型的评价
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101144
Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen
{"title":"Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems","authors":"Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen","doi":"10.1016/j.dmpk.2025.101144","DOIUrl":"10.1016/j.dmpk.2025.101144","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101144"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetic modeling leveraging in vitro to in vivo extrapolation of the gut microbiome’s role in sulfasalazine metabolism into sulfapyridine and mesalamine 利用体外到体内的药代动力学模型，推断肠道微生物组在磺胺吡啶和美沙拉胺代谢中的作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101120
Lisa Cheng , Jingwei Cai , Alexis Auster , Sungjoon Cho , Miaoran Ning
{"title":"Pharmacokinetic modeling leveraging in vitro to in vivo extrapolation of the gut microbiome’s role in sulfasalazine metabolism into sulfapyridine and mesalamine","authors":"Lisa Cheng , Jingwei Cai , Alexis Auster , Sungjoon Cho , Miaoran Ning","doi":"10.1016/j.dmpk.2025.101120","DOIUrl":"10.1016/j.dmpk.2025.101120","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101120"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industrial perspective of reactive metabolites: When to be afraid and when to be very afraid 反应性代谢物的工业观点：什么时候害怕，什么时候非常害怕
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101064
Jonathan Bauman
{"title":"Industrial perspective of reactive metabolites: When to be afraid and when to be very afraid","authors":"Jonathan Bauman","doi":"10.1016/j.dmpk.2025.101064","DOIUrl":"10.1016/j.dmpk.2025.101064","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101064"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions 内源性生物标志物信息评估转运体介导的药物-药物和药物-疾病相互作用的方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101078
Aleksandra Galetin
{"title":"Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions","authors":"Aleksandra Galetin","doi":"10.1016/j.dmpk.2025.101078","DOIUrl":"10.1016/j.dmpk.2025.101078","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101078"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI 机械性静态模型预测CYP和转运体介导的DDI的效用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101083
Sheila Peters
{"title":"Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI","authors":"Sheila Peters","doi":"10.1016/j.dmpk.2025.101083","DOIUrl":"10.1016/j.dmpk.2025.101083","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101083"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture 无免疫捕获的LC - MS/MS定量分析抗体偶联物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101131
Suhong Zhang, Samuel Koppara
{"title":"Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture","authors":"Suhong Zhang, Samuel Koppara","doi":"10.1016/j.dmpk.2025.101131","DOIUrl":"10.1016/j.dmpk.2025.101131","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101131"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions 减轻p糖蛋白在药物发现中的负作用的最佳实践——p糖蛋白介导的非线性PK、脑渗透和相互作用的评估和预测
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101109
Hideki Hirabayashi
{"title":"Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions","authors":"Hideki Hirabayashi","doi":"10.1016/j.dmpk.2025.101109","DOIUrl":"10.1016/j.dmpk.2025.101109","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101109"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A seven cytochrome P450 index substrate cocktail for clinical trials – Profiling the effects of clopidogrel and gemfibrozil on CYP enzymes and OATP1B1 biomarkers 用于临床试验的7细胞色素P450指数底物鸡尾酒-分析氯吡格雷和吉非齐尔对CYP酶和OATP1B1生物标志物的影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101154
Laura Aurinsalo , Outi Lapatto-Reiniluoto , Mikko Neuvonen , Mika Kurkela , Johanna Kiiski , Mikko Niemi , Aleksi Tornio , Janne Backman
{"title":"A seven cytochrome P450 index substrate cocktail for clinical trials – Profiling the effects of clopidogrel and gemfibrozil on CYP enzymes and OATP1B1 biomarkers","authors":"Laura Aurinsalo , Outi Lapatto-Reiniluoto , Mikko Neuvonen , Mika Kurkela , Johanna Kiiski , Mikko Niemi , Aleksi Tornio , Janne Backman","doi":"10.1016/j.dmpk.2025.101154","DOIUrl":"10.1016/j.dmpk.2025.101154","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101154"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书