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Drug Metabolism and Pharmacokinetics最新文献

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Deciphering the cell and zonal distribution of drug metabolizing enzymes and transporters in humans by single cell transcriptomics 通过单细胞转录组学破解药物代谢酶和转运体在人体内的细胞和区域分布
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100931
Joe Lim, Julia Cui, Curtis Klaassen
{"title":"Deciphering the cell and zonal distribution of drug metabolizing enzymes and transporters in humans by single cell transcriptomics","authors":"Joe Lim, Julia Cui, Curtis Klaassen","doi":"10.1016/j.dmpk.2023.100931","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100931","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"33 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141062585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated workflow to study microsomal clearance and analysis of metabolites using collision-induced dissociation and electron-activated dissociation MS/MS data 利用碰撞诱导解离和电子激活解离 MS/MS 数据研究微粒体清除和代谢物分析的自动化工作流程
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100936
Eshani Nandita, Rahul Baghla
{"title":"Automated workflow to study microsomal clearance and analysis of metabolites using collision-induced dissociation and electron-activated dissociation MS/MS data","authors":"Eshani Nandita, Rahul Baghla","doi":"10.1016/j.dmpk.2023.100936","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100936","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"34 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches 利用相对表达因子 (REF) 和 PET 成像方法预测和验证人体肝胆清除率和运输药物的肝脏浓度
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100992
Mengyue (Melody) Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Jashvant Unadkat
{"title":"Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches","authors":"Mengyue (Melody) Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Jashvant Unadkat","doi":"10.1016/j.dmpk.2023.100992","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100992","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"55 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A practical approach for measuring acyl glucuronide migration half life 测量酰基葡萄糖醛酸迁移半衰期的实用方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100944
Ying Tan, Zhoupeng Zhang, Niresh Hariparsad
{"title":"A practical approach for measuring acyl glucuronide migration half life","authors":"Ying Tan, Zhoupeng Zhang, Niresh Hariparsad","doi":"10.1016/j.dmpk.2023.100944","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100944","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"10 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
For hepatically cleared drugs, liver to blood KPUU at steady-state is always equal to FH , which exposes the deficiency of the present extended clearance concept equation 对于肝脏清除的药物，稳态时肝脏到血液的 KPUU 始终等于 FH，这暴露了目前扩展清除概念方程的不足之处
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100919
Leslie Z. Benet, Jasleen K. Sodhi
{"title":"For hepatically cleared drugs, liver to blood KPUU at steady-state is always equal to FH , which exposes the deficiency of the present extended clearance concept equation","authors":"Leslie Z. Benet, Jasleen K. Sodhi","doi":"10.1016/j.dmpk.2023.100919","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100919","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"17 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro 利用人体肝脏微粒体评估含黄素单氧化酶（FMO）的体外代谢情况
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100951
Nathan Delvaux, Morgan Knapp, Michael Schicker, Tyler Wittkopp, Mitchell Lavarias
{"title":"Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro","authors":"Nathan Delvaux, Morgan Knapp, Michael Schicker, Tyler Wittkopp, Mitchell Lavarias","doi":"10.1016/j.dmpk.2023.100951","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100951","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"193 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and characterisation of a novel amino acid conjugate; ergothioneine conjugate of raloxifene through in vitro and in vivo studies 通过体外和体内研究鉴定和描述一种新型氨基酸共轭物；雷洛昔芬的麦角硫因共轭物
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100946
Prakash R. Vachaspati, Abhijth P. Rao, Sivaprasad Putluru, Prasanth Eapen, Hemantha Kumar, Raviraj Landage, Srikanth Sridhar, Silvi Chacko, Khemraj Bairwa, Micheal Sinz, T. Thanga Mariappan
{"title":"Identification and characterisation of a novel amino acid conjugate; ergothioneine conjugate of raloxifene through in vitro and in vivo studies","authors":"Prakash R. Vachaspati, Abhijth P. Rao, Sivaprasad Putluru, Prasanth Eapen, Hemantha Kumar, Raviraj Landage, Srikanth Sridhar, Silvi Chacko, Khemraj Bairwa, Micheal Sinz, T. Thanga Mariappan","doi":"10.1016/j.dmpk.2023.100946","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100946","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-GP limits rodent oral absoprtion of protacs P-GP 限制啮齿动物口服吸收原酸
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100978
Stefanus Steyn, Mark Niosi, Emi Kimoto, Emi Yamaguchi
{"title":"P-GP limits rodent oral absoprtion of protacs","authors":"Stefanus Steyn, Mark Niosi, Emi Kimoto, Emi Yamaguchi","doi":"10.1016/j.dmpk.2023.100978","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100978","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"66 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human 人参皂甙的药代动力学以及乳酸菌对小鼠和人参皂甙药代动力学的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100965
Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Min-Koo Choi, Im-Sook Song
{"title":"Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human","authors":"Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Min-Koo Choi, Im-Sook Song","doi":"10.1016/j.dmpk.2023.100965","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100965","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"54 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel approaches and troubleshooting for developing a high-throughput oligonucleotide LC-MS method beyond the current stage 超越现阶段开发高通量寡核苷酸 LC-MS 方法的新方法和故障排除方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100954
Changhong Yun, Hyun Chong Woo, Ditte Lovatt, Craig A. Parish, Daniel S. Spellman, Honglue Shen
{"title":"Novel approaches and troubleshooting for developing a high-throughput oligonucleotide LC-MS method beyond the current stage","authors":"Changhong Yun, Hyun Chong Woo, Ditte Lovatt, Craig A. Parish, Daniel S. Spellman, Honglue Shen","doi":"10.1016/j.dmpk.2023.100954","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100954","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"129 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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