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Drug Metabolism and Pharmacokinetics最新文献

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Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers 评估 CACO-2 细胞单层基底膜上 OSTΑ/Β 转运体的活性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100991
Emi Yamaguchi, A. David Rodrigues, Emi Kimoto
{"title":"Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers","authors":"Emi Yamaguchi, A. David Rodrigues, Emi Kimoto","doi":"10.1016/j.dmpk.2023.100991","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100991","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a renal OCT2/Mate biomarker (N1-methylnicotinamide) to enable the early clinical assessment of metformin drug interaction potential 利用肾脏 OCT2/Mate 生物标记物（N1-甲基烟酰胺）对二甲双胍药物相互作用潜力进行早期临床评估
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100985
Sumathy Mathialagan, A. David Rodrigues
{"title":"Use of a renal OCT2/Mate biomarker (N1-methylnicotinamide) to enable the early clinical assessment of metformin drug interaction potential","authors":"Sumathy Mathialagan, A. David Rodrigues","doi":"10.1016/j.dmpk.2023.100985","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100985","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilization of target engagement in tissues measured by immunoaffinity LC-MS/MS for PBPK modeling of monoclonal antibody 利用免疫亲和力 LC-MS/MS 测定的组织中的目标参与度建立单克隆抗体的 PBPK 模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100972
Yutaro Hoshi, Yuki Oda, Junji Komaba, Yoshiyuki Yamaura
{"title":"Utilization of target engagement in tissues measured by immunoaffinity LC-MS/MS for PBPK modeling of monoclonal antibody","authors":"Yutaro Hoshi, Yuki Oda, Junji Komaba, Yoshiyuki Yamaura","doi":"10.1016/j.dmpk.2023.100972","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100972","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS) 利用液相色谱-高分辨质谱法（LC-HRMS）鉴定和定量反义寡核苷酸的代谢物
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100949
Xin Zhang, Khishig Tsogtbaatar, Mai Thayer, Ryan Takahashi
{"title":"Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS)","authors":"Xin Zhang, Khishig Tsogtbaatar, Mai Thayer, Ryan Takahashi","doi":"10.1016/j.dmpk.2023.100949","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100949","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologically based pharmacokinetic modeling of adeno-associated viruses and the transgene product 腺相关病毒和转基因产物的生理学药代动力学建模
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100974
Shufang Liu, Ekram Chowdhury, Guy Meno-Tetang, Dhaval Shah
{"title":"Physiologically based pharmacokinetic modeling of adeno-associated viruses and the transgene product","authors":"Shufang Liu, Ekram Chowdhury, Guy Meno-Tetang, Dhaval Shah","doi":"10.1016/j.dmpk.2023.100974","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100974","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in PBPK modeling of phenolic drugs extensively metabolized by intestinal phase II enzyme 酚类药物经肠道二期酶广泛代谢的 PBPK 建模难题
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100977
Rashim Singh, Ming Hu, Lu Wang, Yifan Tu
{"title":"Challenges in PBPK modeling of phenolic drugs extensively metabolized by intestinal phase II enzyme","authors":"Rashim Singh, Ming Hu, Lu Wang, Yifan Tu","doi":"10.1016/j.dmpk.2023.100977","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100977","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating cross-species differences of MDR1-mediated drug transport 调查 MDR1 介导的药物转运的跨物种差异
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100983
Csilla Temesszentandrasi-Ambrus, Krisztina Heredi-Szabo, Emoke Soskuti, Nora Szilvasy, Emese Kis, Zsuzsanna Gaborik
{"title":"Investigating cross-species differences of MDR1-mediated drug transport","authors":"Csilla Temesszentandrasi-Ambrus, Krisztina Heredi-Szabo, Emoke Soskuti, Nora Szilvasy, Emese Kis, Zsuzsanna Gaborik","doi":"10.1016/j.dmpk.2023.100983","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100983","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation 通过微生物生物转化合成棘白类药物雷沙芬净的人体代谢物并确定其特征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100942
Julia Shanu-Wilson, Ravi Manohar, Adriana Gomez, Richard Phipps, Jonathan Steele, Stephen Wrigley, Liam Evans, Frank Scheffler
{"title":"Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation","authors":"Julia Shanu-Wilson, Ravi Manohar, Adriana Gomez, Richard Phipps, Jonathan Steele, Stephen Wrigley, Liam Evans, Frank Scheffler","doi":"10.1016/j.dmpk.2023.100942","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100942","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous metabolites change associated with pioglitazone administration in healthy male subjects 健康男性服用吡格列酮后的内源性代谢物变化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100968
Jihyun Kang, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho
{"title":"Endogenous metabolites change associated with pioglitazone administration in healthy male subjects","authors":"Jihyun Kang, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho","doi":"10.1016/j.dmpk.2023.100968","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100968","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials 用定量系统药理学洞察药物开发：利用虚拟临床试验揭示糖尿病肾病高钾血症风险的前瞻性案例研究
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-09 DOI: 10.1016/j.dmpk.2024.101019
Ryuta Saito, Tomohisa Nakada
{"title":"Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials","authors":"Ryuta Saito,&nbsp;Tomohisa Nakada","doi":"10.1016/j.dmpk.2024.101019","DOIUrl":"10.1016/j.dmpk.2024.101019","url":null,"abstract":"<div><p>The quantitative systems pharmacology (QSP) approach is widely applied to address various essential questions in drug discovery and development, such as identification of the mechanism of action of a therapeutic agent, patient stratification, and the mechanistic understanding of the progression of disease. In this review article, we show the current landscape of the application of QSP modeling using a survey of QSP publications over 10 years from 2013 to 2022. We also present a use case for the risk assessment of hyperkalemia in patients with diabetic nephropathy treated with mineralocorticoid receptor antagonists (MRAs, renin-angiotensin-aldosterone system inhibitors), as a prospective simulation of late clinical development. A QSP model for generating virtual patients with diabetic nephropathy was used to quantitatively assess that the nonsteroidal MRAs, finerenone and apararenone, have a lower risk of hyperkalemia than the steroidal MRA, eplerenone. Prospective simulation studies using a QSP model are useful to prioritize pharmaceutical candidates in clinical development and validate mechanism-based pharmacological concepts related to the risk-benefit, before conducting large-scale clinical trials.</p></div>","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1347436724000259/pdfft?md5=a676c8daea72b0c1bd3724cfc4492743&pid=1-s2.0-S1347436724000259-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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