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Drug Metabolism and Pharmacokinetics最新文献

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Development of an in vitro Metabolic Dysfunction-Associated Steatohepatitis (MASH) model to study hepatic transporters 建立体外代谢功能障碍相关脂肪性肝炎（MASH）模型研究肝脏转运体
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101123
Sarina Kyburz , William A. Murphy , Thomas Kralj , John K. Fallon , Jacqueline B. Tiley , Kim L.R. Brouwer
{"title":"Development of an in vitro Metabolic Dysfunction-Associated Steatohepatitis (MASH) model to study hepatic transporters","authors":"Sarina Kyburz , William A. Murphy , Thomas Kralj , John K. Fallon , Jacqueline B. Tiley , Kim L.R. Brouwer","doi":"10.1016/j.dmpk.2025.101123","DOIUrl":"10.1016/j.dmpk.2025.101123","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101123"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and qualification of an in vitro assay to determine target mediated internalization of TREM2 receptor specific antibodies for TMDD assessment 开发和鉴定用于TMDD评估的TREM2受体特异性抗体靶介导内化的体外测定方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101134
Thomas Kraft , Anna-Lena Bolender , Aman Padamsey , Erich Koller , Markus Britschgi , Jens Niewoehner , Hans Peter Grimm
{"title":"Development and qualification of an in vitro assay to determine target mediated internalization of TREM2 receptor specific antibodies for TMDD assessment","authors":"Thomas Kraft , Anna-Lena Bolender , Aman Padamsey , Erich Koller , Markus Britschgi , Jens Niewoehner , Hans Peter Grimm","doi":"10.1016/j.dmpk.2025.101134","DOIUrl":"10.1016/j.dmpk.2025.101134","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101134"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation for biotransformation of antibody-peptide conjugates using native mass spectrometry 利用天然质谱法评价抗体-肽偶联物的生物转化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101135
Hiraku Hagita, Sahana Iwamura, Tomoki Suzuki, Kenichi Sasahara, Keisuke Maki, Yosuke Kaneko
{"title":"Evaluation for biotransformation of antibody-peptide conjugates using native mass spectrometry","authors":"Hiraku Hagita, Sahana Iwamura, Tomoki Suzuki, Kenichi Sasahara, Keisuke Maki, Yosuke Kaneko","doi":"10.1016/j.dmpk.2025.101135","DOIUrl":"10.1016/j.dmpk.2025.101135","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101135"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do i build an ‘Ideal’ PBPK model if my drug is either a substrate or inducer 如果我的药物是底物或诱导剂，我如何建立一个“理想的”PBPK模型
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101061
Ryuta Asaumi
{"title":"How do i build an ‘Ideal’ PBPK model if my drug is either a substrate or inducer","authors":"Ryuta Asaumi","doi":"10.1016/j.dmpk.2025.101061","DOIUrl":"10.1016/j.dmpk.2025.101061","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101061"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel mechanisms of drug-metabolizing hydrolases regulating the toxicity caused by reactive metabolites 药物代谢水解酶调节活性代谢物毒性的新机制
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101066
Tatsuki Fukami
{"title":"Novel mechanisms of drug-metabolizing hydrolases regulating the toxicity caused by reactive metabolites","authors":"Tatsuki Fukami","doi":"10.1016/j.dmpk.2025.101066","DOIUrl":"10.1016/j.dmpk.2025.101066","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101066"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotyping assay using genetically manipulated human IPS cell-derived hepatocyte- like cells 利用基因操纵的人IPS细胞衍生的肝细胞样细胞进行表型分析
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101102
Hiroyuki Mizuguchi
{"title":"Phenotyping assay using genetically manipulated human IPS cell-derived hepatocyte- like cells","authors":"Hiroyuki Mizuguchi","doi":"10.1016/j.dmpk.2025.101102","DOIUrl":"10.1016/j.dmpk.2025.101102","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101102"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioanlaysis, biotransformation and pharmacokinetics of antibody-drug conjugate 抗体-药物偶联物的生物分析、生物转化和药代动力学
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101074
Yuki Kishino
{"title":"Bioanlaysis, biotransformation and pharmacokinetics of antibody-drug conjugate","authors":"Yuki Kishino","doi":"10.1016/j.dmpk.2025.101074","DOIUrl":"10.1016/j.dmpk.2025.101074","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101074"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Botanical-drug interactions: Blazing the trail using translational tools 植物-药物相互作用：利用翻译工具开辟道路
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101116
Mary Paine
{"title":"Botanical-drug interactions: Blazing the trail using translational tools","authors":"Mary Paine","doi":"10.1016/j.dmpk.2025.101116","DOIUrl":"10.1016/j.dmpk.2025.101116","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101116"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery, validation, and application of transporter endogenous biomarkers: A work of translation 转运体内源性生物标志物的发现、验证和应用：翻译工作
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101093
Hong Shen
{"title":"Discovery, validation, and application of transporter endogenous biomarkers: A work of translation","authors":"Hong Shen","doi":"10.1016/j.dmpk.2025.101093","DOIUrl":"10.1016/j.dmpk.2025.101093","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101093"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selection of liver models of hepatic drug clearance: Improvements and implications for ivive and PBPK modeling 肝脏药物清除模型的选择：活体和PBPK模型的改进和意义
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101148
K. Sandy Pang, Weijia Ivy Lu, Gerard Mulder
{"title":"Selection of liver models of hepatic drug clearance: Improvements and implications for ivive and PBPK modeling","authors":"K. Sandy Pang, Weijia Ivy Lu, Gerard Mulder","doi":"10.1016/j.dmpk.2025.101148","DOIUrl":"10.1016/j.dmpk.2025.101148","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101148"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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