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Drug Metabolism and Pharmacokinetics最新文献

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Exploring the human 3D small intestinal model (epiintestinaltm) for improved prediction of oral absorption, metabolism and complex drug-drug interactions of small molecule drugs 探索人体三维小肠模型（epiintestinaltm），以改进小分子药物的口服吸收、代谢和复杂的药物相互作用预测
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100908
Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad, Diane Ramsden
{"title":"Exploring the human 3D small intestinal model (epiintestinaltm) for improved prediction of oral absorption, metabolism and complex drug-drug interactions of small molecule drugs","authors":"Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad, Diane Ramsden","doi":"10.1016/j.dmpk.2023.100908","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100908","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma protein binding in special populations: do current PBPK models correctly account for potential changes to fraction unbound? 特殊人群的血浆蛋白结合：当前的 PBPK 模型是否正确地考虑了未结合部分的潜在变化？
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100976
Jokha Al-Qassabi, Shawn Tan, Aleksandra Galetin, Amin Rostami-Hodjegan, Daniel Scotcher
{"title":"Plasma protein binding in special populations: do current PBPK models correctly account for potential changes to fraction unbound?","authors":"Jokha Al-Qassabi, Shawn Tan, Aleksandra Galetin, Amin Rostami-Hodjegan, Daniel Scotcher","doi":"10.1016/j.dmpk.2023.100976","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100976","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding CYP3A4 and P-GP mediated drug-drug interactions through PBPK modeling - case example of pralsetinib 通过 PBPK 建模了解 CYP3A4 和 P-GP 介导的药物间相互作用--普拉塞替尼案例
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100969
Christine Bowman, Michael Dolton, Fang Ma, Sravanthi Cheeti, Denison Kuruvilla, Rucha Sane, Nastya Kassir, Yuan Chen
{"title":"Understanding CYP3A4 and P-GP mediated drug-drug interactions through PBPK modeling - case example of pralsetinib","authors":"Christine Bowman, Michael Dolton, Fang Ma, Sravanthi Cheeti, Denison Kuruvilla, Rucha Sane, Nastya Kassir, Yuan Chen","doi":"10.1016/j.dmpk.2023.100969","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100969","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for DDI risk assessment between novel oncology agents and combination generic standard of care (SOC) agents 新型肿瘤药物与普通标准疗法 (SOC) 联合用药之间的 DDI 风险评估策略
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100945
Ravi Visswanathan, Elaine Tseng, Loretta Cox, Julie Cianfrogna, R. Scott Obach, Rhys Jones
{"title":"Strategies for DDI risk assessment between novel oncology agents and combination generic standard of care (SOC) agents","authors":"Ravi Visswanathan, Elaine Tseng, Loretta Cox, Julie Cianfrogna, R. Scott Obach, Rhys Jones","doi":"10.1016/j.dmpk.2023.100945","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100945","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes 蛋白质降解剂巴夫地加鲁胺和 XL01126 在透化低温保存的人肝细胞中的生物转化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100934
Bin Ma, Susan Wong, Joyce Liu, Jingwei Cai, Cyrus Khojasteh, Donglu Zhang
{"title":"Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes","authors":"Bin Ma, Susan Wong, Joyce Liu, Jingwei Cai, Cyrus Khojasteh, Donglu Zhang","doi":"10.1016/j.dmpk.2023.100934","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100934","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tenofovir activation is diminished in the brain and liver of creatine kinase brain-type knockout mice 脑型肌酸激酶基因敲除小鼠的大脑和肝脏中替诺福韦的激活作用减弱
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100956
Colten Eberhard, Benjamin Orsburn, Namandjé Bumpus
{"title":"Tenofovir activation is diminished in the brain and liver of creatine kinase brain-type knockout mice","authors":"Colten Eberhard, Benjamin Orsburn, Namandjé Bumpus","doi":"10.1016/j.dmpk.2023.100956","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100956","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis 局部生物活性草药成分通过维持肠道氧化应激平衡预防伊立替康诱导的肠道毒性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100892
Vesna Tumbas Saponjac, Rongjin Sun, Zicong Zheng, Jie Chen, Songpol Srinual, Ming Hu, Rashim Singh
{"title":"Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis","authors":"Vesna Tumbas Saponjac, Rongjin Sun, Zicong Zheng, Jie Chen, Songpol Srinual, Ming Hu, Rashim Singh","doi":"10.1016/j.dmpk.2023.100892","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100892","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice 暴露于混合微塑料颗粒会改变小鼠的粪便微生物群及其相关的预测功能途径
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100928
Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero
{"title":"Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice","authors":"Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero","doi":"10.1016/j.dmpk.2023.100928","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100928","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase 厄洛替尼作为基于机制的人类醛氧化酶强效失活剂的鉴定和表征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100952
Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith
{"title":"Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase","authors":"Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith","doi":"10.1016/j.dmpk.2023.100952","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100952","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment and characterization of an in vitro model for NTCP substrate and inhibition assessment 建立并鉴定用于评估 NTCP 底物和抑制作用的体外模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100982
Tao Xiong, Yuxi Wang, Xuan Zhang, Xiangling Wang, Hong Zhang, Weiqun Cao, Yi Tao, Liang Shen, Genfu Chen
{"title":"Establishment and characterization of an in vitro model for NTCP substrate and inhibition assessment","authors":"Tao Xiong, Yuxi Wang, Xuan Zhang, Xiangling Wang, Hong Zhang, Weiqun Cao, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100982","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100982","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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