Drug Metabolism and Pharmacokinetics最新文献_第3页

Gastrointestinal imaging with MRI: Insights into the behavior of dosage forms and the conditions at the site of drug release 胃肠道成像与MRI：洞察剂量形式的行为和药物释放部位的条件

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101069

Werner Weitschies

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Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor, a master regulator of drug-metabolizing and gluconeogenesis enzymes 人醛酮还原酶（AKR） 1C1和1C2是孕激素X受体的共激活因子，是药物代谢和糖异生酶的主要调节因子

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101481

Rei Mitamura , Seiya Takemoto , Yuka Aoyama , Koki Morita , Yuichiro Higuchi , Shotaro Uehara , Nao Yoneda , Hiroshi Suemizu , Tatsuki Fukami , Masataka Nakano , Miki Nakajima

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引用次数: 0

Advances in enabling IVIVE and enzyme phenotyping of low clearance compounds 低清除率化合物的激活IVIVE和酶表型研究进展

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101103

Mitesh Patel

引用次数: 0

Enhanced effect of ionic liquid on intestinal absorption of macromolecules (< 10 kDa) 离子液体对肠道大分子（< 10 kDa）吸收的促进作用

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101137

Shoichiro Fukuda , Haruka Takata , Takashi Nakae , Noboru Tatsumi , Hidetoshi Hamamoto , Hidenori Ando , Tatsuhiro Ishida

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Utilizing PBPK modeling and in vitro data for predicting complex DDIS of OATP1B and CYP substrates caused by various perpetrators 利用PBPK模型和体外数据预测多种作案者引起的OATP1B和CYP底物的复杂DDIS

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101082

Yuichi Sugiyama

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Implementation of blood collection using the Tasso microsampling device to measure thyroid hormone biomarkers 利用Tasso微采样装置采集血液，测量甲状腺激素生物标志物

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101145

Chad Christianson, Brooke Whitson, Jason Watts, Jennifer Zimmer

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Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors 揭示小分子脑渗透EBP抑制剂的靶介导药物处置（TMDD）

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101107

Laurent Salphati

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Model-based meta-analysis of ethnic differences - General changes in clearance by pathways and aging 基于模型的种族差异荟萃分析-清除途径和衰老的一般变化

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101111

Akihiro Hisaka

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Does cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC) induce drug metabolizing enzymes in human hepatocytes? 大麻二酚（CBD）或德尔塔-9-四氢大麻酚（THC）诱导人肝细胞药物代谢酶吗？

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101126

Ankit Balhara, Yik Pui Tsang, Jashvant D. Unadkat

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Assessment of ADME and DDI for LNP-MRNA therapeutics 评估ADME和DDI对LNP-MRNA治疗的影响

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101084

Lei Ci

引用次数: 0