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Drug Metabolism and Pharmacokinetics最新文献

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Enhanced effect of ionic liquid on intestinal absorption of macromolecules (< 10 kDa) 离子液体对肠道大分子（< 10 kDa）吸收的促进作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101137
Shoichiro Fukuda , Haruka Takata , Takashi Nakae , Noboru Tatsumi , Hidetoshi Hamamoto , Hidenori Ando , Tatsuhiro Ishida
{"title":"Enhanced effect of ionic liquid on intestinal absorption of macromolecules (< 10 kDa)","authors":"Shoichiro Fukuda ,&nbsp;Haruka Takata ,&nbsp;Takashi Nakae ,&nbsp;Noboru Tatsumi ,&nbsp;Hidetoshi Hamamoto ,&nbsp;Hidenori Ando ,&nbsp;Tatsuhiro Ishida","doi":"10.1016/j.dmpk.2025.101137","DOIUrl":"10.1016/j.dmpk.2025.101137","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101137"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors 揭示小分子脑渗透EBP抑制剂的靶介导药物处置（TMDD）
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101107
Laurent Salphati
{"title":"Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors","authors":"Laurent Salphati","doi":"10.1016/j.dmpk.2025.101107","DOIUrl":"10.1016/j.dmpk.2025.101107","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101107"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Model-based meta-analysis of ethnic differences - General changes in clearance by pathways and aging 基于模型的种族差异荟萃分析-清除途径和衰老的一般变化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101111
Akihiro Hisaka
{"title":"Model-based meta-analysis of ethnic differences - General changes in clearance by pathways and aging","authors":"Akihiro Hisaka","doi":"10.1016/j.dmpk.2025.101111","DOIUrl":"10.1016/j.dmpk.2025.101111","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101111"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC) induce drug metabolizing enzymes in human hepatocytes? 大麻二酚（CBD）或德尔塔-9-四氢大麻酚（THC）诱导人肝细胞药物代谢酶吗？
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101126
Ankit Balhara, Yik Pui Tsang, Jashvant D. Unadkat
{"title":"Does cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC) induce drug metabolizing enzymes in human hepatocytes?","authors":"Ankit Balhara,&nbsp;Yik Pui Tsang,&nbsp;Jashvant D. Unadkat","doi":"10.1016/j.dmpk.2025.101126","DOIUrl":"10.1016/j.dmpk.2025.101126","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101126"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of blood collection using the Tasso microsampling device to measure thyroid hormone biomarkers 利用Tasso微采样装置采集血液，测量甲状腺激素生物标志物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101145
Chad Christianson, Brooke Whitson, Jason Watts, Jennifer Zimmer
{"title":"Implementation of blood collection using the Tasso microsampling device to measure thyroid hormone biomarkers","authors":"Chad Christianson,&nbsp;Brooke Whitson,&nbsp;Jason Watts,&nbsp;Jennifer Zimmer","doi":"10.1016/j.dmpk.2025.101145","DOIUrl":"10.1016/j.dmpk.2025.101145","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101145"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in enabling IVIVE and enzyme phenotyping of low clearance compounds 低清除率化合物的激活IVIVE和酶表型研究进展
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101103
Mitesh Patel
{"title":"Advances in enabling IVIVE and enzyme phenotyping of low clearance compounds","authors":"Mitesh Patel","doi":"10.1016/j.dmpk.2025.101103","DOIUrl":"10.1016/j.dmpk.2025.101103","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101103"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the mechanism of metronidazole-induced encephalopathy focusing on the possible effect on thiamine transport 甲硝唑致脑病机制的研究重点是对硫胺素运输的可能影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101130
Yoshiaki Yamagishi, Mitsuhiro Hashimoto, Miyuki Sugita, Satomi Watanabe, Nana Sekine, Yuki Takahashi, Yasuko Ogawa, Toshiyuki Kudo, Kiyomi Ito
{"title":"Investigation of the mechanism of metronidazole-induced encephalopathy focusing on the possible effect on thiamine transport","authors":"Yoshiaki Yamagishi,&nbsp;Mitsuhiro Hashimoto,&nbsp;Miyuki Sugita,&nbsp;Satomi Watanabe,&nbsp;Nana Sekine,&nbsp;Yuki Takahashi,&nbsp;Yasuko Ogawa,&nbsp;Toshiyuki Kudo,&nbsp;Kiyomi Ito","doi":"10.1016/j.dmpk.2025.101130","DOIUrl":"10.1016/j.dmpk.2025.101130","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101130"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling 通过PBPK模型整合肠道生理学和药物代谢、处置和相互作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101072
Bhagwat Prasad
{"title":"Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling","authors":"Bhagwat Prasad","doi":"10.1016/j.dmpk.2025.101072","DOIUrl":"10.1016/j.dmpk.2025.101072","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101072"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro study of payload release of an anti-TNF glucocorticoid receptor modulator immunology antibody-drug conjugate (ADC-T) and payload metabolism 抗肿瘤坏死因子糖皮质激素受体调节剂免疫抗体-药物偶联物（ADC-T）和有效载荷代谢的体外研究
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101132
Mingshe Zhu , Zhiqiang Li , Chongzhuang Tang , Yang Gao , Lijuan Chen , Xingxing Diao
{"title":"In vitro study of payload release of an anti-TNF glucocorticoid receptor modulator immunology antibody-drug conjugate (ADC-T) and payload metabolism","authors":"Mingshe Zhu ,&nbsp;Zhiqiang Li ,&nbsp;Chongzhuang Tang ,&nbsp;Yang Gao ,&nbsp;Lijuan Chen ,&nbsp;Xingxing Diao","doi":"10.1016/j.dmpk.2025.101132","DOIUrl":"10.1016/j.dmpk.2025.101132","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101132"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of PF-07817883, a second-generation oral SARS-CoV2 main protease inhibitor 第二代口服SARS-CoV2主要蛋白酶抑制剂PF-07817883的发现
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101106
Amit Kalgutkar
{"title":"Discovery of PF-07817883, a second-generation oral SARS-CoV2 main protease inhibitor","authors":"Amit Kalgutkar","doi":"10.1016/j.dmpk.2025.101106","DOIUrl":"10.1016/j.dmpk.2025.101106","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101106"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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