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Drug Metabolism and Pharmacokinetics最新文献

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Identifying accurate metabolism sites of vepdegestrant using novel electron-activated dissociation high-resolution mass spectrometry 利用新型电子激活解离高分辨质谱法确定维替孕甾的准确代谢位点
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100950
Yifei He, Pengyi Hou, Zhimin Long, Yuadong Zheng, Chongzhuang Tang, Elliott Jones, Xingxing Diao, Mingshe Zhu
{"title":"Identifying accurate metabolism sites of vepdegestrant using novel electron-activated dissociation high-resolution mass spectrometry","authors":"Yifei He, Pengyi Hou, Zhimin Long, Yuadong Zheng, Chongzhuang Tang, Elliott Jones, Xingxing Diao, Mingshe Zhu","doi":"10.1016/j.dmpk.2023.100950","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100950","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologically based pharmacokinetic model for miltefosine in mice 基于生理学的小鼠米替福新药代动力学模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100975
Bhargavi Srija Ramisetty, Sihyung Yang, Michael Zhuo Wang
{"title":"Physiologically based pharmacokinetic model for miltefosine in mice","authors":"Bhargavi Srija Ramisetty, Sihyung Yang, Michael Zhuo Wang","doi":"10.1016/j.dmpk.2023.100975","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100975","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of plasma stability assay for oligonucleotides 开发寡核苷酸血浆稳定性检测方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100948
Xiangling Wang, Haijuan Liu, Yilin Wei, Jie Wang, Nan Zhao, Yi Tao, Liang Shen, Genfu Chen
{"title":"Development of plasma stability assay for oligonucleotides","authors":"Xiangling Wang, Haijuan Liu, Yilin Wei, Jie Wang, Nan Zhao, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100948","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100948","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling 利用伽马分布延迟模型，通过预测药代动力学-药效学模型评估多柔比星包封聚合物胶束的抗癌效果
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100961
Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama
{"title":"An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling","authors":"Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama","doi":"10.1016/j.dmpk.2023.100961","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100961","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption 验证基于生理学的咖啡因药代动力学模型，该模型纳入了吸收机理描述指标
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100963
Jessica Rehmel, Maria Posada
{"title":"Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption","authors":"Jessica Rehmel, Maria Posada","doi":"10.1016/j.dmpk.2023.100963","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100963","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From quantum mechanics to metabolism pathways 从量子力学到新陈代谢途径
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100935
Mario Oeren, Peter Walton, Sylvia Kaempf, James Suri, David Ponting, Peter Hunt, Tamsin Mansley, Matthew Segall
{"title":"From quantum mechanics to metabolism pathways","authors":"Mario Oeren, Peter Walton, Sylvia Kaempf, James Suri, David Ponting, Peter Hunt, Tamsin Mansley, Matthew Segall","doi":"10.1016/j.dmpk.2023.100935","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100935","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel 3D imaging pipeline for analyzing efficacy of compounds on amyloid-beta plaque dynamics in preclinical alzheimer’s disease animal models 用于分析临床前阿尔茨海默病动物模型中化合物对淀粉样蛋白-β斑块动力学疗效的新型三维成像管道
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100958
Gianna Ferron, Stefan Linehan, Tim Ragan, Dylan Garceau, Kevin Elk, Mike Sasner
{"title":"A novel 3D imaging pipeline for analyzing efficacy of compounds on amyloid-beta plaque dynamics in preclinical alzheimer’s disease animal models","authors":"Gianna Ferron, Stefan Linehan, Tim Ragan, Dylan Garceau, Kevin Elk, Mike Sasner","doi":"10.1016/j.dmpk.2023.100958","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100958","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transporter activity characterization in a novel human hepatic cell-based tri-culture system 新型人肝细胞三层培养系统中转运体活性的表征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100986
Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Mitchell Taub
{"title":"Transporter activity characterization in a novel human hepatic cell-based tri-culture system","authors":"Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Mitchell Taub","doi":"10.1016/j.dmpk.2023.100986","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100986","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs 评估糖萼对基本药物分配和分布的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100964
Yifan Gong, Ken Korzekwa, Swati Nagar
{"title":"Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs","authors":"Yifan Gong, Ken Korzekwa, Swati Nagar","doi":"10.1016/j.dmpk.2023.100964","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100964","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes 三维培养的原代人类肝细胞中的 OCT1 转运体动力学和长期调节研究
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100894
Maria Karlgren
{"title":"OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes","authors":"Maria Karlgren","doi":"10.1016/j.dmpk.2023.100894","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100894","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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